Result of FASTA (omim) for
pFN21AE6686
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6686, 282 aa
1>>>pF1KE6686 282 - 282 aa - 282 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5290+/-0.000274; mu= 12.0916+/- 0.017
mean_var=145.6272+/-28.356, 0's: 0 Z-trim(124.0): 98 B-trim: 216 in 1/61
Lambda= 0.106280
statistics sampled from 44581 (44703) to 44581 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.524), width: 16
Scan time: 7.360
The best scores are: opt bits E(85289)
NP_057663 (OMIM: 606475,613646) CD320 antigen isof ( 282) 1952 309.8 3.6e-84
NP_001159367 (OMIM: 606475,613646) CD320 antigen i ( 240) 1315 212.1 8.2e-55
NP_059992 (OMIM: 602600,608446) low-density lipopr ( 700) 399 72.1 3.3e-12
XP_005271232 (OMIM: 602600,608446) PREDICTED: low- ( 834) 399 72.2 3.7e-12
XP_005271231 (OMIM: 602600,608446) PREDICTED: low- ( 847) 399 72.2 3.7e-12
NP_001309155 (OMIM: 192977,224050) very low-densit ( 804) 347 64.2 9.1e-10
NP_001309154 (OMIM: 192977,224050) very low-densit ( 832) 347 64.2 9.3e-10
NP_002323 (OMIM: 107770) prolow-density lipoprotei (4544) 330 62.4 1.8e-08
XP_016874792 (OMIM: 107770) PREDICTED: prolow-dens (4561) 330 62.4 1.8e-08
XP_016859831 (OMIM: 608766) PREDICTED: low-density (2883) 321 60.8 3.5e-08
XP_016859830 (OMIM: 608766) PREDICTED: low-density (4469) 321 61.0 4.7e-08
NP_061027 (OMIM: 608766) low-density lipoprotein r (4599) 321 61.0 4.8e-08
NP_001018066 (OMIM: 192977,224050) very low-densit ( 845) 308 58.3 5.9e-08
NP_003374 (OMIM: 192977,224050) very low-density l ( 873) 308 58.3 6.1e-08
XP_011509486 (OMIM: 222448,600073) PREDICTED: low- (3892) 314 59.8 9e-08
XP_011540398 (OMIM: 602600,608446) PREDICTED: low- ( 762) 303 57.4 9.4e-08
XP_016857755 (OMIM: 602600,608446) PREDICTED: low- ( 842) 303 57.5 1e-07
XP_011509485 (OMIM: 222448,600073) PREDICTED: low- (4612) 314 59.9 1e-07
NP_004516 (OMIM: 222448,600073) low-density lipopr (4655) 314 59.9 1e-07
XP_006710945 (OMIM: 602600,608446) PREDICTED: low- ( 901) 303 57.5 1.1e-07
NP_001018064 (OMIM: 602600,608446) low-density lip ( 904) 303 57.5 1.1e-07
XP_006710944 (OMIM: 602600,608446) PREDICTED: low- ( 917) 303 57.5 1.1e-07
XP_016857754 (OMIM: 602600,608446) PREDICTED: low- ( 921) 303 57.5 1.1e-07
XP_011540396 (OMIM: 602600,608446) PREDICTED: low- ( 934) 303 57.5 1.1e-07
NP_004622 (OMIM: 602600,608446) low-density lipopr ( 963) 303 57.5 1.1e-07
XP_005271230 (OMIM: 602600,608446) PREDICTED: low- ( 976) 303 57.5 1.1e-07
XP_011526312 (OMIM: 143890,606945) PREDICTED: low- ( 834) 298 56.7 1.7e-07
NP_001182727 (OMIM: 143890,606945) low-density lip ( 858) 298 56.7 1.7e-07
NP_000518 (OMIM: 143890,606945) low-density lipopr ( 860) 298 56.7 1.7e-07
XP_011541269 (OMIM: 104300,602005) PREDICTED: sort (1158) 296 56.6 2.6e-07
XP_016873661 (OMIM: 104300,602005) PREDICTED: sort (1334) 296 56.6 2.9e-07
XP_011541267 (OMIM: 104300,602005) PREDICTED: sort (1701) 296 56.7 3.4e-07
XP_016873660 (OMIM: 104300,602005) PREDICTED: sort (1769) 296 56.7 3.5e-07
XP_016873659 (OMIM: 104300,602005) PREDICTED: sort (2039) 296 56.8 3.9e-07
XP_016873658 (OMIM: 104300,602005) PREDICTED: sort (2110) 296 56.8 4e-07
