Result of FASTA (omim) for
pFN21AE6415
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6415, 480 aa
1>>>pF1KE6415 480 - 480 aa - 480 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7903+/-0.000396; mu= 20.8884+/- 0.025
mean_var=65.1541+/-13.605, 0's: 0 Z-trim(110.0): 81 B-trim: 0 in 0/56
Lambda= 0.158893
statistics sampled from 18201 (18282) to 18201 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.578), E-opt: 0.2 (0.214), width: 16
Scan time: 7.270
The best scores are: opt bits E(85289)
NP_733797 (OMIM: 603687) retinal dehydrogenase 2 i ( 480) 3185 739.4 5.1e-213
NP_733798 (OMIM: 603687) retinal dehydrogenase 2 i ( 422) 1652 387.9 2.8e-107
NP_001193826 (OMIM: 603687) retinal dehydrogenase ( 497) 1652 388.0 3.2e-107
NP_003879 (OMIM: 603687) retinal dehydrogenase 2 i ( 518) 1652 388.0 3.3e-107
NP_000680 (OMIM: 100640) retinal dehydrogenase 1 [ ( 501) 1294 305.9 1.6e-82
NP_001280744 (OMIM: 600463,615113) aldehyde dehydr ( 405) 1271 300.6 5.4e-81
NP_000684 (OMIM: 600463,615113) aldehyde dehydroge ( 512) 1271 300.7 6.4e-81
NP_001191818 (OMIM: 100650,610251) aldehyde dehydr ( 470) 1201 284.6 4.1e-76
NP_000681 (OMIM: 100650,610251) aldehyde dehydroge ( 517) 1201 284.6 4.4e-76
NP_000683 (OMIM: 100670) aldehyde dehydrogenase X, ( 517) 1180 279.8 1.2e-74
XP_011516104 (OMIM: 100670) PREDICTED: aldehyde de ( 517) 1180 279.8 1.2e-74
NP_001257294 (OMIM: 600249) cytosolic 10-formyltet ( 801) 870 208.9 4.2e-53
XP_016861103 (OMIM: 600249) PREDICTED: cytosolic 1 ( 828) 870 208.9 4.3e-53
XP_016861102 (OMIM: 600249) PREDICTED: cytosolic 1 ( 838) 870 208.9 4.4e-53
XP_011510657 (OMIM: 600249) PREDICTED: cytosolic 1 ( 902) 870 209.0 4.6e-53
NP_036322 (OMIM: 600249) cytosolic 10-formyltetrah ( 902) 870 209.0 4.6e-53
XP_006713544 (OMIM: 600249) PREDICTED: cytosolic 1 ( 902) 870 209.0 4.6e-53
NP_001257293 (OMIM: 600249) cytosolic 10-formyltet ( 912) 870 209.0 4.7e-53
XP_011536288 (OMIM: 613584) PREDICTED: mitochondri ( 777) 829 199.5 2.8e-50
XP_016874378 (OMIM: 613584) PREDICTED: mitochondri ( 777) 829 199.5 2.8e-50
NP_001029345 (OMIM: 613584) mitochondrial 10-formy ( 923) 829 199.6 3.2e-50
NP_001180409 (OMIM: 606467) aldehyde dehydrogenase ( 437) 821 197.5 6.4e-50
XP_011507596 (OMIM: 602733) PREDICTED: 4-trimethyl ( 424) 683 165.8 2.1e-40
NP_000687 (OMIM: 602733) 4-trimethylaminobutyralde ( 518) 683 165.9 2.4e-40
NP_072090 (OMIM: 606467) aldehyde dehydrogenase fa ( 487) 628 153.3 1.5e-36
XP_011536290 (OMIM: 613584) PREDICTED: mitochondri ( 622) 578 141.9 4.9e-33
NP_001071 (OMIM: 271980,610045) succinate-semialde ( 535) 542 133.6 1.3e-30
NP_733936 (OMIM: 271980,610045) succinate-semialde ( 548) 542 133.6 1.4e-30
NP_001188306 (OMIM: 107323,266100) alpha-aminoadip ( 511) 472 117.5 8.8e-26
NP_001173 (OMIM: 107323,266100) alpha-aminoadipic ( 539) 472 117.5 9.1e-26
XP_011541719 (OMIM: 107323,266100) PREDICTED: alph ( 404) 466 116.1 1.9e-25
XP_016864982 (OMIM: 107323,266100) PREDICTED: alph ( 404) 466 116.1 1.9e-25
XP_011522033 (OMIM: 100660) PREDICTED: aldehyde de ( 380) 376 95.4 3e-19
NP_001317079 (OMIM: 100660) aldehyde dehydrogenase ( 380) 376 95.4 3e-19
NP_001128640 (OMIM: 100660) aldehyde dehydrogenase ( 453) 376 95.5 3.4e-19
NP_000682 (OMIM: 100660) aldehyde dehydrogenase, d ( 453) 376 95.5 3.4e-19
NP_001128639 (OMIM: 100660) aldehyde dehydrogenase ( 453) 376 95.5 3.4e-19
XP_005256579 (OMIM: 100660) PREDICTED: aldehyde de ( 570) 376 95.6 4e-19
XP_005256580 (OMIM: 100660) PREDICTED: aldehyde de ( 570) 376 95.6 4e-19
XP_005256581 (OMIM: 100660) PREDICTED: aldehyde de ( 570) 376 95.6 4e-19
NP_739577 (OMIM: 606467) aldehyde dehydrogenase fa ( 433) 369 93.9 9.9e-19
XP_016879846 (OMIM: 270200,609523) PREDICTED: fatt ( 485) 361 92.1 3.9e-18
XP_016879845 (OMIM: 270200,609523) PREDICTED: fatt ( 485) 361 92.1 3.9e-18
NP_000373 (OMIM: 270200,609523) fatty aldehyde deh ( 485) 361 92.1 3.9e-18
XP_011522034 (OMIM: 270200,609523) PREDICTED: fatt ( 508) 361 92.1 4e-18
XP_011522035 (OMIM: 270200,609523) PREDICTED: fatt ( 508) 361 92.1 4e-18
NP_001026976 (OMIM: 270200,609523) fatty aldehyde ( 508) 361 92.1 4e-18
XP_016879844 (OMIM: 270200,609523) PREDICTED: fatt ( 424) 333 85.6 3e-16
