Result of FASTA (omim) for
pFN21AE6633
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6633, 316 aa
1>>>pF1KE6633 316 - 316 aa - 316 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9708+/-0.00041; mu= 17.0898+/- 0.025
mean_var=61.2414+/-12.736, 0's: 0 Z-trim(110.2): 133 B-trim: 264 in 1/53
Lambda= 0.163890
statistics sampled from 18381 (18543) to 18381 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.585), E-opt: 0.2 (0.217), width: 16
Scan time: 4.960
The best scores are: opt bits E(85289)
NP_689656 (OMIM: 608830,612712) retinol dehydrogen ( 316) 2063 496.6 2.7e-140
NP_057110 (OMIM: 607849,616108) retinol dehydrogen ( 318) 1518 367.8 1.7e-101
NP_653284 (OMIM: 616157) dehydrogenase/reductase S ( 377) 810 200.4 4.8e-51
NP_065956 (OMIM: 616796) retinol dehydrogenase 14 ( 336) 745 185.0 1.8e-46
NP_001239579 (OMIM: 607849,616108) retinol dehydro ( 248) 739 183.5 3.8e-46
XP_011521403 (OMIM: 605131,614322,616211) PREDICTE ( 414) 540 136.6 8.5e-32
XP_011521406 (OMIM: 605131,614322,616211) PREDICTE ( 353) 538 136.1 1e-31
XP_011521405 (OMIM: 605131,614322,616211) PREDICTE ( 367) 538 136.1 1.1e-31
NP_057457 (OMIM: 605131,614322,616211) WW domain-c ( 414) 538 136.1 1.2e-31
NP_001278926 (OMIM: 605131,614322,616211) WW domai ( 301) 529 133.9 4e-31
NP_001257353 (OMIM: 616163) dehydrogenase/reductas ( 317) 474 120.9 3.4e-27
XP_011533538 (OMIM: 616163) PREDICTED: dehydrogena ( 323) 423 108.9 1.5e-23
XP_016876239 (OMIM: 616163) PREDICTED: dehydrogena ( 225) 416 107.1 3.5e-23
XP_005266585 (OMIM: 616163) PREDICTED: dehydrogena ( 232) 415 106.9 4.2e-23
XP_016876238 (OMIM: 616163) PREDICTED: dehydrogena ( 255) 354 92.5 1e-18
XP_011533537 (OMIM: 616163) PREDICTED: dehydrogena ( 346) 354 92.6 1.3e-18
XP_005266584 (OMIM: 616163) PREDICTED: dehydrogena ( 268) 302 80.2 5.2e-15
NP_078981 (OMIM: 616163) dehydrogenase/reductase S ( 242) 292 77.8 2.5e-14
XP_016876240 (OMIM: 616163) PREDICTED: dehydrogena ( 216) 261 70.4 3.6e-12
NP_001026889 (OMIM: 616163) dehydrogenase/reductas ( 271) 261 70.5 4.4e-12
XP_011533540 (OMIM: 616163) PREDICTED: dehydrogena ( 274) 251 68.1 2.3e-11
XP_016876241 (OMIM: 616163) PREDICTED: dehydrogena ( 183) 243 66.1 6e-11
NP_057113 (OMIM: 612833) dehydrogenase/reductase S ( 339) 232 63.7 6.1e-10
XP_016876857 (OMIM: 612833) PREDICTED: dehydrogena ( 404) 232 63.8 7e-10
NP_001309209 (OMIM: 612833) dehydrogenase/reductas ( 289) 226 62.2 1.4e-09
NP_002026 (OMIM: 136440) 3-ketodihydrosphingosine ( 332) 224 61.8 2.2e-09
XP_005266734 (OMIM: 136440) PREDICTED: 3-ketodihyd ( 298) 222 61.3 2.8e-09
NP_001317088 (OMIM: 616160) dehydrogenase/reductas ( 310) 207 57.8 3.4e-08
NP_056325 (OMIM: 616160) dehydrogenase/reductase S ( 325) 207 57.8 3.5e-08
XP_016879915 (OMIM: 616160) PREDICTED: dehydrogena ( 325) 207 57.8 3.5e-08
XP_011522088 (OMIM: 616160) PREDICTED: dehydrogena ( 334) 207 57.8 3.6e-08
XP_005256652 (OMIM: 616160) PREDICTED: dehydrogena ( 372) 207 57.8 3.9e-08
XP_016879914 (OMIM: 616160) PREDICTED: dehydrogena ( 372) 207 57.8 3.9e-08
XP_006719735 (OMIM: 606623) PREDICTED: 17-beta-hyd ( 317) 206 57.5 4.1e-08
XP_011537227 (OMIM: 606623) PREDICTED: 17-beta-hyd ( 317) 206 57.5 4.1e-08
XP_005269264 (OMIM: 606623) PREDICTED: 17-beta-hyd ( 317) 206 57.5 4.1e-08