XP_011541265 (OMIM: 104300,602005) PREDICTED: sort (2176) 296 56.8 4.1e-07
NP_003096 (OMIM: 104300,602005) sortilin-related r (2214) 296 56.8 4.1e-07
NP_001316155 (OMIM: 609921) low-density lipoprotei ( 556) 264 51.3 4.8e-06
NP_054764 (OMIM: 609921) low-density lipoprotein r ( 713) 264 51.4 5.7e-06
XP_005267567 (OMIM: 609921) PREDICTED: low-density ( 721) 264 51.4 5.7e-06
NP_002324 (OMIM: 603159) low-density lipoprotein r ( 770) 249 49.2 2.9e-05
XP_005259002 (OMIM: 603159) PREDICTED: low-density ( 785) 249 49.2 3e-05
XP_016873223 (OMIM: 212780,604270,614305,616304) P (1809) 251 49.8 4.3e-05
NP_002325 (OMIM: 212780,604270,614305,616304) low- (1905) 251 49.9 4.4e-05
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 239 47.7 9.1e-05
NP_001182729 (OMIM: 143890,606945) low-density lip ( 692) 228 45.9 0.00025
NP_001182732 (OMIM: 143890,606945) low-density lip ( 682) 221 44.8 0.00053
NP_001182728 (OMIM: 143890,606945) low-density lip ( 819) 205 42.4 0.0033
NP_001265515 (OMIM: 605236,614595) atrial natriure ( 734) 198 41.3 0.0064
NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 199 41.6 0.0074
>>NP_057663 (OMIM: 606475,613646) CD320 antigen isoform (282 aa)
initn: 1952 init1: 1952 opt: 1952 Z-score: 1632.0 bits: 309.8 E(85289): 3.6e-84
Smith-Waterman score: 1952; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282)
10 20 30 40 50 60
pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA
190 200 210 220 230 240
250 260 270 280
pF1KE6 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP
::::::::::::::::::::::::::::::::::::::::::
NP_057 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP
250 260 270 280
>>NP_001159367 (OMIM: 606475,613646) CD320 antigen isofo (240 aa)
initn: 1609 init1: 1315 opt: 1315 Z-score: 1105.1 bits: 212.1 E(85289): 8.2e-55
Smith-Waterman score: 1529; 85.1% identity (85.1% similar) in 282 aa overlap (1-282:1-240)
10 20 30 40 50 60
pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAG------------
10 20 30 40
70 80 90 100 110 120
pF1KE6 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGT
::::::::::::::::::::::::::::::
NP_001 ------------------------------IEPCTQKGQCPPPPGLPCPCTGVSDCSGGT
50 60 70
130 140 150 160 170 180
pF1KE6 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT
80 90 100 110 120 130
190 200 210 220 230 240
pF1KE6 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA
140 150 160 170 180 190
250 260 270 280
pF1KE6 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP
::::::::::::::::::::::::::::::::::::::::::
NP_001 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP
200 210 220 230 240
>>NP_059992 (OMIM: 602600,608446) low-density lipoprotei (700 aa)
initn: 398 init1: 143 opt: 399 Z-score: 340.2 bits: 72.1 E(85289): 3.3e-12
Smith-Waterman score: 399; 37.7% identity (57.9% similar) in 183 aa overlap (6-182:3-178)
10 20 30 40 50
pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLG--LEAAASPLSTPTSAQAAGPSSGSCPPTK
. . : : :: : ::::: : : :::.:: ..: ::.. .: .
NP_059 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPL---LGGQ--GPAK-DCEKDQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-QCPPPPGLPC--PCTGVSD
::::. :.: .::::.: :: : :::..: . :... : . : : .
