FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE6641, 259 aa
  1>>>pF1KE6641 259 - 259 aa - 259 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.8749+/-0.000346; mu= 12.8348+/- 0.021
 mean_var=100.5732+/-20.280, 0's: 0 Z-trim(116.8): 40  B-trim: 379 in 2/52
 Lambda= 0.127889
 statistics sampled from 28181 (28220) to 28181 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.331), width:  16
 Scan time:  5.210

The best scores are:                                      opt bits E(85289)
NP_055236 (OMIM: 605415) dickkopf-related protein  ( 259) 1869 354.9 8.3e-98
NP_036374 (OMIM: 605189) dickkopf-related protein  ( 266)  729 144.6 1.8e-34
NP_055235 (OMIM: 605417) dickkopf-related protein  ( 224)  568 114.8 1.4e-25
XP_011542790 (OMIM: 605417) PREDICTED: dickkopf-re ( 224)  568 114.8 1.4e-25
XP_016868805 (OMIM: 605417) PREDICTED: dickkopf-re ( 224)  568 114.8 1.4e-25


>>NP_055236 (OMIM: 605415) dickkopf-related protein 2 pr  (259 aa)
 initn: 1869 init1: 1869 opt: 1869  Z-score: 1876.9  bits: 354.9 E(85289): 8.3e-98
Smith-Waterman score: 1869; 99.6% identity (100.0% similar) in 259 aa overlap (1-259:1-259)

               10        20        30        40        50        60
pF1KE6 MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 LAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPST
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE6 RCNNGICIPVTESILTPHIPALDGTQHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEG
       :::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::
NP_055 RCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE6 DPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCK
              190       200       210       220       230       240

              250         
pF1KE6 VWKDATYSSKARLHVCQKI
       :::::::::::::::::::
NP_055 VWKDATYSSKARLHVCQKI
              250         

>>NP_036374 (OMIM: 605189) dickkopf-related protein 1 pr  (266 aa)
 initn: 595 init1: 436 opt: 729  Z-score: 740.0  bits: 144.6 E(85289): 1.8e-34
Smith-Waterman score: 729; 42.9% identity (68.1% similar) in 273 aa overlap (1-258:1-265)

               10        20            30        40             50 
pF1KE6 MAALMRSKDSSCCLLLLAAVL----MVESSQIGSSRAKLNSIKS---SLGGET--PGQAA
       : ::  .  .   . ..::.:    ..  :   .:  . :.::.    ::: .  ::.:.
NP_036 MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAV
               10        20        30        40        50        60

              60         70        80        90           100      
pF1KE6 NRSAGMYQGLAFGGSK-KGKNLGQAYPCSSDKECEVGRYCHSPHQGSSA----CMVCRRK
       . . :.   :  ::.: .  .  : :::. :.:: . .:: :: .:..:    :..::..
NP_036 SAAPGI---LYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKR
                  70        80        90       100       110       

        110       120       130       140       150       160      
pF1KE6 KKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTQHRDRNHGHYSNHDLGWQNLG
       .::: : .::::.. :.::::.   .. .  .:   . :  .. .. : :. : :..   
NP_036 RKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEI---EETITESFGNDH-STLD-GYSRRT
       120       130       140       150          160         170  

        170       180       190       200       210       220      
pF1KE6 RPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLE
          .:: : ::.::. :::::::  :.:::::::.:::::::..:.::::.:.:::::::
NP_036 TLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLE
            180       190       200       210       220       230  

        230       240       250          
pF1KE6 IFQRCDCAKGLSCKVWKDATYSSKA-RLHVCQKI
       ::::: :..::::.. ::   .:.. :::.::. 
NP_036 IFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
            240       250       260      

>>NP_055235 (OMIM: 605417) dickkopf-related protein 4 pr  (224 aa)
 initn: 429 init1: 242 opt: 568  Z-score: 580.5  bits: 114.8 E(85289): 1.4e-25
Smith-Waterman score: 568; 42.2% identity (68.8% similar) in 199 aa overlap (65-259:34-221)

           40        50        60        70        80        90    
pF1KE6 LNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPH
                                     :..::..      : :: .:.. ..: .:.
NP_055 AVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQ------CLSDTDCNTRKFCLQPR
            10        20        30        40              50       