XP_016879847 (OMIM: 270200,609523) PREDICTED: fatt ( 424) 333 85.6 3e-16
NP_005580 (OMIM: 603178,614105) methylmalonate-sem ( 535) 323 83.4 1.7e-15
>>NP_733797 (OMIM: 603687) retinal dehydrogenase 2 isofo (480 aa)
initn: 3185 init1: 3185 opt: 3185 Z-score: 3945.3 bits: 739.4 E(85289): 5.1e-213
Smith-Waterman score: 3185; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480)
10 20 30 40 50 60
pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVGKLIQEAAGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVGKLIQEAAGRS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
430 440 450 460 470 480
>>NP_733798 (OMIM: 603687) retinal dehydrogenase 2 isofo (422 aa)
initn: 1652 init1: 1652 opt: 1652 Z-score: 2046.9 bits: 387.9 E(85289): 2.8e-107
Smith-Waterman score: 2466; 91.0% identity (91.0% similar) in 422 aa overlap (97-480:1-422)
70 80 90 100 110 120
pF1KE6 CEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESL
::::::::::::::::::::::::::::::
NP_733 MDASERGRLLDKLADLVERDRAVLATMESL
10 20 30
130 140 150 160 170 180
pF1KE6 NGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 NGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPW
40 50 60 70 80 90
190 200 210 220
pF1KE6 NFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------------
::::::::::::::::::::::::::::::::::::::::::
NP_733 NFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTA
100 110 120 130 140 150
230 240 250 260
pF1KE6 --------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVE
::::::::::::::::::::::::::::::::::::::::
NP_733 GAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVE
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE6 QAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 QAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKK
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE6 QYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 QYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE6 RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGF
340 350 360 370 380 390
450 460 470 480
pF1KE6 KMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
::::::::::::::::::::::::::::::::
NP_733 KMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
400 410 420
>>NP_001193826 (OMIM: 603687) retinal dehydrogenase 2 is (497 aa)
initn: 1652 init1: 1652 opt: 1652 Z-score: 2045.9 bits: 388.0 E(85289): 3.2e-107
Smith-Waterman score: 2856; 91.5% identity (91.5% similar) in 484 aa overlap (35-480:14-497)
10 20 30 40 50 60
pF1KE6 KIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGE
:: :::::::::::::::::::::::::
NP_001 MKNQCETVWLKSPIKLKLIFINNEWQNSESGRVFPVYNPATGE
10 20 30 40
70 80 90 100 110 120
pF1KE6 QVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATME
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 SLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQII
110 120 130 140 150 160
190 200 210 220
pF1KE6 PWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE----------------
::::::::::::::::::::::::::::::::::::::::::::
NP_001 PWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGP
170 180 190 200 210 220
230 240 250 260
pF1KE6 ----------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA
::::::::::::::::::::::::::::::::::::::
NP_001 TAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA
230 240 250 260 270 280
270 280 290 300 310 320
pF1KE6 VEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQID
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE6 KKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQE
350 360 370 380 390 400
390 400 410 420 430 440
pF1KE6 ILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFG
410 420 430 440 450 460
450 460 470 480
pF1KE6 GFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
::::::::::::::::::::::::::::::::::
NP_001 GFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
470 480 490
>>NP_003879 (OMIM: 603687) retinal dehydrogenase 2 isofo (518 aa)
initn: 1652 init1: 1652 opt: 1652 Z-score: 2045.7 bits: 388.0 E(85289): 3.3e-107
Smith-Waterman score: 3066; 92.6% identity (92.6% similar) in 512 aa overlap (7-480:7-518)
10 20 30 40 50 60
pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
130 140 150 160 170 180
190 200 210 220
pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------
::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP
190 200 210 220 230 240
230 240 250 260
pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
::::::::::::::::::::::::::::::::::
NP_003 GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
430 440 450 460 470 480
450 460 470 480
pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
::::::::::::::::::::::::::::::::::::::
NP_003 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
490 500 510
>>NP_000680 (OMIM: 100640) retinal dehydrogenase 1 [Homo (501 aa)
initn: 1294 init1: 1294 opt: 1294 Z-score: 1602.3 bits: 305.9 E(85289): 1.6e-82
Smith-Waterman score: 2212; 66.7% identity (84.0% similar) in 493 aa overlap (26-480:9-501)
10 20 30 40 50 60
pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
:: .:.:.::::::::::..: ::. :::.::
NP_000 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNP
10 20 30 40
70 80 90 100 110 120
pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
:: :..:.:.:.:: :.::::.::: ::..:: :: :::::::::: :::::.:::: .:
NP_000 ATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
:::::.:::: . .:. :: : :::.:: :::::::.: :::.::..::.:::::::::
NP_000 ATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVC
110 120 130 140 150 160
190 200 210 220
pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------
::::::::::.:. :::.::: ::::::.::::::::.::....::::
NP_000 GQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVP
170 180 190 200 210 220
230 240 250 260
pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
:::::.::::.::::::::::::::: :..::::
NP_000 GYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADAD
230 240 250 260 270 280
270 280 290 300 310 320
pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
:: ::: ::.:::..::::: :.::::::::::.:::::::::::. ..:.:. : . ::
NP_000 LDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQG
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
:::::.::.:::.::.:: ::::::::: : ::.:..:::::::::.::::::::::
NP_000 PQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFG
350 360 370 380 390 400
390 400 410 420 430 440
pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
:::.:..::..:.::.::::. .:: :.:::.::.::.:.:::.::::::.:::....::
NP_000 PVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQ
410 420 430 440 450 460
450 460 470 480
pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
:::::::::::::.::.:..::.::::::::: ::::
NP_000 CPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS
470 480 490 500
>>NP_001280744 (OMIM: 600463,615113) aldehyde dehydrogen (405 aa)
initn: 1694 init1: 1271 opt: 1271 Z-score: 1575.1 bits: 300.6 E(85289): 5.4e-81
Smith-Waterman score: 1584; 57.7% identity (74.7% similar) in 454 aa overlap (26-479:20-404)
10 20 30 40 50 60
pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
:: : :::.:.:::::::::..:.::. : . ::
NP_001 MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNP
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
.: ::.:::.:.:: :.::::.::..::. :: :::.:: ::::: .::::::::::.:
NP_001 STREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
: ::. : ::
NP_001 A-----------------------------AGF----------------------PPGVV
120
190 200 210 220 230 240
pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVGKLIQEAAGRS
. :.: : . : . : . : .. . :. :::::..:::.::
NP_001 N-IVPGFGPTVGAAISSHPQI---NKIA------------FTGS--TEVGKLVKEAASRS
130 140 150 160
250 260 270 280 290 300
pF1KE6 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR
::::::::::::.: :. :::::: ::: :::::::::::::::.::.::::..: ::::
NP_001 NLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVR
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE6 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF
:::: ::.: ::.::: ::::::::.::..::::::.:: :::::::::... ::.:
NP_001 RSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLF
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE6 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL
:.:::::.:::.::::::::::::: ::.::...:::.:::..:.::.:::::....:::