XP_011537229 (OMIM: 606623) PREDICTED: 17-beta-hyd ( 317) 206 57.5 4.1e-08
XP_011537228 (OMIM: 606623) PREDICTED: 17-beta-hyd ( 317) 206 57.5 4.1e-08
NP_003716 (OMIM: 606623) 17-beta-hydroxysteroid de ( 317) 206 57.5 4.1e-08
XP_005269265 (OMIM: 606623) PREDICTED: 17-beta-hyd ( 317) 206 57.5 4.1e-08
XP_005269266 (OMIM: 606623) PREDICTED: 17-beta-hyd ( 317) 206 57.5 4.1e-08
XP_011523032 (OMIM: 109684) PREDICTED: estradiol 1 ( 383) 204 57.1 6.6e-08
NP_057329 (OMIM: 612831) estradiol 17-beta-dehydro ( 300) 201 56.3 8.8e-08
NP_001207422 (OMIM: 616161) dehydrogenase/reductas ( 312) 201 56.4 9.1e-08
NP_612461 (OMIM: 610410) dehydrogenase/reductase S ( 313) 201 56.4 9.1e-08
NP_001129522 (OMIM: 610410) dehydrogenase/reductas ( 313) 201 56.4 9.1e-08
XP_005259026 (OMIM: 612832) PREDICTED: 17-beta-hyd ( 212) 199 55.8 9.2e-08
NP_057330 (OMIM: 612832) 17-beta-hydroxysteroid de ( 270) 199 55.8 1.1e-07
NP_835236 (OMIM: 612127) 17-beta-hydroxysteroid de ( 300) 197 55.4 1.7e-07
NP_001099041 (OMIM: 616161) dehydrogenase/reductas ( 311) 196 55.2 2.1e-07
>>NP_689656 (OMIM: 608830,612712) retinol dehydrogenase (316 aa)
initn: 2063 init1: 2063 opt: 2063 Z-score: 2639.7 bits: 496.6 E(85289): 2.7e-140
Smith-Waterman score: 2063; 99.7% identity (100.0% similar) in 316 aa overlap (1-316:1-316)
10 20 30 40 50 60
pF1KE6 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLEQLKVSAPARVVNVSSVAHHI
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
NP_689 ILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 GKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 GKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 SSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 SSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTA
250 260 270 280 290 300
310
pF1KE6 ERLWNVSCELLGIRWE
::::::::::::::::
NP_689 ERLWNVSCELLGIRWE
310
>>NP_057110 (OMIM: 607849,616108) retinol dehydrogenase (318 aa)
initn: 1550 init1: 1511 opt: 1518 Z-score: 1943.2 bits: 367.8 E(85289): 1.7e-101
Smith-Waterman score: 1518; 72.5% identity (91.4% similar) in 313 aa overlap (1-313:5-315)
10 20 30 40 50
pF1KE6 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETA
:. : :: :. :::.::.:::....::: ..:::::::::.::::::::::::
NP_057 MVELMFPLLLLLLPFL--LYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETA
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 RELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEE
.:::.::::::.::::: ::: .:.::.. : :.:::::::::::::::::::.::::::
NP_057 KELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 KQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLEQLKVSAPARVVNVSSV
:.::.:::::::::::::::::::: :.:::::::::::.::::.:: :::.:.:::::.
NP_057 KHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 AHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSE
:::.:.: ::.::.:: :. :.:::::::::.:::.:::.::.:.:::::.::::.:.::
NP_057 AHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 LVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARN
::::::.. .: ::: :.:: ..::::::::::.:::: :::..::::. .::: .:::
NP_057 LVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARN
240 250 260 270 280 290
300 310
pF1KE6 NKTAERLWNVSCELLGIRWE
. :.:::.:::.:::.
