Result of FASTA (omim) for
pFN21AE6505
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6505, 200 aa
1>>>pF1KE6505 200 - 200 aa - 200 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6447+/-0.000292; mu= 16.9234+/- 0.018
mean_var=58.8986+/-11.798, 0's: 0 Z-trim(117.7): 21 B-trim: 886 in 1/56
Lambda= 0.167117
statistics sampled from 29908 (29929) to 29908 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.74), E-opt: 0.2 (0.351), width: 16
Scan time: 4.770
The best scores are: opt bits E(85289)
NP_973733 (OMIM: 602390,608374) hemojuvelin isofor ( 200) 1323 326.6 1.7e-89
NP_998817 (OMIM: 602390,608374) hemojuvelin isofor ( 200) 1323 326.6 1.7e-89
NP_001303696 (OMIM: 602390,608374) hemojuvelin iso ( 200) 1323 326.6 1.7e-89
NP_660320 (OMIM: 602390,608374) hemojuvelin isofor ( 313) 1323 326.7 2.3e-89
XP_005272989 (OMIM: 602390,608374) PREDICTED: hemo ( 426) 1323 326.8 3e-89
NP_998818 (OMIM: 602390,608374) hemojuvelin isofor ( 426) 1323 326.8 3e-89
NP_001159758 (OMIM: 607362) repulsive guidance mol ( 434) 366 96.1 8.7e-20
NP_001159760 (OMIM: 607362) repulsive guidance mol ( 434) 366 96.1 8.7e-20
NP_001159759 (OMIM: 607362) repulsive guidance mol ( 434) 366 96.1 8.7e-20
NP_001159761 (OMIM: 607362) repulsive guidance mol ( 434) 366 96.1 8.7e-20
NP_064596 (OMIM: 607362) repulsive guidance molecu ( 450) 366 96.1 8.9e-20
NP_001159755 (OMIM: 607362) repulsive guidance mol ( 458) 366 96.1 9e-20
XP_011541648 (OMIM: 612687) PREDICTED: RGM domain ( 396) 256 69.6 7.8e-12
XP_005272023 (OMIM: 612687) PREDICTED: RGM domain ( 477) 256 69.6 9e-12
XP_016864879 (OMIM: 612687) PREDICTED: RGM domain ( 478) 256 69.6 9e-12
XP_011541647 (OMIM: 612687) PREDICTED: RGM domain ( 478) 256 69.6 9e-12
NP_001012779 (OMIM: 612687) RGM domain family memb ( 478) 256 69.6 9e-12
XP_016864880 (OMIM: 612687) PREDICTED: RGM domain ( 478) 256 69.6 9e-12
>>NP_973733 (OMIM: 602390,608374) hemojuvelin isoform c (200 aa)
initn: 1323 init1: 1323 opt: 1323 Z-score: 1727.9 bits: 326.6 E(85289): 1.7e-89
Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:1-200)
10 20 30 40 50 60
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_973 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_973 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_973 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
130 140 150 160 170 180
190 200
pF1KE6 SATLLAPLLSGLFVLWLCIQ
::::::::::::::::::::
NP_973 SATLLAPLLSGLFVLWLCIQ
190 200
>>NP_998817 (OMIM: 602390,608374) hemojuvelin isoform c (200 aa)
initn: 1323 init1: 1323 opt: 1323 Z-score: 1727.9 bits: 326.6 E(85289): 1.7e-89
Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:1-200)
10 20 30 40 50 60
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
130 140 150 160 170 180
190 200
pF1KE6 SATLLAPLLSGLFVLWLCIQ
::::::::::::::::::::
NP_998 SATLLAPLLSGLFVLWLCIQ
190 200
>>NP_001303696 (OMIM: 602390,608374) hemojuvelin isoform (200 aa)
initn: 1323 init1: 1323 opt: 1323 Z-score: 1727.9 bits: 326.6 E(85289): 1.7e-89
Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:1-200)
10 20 30 40 50 60
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
130 140 150 160 170 180
190 200
pF1KE6 SATLLAPLLSGLFVLWLCIQ
::::::::::::::::::::
NP_001 SATLLAPLLSGLFVLWLCIQ
190 200
>>NP_660320 (OMIM: 602390,608374) hemojuvelin isoform b (313 aa)
initn: 1323 init1: 1323 opt: 1323 Z-score: 1725.2 bits: 326.7 E(85289): 2.3e-89
Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:114-313)
