Result of FASTA (omim) for
pFN21AE6387
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6387, 328 aa
1>>>pF1KE6387 328 - 328 aa - 328 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8285+/-0.000363; mu= 18.2422+/- 0.022
mean_var=64.7401+/-13.109, 0's: 0 Z-trim(114.1): 308 B-trim: 0 in 0/51
Lambda= 0.159400
statistics sampled from 23476 (23796) to 23476 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.279), width: 16
Scan time: 5.330
The best scores are: opt bits E(85289)
NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312) 700 169.7 7.1e-42
NP_006790 (OMIM: 608159) testisin isoform 1 prepro ( 314) 698 169.3 9.8e-42
NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 694 168.3 1.7e-41
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 689 167.2 4.4e-41
NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 676 164.2 3e-40
XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 676 164.2 3e-40
XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 676 164.2 3e-40
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 651 158.5 1.8e-38
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 651 158.5 1.8e-38
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 645 157.1 4.6e-38
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 641 156.2 9.3e-38
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 641 156.2 9.3e-38
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 624 152.5 2.2e-36
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 624 152.5 2.2e-36
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 624 152.5 2.2e-36
NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 624 152.5 2.5e-36
XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 624 152.5 2.6e-36
NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 624 152.6 2.8e-36
NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 624 152.6 2.8e-36
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 614 149.9 5.8e-36
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 609 148.8 1.3e-35
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 599 146.5 7.2e-35
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 599 146.6 9.3e-35
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 598 146.3 9.6e-35
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 601 147.3 1e-34
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 601 147.3 1.1e-34
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 598 146.4 1.1e-34
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 598 146.4 1.2e-34
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 598 146.4 1.2e-34
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 598 146.4 1.2e-34
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 592 145.1 3.2e-34
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 592 145.1 3.3e-34
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 592 145.1 3.4e-34
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 574 140.8 4.6e-33
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 574 140.9 4.9e-33
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 574 140.9 5e-33
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 540 133.0 1e-30
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 540 133.0 1.1e-30
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 540 133.0 1.1e-30
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 540 133.0 1.1e-30
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 540 133.0 1.1e-30
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 540 133.0 1.1e-30
NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 505 124.8 2e-28
NP_036349 (OMIM: 609272) tryptase delta precursor ( 242) 482 119.5 7.2e-27
NP_037402 (OMIM: 607950) probable threonine protea ( 385) 468 116.4 9.6e-26
NP_001305324 (OMIM: 608018) serine protease 27 iso ( 188) 464 115.3 1e-25
XP_011520991 (OMIM: 608018) PREDICTED: serine prot ( 188) 464 115.3 1e-25
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 459 114.4 3.8e-25
NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 459 114.4 4e-25
XP_006720026 (OMIM: 227500,608446,613878) PREDICTE ( 412) 459 114.4 4.2e-25
>>NP_659205 (OMIM: 608159) testisin isoform 2 preproprot (312 aa)
initn: 662 init1: 219 opt: 700 Z-score: 872.8 bits: 169.7 E(85289): 7.1e-42
Smith-Waterman score: 700; 41.2% identity (66.9% similar) in 284 aa overlap (19-291:33-311)
10 20 30 40
pF1KE6 MGPAGCAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFD
::. : .::.:::.:: :::::: ::..
NP_659 ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLW
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 HNFIYGGSLVSERLILTAAHCIQPTWTTFS-YTVWLGSITVGDS-----RKRVKYYVSKI
. . : ::.:.: ::::::.. . : . : .:..: : ..:.::.:
NP_659 DSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE6 VIHPKYQ-DTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSD
. :.: .. :.::.:::. ::.:. : :::: . : .. ::::::: .::.
NP_659 YLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEA
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE6 RDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSG
.:::..: ::. . :..:. . ... : : .:::..:. ::.: ::::
NP_659 LPSPHTLQEVQVAIINNSMCNHLF-----LKYSFRKDIFGDMVCAGNAQGGKDACFGDSG
190 200 210 220 230
230 240 250 260 270
pF1KE6 GPLSCHIDGVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRA--NNLDFS-DF
:::.:. .:.: : ::::::. ::. . ::::::. .. .::. .... .. : : .
NP_659 GPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPL
240 250 260 270 280 290
280 290 300 310 320
pF1KE6 LFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
:: .: .: :: :
NP_659 LFFPLLWALPLLGPV
300 310
>>NP_006790 (OMIM: 608159) testisin isoform 1 preproprot (314 aa)
initn: 662 init1: 219 opt: 698 Z-score: 870.3 bits: 169.3 E(85289): 9.8e-42
Smith-Waterman score: 698; 41.1% identity (67.2% similar) in 287 aa overlap (19-291:33-313)
10 20 30 40
pF1KE6 MGPAGCAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFD
::. : .::.:::.:: :::::: ::..