NP_001 IKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKAL
290 300 310 320 330 340
430 440 450 460 470 480
pF1KE6 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
..::...::::::::::: ::.:::::::::::::.::..: ::.::::::.:. .::
NP_001 KLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
350 360 370 380 390 400
>>NP_000684 (OMIM: 600463,615113) aldehyde dehydrogenase (512 aa)
initn: 1271 init1: 1271 opt: 1271 Z-score: 1573.7 bits: 300.7 E(85289): 6.4e-81
Smith-Waterman score: 2195; 65.9% identity (84.1% similar) in 492 aa overlap (26-479:20-511)
10 20 30 40 50 60
pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
:: : :::.:.:::::::::..:.::. : . ::
NP_000 MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNP
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
.: ::.:::.:.:: :.::::.::..::. :: :::.:: ::::: .::::::::::.:
NP_000 STREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
:..:... :::::.::..::.: :.:.::.:::::::.: :::.: . ::::::::::
NP_000 AALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVC
120 130 140 150 160 170
190 200 210 220
pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------
: : ::::::::..::.:::::::::.:.::::::::.:::.:.::::
NP_000 GAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVP
180 190 200 210 220 230
230 240 250 260
pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
::::..:::.::::::::::::::.: :. ::::
NP_000 GFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADAD
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
:: ::: :::::::::::::::.::.::::..: :::::::: ::.: ::.::: ::::
NP_000 LDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQG
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
::::.::..::::::.:: :::::::::... ::.::.:::::.:::.::::::::::
NP_000 PQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFG
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
::: ::.::...:::.:::..:.::.:::::....::: ..::...::::::::::: ::
NP_000 PVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQ
420 430 440 450 460 470
450 460 470 480
pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
.:::::::::::::.::..: ::.::::::.:. .::
NP_000 APFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
480 490 500 510
>>NP_001191818 (OMIM: 100650,610251) aldehyde dehydrogen (470 aa)
initn: 1347 init1: 1201 opt: 1201 Z-score: 1487.5 bits: 284.6 E(85289): 4.1e-76
Smith-Waterman score: 1728; 54.2% identity (73.1% similar) in 498 aa overlap (21-480:20-470)
10 20 30 40 50 60
pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
:. . .:.:. . :. ..:::::::... : ..::. ::
NP_001 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNP
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
.::: .:.: :.:::
NP_001 STGEVICQVAEGDKA---------------------------------------------
60 70
130 140 150 160 170 180
pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
.:.:..:::.. .. :::. :.: .::::::::: :: :::.:::.:..:::::.:::
NP_001 --LETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVC
80 90 100 110 120 130
190 200 210 220
pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------
:::::::::::: :::..::: ::.::.: ::::::.:::.. ::::
NP_001 GQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVP
140 150 160 170 180 190
230 240 250 260
pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
.:..:: ::: ::::::::::::::::::..:::
NP_001 GFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDAD
200 210 220 230 240 250
270 280 290 300 310 320
pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
.:.:::::: ..:::::::: :::: ::.:.::.:::.::: ::: ::::.::: ::::
NP_001 MDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQG
260 270 280 290 300 310
330 340 350 360 370 380
pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
::.:. :..::: :..: ::::: ::: . .:.::.::::..: : : ::::::::
NP_001 PQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFG
320 330 340 350 360 370
390 400 410 420 430 440
pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
::..::.:::..::. ::::: .::.:::::.:..:: .:.:.::::::.:::....::
NP_001 PVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQ
380 390 400 410 420 430
450 460 470 480
pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
:::::.::::.:::.::.::. :.::::::::.:::::
NP_001 SPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
440 450 460 470
>>NP_000681 (OMIM: 100650,610251) aldehyde dehydrogenase (517 aa)
initn: 1201 init1: 1201 opt: 1201 Z-score: 1486.9 bits: 284.6 E(85289): 4.4e-76
Smith-Waterman score: 2062; 61.0% identity (81.7% similar) in 498 aa overlap (21-480:20-517)
10 20 30 40 50 60
pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
:. . .:.:. . :. ..:::::::... : ..::. ::
NP_000 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNP
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
.::: .:.: :.:: :.::::.::: ::.::: :::::::.:::::..::::.::::. :
NP_000 STGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
:..:.:..:::.. .. :::. :.: .::::::::: :: :::.:::.:..:::::.:::
NP_000 AALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVC
120 130 140 150 160 170
190 200 210 220
pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------
:::::::::::: :::..::: ::.::.: ::::::.:::.. ::::
NP_000 GQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVP
180 190 200 210 220 230
230 240 250 260
pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
.:..:: ::: ::::::::::::::::::..:::
NP_000 GFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDAD
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
.:.:::::: ..:::::::: :::: ::.:.::.:::.::: ::: ::::.::: ::::
NP_000 MDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQG
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
::.:. :..::: :..: ::::: ::: . .:.::.::::..: : : ::::::::
NP_000 PQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFG
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
::..::.:::..::. ::::: .::.:::::.:..:: .:.:.::::::.:::....::
NP_000 PVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQ
420 430 440 450 460 470
450 460 470 480
pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
:::::.::::.:::.::.::. :.::::::::.:::::
NP_000 SPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
480 490 500 510
>>NP_000683 (OMIM: 100670) aldehyde dehydrogenase X, mit (517 aa)
initn: 1180 init1: 1180 opt: 1180 Z-score: 1460.9 bits: 279.8 E(85289): 1.2e-74
Smith-Waterman score: 2051; 60.5% identity (81.4% similar) in 501 aa overlap (18-480:17-517)
10 20 30 40 50 60
pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
: ..: :::: : .: :...:::::::.. : ..::. ::
NP_000 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNP
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
.::: . .: :.:.::.:.::.::: :: ::: :::::::::::::..:::::::::. :
NP_000 TTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
:..:.:..:::: ... .::. :::..::.:::::: :: :::.::..: ::::::.:::
NP_000 ASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVC
120 130 140 150 160 170
190 200 210 220
pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------
::::::::::.: .::.:::: :::::.: ::::::::::...::::
NP_000 GQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIIT
180 190 200 210 220 230
230 240 250 260
pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
::.:::.::: :::::::::::::::.:..::::
NP_000 GYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADAD
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
...:::: :...:::.:::: :::: :::::::.::..:.::.::.: ::.::. :.::
NP_000 MEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQG
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
::.::.:....: :: : ::::: :::. .:..::::.::::..: ::::::::::::
NP_000 PQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFG
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
::: ...:: ..::.:::::. .::.::::: :..::. ..:.::::::.: :: .. .
NP_000 PVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCH
420 430 440 450 460 470
450 460 470 480
pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
.:::::: ::::::.:: ::. :.::::::.:.:::::
NP_000 TPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS
480 490 500 510
480 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:03:37 2016 done: Tue Nov 8 13:03:39 2016
Total Scan time: 7.270 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]