Result of FASTA (omim) for
pFN21AE6328
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6328, 440 aa
1>>>pF1KE6328 440 - 440 aa - 440 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1129+/-0.000524; mu= 2.3745+/- 0.032
mean_var=135.1776+/-28.630, 0's: 0 Z-trim(110.7): 290 B-trim: 828 in 1/53
Lambda= 0.110312
statistics sampled from 18764 (19144) to 18764 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.58), E-opt: 0.2 (0.224), width: 16
Scan time: 7.970
The best scores are: opt bits E(85289)
NP_002535 (OMIM: 164345) oligodendrocyte-myelin gl ( 440) 2865 468.3 1.8e-131
NP_000164 (OMIM: 153670,177820,231200,258660,60667 ( 652) 273 55.8 3.8e-07
NP_079269 (OMIM: 610870) leucine-rich repeat trans ( 518) 266 54.7 6.8e-07
NP_001269857 (OMIM: 610870) leucine-rich repeat tr ( 519) 266 54.7 6.8e-07
NP_001128217 (OMIM: 610870) leucine-rich repeat tr ( 590) 266 54.7 7.6e-07
NP_001269853 (OMIM: 610870) leucine-rich repeat tr ( 590) 266 54.7 7.6e-07
NP_001317299 (OMIM: 610870) leucine-rich repeat tr ( 591) 266 54.7 7.6e-07
XP_016876621 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06
XP_016876620 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06
XP_005267547 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06
XP_016876622 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06
XP_016876623 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06
NP_001333072 (OMIM: 604807) leucine-rich repeat tr ( 660) 252 52.5 3.9e-06
XP_016876619 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06
NP_037363 (OMIM: 604807) leucine-rich repeat trans ( 660) 252 52.5 3.9e-06
NP_001333073 (OMIM: 604807) leucine-rich repeat tr ( 660) 252 52.5 3.9e-06
XP_016876618 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06
XP_016876624 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06
XP_011534913 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06
NP_001333075 (OMIM: 604807) leucine-rich repeat tr ( 660) 252 52.5 3.9e-06
NP_001333074 (OMIM: 604807) leucine-rich repeat tr ( 660) 252 52.5 3.9e-06
XP_011543185 (OMIM: 604806) PREDICTED: leucine-ric ( 674) 244 51.2 9.7e-06
NP_037412 (OMIM: 604806) leucine-rich repeat trans ( 674) 244 51.2 9.7e-06
XP_005273918 (OMIM: 604806) PREDICTED: leucine-ric ( 674) 244 51.2 9.7e-06
XP_005270514 (OMIM: 608661) PREDICTED: podocan iso ( 613) 241 50.7 1.2e-05
NP_001186009 (OMIM: 608661) podocan isoform 2 [Hom ( 642) 241 50.7 1.3e-05
NP_001186010 (OMIM: 608661) podocan isoform 2 [Hom ( 642) 241 50.7 1.3e-05
XP_016855783 (OMIM: 608661) PREDICTED: podocan iso ( 652) 241 50.7 1.3e-05
NP_714914 (OMIM: 608661) podocan isoform 1 [Homo s ( 661) 241 50.7 1.3e-05
XP_011518513 (OMIM: 605247) PREDICTED: p53-induced ( 893) 229 48.9 6.5e-05
NP_665894 (OMIM: 605247) p53-induced protein with ( 893) 229 48.9 6.5e-05
XP_011518512 (OMIM: 605247) PREDICTED: p53-induced ( 910) 229 48.9 6.6e-05
NP_665893 (OMIM: 605247) p53-induced protein with ( 910) 229 48.9 6.6e-05
XP_011518511 (OMIM: 605247) PREDICTED: p53-induced ( 920) 229 48.9 6.7e-05
XP_005253062 (OMIM: 605247) PREDICTED: p53-induced ( 934) 229 48.9 6.8e-05
XP_005253064 (OMIM: 605247) PREDICTED: p53-induced ( 934) 229 48.9 6.8e-05
XP_005253063 (OMIM: 605247) PREDICTED: p53-induced ( 934) 229 48.9 6.8e-05
XP_016866486 (OMIM: 608195) PREDICTED: leucine-ric ( 331) 218 47.0 9e-05