NP_006 ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLW
10 20 30 40 50 60
50 60 70 80 90
pF1KE6 HNFIYGGSLVSERLILTAAHCIQPTWTTFS----YTVWLGSITVGDS-----RKRVKYYV
. . : ::.:.: ::::::.. :.. .: . : .:..: : ..:.:
NP_006 DSHVCGVSLLSHRWALTAAHCFE-TYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFV
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE6 SKIVIHPKYQ-DTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKE
:.: . :.: .. :.::.:::. ::.:. : :::: . : .. ::::::: .::
NP_006 SNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKE
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE6 SSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKG
. .:::..: ::. . :..:. . ... : : .:::..:. ::.: :
NP_006 DEALPSPHTLQEVQVAIINNSMCNHLF-----LKYSFRKDIFGDMVCAGNAQGGKDACFG
190 200 210 220 230
220 230 240 250 260 270
pF1KE6 DSGGPLSCHIDGVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRA--NNLDFS
::::::.:. .:.: : ::::::. ::. . ::::::. .. .::. .... .. : :
NP_006 DSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPS
240 250 260 270 280 290
280 290 300 310 320
pF1KE6 -DFLFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
.:: .: .: :: :
NP_006 WPLLFFPLLWALPLLGPV
300 310
>>NP_114154 (OMIM: 608018) serine protease 27 isoform 1 (290 aa)
initn: 643 init1: 238 opt: 694 Z-score: 865.8 bits: 168.3 E(85289): 1.7e-41
Smith-Waterman score: 694; 41.2% identity (64.6% similar) in 277 aa overlap (3-268:4-278)
10 20 30 40 50
pF1KE6 MGPAGCAFTLLLLLG------ISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFIY
::. . ::: .: ..::.: . .:.:::::. :.::::::.. . . .
NP_114 MRRPAAVPLLLLLCFGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 GGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKY-YVSKIVIHPKYQDT-
::::..:. .::::::.. : : : : ::. . . .. : : .. .: :: :
NP_114 GGSLIAEQWVLTAAHCFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 -TADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQE
.:::::..: . : ::. :::.:::. . . :::::::. .: . ::.
NP_114 SSADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQK
130 140 150 160 170 180
180 190 200 210 220
pF1KE6 AEVPIIDRQACEQLYNPIGIFLPALEP-VIKEDKICAGDTQNMKDSCKGDSGGPLSCHID
::::: :. ::. : . .: .::.: .::: .. ::.::::::::: : .
NP_114 LAVPIIDTPKCNLLYSKDTEF--GYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVG
190 200 210 220 230
230 240 250 260 270 280
pF1KE6 GVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLSLAL
:.:.::.::: :.. . :::: : ...::. : .
NP_114 QSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRIIPKLQFQPARLGGQK
240 250 260 270 280 290
290 300 310 320
pF1KE6 LCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
>>NP_002764 (OMIM: 600823) prostasin preproprotein [Homo (343 aa)
initn: 671 init1: 235 opt: 689 Z-score: 858.6 bits: 167.2 E(85289): 4.4e-41
Smith-Waterman score: 690; 40.4% identity (65.6% similar) in 285 aa overlap (1-267:7-286)
10 20 30 40
pF1KE6 MGPAGC-AFTLLLLLGI-----------SVCG-QPVYSSRVVGGQDAAAGRWPW
.::. : ..:: ::. . :: : ..:..::..:.::.:::
NP_002 MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAP--QARITGGSSAVAGQWPW
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 QVSLHFDHNFIYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSK
:::. .. . :::::::. .:.::::. .: : ::. . . . .: . :
NP_002 QVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLK
60 70 80 90 100 110
110 120 130 140 150
pF1KE6 -IVIHPKY--QDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKE
:. ::.: . . .:.:::.:: .::. : :::::... .. : :::::.:
NP_002 DIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAP
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE6 SSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEP-VIKEDKICAGDTQNMKDSCK
: . . ::. :::.:.:..:. ::: : :: ..:: .::: ... ::.:.
NP_002 SVSLLTPKPLQQLEVPLISRETCNCLYN---IDAKPEEPHFVQEDMVCAGYVEGGKDACQ
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE6 GDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNLDFSD
::::::::: ..:.: ::.:::: :: .. ::::: . : .::.. ..
