Result of FASTA (omim) for
pFN21AE6637
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6637, 215 aa
1>>>pF1KE6637 215 - 215 aa - 215 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0981+/-0.000318; mu= 14.4249+/- 0.020
mean_var=56.1974+/-11.208, 0's: 0 Z-trim(115.3): 31 B-trim: 104 in 1/54
Lambda= 0.171087
statistics sampled from 25693 (25724) to 25693 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.302), width: 16
Scan time: 4.940
The best scores are: opt bits E(85289)
NP_005199 (OMIM: 123610,600881) beta-crystallin A3 ( 215) 1537 387.1 1.2e-107
XP_016879687 (OMIM: 123610,600881) PREDICTED: beta ( 316) 1476 372.1 5.5e-103
NP_001877 (OMIM: 123631,610425) beta-crystallin A4 ( 196) 1002 255.0 6e-68
XP_006724203 (OMIM: 123631,610425) PREDICTED: beta ( 201) 1002 255.0 6.2e-68
XP_016884087 (OMIM: 123631,610425) PREDICTED: beta ( 207) 1002 255.1 6.3e-68
NP_476434 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 788 202.2 4.8e-52
NP_476435 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 788 202.2 4.8e-52
XP_011528201 (OMIM: 600929,611544) PREDICTED: beta ( 252) 659 170.4 2.3e-42
NP_001878 (OMIM: 600929,611544) beta-crystallin B1 ( 252) 659 170.4 2.3e-42
XP_006724204 (OMIM: 123620,601547) PREDICTED: beta ( 205) 579 150.6 1.7e-36
XP_011528202 (OMIM: 123620,601547) PREDICTED: beta ( 205) 579 150.6 1.7e-36
NP_000487 (OMIM: 123620,601547) beta-crystallin B2 ( 205) 579 150.6 1.7e-36
NP_004067 (OMIM: 123630,609741) beta-crystallin B3 ( 211) 578 150.4 2.1e-36
XP_011528204 (OMIM: 123630,609741) PREDICTED: beta ( 267) 579 150.7 2.1e-36
XP_005250009 (OMIM: 609603) PREDICTED: gamma-cryst ( 182) 449 118.5 6.9e-27
XP_011514138 (OMIM: 609603) PREDICTED: gamma-cryst ( 295) 449 118.6 1.1e-26
XP_016858891 (OMIM: 123670,615188) PREDICTED: gamm ( 177) 376 100.5 1.8e-21
NP_066269 (OMIM: 123680,604307) gamma-crystallin C ( 174) 371 99.3 4.2e-21
XP_011508964 (OMIM: 123680,604307) PREDICTED: gamm ( 174) 371 99.3 4.2e-21
NP_060011 (OMIM: 116100,123730) beta-crystallin S ( 178) 370 99.0 5e-21
XP_011514139 (OMIM: 609603) PREDICTED: gamma-cryst ( 260) 370 99.1 7e-21
NP_008822 (OMIM: 115700,123690) gamma-crystallin D ( 174) 363 97.3 1.6e-20
NP_653328 (OMIM: 609603) gamma-crystallin N isofor ( 182) 353 94.8 9.4e-20
NP_005201 (OMIM: 123670,615188) gamma-crystallin B ( 175) 348 93.6 2.1e-19
XP_016884088 (OMIM: 123630,609741) PREDICTED: beta ( 169) 331 89.4 3.8e-18
NP_055432 (OMIM: 123660) gamma-crystallin A [Homo ( 174) 322 87.2 1.8e-17
XP_016865822 (OMIM: 601797) PREDICTED: absent in m (1544) 302 82.6 3.7e-15
NP_001615 (OMIM: 601797) absent in melanoma 1 prot (1723) 302 82.7 4.1e-15
XP_005266896 (OMIM: 601797) PREDICTED: absent in m (2131) 302 82.7 5e-15
XP_016867262 (OMIM: 609603) PREDICTED: gamma-cryst ( 125) 251 69.6 2.6e-12
NP_001295221 (OMIM: 609603) gamma-crystallin N iso ( 125) 251 69.6 2.6e-12
>>NP_005199 (OMIM: 123610,600881) beta-crystallin A3 [Ho (215 aa)
initn: 1537 init1: 1537 opt: 1537 Z-score: 2053.9 bits: 387.1 E(85289): 1.2e-107
Smith-Waterman score: 1537; 100.0% identity (100.0% similar) in 215 aa overlap (1-215:1-215)
10 20 30 40 50 60
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ
130 140 150 160 170 180
190 200 210
pF1KE6 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
:::::::::::::::::::::::::::::::::::
NP_005 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
190 200 210
>>XP_016879687 (OMIM: 123610,600881) PREDICTED: beta-cry (316 aa)
initn: 1523 init1: 1476 opt: 1476 Z-score: 1969.9 bits: 372.1 E(85289): 5.5e-103
Smith-Waterman score: 1476; 100.0% identity (100.0% similar) in 205 aa overlap (11-215:112-316)
10 20 30 40
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQEN
::::::::::::::::::::::::::::::
XP_016 RLQVSFTFQGIPSPPPPPKRPHHSCVLCLPETLPTTKMAQTNPTPGSLGPWKITIYDQEN
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE6 FQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWS
150 160 170 180 190 200
110 120 130 140 150 160
pF1KE6 GSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGS
210 220 230 240 250 260
170 180 190 200 210
pF1KE6 MKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
270 280 290 300 310
>>NP_001877 (OMIM: 123631,610425) beta-crystallin A4 [Ho (196 aa)
initn: 1002 init1: 1002 opt: 1002 Z-score: 1340.8 bits: 255.0 E(85289): 6e-68