          100       110       120       130         140       150  
pF1KE6 QGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTES--ILTPHIPALDGTQHRDRNH
       . .  : .::  ..::.::.::::.: : : .:  . ..  ::  ..   ::: : . . 
NP_055 DEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGT-HAEGTT
        60        70        80        90       100       110       

            160       170        180       190       200       210 
pF1KE6 GHYSNHDLGWQNLGRPHTKMSHI-KGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQG
       ::  ...   :   .:  : :.  ::.::. :::. ::  :.::::::::::::::: .:
NP_055 GHPVQEN---QPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEG
        120          130       140       150       160       170   

             220        230       240       250            
pF1KE6 EVCTKQRKKGS-HGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI   
       .::... .: . .. ::::::::. :: :.  . ..  ..:::.:::::   
NP_055 QVCSRRGHKDTAQAPEIFQRCDCGPGLLCRS-QLTSNRQHARLRVCQKIEKL
           180       190       200        210       220    

>>XP_011542790 (OMIM: 605417) PREDICTED: dickkopf-relate  (224 aa)
 initn: 429 init1: 242 opt: 568  Z-score: 580.5  bits: 114.8 E(85289): 1.4e-25
Smith-Waterman score: 568; 42.2% identity (68.8% similar) in 199 aa overlap (65-259:34-221)

           40        50        60        70        80        90    
pF1KE6 LNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPH
                                     :..::..      : :: .:.. ..: .:.
XP_011 AVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQ------CLSDTDCNTRKFCLQPR
            10        20        30        40              50       

          100       110       120       130         140       150  
pF1KE6 QGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTES--ILTPHIPALDGTQHRDRNH
       . .  : .::  ..::.::.::::.: : : .:  . ..  ::  ..   ::: : . . 
XP_011 DEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGT-HAEGTT
        60        70        80        90       100       110       

            160       170        180       190       200       210 
pF1KE6 GHYSNHDLGWQNLGRPHTKMSHI-KGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQG
       ::  ...   :   .:  : :.  ::.::. :::. ::  :.::::::::::::::: .:
XP_011 GHPVQEN---QPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEG
        120          130       140       150       160       170   

             220        230       240       250            
pF1KE6 EVCTKQRKKGS-HGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI   
       .::... .: . .. ::::::::. :: :.  . ..  ..:::.:::::   
XP_011 QVCSRRGHKDTAQAPEIFQRCDCGPGLLCRS-QLTSNRQHARLRVCQKIEKL
           180       190       200        210       220    

>>XP_016868805 (OMIM: 605417) PREDICTED: dickkopf-relate  (224 aa)
 initn: 429 init1: 242 opt: 568  Z-score: 580.5  bits: 114.8 E(85289): 1.4e-25
Smith-Waterman score: 568; 42.2% identity (68.8% similar) in 199 aa overlap (65-259:34-221)

           40        50        60        70        80        90    
pF1KE6 LNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPH
                                     :..::..      : :: .:.. ..: .:.
XP_016 AVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQ------CLSDTDCNTRKFCLQPR
            10        20        30        40              50       

          100       110       120       130         140       150  
pF1KE6 QGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTES--ILTPHIPALDGTQHRDRNH
       . .  : .::  ..::.::.::::.: : : .:  . ..  ::  ..   ::: : . . 
XP_016 DEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGT-HAEGTT
        60        70        80        90       100       110       

            160       170        180       190       200       210 
pF1KE6 GHYSNHDLGWQNLGRPHTKMSHI-KGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQG
       ::  ...   :   .:  : :.  ::.::. :::. ::  :.::::::::::::::: .:
XP_016 GHPVQEN---QPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEG
        120          130       140       150       160       170   

             220        230       240       250            
pF1KE6 EVCTKQRKKGS-HGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI   
       .::... .: . .. ::::::::. :: :.  . ..  ..:::.:::::   
XP_016 QVCSRRGHKDTAQAPEIFQRCDCGPGLLCRS-QLTSNRQHARLRVCQKIEKL
           180       190       200        210       220    




259 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Nov  8 15:02:01 2016 done: Tue Nov  8 15:02:02 2016
 Total Scan time:  5.210 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]