NP_002 GDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQ
240 250 260 270 280 290
280 290 300 310 320
pF1KE6 FLFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
NP_002 TQESQPDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
300 310 320 330 340
>>NP_690851 (OMIM: 613797) serine protease 33 precursor (280 aa)
initn: 565 init1: 244 opt: 676 Z-score: 843.6 bits: 164.2 E(85289): 3e-40
Smith-Waterman score: 677; 38.7% identity (63.8% similar) in 282 aa overlap (1-267:1-279)
10 20 30 40 50
pF1KE6 MGPAGCAFTLLLL-LGIS--------VCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNF
: ..: .:::: :: . .:::: .:::.:::.:. :.::::.:..
NP_690 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 IYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKR-VKYYVSKIVIHPKYQD
. ::::.. . .::::::. : : ::.. .:.. : .. : .... : :..
NP_690 VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSE
70 80 90 100 110 120
120 130 140 150 160
pF1KE6 TTA--DVALLKLSSQVTFTSAILPICLPSVTKQLAIPPF--CWVTGWGKVKESSDRDYHS
: :.:::.: : ... . :.::: . :: : :::::... .
NP_690 DGARGDLALLQLRRPVPLSARVQPVCLPVPGAR--PPPGTPCRVTGWGSLRPGVPLPEWR
130 140 150 160 170
170 180 190 200 210 220
pF1KE6 ALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSC
:: ..::..: ..:. ::. .: .: : .. ..::: :. ::.:.:::::::.:
NP_690 PLQGVRVPLLDSRTCDGLYH-VGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTC
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 HIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLS
.: :. .:::::: :. . :::::.: :. ::.: .:
NP_690 LQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
240 250 260 270 280
290 300 310 320
pF1KE6 LALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
>>XP_011520753 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 565 init1: 244 opt: 676 Z-score: 843.6 bits: 164.2 E(85289): 3e-40
Smith-Waterman score: 677; 38.7% identity (63.8% similar) in 282 aa overlap (1-267:1-279)
10 20 30 40 50
pF1KE6 MGPAGCAFTLLLL-LGIS--------VCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNF
: ..: .:::: :: . .:::: .:::.:::.:. :.::::.:..
XP_011 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 IYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKR-VKYYVSKIVIHPKYQD
. ::::.. . .::::::. : : ::.. .:.. : .. : .... : :..
XP_011 VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSE
70 80 90 100 110 120
120 130 140 150 160
pF1KE6 TTA--DVALLKLSSQVTFTSAILPICLPSVTKQLAIPPF--CWVTGWGKVKESSDRDYHS
: :.:::.: : ... . :.::: . :: : :::::... .
XP_011 DGARGDLALLQLRRPVPLSARVQPVCLPVPGAR--PPPGTPCRVTGWGSLRPGVPLPEWR
130 140 150 160 170
170 180 190 200 210 220
pF1KE6 ALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSC
:: ..::..: ..:. ::. .: .: : .. ..::: :. ::.:.:::::::.:
XP_011 PLQGVRVPLLDSRTCDGLYH-VGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTC
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 HIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLS
.: :. .:::::: :. . :::::.: :. ::.: .:
XP_011 LQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
240 250 260 270 280
290 300 310 320
pF1KE6 LALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
>>XP_011520754 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 565 init1: 244 opt: 676 Z-score: 843.6 bits: 164.2 E(85289): 3e-40
Smith-Waterman score: 677; 38.7% identity (63.8% similar) in 282 aa overlap (1-267:1-279)
10 20 30 40 50
pF1KE6 MGPAGCAFTLLLL-LGIS--------VCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNF
: ..: .:::: :: . .:::: .:::.:::.:. :.::::.:..
XP_011 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 IYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKR-VKYYVSKIVIHPKYQD
. ::::.. . .::::::. : : ::.. .:.. : .. : .... : :..
XP_011 VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSE
70 80 90 100 110 120
120 130 140 150 160
pF1KE6 TTA--DVALLKLSSQVTFTSAILPICLPSVTKQLAIPPF--CWVTGWGKVKESSDRDYHS
: :.:::.: : ... . :.::: . :: : :::::... .
XP_011 DGARGDLALLQLRRPVPLSARVQPVCLPVPGAR--PPPGTPCRVTGWGSLRPGVPLPEWR
130 140 150 160 170
170 180 190 200 210 220
pF1KE6 ALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSC
:: ..::..: ..:. ::. .: .: : .. ..::: :. ::.:.:::::::.:
XP_011 PLQGVRVPLLDSRTCDGLYH-VGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTC
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 HIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLS
.: :. .:::::: :. . :::::.: :. ::.: .:
XP_011 LQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
240 250 260 270 280
290 300 310 320
pF1KE6 LALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
>>NP_071402 (OMIM: 609343) brain-specific serine proteas (317 aa)
initn: 252 init1: 252 opt: 651 Z-score: 811.8 bits: 158.5 E(85289): 1.8e-38
Smith-Waterman score: 653; 35.1% identity (65.6% similar) in 282 aa overlap (5-266:13-289)
10 20 30
pF1KE6 MGPAGC--AFTLLLLLGISV------------CGQPVYSSRVVGGQDAAAGR
:: .:: ::::. .. ::.: .:::::.:.. ..