NP_059 FQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 CSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILP
: :.:.. .:.. .: : .: : : :.: .:::::. :: ..:: ::.:.
NP_059 CPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTC
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 EGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAA
.:: :
NP_059 RGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFE
180 190 200 210 220 230
>>XP_005271232 (OMIM: 602600,608446) PREDICTED: low-dens (834 aa)
initn: 398 init1: 143 opt: 399 Z-score: 339.3 bits: 72.2 E(85289): 3.7e-12
Smith-Waterman score: 399; 37.7% identity (57.9% similar) in 183 aa overlap (6-182:3-178)
10 20 30 40 50
pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLG--LEAAASPLSTPTSAQAAGPSSGSCPPTK
. . : : :: : ::::: : : :::.:: ..: ::.. .: .
XP_005 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPL---LGGQ--GPAK-DCEKDQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-QCPPPPGLPC--PCTGVSD
::::. :.: .::::.: :: : :::..: . :... : . : : .
XP_005 FQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 CSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILP
: :.:.. .:.. .: : .: : : :.: .:::::. :: ..:: ::.:.
XP_005 CPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTC
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 EGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAA
.:: :
XP_005 RGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFE
180 190 200 210 220 230
>>XP_005271231 (OMIM: 602600,608446) PREDICTED: low-dens (847 aa)
initn: 398 init1: 143 opt: 399 Z-score: 339.2 bits: 72.2 E(85289): 3.7e-12
Smith-Waterman score: 399; 37.7% identity (57.9% similar) in 183 aa overlap (6-182:3-178)
10 20 30 40 50
pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLG--LEAAASPLSTPTSAQAAGPSSGSCPPTK
. . : : :: : ::::: : : :::.:: ..: ::.. .: .
XP_005 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPL---LGGQ--GPAK-DCEKDQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-QCPPPPGLPC--PCTGVSD
::::. :.: .::::.: :: : :::..: . :... : . : : .
XP_005 FQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 CSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILP
: :.:.. .:.. .: : .: : : :.: .:::::. :: ..:: ::.:.
XP_005 CPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTC
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 EGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAA
.:: :
XP_005 RGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQVPPTFLGNRRRPRGLNECLHNNGG
180 190 200 210 220 230
>>NP_001309155 (OMIM: 192977,224050) very low-density li (804 aa)
initn: 430 init1: 133 opt: 347 Z-score: 296.4 bits: 64.2 E(85289): 9.1e-10
Smith-Waterman score: 348; 40.7% identity (61.9% similar) in 118 aa overlap (56-167:35-147)
30 40 50 60 70 80
pF1KE6 GLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSD
:..::: :.: :. : :.:: : :: ::::
NP_001 ALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSD
10 20 30 40 50 60
90 100 110 120 130
pF1KE6 EEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRC
:..: . :... ::: : : : :: :.:.. ..: ..: :. :
NP_001 EKNCVKKTCAESDFVCNNGQCVPSRW---KCDGDPDCEDGSDESPEQCRNITCSPDEFTC
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE6 TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTM
. : :: .. :.:. :: :.:::: :
NP_001 S-SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSD
130 140 150 160 170
>>NP_001309154 (OMIM: 192977,224050) very low-density li (832 aa)
initn: 430 init1: 133 opt: 347 Z-score: 296.2 bits: 64.2 E(85289): 9.3e-10
Smith-Waterman score: 348; 40.7% identity (61.9% similar) in 118 aa overlap (56-167:35-147)
30 40 50 60 70 80
pF1KE6 GLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSD
:..::: :.: :. : :.:: : :: ::::
NP_001 ALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSD
10 20 30 40 50 60
90 100 110 120 130
pF1KE6 EEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRC
:..: . :... ::: : : : :: :.:.. ..: ..: :. :
NP_001 EKNCVKKTCAESDFVCNNGQCVPSRW---KCDGDPDCEDGSDESPEQCRNITCSPDEFTC