NP_057 ETIARRLWDVSCDLLGLPID
300 310
>>NP_653284 (OMIM: 616157) dehydrogenase/reductase SDR f (377 aa)
initn: 618 init1: 416 opt: 810 Z-score: 1037.4 bits: 200.4 E(85289): 4.8e-51
Smith-Waterman score: 810; 46.9% identity (71.7% similar) in 318 aa overlap (1-313:4-313)
10 20 30 40 50
pF1KE6 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETAR
.:. ::: . . ..:. .. ::. .: :...:.::::.:::: ::
NP_653 MEALLLGAGLLLGAYVLVYYNL--VKAPPCGGMG----NLRGRTAVVTGANSGIGKMTAL
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 ELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEK
::: ::::: .:::. .::.:: ..: .. :..:. :::.. :.:::: .::. :
NP_653 ELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 QLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLEQLKVSAPARVVNVSSVA
.: :::.:::. : ..: ..:. : :::.: ::::.::: ::. ::.::: :.:.:
NP_653 RLDILIHNAGISSC--GRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 HHIGKIPFHDLQSEKRYSRGF--AYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRS
: :.. :. :. : :: .:::::::.::::..:..:::: ::.::: : :
NP_653 HCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 EL-VRH-SSLLCLLWRLFSPFV-KTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSP
:: .:: . : : : .. .: .. : :::: :.::: ::.:::::.::..:. : :
NP_653 ELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPP
240 250 260 270 280 290
300 310
pF1KE6 RARNNKTAERLWNVSCELLGIRWE
::....:.:::..: .: :.
NP_653 AARDDRAAHRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPSSLSTPHPEEPTVSQPYPS
300 310 320 330 340 350
>>NP_065956 (OMIM: 616796) retinol dehydrogenase 14 [Hom (336 aa)
initn: 881 init1: 584 opt: 745 Z-score: 955.1 bits: 185.0 E(85289): 1.8e-46
Smith-Waterman score: 884; 46.3% identity (72.8% similar) in 313 aa overlap (18-313:25-334)
10 20 30 40 50
pF1KE6 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGK
:.: .... :: . ::.:.:::::.:.:.
NP_065 MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGG---DPGLMHGKTVLITGANSGLGR
10 20 30 40 50
60 70 80 90 100
pF1KE6 ETARELASRGARVYIACRDVLKGESAASEIRVDTKNS-------------QVLVRKLDLS
:: :: :::: ..::: ..: ::...: . ... ...::.:::.
NP_065 ATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLA
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 DTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLE
. .:.::: . .: :: .: .::::::...::: :: :::: ..::::::::::: :::
NP_065 SLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 QLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQG
:: :::.:.: ::: .. : : : ::.::. :...: : .:::::.:::::::.::.:
NP_065 LLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEG
180 190 200 210 220 230
230 240 250 260 270
pF1KE6 TGVTTYAVHPGVVRSELVRHSSLLCLLWRLFS----PFVKTAREGAQTSLHCALAEGLEP
:.::. ..:::.::..: :: . :. ::. : :: ::::::.. : . .:
NP_065 TNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEG
240 250 260 270 280 290
280 290 300 310
pF1KE6 LSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE
.::.::.:::. . :.: ....:..::..: ..:.
NP_065 VSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK
300 310 320 330
>>NP_001239579 (OMIM: 607849,616108) retinol dehydrogena (248 aa)
initn: 1151 init1: 732 opt: 739 Z-score: 949.4 bits: 183.5 E(85289): 3.8e-46
Smith-Waterman score: 1016; 56.2% identity (70.3% similar) in 313 aa overlap (1-313:5-245)
10 20 30 40 50
pF1KE6 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETA
:. : :: :. :::.::.:::....::: ..:::::::::.::::::::::::
NP_001 MVELMFPLLLLLLPFL--LYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETA
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 RELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEE
.:::.::::::.::::: ::: .:.::.. : :.:::::::::::::::::::.::::::
NP_001 KELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 KQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLEQLKVSAPARVVNVSSV
:.::.:::::::::::::::::::: :.::::::
NP_001 KHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLG--------------------------
120 130 140 150
180 190 200 210 220 230
pF1KE6 AHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSE
.:::::.::::.:.::
NP_001 --------------------------------------------SGVTTYSVHPGTVQSE
160
240 250 260 270 280 290
pF1KE6 LVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARN
::::::.. .: ::: :.:: ..::::::::::.:::: :::..::::. .::: .:::
NP_001 LVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARN
170 180 190 200 210 220
300 310
pF1KE6 NKTAERLWNVSCELLGIRWE
. :.:::.:::.:::.