NP_071 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE6 WPWQVSLHFDHNFIYGGSLVSERLILTAAHCIQPTWTT-FSYTVWLGSITVGDSRKRV-K
::: ::.. . . .:::.. : ..:::::.. . . . ..: ::. .:. .: :
NP_071 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE6 YYVSKIVIHPKY---QDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGW
:. . :: : . . ::.::..: .. :. .::::::... .: ::..::
NP_071 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE6 GKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMK
:..... . ..::. .::::: ..: .:: . : . : :: .::: .. .
NP_071 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLY-----WRGAGQGPITEDMLCAGYLEGER
190 200 210 220 230
220 230 240 250 260 270
pF1KE6 DSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNL
:.: ::::::: :..::.:. .:..::: :. .. :::: .. ...:.. .
NP_071 DACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLR
240 250 260 270 280 290
280 290 300 310 320
pF1KE6 DFSDFLFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
NP_071 GRAQGGGALRAPSQGSGAAARS
300 310
>>XP_005255530 (OMIM: 609343) PREDICTED: brain-specific (317 aa)
initn: 252 init1: 252 opt: 651 Z-score: 811.8 bits: 158.5 E(85289): 1.8e-38
Smith-Waterman score: 653; 35.1% identity (65.6% similar) in 282 aa overlap (5-266:13-289)
10 20 30
pF1KE6 MGPAGC--AFTLLLLLGISV------------CGQPVYSSRVVGGQDAAAGR
:: .:: ::::. .. ::.: .:::::.:.. ..
XP_005 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE6 WPWQVSLHFDHNFIYGGSLVSERLILTAAHCIQPTWTT-FSYTVWLGSITVGDSRKRV-K
::: ::.. . . .:::.. : ..:::::.. . . . ..: ::. .:. .: :
XP_005 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE6 YYVSKIVIHPKY---QDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGW
:. . :: : . . ::.::..: .. :. .::::::... .: ::..::
XP_005 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE6 GKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMK
:..... . ..::. .::::: ..: .:: . : . : :: .::: .. .
XP_005 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLY-----WRGAGQGPITEDMLCAGYLEGER
190 200 210 220 230
220 230 240 250 260 270
pF1KE6 DSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNL
:.: ::::::: :..::.:. .:..::: :. .. :::: .. ...:.. .
XP_005 DACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLR
240 250 260 270 280 290
280 290 300 310 320
pF1KE6 DFSDFLFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
XP_005 GRAQGGGALRAPSQGSGAAARS
300 310
>>NP_036599 (OMIM: 609341) tryptase gamma preproprotein (321 aa)
initn: 550 init1: 199 opt: 645 Z-score: 804.3 bits: 157.1 E(85289): 4.6e-38
Smith-Waterman score: 659; 36.6% identity (65.0% similar) in 314 aa overlap (1-295:1-302)
10 20 30 40 50
pF1KE6 MGPAGCAFTLLLLL-GISV------CGQPVYSS---RVVGGQDAAAGRWPWQVSLHFDHN
:. ..:.. ::: . :.:. ::.: :. :.:::. : :: ::::.::.. .
NP_036 MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRV
10 20 30 40 50 60
60 70 80 90 100
pF1KE6 FIYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIH--PKY
. ::::.: . .::::::.. . .. .: : :: . . : . : .:..: :.
NP_036 HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST--VRQIILHSSPSG
70 80 90 100 110
110 120 130 140 150 160
pF1KE6 QD-TTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSA
: :..:.::..:: ::..: :::.::: .. .. ::::::: ..:. .
NP_036 QPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYS
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 LQEAEVPIIDRQACEQLY-NPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSC
:.:..: ..: ..:.. : .: : ... : .:: .. :.:. :::::: :
NP_036 LREVKVSVVDTETCRRDYPGPGG-------SILQPDMLCA---RGPGDACQDDSGGPLVC
180 190 200 210 220
230 240 250 260 270 280
pF1KE6 HIDGVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIV---
...:.:.:.:.:::: ::. . ::::: : : .:: :. ... . . .:..
NP_036 QVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGF
230 240 250 260 270 280
290 300 310 320
pF1KE6 -LLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR
: .: :: ::..
NP_036 FLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD
290 300 310 320
328 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:49:00 2016 done: Tue Nov 8 12:49:01 2016
Total Scan time: 5.330 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]