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE6 TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTM
. : :: .. :.:. :: :.:::: :
NP_001 S-SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSD
130 140 150 160 170
>>NP_002323 (OMIM: 107770) prolow-density lipoprotein re (4544 aa)
initn: 363 init1: 202 opt: 330 Z-score: 272.9 bits: 62.4 E(85289): 1.8e-08
Smith-Waterman score: 344; 40.5% identity (58.7% similar) in 121 aa overlap (55-167:978-1097)
30 40 50 60 70 80
pF1KE6 LGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGS
: :.: : ..: :. ..:::: : ::.:.:
NP_002 CIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTC-NNGRCININWRCDNDNDCGDNS
950 960 970 980 990 1000
90 100 110 120 130
pF1KE6 DEEECRIEPCTQKGQCPPPPGLPC--PCTGVSDCSGGTDKKLRNCSRLA------CLAGE
:: : . . .: .: : : .::. .:. ::. : : . :
NP_002 DEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDE
1010 1020 1030 1040 1050 1060
140 150 160 170 180 190
pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNA
..: :. :::: ::::: :: ::::: .:
NP_002 FQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCD
1070 1080 1090 1100 1110 1120
200 210 220 230 240 250
pF1KE6 TTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQ
NP_002 GDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCS
1130 1140 1150 1160 1170 1180
>--
initn: 439 init1: 175 opt: 322 Z-score: 266.3 bits: 61.1 E(85289): 4.3e-08
Smith-Waterman score: 360; 41.5% identity (61.8% similar) in 123 aa overlap (53-169:3535-3649)
30 40 50 60 70 80
pF1KE6 LLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSD
.: : .:.:... ::: :.:: : ::.:
NP_002 GRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNR-CVPGRWQCDYDNDCGD
3510 3520 3530 3540 3550 3560
90 100 110 120 130
pF1KE6 GSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGE
.:::: : .::... :.: : : ::. :.:.: .:. : .
NP_002 NSDEESCTPRPCSESEFSCANGRCIAGRW---KCDGDHDCADGSDEK--DCTP-RCDMDQ
3570 3580 3590 3600 3610
140 150 160 170 180 190
pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNA
..: : :::: ::::. :: :.::: .:::
NP_002 FQCK-SGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGE
3620 3630 3640 3650 3660 3670
200 210 220 230 240 250
pF1KE6 TTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQ
NP_002 DDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTA
3680 3690 3700 3710 3720 3730
>--
initn: 332 init1: 175 opt: 322 Z-score: 266.3 bits: 61.1 E(85289): 4.3e-08
Smith-Waterman score: 323; 37.4% identity (63.4% similar) in 131 aa overlap (54-171:3374-3498)
30 40 50 60 70 80
pF1KE6 LLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDG
: : .::: : :.:. .. :: : ::.:.
NP_002 DKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCST-GICTNPAFICDGDNDCQDN
3350 3360 3370 3380 3390 3400
90 100 110 120 130
pF1KE6 SDEEECRIE---P----CTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGE
::: .: :. : ::. ..: : :. :.: ..:. : :. :.: ...: ..
NP_002 SDEANCDIHVCLPSQFKCTNTNRCIP--GI-FRCNGQDNCGDGEDE--RDCPEVTCAPNQ
3410 3420 3430 3440 3450
140 150 160 170 180 190
pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDE------LGCGTNEILPEGDATTMGPPVTLESV
..:... ::: .: :: :: :.::: . ::..:
NP_002 FQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGE
3460 3470 3480 3490 3500 3510
200 210 220 230 240 250
pF1KE6 TSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLL
NP_002 DDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE
3520 3530 3540 3550 3560 3570
>--
initn: 309 init1: 160 opt: 280 Z-score: 231.5 bits: 54.7 E(85289): 3.7e-06
Smith-Waterman score: 301; 34.1% identity (52.3% similar) in 132 aa overlap (48-170:2690-2815)
20 30 40 50 60 70
pF1KE6 GLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRD
: . :: . : : :: :.:..: ::..
NP_002 CERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFAC-PSGRCIPMSWTCDKE
2660 2670 2680 2690 2700 2710
80 90 100 110 120 130
pF1KE6 LDCSDGSDEEECRIEPCT------QKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLA
:: : :: .: . :. :. .: : : : .::. :.:. .: .
