Result of FASTA (omim) for
pFN21AE6585
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6585, 159 aa
1>>>pF1KE6585 159 - 159 aa - 159 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2738+/-0.00052; mu= 11.0581+/- 0.032
mean_var=262.0150+/-50.694, 0's: 0 Z-trim(118.3): 137 B-trim: 54 in 1/48
Lambda= 0.079234
statistics sampled from 30908 (31061) to 30908 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.364), width: 16
Scan time: 4.480
The best scores are: opt bits E(85289)
NP_114163 (OMIM: 608822) keratin-associated protei ( 174) 429 61.1 9.4e-10
NP_112228 (OMIM: 608820) keratin-associated protei ( 167) 389 56.5 2.2e-08
NP_005544 (OMIM: 148021) keratin-associated protei ( 169) 378 55.3 5.3e-08
NP_112229 (OMIM: 608819) keratin-associated protei ( 177) 336 50.5 1.5e-06
NP_001244234 (OMIM: 608821) keratin-associated pro ( 121) 309 47.1 1.1e-05
NP_001005922 (OMIM: 148022) keratin-associated pro ( 278) 272 43.5 0.0003
NP_853630 (OMIM: 608718) keratin-associated protei ( 172) 231 38.5 0.0061
NP_848525 (OMIM: 612619) late cornified envelope p ( 118) 226 37.6 0.0075
NP_848516 (OMIM: 612611) late cornified envelope p ( 110) 222 37.1 0.0099
>>NP_114163 (OMIM: 608822) keratin-associated protein 1- (174 aa)
initn: 519 init1: 225 opt: 429 Z-score: 296.1 bits: 61.1 E(85289): 9.4e-10
Smith-Waterman score: 519; 42.3% identity (56.0% similar) in 182 aa overlap (12-158:2-174)
10 20 30 40 50
pF1KE6 MTHCCSPCCQPTCCRTT-CWQPT-TVT-TCSSTPCCQPSCCVSSCCQP-------CCHPT
:::.:. : :. ... ::.:. ::::::: .::::: : :.
NP_114 MTCCQTSFCGYPSFSISGTCGSS-CCQPSCCETSCCQPRSCQTSFCGFPS
10 20 30 40
60 70 80 90
pF1KE6 CCQNTCCRTTCCQPICV-TSCCQPSCCSTPCCQPTCC-----GSSCG--------QSSSC
. : ..:::: : ::::::::: : ::::.:: :..:: : .:
NP_114 FSTSGTCSSSCCQPSCCETSCCQPSCCETSCCQPSCCQISSCGTGCGIGGGISYGQEGSS
50 60 70 80 90 100
100 110 120 130 140
pF1KE6 APVYCR-RTCYHPTSVC---LPGCLNQSCGS-NCCQ------PCCRPACCETTCCRTTCF
. : : : : . : :: : :: .::: ::::. : .:::
NP_114 GAVSTRIRWCRPDSRVEGTYLPPCCVVSCTPPSCCQLHHAQASCCRPSYCGQSCCR----
110 120 130 140 150 160
150
pF1KE6 QPTCVYSCCQPSCC
:.: ::.:.:
NP_114 -PVC---CCEPTC
170
>>NP_112228 (OMIM: 608820) keratin-associated protein 1- (167 aa)
initn: 345 init1: 224 opt: 389 Z-score: 271.5 bits: 56.5 E(85289): 2.2e-08
Smith-Waterman score: 514; 42.4% identity (57.6% similar) in 177 aa overlap (12-158:2-167)
10 20 30 40 50
pF1KE6 MTHCCSPCCQPTCCRTT-CWQPTTVT--TCSSTPCCQPSCCVSSCCQPCCHPTCCQNTCC
:::.:. : :. : ::.:. ::::::: .::::: .:::.. :
NP_112 MTCCQTSFCGYPSCSTSGTCGSS-CCQPSCCETSCCQP----SCCQTSFC
10 20 30 40
60 70 80 90
pF1KE6 R--TTCCQPICVTSCCQPSCCSTPCCQPTCC-----GSSCG--------QSSSCAPV---
. . : .:::::::: : ::::.:: :..:: : .: . :
NP_112 GFPSFSTSGTCSSSCCQPSCCETSCCQPSCCQTSSCGTGCGIGGGIGYGQEGSSGAVSTR
50 60 70 80 90 100
100 110 120 130 140 150
pF1KE6 --YCRRTCYHPTSVCLPGCLNQSCGS-NCCQ------PCCRPACCETTCCRTTCFQPTCV
.:: : . ..::: : :: .::: ::::. : .::: .: :
NP_112 IRWCRPDC-RVEGTCLPPCCVVSCTPPTCCQLHHAEASCCRPSYCGQSCCRPVC----CC
110 120 130 140 150 160
pF1KE6 YSCCQPSCC
::: .:.:
NP_112 YSC-EPTC
>>NP_005544 (OMIM: 148021) keratin-associated protein 5- (169 aa)
initn: 1210 init1: 336 opt: 378 Z-score: 264.7 bits: 55.3 E(85289): 5.3e-08
Smith-Waterman score: 461; 39.5% identity (61.9% similar) in 147 aa overlap (3-146:40-166)
10 20 30
pF1KE6 MTHCCSP--CCQPTCCRTTCWQPTTVTTCSST
.::.: :: :.: ..: . .:...
