Result of FASTA (omim) for
pFN21AE6656
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6656, 259 aa
1>>>pF1KE6656 259 - 259 aa - 259 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0866+/-0.000306; mu= 12.3992+/- 0.019
mean_var=106.3756+/-21.062, 0's: 0 Z-trim(119.4): 16 B-trim: 0 in 0/55
Lambda= 0.124352
statistics sampled from 33370 (33386) to 33370 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.391), width: 16
Scan time: 5.770
The best scores are: opt bits E(85289)
NP_003837 (OMIM: 603867,614920) peroxisomal membra ( 259) 1741 322.3 5.6e-88
NP_001171724 (OMIM: 603867,614920) peroxisomal mem ( 245) 1614 299.5 3.9e-81
NP_003838 (OMIM: 603866) peroxisomal membrane prot ( 247) 466 93.5 3.9e-19
NP_001258502 (OMIM: 603866) peroxisomal membrane p ( 102) 266 57.3 1.3e-08
NP_001258501 (OMIM: 603866) peroxisomal membrane p ( 216) 266 57.6 2.2e-08
NP_001257468 (OMIM: 607583) peroxisomal membrane p ( 180) 163 39.0 0.007
XP_011526729 (OMIM: 607583) PREDICTED: peroxisomal ( 198) 162 38.9 0.0085
NP_542393 (OMIM: 607583) peroxisomal membrane prot ( 241) 163 39.1 0.0088
>>NP_003837 (OMIM: 603867,614920) peroxisomal membrane p (259 aa)
initn: 1741 init1: 1741 opt: 1741 Z-score: 1700.5 bits: 322.3 E(85289): 5.6e-88
Smith-Waterman score: 1741; 99.6% identity (100.0% similar) in 259 aa overlap (1-259:1-259)
10 20 30 40 50 60
pF1KE6 MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 LGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFVCDNVLWAGKSGLAPRVDQEKWA
:::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_003 LGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 GGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGL
190 200 210 220 230 240
250
pF1KE6 VSSILSILTLIYPWLRLKP
:::::::::::::::::::
NP_003 VSSILSILTLIYPWLRLKP
250
>>NP_001171724 (OMIM: 603867,614920) peroxisomal membran (245 aa)
initn: 1614 init1: 1614 opt: 1614 Z-score: 1577.7 bits: 299.5 E(85289): 3.9e-81
Smith-Waterman score: 1614; 99.6% identity (100.0% similar) in 241 aa overlap (19-259:5-245)
10 20 30 40 50 60
pF1KE6 MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLR
::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKLRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLR
10 20 30 40
70 80 90 100 110 120
pF1KE6 LGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFVCDNVLWAGKSGLAPRVDQEKWA
:::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_001 LGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWA
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 QRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE6 GGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGL
170 180 190 200 210 220
250
pF1KE6 VSSILSILTLIYPWLRLKP
:::::::::::::::::::
NP_001 VSSILSILTLIYPWLRLKP
230 240
>>NP_003838 (OMIM: 603866) peroxisomal membrane protein (247 aa)
initn: 715 init1: 463 opt: 466 Z-score: 464.6 bits: 93.5 E(85289): 3.9e-19
Smith-Waterman score: 677; 40.7% identity (73.3% similar) in 258 aa overlap (1-258:1-245)
10 20 30 40 50 60
pF1KE6 MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLR
:::..::. :.:.:.:: ::.::.: :: . :. .... .. ....::: .: ::: .:
NP_003 MDAFTRFTNQTQGRDRLFRATQYTCMLLRYLLEPKAGKEKVVMKLKKLESSVSTGRKWFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 LGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFVCDNVLWAGKSGLAPRVDQEKWA
::: . :........: .:.: :.:.:...:::..::.::..::. . ::. ...:::
NP_003 LGNVVHAIQATEQSIHATDLVPRLCLTLANLNRVIYFICDTILWVRSVGLTSGINKEKWR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPG
:. ..: .::...: :: ::: : :.. . :.: : : .. : .