NP_002 DDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWL---CDGSDDCGDGSDEAA-HCEGKT
2720 2730 2740 2750 2760 2770
140 150 160 170 180
pF1KE6 CLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE---LGCGTNEILPEGDATTMGPPVTLE
: . . : . :.: : ::: :: :..:: :: :
NP_002 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPK
2780 2790 2800 2810 2820 2830
190 200 210 220 230 240
pF1KE6 SVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLL
NP_002 HFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPK
2840 2850 2860 2870 2880 2890
>--
initn: 284 init1: 154 opt: 237 Z-score: 195.8 bits: 48.1 E(85289): 0.00036
Smith-Waterman score: 237; 35.5% identity (50.0% similar) in 138 aa overlap (37-158:11-133)
10 20 30 40 50 60
pF1KE6 AQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGL
:: . : :: . .: : .: :: .
NP_002 MLTPPLLLLLPLLSALVA-AAIDAPKTCSPKQFACRDQIT
10 20 30
70 80 90 100 110
pF1KE6 CVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPP----GLP-C-P----CTGVSDC
:. :::: . :: ::::: .: : .. .: : : : : :.::.::
NP_002 CISKGWRCDGERDCPDGSDEAP-EICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDC
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE6 SGGTD-----KKLR-NCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTN
:.: ..:. :::::.: . :.: :: : :
NP_002 MDGSDEGPHCRELQGNCSRLGC---------QHHCVPTL---DG-PTCYCNSSFQLQADG
100 110 120 130 140
180 190 200 210 220 230
pF1KE6 EILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYG
NP_002 KTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIAN
150 160 170 180 190 200
>>XP_016874792 (OMIM: 107770) PREDICTED: prolow-density (4561 aa)
initn: 470 init1: 202 opt: 330 Z-score: 272.9 bits: 62.4 E(85289): 1.8e-08
Smith-Waterman score: 334; 34.9% identity (52.1% similar) in 169 aa overlap (43-188:1069-1230)
20 30 40 50 60 70
pF1KE6 RTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTW
. ::. : :.: .:::: .:::.:: :
XP_016 CNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPP-GGCHTDEFQCRLDGLCIPLRW
1040 1050 1060 1070 1080 1090
80 90 100 110 120
pF1KE6 RCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCP-----------CTGVSDCSGGTD
::: : :: :.:::. : : :. : : . : : : .:: ..:
XP_016 RCDGDTDCMDSSDEKSC--EGVTH--VCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSD
1100 1110 1120 1130 1140 1150
130 140 150 160
pF1KE6 KKLRNCSRLACLAGELRCTLSDD-CIPLTWRCDGHPDCPDSSDEL-----------GCGT
.. :: ::: :. . . :.: :::. :: :.::: ::.
XP_016 EE--NCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSH
1160 1170 1180 1190 1200 1210
170 180 190 200 210 220
pF1KE6 NEILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAY
: . :.. . . :. .:
XP_016 NCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVL
1220 1230 1240 1250 1260 1270
>--
initn: 439 init1: 175 opt: 322 Z-score: 266.3 bits: 61.1 E(85289): 4.3e-08
Smith-Waterman score: 360; 41.5% identity (61.8% similar) in 123 aa overlap (53-169:3552-3666)
30 40 50 60 70 80
pF1KE6 LLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSD
.: : .:.:... ::: :.:: : ::.:
XP_016 GRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNR-CVPGRWQCDYDNDCGD
3530 3540 3550 3560 3570 3580
90 100 110 120 130
pF1KE6 GSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGE
.:::: : .::... :.: : : ::. :.:.: .:. : .
XP_016 NSDEESCTPRPCSESEFSCANGRCIAGRW---KCDGDHDCADGSDEK--DCTP-RCDMDQ
3590 3600 3610 3620 3630
140 150 160 170 180 190
pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNA
..: : :::: ::::. :: :.::: .:::
XP_016 FQCK-SGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGE
3640 3650 3660 3670 3680 3690
200 210 220 230 240 250
pF1KE6 TTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQ
XP_016 DDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTA
3700 3710 3720 3730 3740 3750
>--
initn: 332 init1: 175 opt: 322 Z-score: 266.3 bits: 61.1 E(85289): 4.3e-08
Smith-Waterman score: 323; 37.4% identity (63.4% similar) in 131 aa overlap (54-171:3391-3515)
30 40 50 60 70 80
pF1KE6 LLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDG
: : .::: : :.:. .. :: : ::.:.