NP_005 CGSSCGGCDSSCGSCGSGCRGCGPSCCAPVYCCKPVCCCVPACSCSSCGK-RGCGSCGGS
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE6 PCCQPSCCVSSCCQPCCHPTCCQNTCCRTTCCQPICVTSCCQPSCCSTPCCQPTCCGSSC
:: :.: ::.: :: .. : ..::: : :::.: : . ::.: ::.::
NP_005 KGGCGSCGCSQC--SCCKPCCC-SSGCGSSCCQ--C--SCCKPYCSQCSCCKP-CCSSS-
70 80 90 100 110
100 110 120 130 140
pF1KE6 GQSSSCAPVYCRRTCYHPTSVCLPGCLNQSCGSNCCQP-CCRPACCETTCCRTTCFQPTC
:..::: :. .: : : : ...:::.::: ::.: : .. :: .:.:
NP_005 GRGSSC----CQSSC------CKPCCSSSGCGSSCCQSSCCKPCCSQSRCCVPVCYQCKI
120 130 140 150 160
150
pF1KE6 VYSCCQPSCC
>>NP_112229 (OMIM: 608819) keratin-associated protein 1- (177 aa)
initn: 444 init1: 225 opt: 336 Z-score: 238.6 bits: 50.5 E(85289): 1.5e-06
Smith-Waterman score: 451; 42.2% identity (55.9% similar) in 161 aa overlap (8-159:3-144)
10 20 30 40 50
pF1KE6 MTHCCSPCCQPTCCR-TTCWQPTTVTTCSSTPCCQPSCCVSSCCQP-CCHPTCCQNTCCR
::: . : .: .: ::.:. ::::::: .: ::: ::. .::: .::.
NP_112 MACCQTSFCGFPSC---STSGTCGSS-CCQPSCCETSSCQPRCCETSCCQPSCCQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 TTCCQ-P------ICVTSCCQPSCCSTPCCQPTCCGSSCGQSSSCAPVYCRRTCYHPTSV
:. : : : .:::::::: : :::: :: :.:::. : ..