NP_001 ETIARRLWDVSCDLLGLPID
230 240
>>XP_011521403 (OMIM: 605131,614322,616211) PREDICTED: W (414 aa)
initn: 546 init1: 408 opt: 540 Z-score: 691.8 bits: 136.6 E(85289): 8.5e-32
Smith-Waterman score: 580; 37.3% identity (62.7% similar) in 314 aa overlap (20-310:101-414)
10 20 30 40
pF1KE6 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNV----QLPGKVVVIT
:. :. . :.. .. .. :::::.:
XP_011 GQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVT
80 90 100 110 120 130
50 60 70 80 90 100
pF1KE6 GANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSI
:::.::: :::. .: .::.: .:::.. .. :.:.: . ....: . :::. .:.
XP_011 GANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSV
140 150 160 170 180 190
110 120 130 140 150 160
pF1KE6 RAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLEQLKVS
. :::.: :.. ::.:. ::... :.: : ::.:: . ::::::: :. :: . : :
XP_011 QHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRS
200 210 220 230 240 250
170 180 190 200 210
pF1KE6 APARVVNVSSVAHH-------IGKIPFHDLQSEKR-YSRGFAYCHSKLANVLFTRELAKR
:::::. ::: .:. .::. : :. : : .:: .::: :.::. :: .:
XP_011 APARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRR
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE6 LQGTGVTTYAVHPG-VVRSELVRHSSLLCLLWRLFSPFVKTAR-EGAQTSLHCALAEGLE
:. :::. ::::: .. :.. : . ::. : ::.:. ..: : : :
XP_011 LSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMLFDSAWLLADCWLLAGGT
320 330 340 350 360 370
280 290 300 310
pF1KE6 P------LSGKY--FSDCKRTWVSPRAR-NNKTAERLWNVSCELLGIRWE
: .: :: ....: .: .. . : ..: .
XP_011 PQLLEASTVPEYLGFSHKAASFIKPATRVSGASWSTRWCLTCPM
380 390 400 410
>>XP_011521406 (OMIM: 605131,614322,616211) PREDICTED: W (353 aa)
initn: 546 init1: 408 opt: 538 Z-score: 690.3 bits: 136.1 E(85289): 1e-31
Smith-Waterman score: 563; 41.8% identity (68.1% similar) in 251 aa overlap (20-257:101-351)
10 20 30 40
pF1KE6 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNV----QLPGKVVVIT
:. :. . :.. .. .. :::::.:
XP_011 GQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVT
80 90 100 110 120 130
50 60 70 80 90 100
pF1KE6 GANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSI
:::.::: :::. .: .::.: .:::.. .. :.:.: . ....: . :::. .:.
XP_011 GANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSV
140 150 160 170 180 190
110 120 130 140 150 160
pF1KE6 RAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLEQLKVS
. :::.: :.. ::.:. ::... :.: : ::.:: . ::::::: :. :: . : :
XP_011 QHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRS
200 210 220 230 240 250
170 180 190 200 210
pF1KE6 APARVVNVSSVAHH-------IGKIPFHDLQSEKR-YSRGFAYCHSKLANVLFTRELAKR
:::::. ::: .:. .::. : :. : : .:: .::: :.::. :: .:
XP_011 APARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRR
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE6 LQGTGVTTYAVHPG-VVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEP
:. :::. ::::: .. :.. : . ::. : ::.:.
XP_011 LSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMD
320 330 340 350
280 290 300 310
pF1KE6 LSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE
>>XP_011521405 (OMIM: 605131,614322,616211) PREDICTED: W (367 aa)
initn: 549 init1: 408 opt: 538 Z-score: 690.0 bits: 136.1 E(85289): 1.1e-31
Smith-Waterman score: 566; 41.4% identity (68.0% similar) in 256 aa overlap (20-262:101-356)
10 20 30 40
pF1KE6 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNV----QLPGKVVVIT
:. :. . :.. .. .. :::::.:
XP_011 GQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVT
80 90 100 110 120 130
50 60 70 80 90 100
pF1KE6 GANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSI
:::.::: :::. .: .::.: .:::.. .. :.:.: . ....: . :::. .:.