XP_016 DKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCST-GICTNPAFICDGDNDCQDN
3370 3380 3390 3400 3410
90 100 110 120 130
pF1KE6 SDEEECRIE---P----CTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGE
::: .: :. : ::. ..: : :. :.: ..:. : :. :.: ...: ..
XP_016 SDEANCDIHVCLPSQFKCTNTNRCIP--GI-FRCNGQDNCGDGEDE--RDCPEVTCAPNQ
3420 3430 3440 3450 3460 3470
140 150 160 170 180 190
pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDE------LGCGTNEILPEGDATTMGPPVTLESV
..:... ::: .: :: :: :.::: . ::..:
XP_016 FQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGE
3480 3490 3500 3510 3520 3530
200 210 220 230 240 250
pF1KE6 TSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLL
XP_016 DDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE
3540 3550 3560 3570 3580 3590
>--
initn: 309 init1: 160 opt: 280 Z-score: 231.5 bits: 54.7 E(85289): 3.7e-06
Smith-Waterman score: 301; 34.1% identity (52.3% similar) in 132 aa overlap (48-170:2707-2832)
20 30 40 50 60 70
pF1KE6 GLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRD
: . :: . : : :: :.:..: ::..
XP_016 CERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFAC-PSGRCIPMSWTCDKE
2680 2690 2700 2710 2720 2730
80 90 100 110 120 130
pF1KE6 LDCSDGSDEEECRIEPCT------QKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLA
:: : :: .: . :. :. .: : : : .::. :.:. .: .
XP_016 DDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWL---CDGSDDCGDGSDEAA-HCEGKT
2740 2750 2760 2770 2780 2790
140 150 160 170 180
pF1KE6 CLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE---LGCGTNEILPEGDATTMGPPVTLE
: . . : . :.: : ::: :: :..:: :: :
XP_016 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPK
2800 2810 2820 2830 2840 2850
190 200 210 220 230 240
pF1KE6 SVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLL
XP_016 HFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPK
2860 2870 2880 2890 2900 2910
>--
initn: 346 init1: 154 opt: 237 Z-score: 195.8 bits: 48.1 E(85289): 0.00036
Smith-Waterman score: 237; 35.5% identity (50.0% similar) in 138 aa overlap (37-158:11-133)
10 20 30 40 50 60
pF1KE6 AQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGL
:: . : :: . .: : .: :: .
XP_016 MLTPPLLLLLPLLSALVA-AAIDAPKTCSPKQFACRDQIT
10 20 30
70 80 90 100 110
pF1KE6 CVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPP----GLP-C-P----CTGVSDC
:. :::: . :: ::::: .: : .. .: : : : : :.::.::
XP_016 CISKGWRCDGERDCPDGSDEAP-EICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDC
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE6 SGGTD-----KKLR-NCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTN
:.: ..:. :::::.: . :.: :: : :
XP_016 MDGSDEGPHCRELQGNCSRLGC---------QHHCVPTL---DG-PTCYCNSSFQLQADG
100 110 120 130 140
180 190 200 210 220 230
pF1KE6 EILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYG
XP_016 KTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIAN
150 160 170 180 190 200
>>XP_016859831 (OMIM: 608766) PREDICTED: low-density lip (2883 aa)
initn: 808 init1: 212 opt: 321 Z-score: 267.9 bits: 60.8 E(85289): 3.5e-08
Smith-Waterman score: 346; 38.8% identity (62.8% similar) in 129 aa overlap (53-175:1600-1723)
30 40 50 60 70 80
pF1KE6 LLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSD
.: ..:.:.:. :.:. :.:: ::.:
XP_016 HLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDK-CIPFWWKCDTVDDCGD
1570 1580 1590 1600 1610 1620
90 100 110 120 130
pF1KE6 GSDE-EECRIEPCTQKGQCPPPPGLPC--P---CTGVSDCSGGTDKKLRNCSRLACLAGE
:::: ..: : : :. :: : : : : .::. ..:. ::. .::.:.