NP_112 TSFCGFPSFSTGGTCDSSCCQPSCCETSCCQP-----SCYQTSSCG-----TGCGIGGGI
60 70 80 90 100
120 130 140 150
pF1KE6 CLPGCLNQSCGSNCCQPCCRPACCETTCCRTTCFQPTCVYSCCQPSCC
: ..: . . ::: : . ::. : :: :: ::::
NP_112 GY-GQEGSSGAVSTRIRWCRPDCR----VEGTCLPPCCVVSCTPPSCCQLHHAEASCCRP
110 120 130 140 150
NP_112 SYCGQSCCRPVCCCYCSEPTC
160 170
>>NP_001244234 (OMIM: 608821) keratin-associated protein (121 aa)
initn: 328 init1: 211 opt: 309 Z-score: 223.4 bits: 47.1 E(85289): 1.1e-05
Smith-Waterman score: 358; 41.1% identity (54.8% similar) in 124 aa overlap (50-158:3-121)
20 30 40 50 60 70
pF1KE6 QPTTVTTCSSTPCCQPSCCVSSCCQPCCHPTCCQNTCCRTTCCQPICV-TSCCQPSCCST
.: . : ..:::: : :::::::::.:
NP_001 MASCSTSGTCGSSCCQPSCCETSCCQPSCCQT
10 20 30
80 90 100 110 120
pF1KE6 PCCQPTCC---GSSCGQSSSCAPVYCR-RTCY---HPTSVCLPGCLNQSCGS-NCCQ---
: : : . :: .: . : : : :. : ..::: : :: .:::
NP_001 SSCGTGCGIGGGIGYGQEGSGGSVSTRIRWCHPDCHVEGTCLPPCYLVSCTPPSCCQLHH
40 50 60 70 80 90
130 140 150
pF1KE6 ---PCCRPACCETTCCRTTCFQPTCVYSCCQPSCC
::::. : .::: :.: ::.:.:
NP_001 AEASCCRPSYCGQSCCR-----PACCCHCCEPTC
100 110 120
>>NP_001005922 (OMIM: 148022) keratin-associated protein (278 aa)
initn: 382 init1: 224 opt: 272 Z-score: 197.3 bits: 43.5 E(85289): 0.0003
Smith-Waterman score: 318; 34.9% identity (48.5% similar) in 169 aa overlap (1-154:1-152)
10 20 30 40 50
pF1KE6 MTHC-CSPCCQPTC--CRTTCWQPTTVTTCSSTPC--CQPSC--CVSSCCQP--CCHPTC
: : :: : .: : . : :.: : : .: :::: : ::.:.:
NP_001 MGCCGCSGGCGSSCGGCGSGC------GGCGSG-CGGCGSGCGGSGSSCCVPVCCCKPVC
10 20 30 40 50
60 70 80 90 100
pF1KE6 CQ-NTCCRTTCCQPICVTSC-CQPSCCSTPCCQPTC--CGSSCGQSSSCAPVY--CRRTC
:. :: ..: . : .: . .: : :. : ::.: : .::. : .:
NP_001 CRVPTCSCSSCGKGGCGSSGGSKGGCGSCGGCKGGCGSCGGSKGGCGSCGGSKGGCG-SC
60 70 80 90 100 110
110 120 130 140 150
pF1KE6 YHPTSVCLPGCLNQSCGSNCCQPCCRPACCETTCCRTTCFQPTCVYSCCQPSCC
. : :: .:::.:: : : ::. :: : :.: : :
NP_001 GGSKGGCGSGC--GGCGSSCCVPVC---CCKPMCC---CV-PACSCSSCGKGGCGSCGCS
120 130 140 150 160
NP_001 KGACGSCGGSKGGCGSCGGCKGGCGSCGGSKGGCGSGCGGCGSGCGVPVCCCSCSSCGSC
170 180 190 200 210 220
>--
initn: 382 init1: 224 opt: 277 Z-score: 200.4 bits: 44.1 E(85289): 0.0002
Smith-Waterman score: 293; 32.0% identity (55.2% similar) in 125 aa overlap (27-146:157-275)
10 20 30 40 50
pF1KE6 MTHCCSPCCQPTCCRTTCWQPTTVTTCSSTPCCQPSCCVSSCCQPCCHPTC--CQN
:.: : . .: . . : .: :..