Smith-Waterman score: 1002; 68.3% identity (89.9% similar) in 189 aa overlap (27-215:8-196)
10 20 30 40 50 60
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF
: ::::....:...:::.: :::. ::.: : .:
NP_001 MTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGF
10 20 30 40
70 80 90 100 110 120
pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN
..:::::: ::::.:.::..: :::.:::::::: ::::.:..:: ::: :::: ::
NP_001 ETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACAN
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ
:..:..::::.:::.:.. :.:::::::::::: .:::::....:::::: :.:::::.:
NP_001 HRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQ
110 120 130 140 150 160
190 200 210
pF1KE6 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
:.::::::.:::::.::::::: : :.::::::::
NP_001 YVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ
170 180 190
>>XP_006724203 (OMIM: 123631,610425) PREDICTED: beta-cry (201 aa)
initn: 1002 init1: 1002 opt: 1002 Z-score: 1340.7 bits: 255.0 E(85289): 6.2e-68
Smith-Waterman score: 1002; 68.3% identity (89.9% similar) in 189 aa overlap (27-215:13-201)
10 20 30 40 50 60
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF
: ::::....:...:::.: :::. ::.: : .:
XP_006 MEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGF
10 20 30 40
70 80 90 100 110 120
pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN
..:::::: ::::.:.::..: :::.:::::::: ::::.:..:: ::: :::: ::
XP_006 ETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACAN
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ
:..:..::::.:::.:.. :.:::::::::::: .:::::....:::::: :.:::::.:
XP_006 HRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQ
110 120 130 140 150 160
190 200 210
pF1KE6 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
:.::::::.:::::.::::::: : :.::::::::
XP_006 YVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ
170 180 190 200
>>XP_016884087 (OMIM: 123631,610425) PREDICTED: beta-cry (207 aa)
initn: 1002 init1: 1002 opt: 1002 Z-score: 1340.5 bits: 255.1 E(85289): 6.3e-68
Smith-Waterman score: 1002; 68.3% identity (89.9% similar) in 189 aa overlap (27-215:19-207)
10 20 30 40 50 60
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF
: ::::....:...:::.: :::. ::.: : .:
XP_016 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGF
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN
..:::::: ::::.:.::..: :::.:::::::: ::::.:..:: ::: :::: ::
XP_016 ETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACAN
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ
:..:..::::.:::.:.. :.:::::::::::: .:::::....:::::: :.:::::.:
XP_016 HRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQ
120 130 140 150 160 170
190 200 210
pF1KE6 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
:.::::::.:::::.::::::: : :.::::::::
XP_016 YVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ
180 190 200
>>NP_476434 (OMIM: 115900,600836) beta-crystallin A2 [Ho (197 aa)
initn: 907 init1: 677 opt: 788 Z-score: 1055.3 bits: 202.2 E(85289): 4.8e-52
Smith-Waterman score: 788; 53.1% identity (85.7% similar) in 196 aa overlap (21-215:3-197)
10 20 30 40 50
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERS-
. :.:: .: ..:..:.:.:::.: .. :.: :: ::.
NP_476 MSSAPAPGP-APASLTLWDEEDFQGRRCRLLSDCANVCERGG
10 20 30 40
60 70 80 90 100 110
pF1KE6 FDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSA
. :::.:::.:.:...:. .: :::::::.:.::::.:::::.... ..:.::::. :
NP_476 LPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE6 NHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGY
::..:..:.:: .:: : .... :::::: .::: ...:::.:..::::: :::::::::
NP_476 NHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGY
110 120 130 140 150 160
180 190 200 210
pF1KE6 QYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
::.:: :.:.:.. . : :..:.:.:.:::::.:.
NP_476 QYVLERDRHSGEFCTYGELGTQAHTGQLQSIRRVQH
170 180 190
>>NP_476435 (OMIM: 115900,600836) beta-crystallin A2 [Ho (197 aa)
initn: 907 init1: 677 opt: 788 Z-score: 1055.3 bits: 202.2 E(85289): 4.8e-52
Smith-Waterman score: 788; 53.1% identity (85.7% similar) in 196 aa overlap (21-215:3-197)
10 20 30 40 50
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERS-
. :.:: .: ..:..:.:.:::.: .. :.: :: ::.