10 20 30
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGD
::::::::::::::::::::::::::::::
NP_660 DFLFVQATSSPMALGANATATRKLTIIFKNMQECIDQKVYQAEVDNLPVAFEDGSINGGD
90 100 110 120 130 140
40 50 60 70 80 90
pF1KE6 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL
150 160 170 180 190 200
100 110 120 130 140 150
pF1KE6 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA
210 220 230 240 250 260
160 170 180 190 200
pF1KE6 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ
270 280 290 300 310
>>XP_005272989 (OMIM: 602390,608374) PREDICTED: hemojuve (426 aa)
initn: 1323 init1: 1323 opt: 1323 Z-score: 1723.4 bits: 326.8 E(85289): 3e-89
Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:227-426)
10 20 30
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGD
::::::::::::::::::::::::::::::
XP_005 DFLFVQATSSPMALGANATATRKLTIIFKNMQECIDQKVYQAEVDNLPVAFEDGSINGGD
200 210 220 230 240 250
40 50 60 70 80 90
pF1KE6 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL
260 270 280 290 300 310
100 110 120 130 140 150
pF1KE6 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA
320 330 340 350 360 370
160 170 180 190 200
pF1KE6 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ
380 390 400 410 420
>>NP_998818 (OMIM: 602390,608374) hemojuvelin isoform a (426 aa)
initn: 1323 init1: 1323 opt: 1323 Z-score: 1723.4 bits: 326.8 E(85289): 3e-89
Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:227-426)
10 20 30
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGD
::::::::::::::::::::::::::::::
NP_998 DFLFVQATSSPMALGANATATRKLTIIFKNMQECIDQKVYQAEVDNLPVAFEDGSINGGD
200 210 220 230 240 250
40 50 60 70 80 90
pF1KE6 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL
260 270 280 290 300 310
100 110 120 130 140 150
pF1KE6 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA
320 330 340 350 360 370
160 170 180 190 200
pF1KE6 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ
380 390 400 410 420
>>NP_001159758 (OMIM: 607362) repulsive guidance molecul (434 aa)
initn: 591 init1: 321 opt: 366 Z-score: 476.3 bits: 96.1 E(85289): 8.7e-20
Smith-Waterman score: 543; 44.4% identity (65.5% similar) in 223 aa overlap (2-195:208-430)
10 20 30
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDR
:::.::::::::.:.::.:: ::: ::::.
NP_001 YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDK
180 190 200 210 220 230
40 50 60 70 80
pF1KE6 PGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSA--EQDLQ
:..::.: :.:::::: ::::::..::.. :.:.... :.:. : : :
NP_001 HGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLY
240 250 260 270 280 290
90 100 110 120 130
pF1KE6 LCVGGCPPSQRL--------SRSERNRRGAIT-----------IDTARRLCKEGLPVEDA
::. ::: .:.. ... :: : . .:: ::: :::::
NP_001 LCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL
300 310 320 330 340 350
140 150 160 170 180
pF1KE6 YFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLF------P--SDAGVPLSSA
:...::::.: .:: :::.:: ::::.. . . .::::. : . ::.::.
NP_001 YYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPR
360 370 380 390 400 410
190 200
pF1KE6 TLLAPLLSGLFVLWLCIQ
::. :. : .:
NP_001 PLLGALVPLLALLPVFC
420 430
>>NP_001159760 (OMIM: 607362) repulsive guidance molecul (434 aa)
initn: 591 init1: 321 opt: 366 Z-score: 476.3 bits: 96.1 E(85289): 8.7e-20
Smith-Waterman score: 543; 44.4% identity (65.5% similar) in 223 aa overlap (2-195:208-430)
10 20 30
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDR
:::.::::::::.:.::.:: ::: ::::.