NP_001278917 (OMIM: 603104) carboxypeptidase N sub ( 545) 221 47.5 0.0001
XP_005269337 (OMIM: 603104) PREDICTED: carboxypept ( 545) 221 47.5 0.0001
NP_001073982 (OMIM: 603104) carboxypeptidase N sub ( 545) 221 47.5 0.0001
NP_056379 (OMIM: 610868) leucine-rich repeat trans ( 516) 219 47.2 0.00012
XP_011513028 (OMIM: 608195) PREDICTED: leucine-ric ( 524) 218 47.0 0.00014
NP_060684 (OMIM: 608195) leucine-rich repeat-conta ( 524) 218 47.0 0.00014
NP_078788 (OMIM: 607180) leucine-rich repeat-conta ( 371) 215 46.5 0.00014
XP_011532412 (OMIM: 607180) PREDICTED: leucine-ric ( 371) 215 46.5 0.00014
XP_016857384 (OMIM: 614453) PREDICTED: leucine-ric (1255) 224 48.1 0.00015
XP_016857383 (OMIM: 614453) PREDICTED: leucine-ric (1438) 224 48.1 0.00017
XP_016857382 (OMIM: 614453) PREDICTED: leucine-ric (1472) 224 48.1 0.00018
XP_016857381 (OMIM: 614453) PREDICTED: leucine-ric (1490) 224 48.1 0.00018
>>NP_002535 (OMIM: 164345) oligodendrocyte-myelin glycop (440 aa)
initn: 2865 init1: 2865 opt: 2865 Z-score: 2481.3 bits: 468.3 E(85289): 1.8e-131
Smith-Waterman score: 2865; 100.0% identity (100.0% similar) in 440 aa overlap (1-440:1-440)
10 20 30 40 50 60
pF1KE6 MEYQILKMSLCLFILLFLTPGILCICPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEYQILKMSLCLFILLFLTPGILCICPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLDKSDTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLDKSDTA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 YQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 QILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 WMMETKAHVIGTPCSTQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WMMETKAHVIGTPCSTQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQPKV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPYPEDTSTETINSHEAAAATLTIHLQDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPYPEDTSTETINSHEAAAATLTIHLQDG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 MVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVAN
370 380 390 400 410 420
430 440
pF1KE6 AWKVNASFLLLLNVVVMLAV
::::::::::::::::::::
NP_002 AWKVNASFLLLLNVVVMLAV
430 440
>>NP_000164 (OMIM: 153670,177820,231200,258660,606672) p (652 aa)
initn: 151 init1: 90 opt: 273 Z-score: 249.2 bits: 55.8 E(85289): 3.8e-07
Smith-Waterman score: 312; 26.4% identity (54.0% similar) in 439 aa overlap (12-417:3-427)
10 20 30 40 50
pF1KE6 MEYQILKMSLCLFILLFLTPGILCICPLQCICTE--RHRHVDCSGRNLSTLPSGLQENII
:..::.: :. : :. : .. : .:.:. :::..:: : ..
NP_000 MPLLLLLLLLPSPLHPHPI-CEVSKVASHLEVNCDKRNLTALPPDLPKDTT
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 HLNLSYNHFTDLH-NQLTQYTNLRTLDISNNRLESLPAH--LPRSLWNMSAANNNIK---
:.:: : . . : :: : :... .: .: . :: : ... ..:...
NP_000 ILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLP-VLGTLDLSHNQLQSLP
60 70 80 90 100
120 130 140 150 160
pF1KE6 LLDKSDTAYQWNLKYLDVSKNMLEKVVLIKNTLRSL---EVLNLSSNKLWTVPTNM--PS
:: .. : : :::: : : .. : ..::.: . : :..:.: :.: .. :.
NP_000 LLGQTLPA----LTVLDVSFNRLTSLPL--GALRGLGELQELYLKGNELKTLPPGLLTPT
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE6 -KLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNR
::. ..:.::.::.. : : .: :: : :..:.. :: : . . : :..:
NP_000 PKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHL-LPFAFLHGNP
170 180 190 200 210 220
230 240 250 260 270
pF1KE6 WSCDHKQNITYLLKWMMETKAHVI----GTPC---STQISSLKEHN-----MYPTPSGFT
: :. . : :. .:.... .: :. .....:.. : .: :.