NP_003 TRAAHHYYYSLLLSLVRDLYEISLQMKRVT--CDRAKK----------EKSASQDPLWFS
130 140 150 160
190 200 210 220 230 240
pF1KE6 GGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGL
. . :. .::: : :. :::::::.:.: ::.. :::.::... .:::.:: ::
NP_003 VAEEETEW-LQSFLLLLFRSLKQHPPLLLDTVKNLCDILNPLDQLGIYKSNPGIIGLGGL
170 180 190 200 210 220
250
pF1KE6 VSSILSILTLIYPWLRLKP
:::: ...:. :: ..::
NP_003 VSSIAGMITVAYPQMKLKTR
230 240
>>NP_001258502 (OMIM: 603866) peroxisomal membrane prote (102 aa)
initn: 266 init1: 266 opt: 266 Z-score: 275.9 bits: 57.3 E(85289): 1.3e-08
Smith-Waterman score: 266; 56.9% identity (84.6% similar) in 65 aa overlap (194-258:36-100)
170 180 190 200 210 220
pF1KE6 VPGGSETGGLGGPGTPGGGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLD
.::: : :. :::::::.:.: ::.. :::
NP_001 CDRAKKEKSASQDPLWFSVAEEETEWLQSFLLLLFRSLKQHPPLLLDTVKNLCDILNPLD
10 20 30 40 50 60
230 240 250
pF1KE6 KLGLWRCGPGIVGLCGLVSSILSILTLIYPWLRLKP
.::... .:::.:: :::::: ...:. :: ..::
NP_001 QLGIYKSNPGIIGLGGLVSSIAGMITVAYPQMKLKTR
70 80 90 100
>>NP_001258501 (OMIM: 603866) peroxisomal membrane prote (216 aa)
initn: 616 init1: 266 opt: 266 Z-score: 271.5 bits: 57.6 E(85289): 2.2e-08
Smith-Waterman score: 520; 36.8% identity (63.2% similar) in 258 aa overlap (1-258:1-214)
10 20 30 40 50 60
pF1KE6 MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLR
:::..::. :.:.:.:: ::.::.: :: . :. .... .. ....::: .: :::
NP_001 MDAFTRFTNQTQGRDRLFRATQYTCMLLRYLLEPKAGKEKVVMKLKKLESSVSTGRK---
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 LGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFVCDNVLWAGKSGLAPRVDQEKWA
:.:::..::.::..::. . ::. ...:::
NP_001 ----------------------------SNLNRVIYFICDTILWVRSVGLTSGINKEKWR
60 70 80
130 140 150 160 170 180
pF1KE6 QRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPG
:. ..: .::...: :: ::: : :.. . :.: : : .. : .
NP_001 TRAAHHYYYSLLLSLVRDLYEISLQMKRVT--CDRAKK----------EKSASQDPLWFS
90 100 110 120 130
190 200 210 220 230 240
pF1KE6 GGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGL
. . :. .::: : :. :::::::.:.: ::.. :::.::... .:::.:: ::
NP_001 VAEEETEW-LQSFLLLLFRSLKQHPPLLLDTVKNLCDILNPLDQLGIYKSNPGIIGLGGL
140 150 160 170 180 190
250
pF1KE6 VSSILSILTLIYPWLRLKP
:::: ...:. :: ..::
NP_001 VSSIAGMITVAYPQMKLKTR
200 210
>>NP_001257468 (OMIM: 607583) peroxisomal membrane prote (180 aa)
initn: 76 init1: 56 opt: 163 Z-score: 172.7 bits: 39.0 E(85289): 0.007
Smith-Waterman score: 163; 26.2% identity (61.4% similar) in 145 aa overlap (12-151:15-157)
10 20 30 40 50
pF1KE6 MDAWVRFSAQSQARERLCRAAQYACSLLGHAL-QRHGASPELQKQIRQLESHLSLGR
..:.:: :. : :.:.: .: .. : :. .. . ..:: :
NP_001 MASLSGLASALESYRGRDRLIRVLGYCCQLVGGVLVEQCPARSEVGTRLLVVSTQLSHCR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 KLLRLGNSADALESAKR---AVHLSDVVLRFCITV-SHLNRALYFVCDNVLWAGKSGLAP
.::: .. . .:. ... :. .: :..: ..: ::. :..: ::. . .