XP_011 GANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSV
140 150 160 170 180 190
110 120 130 140 150 160
pF1KE6 RAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLEQLKVS
. :::.: :.. ::.:. ::... :.: : ::.:: . ::::::: :. :: . : :
XP_011 QHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRS
200 210 220 230 240 250
170 180 190 200 210
pF1KE6 APARVVNVSSVAHH-------IGKIPFHDLQSEKR-YSRGFAYCHSKLANVLFTRELAKR
:::::. ::: .:. .::. : :. : : .:: .::: :.::. :: .:
XP_011 APARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRR
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE6 LQGTGVTTYAVHPG-VVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEP
:. :::. ::::: .. :.. : . ::. : ::.:. .. :
XP_011 LSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMEKPAAMLGGYSSIPV
320 330 340 350 360
280 290 300 310
pF1KE6 LSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE
>>NP_057457 (OMIM: 605131,614322,616211) WW domain-conta (414 aa)
initn: 694 init1: 408 opt: 538 Z-score: 689.3 bits: 136.1 E(85289): 1.2e-31
Smith-Waterman score: 712; 41.6% identity (68.8% similar) in 308 aa overlap (20-314:101-408)
10 20 30 40
pF1KE6 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNV----QLPGKVVVIT
:. :. . :.. .. .. :::::.:
NP_057 GQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVT
80 90 100 110 120 130
50 60 70 80 90 100
pF1KE6 GANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSI
:::.::: :::. .: .::.: .:::.. .. :.:.: . ....: . :::. .:.
NP_057 GANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSV
140 150 160 170 180 190
110 120 130 140 150 160
pF1KE6 RAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLEQLKVS
. :::.: :.. ::.:. ::... :.: : ::.:: . ::::::: :. :: . : :
NP_057 QHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRS
200 210 220 230 240 250
170 180 190 200 210
pF1KE6 APARVVNVSSVAHH-------IGKIPFHDLQSEKR-YSRGFAYCHSKLANVLFTRELAKR
:::::. ::: .:. .::. : :. : : .:: .::: :.::. :: .:
NP_057 APARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRR
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE6 LQGTGVTTYAVHPG-VVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEP
:. :::. ::::: .. :.. : . ::. : ::.:. ..:: :...:: . ::
NP_057 LSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEG
320 330 340 350 360 370
280 290 300 310
pF1KE6 LSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE
:.: ::..: : ::.:....::. :: .: .:. :
NP_057 LGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
380 390 400 410
>>NP_001278926 (OMIM: 605131,614322,616211) WW domain-co (301 aa)
initn: 694 init1: 408 opt: 529 Z-score: 679.8 bits: 133.9 E(85289): 4e-31
Smith-Waterman score: 703; 43.9% identity (70.2% similar) in 285 aa overlap (39-314:11-295)
10 20 30 40 50 60
pF1KE6 TSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYI
:::::.::::.::: :::. .: .::.: .
NP_001 MEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVIL
10 20 30 40
70 80 90 100 110 120
pF1KE6 ACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGV
:::.. .. :.:.: . ....: . :::. .:.. :::.: :.. ::.:. ::..
NP_001 ACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAAT
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 MMCPYSKTADGFETHLGVNHLGHFLLTYLLLEQLKVSAPARVVNVSSVAHH-------IG
. :.: : ::.:: . ::::::: :. :: . : ::::::. ::: .:. .:
NP_001 FALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLG
110 120 130 140 150 160
190 200 210 220 230
pF1KE6 KIPFHDLQSEKR-YSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPG-VVRSELVR
:. : :. : : .:: .::: :.::. :: .::. :::. ::::: .. :.. :
NP_001 KLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 HSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKT
. ::. : ::.:. ..:: :...:: . :: :.: ::..: : ::.:....:
NP_001 SWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEET
230 240 250 260 270 280
300 310
pF1KE6 AERLWNVSCELLGIRWE
:. :: .: .:. :
NP_001 ARTLWALSERLIQERLGSQSG
290 300
316 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 14:57:43 2016 done: Tue Nov 8 14:57:43 2016
Total Scan time: 4.960 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]