NP_476 MSSAPAPGP-APASLTLWDEEDFQGRRCRLLSDCANVCERGG
10 20 30 40
60 70 80 90 100 110
pF1KE6 FDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSA
. :::.:::.:.:...:. .: :::::::.:.::::.:::::.... ..:.::::. :
NP_476 LPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE6 NHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGY
::..:..:.:: .:: : .... :::::: .::: ...:::.:..::::: :::::::::
NP_476 NHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGY
110 120 130 140 150 160
180 190 200 210
pF1KE6 QYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
::.:: :.:.:.. . : :..:.:.:.:::::.:.
NP_476 QYVLERDRHSGEFCTYGELGTQAHTGQLQSIRRVQH
170 180 190
>>XP_011528201 (OMIM: 600929,611544) PREDICTED: beta-cry (252 aa)
initn: 573 init1: 309 opt: 659 Z-score: 881.6 bits: 170.4 E(85289): 2.3e-42
Smith-Waterman score: 676; 48.5% identity (77.0% similar) in 204 aa overlap (12-214:43-233)
10 20 30 40
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENF
:.: :. .. ::. ....... :::
XP_011 VAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGN---YRLVVFELENF
20 30 40 50 60
50 60 70 80 90 100
pF1KE6 QGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSG
::.: ::.. : :...:.:: :::. : .: :...:...: :..::::.::::::..::.
XP_011 QGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE6 SNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEIS-DDYPSLQAMGWFNNEVGS
: :. .:::::::: . . .: :...:: :: : ::. :: ::: ..: :...:::
XP_011 S--YRSDRLMSFRPI-KMDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYG-FSDRVGS
130 140 150 160 170 180
170 180 190 200 210
pF1KE6 MKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
.:..::.:: :::::::::::.:: ::..:: ::: : :.::.::..
XP_011 VKVSSGTWVGYQYPGYRGYQYLLE----PGDFRHWNEWG--AFQPQMQSLRRLRDKQWHL
190 200 210 220 230
XP_011 EGSFPVLATEPPK
240 250
>>NP_001878 (OMIM: 600929,611544) beta-crystallin B1 [Ho (252 aa)
initn: 573 init1: 309 opt: 659 Z-score: 881.6 bits: 170.4 E(85289): 2.3e-42
Smith-Waterman score: 676; 48.5% identity (77.0% similar) in 204 aa overlap (12-214:43-233)
10 20 30 40
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENF
:.: :. .. ::. ....... :::
NP_001 VAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGN---YRLVVFELENF
20 30 40 50 60
50 60 70 80 90 100
pF1KE6 QGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSG
::.: ::.. : :...:.:: :::. : .: :...:...: :..::::.::::::..::.
NP_001 QGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE6 SNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEIS-DDYPSLQAMGWFNNEVGS
: :. .:::::::: . . .: :...:: :: : ::. :: ::: ..: :...:::
NP_001 S--YRSDRLMSFRPI-KMDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYG-FSDRVGS
130 140 150 160 170 180
170 180 190 200 210
pF1KE6 MKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
.:..::.:: :::::::::::.:: ::..:: ::: : :.::.::..
NP_001 VKVSSGTWVGYQYPGYRGYQYLLE----PGDFRHWNEWG--AFQPQMQSLRRLRDKQWHL
190 200 210 220 230
NP_001 EGSFPVLATEPPK
240 250
>>XP_006724204 (OMIM: 123620,601547) PREDICTED: beta-cry (205 aa)
initn: 511 init1: 282 opt: 579 Z-score: 776.3 bits: 150.6 E(85289): 1.7e-36
Smith-Waterman score: 585; 46.1% identity (76.4% similar) in 191 aa overlap (25-214:12-191)
10 20 30 40 50 60
pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF
: ::.: :: :..::::::. :... :::..: .
XP_006 MASDHQTQAGKPQSLNP-KIIIFEQENFQGHSHELNGPCPNLKETGV
10 20 30 40
70 80 90 100 110 120
pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN
... :. :..: :.:::... :.::..:.:::::::.:..: . . : :.::: ...
XP_006 EKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSS--RRTDSLSSLRPI-KVD
50 60 70 80 90 100
130 140 150 160 170
pF1KE6 HKESKMTIFEKENFIGRQWEI-SDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGY
.: :. ..:. :: :.. :: .:: ::..: : ....:.:...:::.:: ::::::::
XP_006 SQEHKIILYENPNFTGKKMEIIDDDVPSFHAHG-YQEKVSSVRVQSGTWVGYQYPGYRGL
110 120 130 140 150 160
180 190 200 210
pF1KE6 QYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
::.:: :::: ..: : :.::.:::.
XP_006 QYLLE----KGDYKDSSDFG--APHPQVQSVRRIRDMQWHQRGAFHPSN
170 180 190 200
215 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 14:59:46 2016 done: Tue Nov 8 14:59:47 2016
Total Scan time: 4.940 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]