NP_001 TILRLFDDLAMFVYTKQYGLGAQEEDAFVR-CVSVLGNLADQLYYPCEHVAWAADARVL-
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 RVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGG
.::. .: : . .::.....:. . . : .. :
NP_001 HVDSSRWWTLSTTLWALSLLLGVARSLWMLLKLRQRLRSPTAPFTSMYQAARAGGQAEAT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 LGGPGTPGGGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGP
NP_001 TP
180
>>XP_011526729 (OMIM: 607583) PREDICTED: peroxisomal mem (198 aa)
initn: 76 init1: 56 opt: 162 Z-score: 171.2 bits: 38.9 E(85289): 0.0085
Smith-Waterman score: 162; 27.5% identity (62.6% similar) in 131 aa overlap (12-137:15-143)
10 20 30 40 50
pF1KE6 MDAWVRFSAQSQARERLCRAAQYACSLLGHAL-QRHGASPELQKQIRQLESHLSLGR
..:.:: :. : :.:.: .: .. : :. .. . ..:: :
XP_011 MASLSGLASALESYRGRDRLIRVLGYCCQLVGGVLVEQCPARSEVGTRLLVVSTQLSHCR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 KLLRLGNSADALESAKR---AVHLSDVVLRFCITV-SHLNRALYFVCDNVLWAGKSGLAP
.::: .. . .:. ... :. .: :..: ..: ::. :..: ::. . .
XP_011 TILRLFDDLAMFVYTKQYGLGAQEEDAFVR-CVSVLGNLADQLYYPCEHVAWAADARVL-
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 RVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGG
.::. .: : . .::.....:
XP_011 HVDSSRWWTLSTTLWALSLLLGVARIKWNCFTAIEVLCAPPAAAFLFRACGFSSFLWICS
120 130 140 150 160 170
>>NP_542393 (OMIM: 607583) peroxisomal membrane protein (241 aa)
initn: 147 init1: 56 opt: 163 Z-score: 171.0 bits: 39.1 E(85289): 0.0088
Smith-Waterman score: 185; 27.4% identity (56.4% similar) in 241 aa overlap (12-247:15-226)
10 20 30 40 50
pF1KE6 MDAWVRFSAQSQARERLCRAAQYACSLLGHAL-QRHGASPELQKQIRQLESHLSLGR
..:.:: :. : :.:.: .: .. : :. .. . ..:: :
NP_542 MASLSGLASALESYRGRDRLIRVLGYCCQLVGGVLVEQCPARSEVGTRLLVVSTQLSHCR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 KLLRLGNSADALESAKR---AVHLSDVVLRFCITV-SHLNRALYFVCDNVLWAGKSGLAP
.::: .. . .:. ... :. .: :..: ..: ::. :..: ::. . .
NP_542 TILRLFDDLAMFVYTKQYGLGAQEEDAFVR-CVSVLGNLADQLYYPCEHVAWAADARVL-
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 RVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGG
.::. .: : . .::.....:. . . : ..: ::. : :.
NP_542 HVDSSRWWTLSTTLWALSLLLGVARSLWML-LKLRQ-------RLR---------SPTAP
120 130 140 150 160
180 190 200 210 220 230
pF1KE6 LGGPGTPGGGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGP
. .: : : . :.. ..: :. .: . : :.. :: ..: : : :
NP_542 FTSP-LPRG--KRRAMEAQMQSEALS-LLSN----LADLA-NAVH-WLPRGVLWAGRFPP
170 180 190 200 210
240 250
pF1KE6 GIVGLCGLVSSILSILTLIYPWLRLKP
.::: : .:::::.
NP_542 WLVGLMGTISSILSMYQAARAGGQAEATTP
220 230 240
259 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:10:38 2016 done: Tue Nov 8 15:10:39 2016
Total Scan time: 5.770 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]