NP_001 GSSCCVPVCCCKPMCCCVPACSCSSCGKGGCGSCGCSKGACGSCGGSKGGCG-SCGGCKG
130 140 150 160 170 180
60 70 80 90 100 110
pF1KE6 TCCRTTCCQPICVTSCCQPSCCSTPCCQPTCCGSSCGQSSSCAPVY--CRRTCYHPTSVC
: . : ..: . :.. : :.:: ::.. .::: : .: . : :
NP_001 GCGSCGGSKGGCGSGC---GGCGSGCGVPVCC-CSCSSCGSCAGSKGGCGSSCSQ-CSCC
190 200 210 220 230 240
120 130 140 150
pF1KE6 LPGCLNQSCGSNCCQP-CCRPACCETTCCRTTCFQPTCVYSCCQPSCC
: : ...:::.::: ::.: : ...:: .: :
NP_001 KPCCCSSGCGSSCCQSSCCKPCCSQSSCCVPVCCQCKI
250 260 270
>>NP_853630 (OMIM: 608718) keratin-associated protein 13 (172 aa)
initn: 289 init1: 109 opt: 231 Z-score: 173.8 bits: 38.5 E(85289): 0.0061
Smith-Waterman score: 238; 31.0% identity (45.6% similar) in 171 aa overlap (3-149:4-166)
10 20 30 40
pF1KE6 MTHCCSPCCQPTCC-------RTTCWQPTTVTTCSSTPCCQPSCC------VSSCCQPC
.::: . : ..: . :: :.:: : .: : :
NP_853 MSYNCCSGNFSSRSCGGYLHYPASSCGFSYPSNQVYSTDLCSPSTCQLGSSLYRGCQQTC
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 CHPTCCQNTCCRTTCCQPICVTSCCQPSC---CSTPCCQPTCCGSSCGQSSSCAPV-YCR
.:: ::.. ... :: ::: .: :: :: : : :: :::: . :
NP_853 WEPTSCQTSYVESSPCQ----TSCYRPRTSLLCS-PC-QTTYSGSLGFGSSSCRSLGYGS
70 80 90 100 110
110 120 130 140 150
pF1KE6 RTCYHP-------TSVCLPGCLNQSCGSNCCQPCCRPACCETTCCRTTCFQPTCVYSCCQ
:.:: :. :: : : . :::. . :...:..:::
NP_853 RSCYSVGCGSSGFRSLGYGGCGFPSLGYGV--GFCRPTYLASRSCQSSCYRPTCGSGFYY
120 130 140 150 160 170
pF1KE6 PSCC
>>NP_848525 (OMIM: 612619) late cornified envelope prote (118 aa)
initn: 239 init1: 92 opt: 226 Z-score: 172.2 bits: 37.6 E(85289): 0.0075
Smith-Waterman score: 234; 33.6% identity (44.8% similar) in 125 aa overlap (33-140:3-118)
10 20 30 40 50
pF1KE6 HCCSPCCQPTCCRTTCWQPTTVTTCSSTPCCQPS---CCVSSCCQPCCHPTCCQNTCCRT
:: : : : : : : : :
NP_848 MSCQQSQQQCQPPPKCTPKCPPKC-------T
10 20
60 70 80 90 100
pF1KE6 TCCQPICVTSCCQPSCCSTPCCQP--TCCGSSCGQSSSCAPVYCRRTCYHP---------
: : : .: : ::.:: : .::::: : : : . ..:
NP_848 PKCPPKCPPKC--PPQCSAPCPPPVSSCCGSSSGGCCSSEGGGCCLSHHRPRQSLRRRPQ
30 40 50 60 70 80
110 120 130 140 150
pF1KE6 -TSVCLPGCLNQSCGSNCCQPCCRPACCETT--CCRTTCFQPTCVYSCCQPSCC
.: : : .:: ::.::. .::... ::
NP_848 SSSCCGSGSGQQSGGSSCCHSSGGSGCCHSSGGCC
90 100 110
>>NP_848516 (OMIM: 612611) late cornified envelope prote (110 aa)
initn: 131 init1: 91 opt: 222 Z-score: 170.0 bits: 37.1 E(85289): 0.0099
Smith-Waterman score: 222; 33.6% identity (48.4% similar) in 122 aa overlap (17-130:2-110)
10 20 30 40 50 60
pF1KE6 MTHCCSPCCQPTCCRTTCWQPTTVTTCSSTPCCQPSCCVSSCCQPCCHPTCCQNTCCRTT
.: : :. : : :.: . : : : : : . : .
NP_848 MSCQQNQQ--QCQPPPKCPPKC--TPKCPPKCPPKCPPQ--CPAP
10 20 30
70 80 90 100 110
pF1KE6 CCQPICVTSCCQPSCCSTPCCQPT---CCGSSCGQSSSCAPVYCRRTCYHPTSVCLPGCL
: : :.::: :: : :: :. ::.:. : .:. . : .: : :
NP_848 CF-PA-VSSCCGPS--SGSCCGPSSGGCCSSGAG---GCSLSHHRPRLFHRRRHQSPDCC
40 50 60 70 80 90
120 130 140 150
pF1KE6 NQ--SCGSNCCQP---CCRPACCETTCCRTTCFQPTCVYSCCQPSCC
.. : ::.::. ::
NP_848 ESEPSGGSGCCHSSGGCC
100 110
159 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 14:35:38 2016 done: Tue Nov 8 14:35:39 2016
Total Scan time: 4.480 Total Display time: -0.040
Function used was FASTA [36.3.4 Apr, 2011]