NP_000 WLCNCE--ILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGC
230 240 250 260 270 280
280 290 300 310 320
pF1KE6 SSLFTVSGMQTVD-----TINSLSVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDK
.: . . : .. .: . :.:.: . .: : .: : .:. ...
NP_000 PTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHT--TPWGLFYSWSTASLDSQM
290 300 310 320 330
330 340 350 360 370 380
pF1KE6 AFVPYPEDTSTETINSHEAA-AATLTIHLQDGMVTNTSLTSSTKSSPTPMTLS-ITSGMP
.: . ::. .. . ..:.:... ..: :.:. .:.: : . :
NP_000 PSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTP-KSTTEPTPSPTTSEPVPEPAP
340 350 360 370 380 390
390 400 410 420 430 440
pF1KE6 NNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV
: . : : : : . . :: :.
NP_000 NMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPT
400 410 420 430 440 450
>>NP_079269 (OMIM: 610870) leucine-rich repeat transmemb (518 aa)
initn: 236 init1: 153 opt: 266 Z-score: 244.8 bits: 54.7 E(85289): 6.8e-07
Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:134-503)
30 40 50 60 70 80
pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI
:. .:.::::.. :... :. .:: : :
NP_079 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII
110 120 130 140 150 160
90 100 110 120 130
pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV
.: :...: .. .. :.. . : .. :... : .:: : . .:.. :.
NP_079 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN
170 180 190 200 210 220
140 150 160 170 180 190
pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH
. . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: .
NP_079 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK
230 240 250 260 270 280
200 210 220 230 240 250
pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS
: : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. :
NP_079 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES
290 300 310 320 330
260 270 280 290 300 310
pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF
:.: . .: . : . . : .:.:.: : : : : ::. : :
NP_079 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF
340 350 360 370 380 390
320 330 340 350 360 370
pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK
....: : : . .: .: :. : .. :. :..... :. .:. . : :
NP_079 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK
400 410 420 430 440
380 390 400 410 420 430
pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL
:. : :. : : .. .. .: .: .. : : : . .::.:
NP_079 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT
450 460 470 480 490 500
440
pF1KE6 LNVVVMLAV
NP_079 YTISGSRECEV
510
>>NP_001269857 (OMIM: 610870) leucine-rich repeat transm (519 aa)
initn: 236 init1: 153 opt: 266 Z-score: 244.8 bits: 54.7 E(85289): 6.8e-07
Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:135-504)
30 40 50 60 70 80
pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI
:. .:.::::.. :... :. .:: : :
NP_001 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII
110 120 130 140 150 160
90 100 110 120 130
pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV
.: :...: .. .. :.. . : .. :... : .:: : . .:.. :.
NP_001 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN
170 180 190 200 210 220
140 150 160 170 180 190
pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH
. . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: .
NP_001 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK
230 240 250 260 270 280
200 210 220 230 240 250
pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS
: : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. :
NP_001 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES
290 300 310 320 330
260 270 280 290 300 310
pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF
:.: . .: . : . . : .:.:.: : : : : ::. : :
NP_001 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF
340 350 360 370 380 390
320 330 340 350 360 370
pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK
....: : : . .: .: :. : .. :. :..... :. .:. . : :
NP_001 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK
400 410 420 430 440
380 390 400 410 420 430
pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL
:. : :. : : .. .. .: .: .. : : : . .::.:
NP_001 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT
450 460 470 480 490 500
440
pF1KE6 LNVVVMLAV
NP_001 YTISGSRECEV
510
>>NP_001128217 (OMIM: 610870) leucine-rich repeat transm (590 aa)
initn: 200 init1: 153 opt: 266 Z-score: 243.9 bits: 54.7 E(85289): 7.6e-07
Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:134-503)
30 40 50 60 70 80
pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI
:. .:.::::.. :... :. .:: : :
NP_001 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII
110 120 130 140 150 160
90 100 110 120 130
pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV
.: :...: .. .. :.. . : .. :... : .:: : . .:.. :.
NP_001 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN
170 180 190 200 210 220
140 150 160 170 180 190
pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH
. . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: .