XP_016 GSDEPDDCPEFRC-QPGRFQCGTGL-CALPAFICDGENDCGDNSDE--LNCDTHVCLSGQ
1630 1640 1650 1660 1670 1680
140 150 160 170 180 190
pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNA
..:: .. :::.. ::.:. :: : :: : : :.
XP_016 FKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDP
1690 1700 1710 1720 1730 1740
200 210 220 230 240 250
pF1KE6 TTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQ
XP_016 DCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDF
1750 1760 1770 1780 1790 1800
>--
initn: 808 init1: 212 opt: 321 Z-score: 267.9 bits: 60.8 E(85289): 3.5e-08
Smith-Waterman score: 364; 39.1% identity (61.7% similar) in 133 aa overlap (41-167:1744-1871)
20 30 40 50 60
pF1KE6 AWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSS---GSCPPTKFQCRTSGLC
: :.:. .. .: : .:::.... :
XP_016 DCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN-C
1720 1730 1740 1750 1760 1770
70 80 90 100 110 120
pF1KE6 VPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-QCPPPPGLPCP--CTGVSDCSGGTDKKL
.: :::: . ::::.::::.:. . :: : : . : : ::. :.:.
XP_016 IPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDE--
1780 1790 1800 1810 1820 1830
130 140 150 160 170 180
pF1KE6 RNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPP
::: . .: ..::. . .::: :.:::: :: . :: .:
XP_016 RNC-ETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASD
1840 1850 1860 1870 1880
190 200 210 220 230 240
pF1KE6 VTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVT
XP_016 GCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDE
1890 1900 1910 1920 1930 1940
>--
initn: 479 init1: 203 opt: 314 Z-score: 262.1 bits: 59.7 E(85289): 7.3e-08
Smith-Waterman score: 314; 37.5% identity (54.7% similar) in 128 aa overlap (54-175:966-1091)
30 40 50 60 70 80
pF1KE6 LLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDG
: . :.: :: :. :: :: . :: ::
XP_016 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSC-PSGRCILNTWICDGQKDCEDG
940 950 960 970 980 990
90 100 110 120 130 140
pF1KE6 SDEEECRIEPCT-QKGQCPPPPGLPCP--CTGVSDCSGGTDKKLRNCSRLACLAGELRCT
:: .: :. .. : . : : .::. : :.. :. ..: : . :
XP_016 RDEFHCD-SSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQ
1000 1010 1020 1030 1040 1050
150 160 170 180 190
pF1KE6 LSDDCIPLTWRCDGHPDCPDSSDEL---GCGTNEILPEGDATTMGPPVTLESVTSLRNAT
: :.: : :::. ::::.:::: ::. :. :
XP_016 GSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDD
1060 1070 1080 1090 1100 1110
200 210 220 230 240 250
pF1KE6 TMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQE
XP_016 CGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQ
1120 1130 1140 1150 1160 1170
>--
initn: 346 init1: 126 opt: 260 Z-score: 217.4 bits: 51.4 E(85289): 2.3e-05
Smith-Waterman score: 260; 35.4% identity (54.9% similar) in 113 aa overlap (67-167:848-958)
40 50 60 70 80 90
pF1KE6 PLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-T
:.: :: . ::.:.::: .:.. : :
XP_016 PHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCAT
820 830 840 850 860 870
100 110 120 130 140
pF1KE6 QKGQCPPPPGLP--CPCTGVSDCSGGTDKKLRNCSRLACL---------AGELRCTLSDD
. .: .: :. ::. ..:.: ::. : .: .::. ..
XP_016 VEFRCADGTCIPRSARCNQNIDCADASDEK--NCNNTDCTHFYKLGVKTTGFIRCNSTSL
880 890 900 910 920 930
150 160 170 180 190 200
pF1KE6 CIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTMGPPVT
:. :: ::: :: : :::: :
XP_016 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGR
940 950 960 970 980 990
282 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:24:51 2016 done: Tue Nov 8 15:24:52 2016
Total Scan time: 7.360 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]