NP_001 YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDK
180 190 200 210 220 230
40 50 60 70 80
pF1KE6 PGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSA--EQDLQ
:..::.: :.:::::: ::::::..::.. :.:.... :.:. : : :
NP_001 HGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLY
240 250 260 270 280 290
90 100 110 120 130
pF1KE6 LCVGGCPPSQRL--------SRSERNRRGAIT-----------IDTARRLCKEGLPVEDA
::. ::: .:.. ... :: : . .:: ::: :::::
NP_001 LCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL
300 310 320 330 340 350
140 150 160 170 180
pF1KE6 YFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLF------P--SDAGVPLSSA
:...::::.: .:: :::.:: ::::.. . . .::::. : . ::.::.
NP_001 YYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPR
360 370 380 390 400 410
190 200
pF1KE6 TLLAPLLSGLFVLWLCIQ
::. :. : .:
NP_001 PLLGALVPLLALLPVFC
420 430
>>NP_001159759 (OMIM: 607362) repulsive guidance molecul (434 aa)
initn: 591 init1: 321 opt: 366 Z-score: 476.3 bits: 96.1 E(85289): 8.7e-20
Smith-Waterman score: 543; 44.4% identity (65.5% similar) in 223 aa overlap (2-195:208-430)
10 20 30
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDR
:::.::::::::.:.::.:: ::: ::::.
NP_001 YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDK
180 190 200 210 220 230
40 50 60 70 80
pF1KE6 PGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSA--EQDLQ
:..::.: :.:::::: ::::::..::.. :.:.... :.:. : : :
NP_001 HGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLY
240 250 260 270 280 290
90 100 110 120 130
pF1KE6 LCVGGCPPSQRL--------SRSERNRRGAIT-----------IDTARRLCKEGLPVEDA
::. ::: .:.. ... :: : . .:: ::: :::::
NP_001 LCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL
300 310 320 330 340 350
140 150 160 170 180
pF1KE6 YFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLF------P--SDAGVPLSSA
:...::::.: .:: :::.:: ::::.. . . .::::. : . ::.::.
NP_001 YYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPR
360 370 380 390 400 410
190 200
pF1KE6 TLLAPLLSGLFVLWLCIQ
::. :. : .:
NP_001 PLLGALVPLLALLPVFC
420 430
>>NP_001159761 (OMIM: 607362) repulsive guidance molecul (434 aa)
initn: 591 init1: 321 opt: 366 Z-score: 476.3 bits: 96.1 E(85289): 8.7e-20
Smith-Waterman score: 543; 44.4% identity (65.5% similar) in 223 aa overlap (2-195:208-430)
10 20 30
pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDR
:::.::::::::.:.::.:: ::: ::::.
NP_001 YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDK
180 190 200 210 220 230
40 50 60 70 80
pF1KE6 PGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSA--EQDLQ
:..::.: :.:::::: ::::::..::.. :.:.... :.:. : : :
NP_001 HGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLY
240 250 260 270 280 290
90 100 110 120 130
pF1KE6 LCVGGCPPSQRL--------SRSERNRRGAIT-----------IDTARRLCKEGLPVEDA
::. ::: .:.. ... :: : . .:: ::: :::::
NP_001 LCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL
300 310 320 330 340 350
140 150 160 170 180
pF1KE6 YFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLF------P--SDAGVPLSSA
:...::::.: .:: :::.:: ::::.. . . .::::. : . ::.::.
NP_001 YYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPR
360 370 380 390 400 410
190 200
pF1KE6 TLLAPLLSGLFVLWLCIQ
::. :. : .:
NP_001 PLLGALVPLLALLPVFC
420 430
200 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:55:30 2016 done: Tue Nov 8 13:55:31 2016
Total Scan time: 4.770 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]