FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE6569, 213 aa
  1>>>pF1KE6569 213 - 213 aa - 213 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.3757+/-0.000264; mu= 14.8109+/- 0.016
 mean_var=84.2881+/-17.163, 0's: 0 Z-trim(122.1): 25  B-trim: 1946 in 1/56
 Lambda= 0.139698
 statistics sampled from 39551 (39579) to 39551 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.813), E-opt: 0.2 (0.464), width:  16
 Scan time:  5.720

The best scores are:                                      opt bits E(85289)
NP_079513 (OMIM: 122860,239100,269500,605740) scle ( 213) 1519 314.8 6.9e-86
NP_056279 (OMIM: 609675) sclerostin domain-contain ( 206)  462 101.7   9e-22
XP_016867432 (OMIM: 609675) PREDICTED: sclerostin  ( 206)  462 101.7   9e-22


>>NP_079513 (OMIM: 122860,239100,269500,605740) sclerost  (213 aa)
 initn: 1519 init1: 1519 opt: 1519  Z-score: 1663.0  bits: 314.8 E(85289): 6.9e-86
Smith-Waterman score: 1519; 100.0% identity (100.0% similar) in 213 aa overlap (1-213:1-213)

               10        20        30        40        50        60
pF1KE6 MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 NGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 NGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE6 RGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELK
              130       140       150       160       170       180

              190       200       210   
pF1KE6 DFGTEAARPQKGRKPRPRARSAKANQAELENAY
       :::::::::::::::::::::::::::::::::
NP_079 DFGTEAARPQKGRKPRPRARSAKANQAELENAY
              190       200       210   

>>NP_056279 (OMIM: 609675) sclerostin domain-containing   (206 aa)
 initn: 469 init1: 227 opt: 462  Z-score: 511.9  bits: 101.7 E(85289): 9e-22
Smith-Waterman score: 464; 39.9% identity (65.4% similar) in 208 aa overlap (3-203:11-202)

                       10        20        30        40         50 
pF1KE6         MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEP-PPELE
                 ::::    :.:... .         :::::::::.   ..  .: : .  
NP_056 MLPPAIHFYLLPLA----CILMKSCL---------AFKNDATEIL--YSHVVKPVPAHPS
               10            20                 30          40     

              60         70        80        90       100       110
pF1KE6 NNKTMNRAENGGRP-PHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCG
       .:.:.:.:.::::   .  .. .   . .::::. :.:..:: : : .:. ::::.:.: 
NP_056 SNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECL
          50        60        70        80        90       100     

              120           130       140       150       160      
pF1KE6 PARLLPNAIGRG---KWW-RPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCK
       :  .::: :: :   :.: : :. ..::. :. :.::.:: :  : . :. :. .:..::
NP_056 PLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDG-STRTYKITVVTACK
         110       120       130       140       150        160    

        170       180       190        200       210   
pF1KE6 CKRLTRFHNQSELKDFGTEAARPQKGRKPRPRA-RSAKANQAELENAY
       ::: :: ::.:  .  .   :.: . .. : :: .:.:          
NP_056 CKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS      
          170       180       190       200            

>>XP_016867432 (OMIM: 609675) PREDICTED: sclerostin doma  (206 aa)
 initn: 469 init1: 227 opt: 462  Z-score: 511.9  bits: 101.7 E(85289): 9e-22
Smith-Waterman score: 464; 39.9% identity (65.4% similar) in 208 aa overlap (3-203:11-202)

                       10        20        30        40         50 
pF1KE6         MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEP-PPELE
                 ::::    :.:... .         :::::::::.   ..  .: : .  
XP_016 MLPPAIHFYLLPLA----CILMKSCL---------AFKNDATEIL--YSHVVKPVPAHPS
               10            20                 30          40     

              60         70        80        90       100       110
pF1KE6 NNKTMNRAENGGRP-PHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCG
       .:.:.:.:.::::   .  .. .   . .::::. :.:..:: : : .:. ::::.:.: 
XP_016 SNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECL
          50        60        70        80        90       100     

              120           130       140       150       160      
pF1KE6 PARLLPNAIGRG---KWW-RPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCK
       :  .::: :: :   :.: : :. ..::. :. :.::.:: :  : . :. :. .:..::
XP_016 PLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDG-STRTYKITVVTACK
         110       120       130       140       150        160    

        170       180       190        200       210   
pF1KE6 CKRLTRFHNQSELKDFGTEAARPQKGRKPRPRA-RSAKANQAELENAY
       ::: :: ::.:  .  .   :.: . .. : :: .:.:          
XP_016 CKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS      
          170       180       190       200            




213 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Nov  8 10:51:20 2016 done: Tue Nov  8 10:51:21 2016
 Total Scan time:  5.720 Total Display time: -0.030

Function used was FASTA [36.3.4 Apr, 2011]