NP_001 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK
230 240 250 260 270 280
200 210 220 230 240 250
pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS
: : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. :
NP_001 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES
290 300 310 320 330
260 270 280 290 300 310
pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF
:.: . .: . : . . : .:.:.: : : : : ::. : :
NP_001 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF
340 350 360 370 380 390
320 330 340 350 360 370
pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK
....: : : . .: .: :. : .. :. :..... :. .:. . : :
NP_001 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK
400 410 420 430 440
380 390 400 410 420 430
pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL
:. : :. : : .. .. .: .: .. : : : . .::.:
NP_001 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT
450 460 470 480 490 500
440
pF1KE6 LNVVVMLAV
NP_001 YTISGSRECEMPHHMKPLPYYSYDQPVIGYCQAHQPLHVTKGYETVSPEQDESPGLELGR
510 520 530 540 550 560
>>NP_001269853 (OMIM: 610870) leucine-rich repeat transm (590 aa)
initn: 200 init1: 153 opt: 266 Z-score: 243.9 bits: 54.7 E(85289): 7.6e-07
Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:134-503)
30 40 50 60 70 80
pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI
:. .:.::::.. :... :. .:: : :
NP_001 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII
110 120 130 140 150 160
90 100 110 120 130
pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV
.: :...: .. .. :.. . : .. :... : .:: : . .:.. :.
NP_001 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN
170 180 190 200 210 220
140 150 160 170 180 190
pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH
. . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: .
NP_001 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK
230 240 250 260 270 280
200 210 220 230 240 250
pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS
: : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. :
NP_001 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES
290 300 310 320 330
260 270 280 290 300 310
pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF
:.: . .: . : . . : .:.:.: : : : : ::. : :
NP_001 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF
340 350 360 370 380 390
320 330 340 350 360 370
pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK
....: : : . .: .: :. : .. :. :..... :. .:. . : :
NP_001 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK
400 410 420 430 440
380 390 400 410 420 430
pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL
:. : :. : : .. .. .: .: .. : : : . .::.:
NP_001 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT
450 460 470 480 490 500
440
pF1KE6 LNVVVMLAV
NP_001 YTISGSRECEMPHHMKPLPYYSYDQPVIGYCQAHQPLHVTKGYETVSPEQDESPGLELGR
510 520 530 540 550 560
>>NP_001317299 (OMIM: 610870) leucine-rich repeat transm (591 aa)
initn: 200 init1: 153 opt: 266 Z-score: 243.9 bits: 54.7 E(85289): 7.6e-07
Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:135-504)
30 40 50 60 70 80
pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI
:. .:.::::.. :... :. .:: : :
NP_001 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII
110 120 130 140 150 160
90 100 110 120 130
pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV
.: :...: .. .. :.. . : .. :... : .:: : . .:.. :.
NP_001 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN
170 180 190 200 210 220
140 150 160 170 180 190
pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH
. . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: .
NP_001 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK
230 240 250 260 270 280
200 210 220 230 240 250
pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS
: : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. :
NP_001 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES
290 300 310 320 330
260 270 280 290 300 310
pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF
:.: . .: . : . . : .:.:.: : : : : ::. : :
NP_001 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF
340 350 360 370 380 390
320 330 340 350 360 370
pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK
....: : : . .: .: :. : .. :. :..... :. .:. . : :
NP_001 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK
400 410 420 430 440
380 390 400 410 420 430
pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL
:. : :. : : .. .. .: .: .. : : : . .::.:
NP_001 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT
450 460 470 480 490 500
440
pF1KE6 LNVVVMLAV
NP_001 YTISGSRECEMPHHMKPLPYYSYDQPVIGYCQAHQPLHVTKGYETVSPEQDESPGLELGR
510 520 530 540 550 560
>>XP_016876621 (OMIM: 604807) PREDICTED: leucine-rich re (660 aa)
initn: 190 init1: 106 opt: 252 Z-score: 231.0 bits: 52.5 E(85289): 3.9e-06
Smith-Waterman score: 255; 26.3% identity (55.5% similar) in 319 aa overlap (79-383:160-453)
50 60 70 80 90 100
pF1KE6 LPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAAN
.:. : .:.:.: :.:. :: .: .. . .
XP_016 AQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDE
130 140 150 160 170 180
110 120 130 140 150 160
pF1KE6 NNIKLLDKSDTAYQ--WNLKYLDVSKNMLEKVVLIKNT---LRSLEVLNLSSNKLWTVPT
: : .. :: :.: .:. : :. :.: . . ..: : .:. ... :.: :
XP_016 NRIAVI--SDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP
190 200 210 220 230 240
170 180 190 200 210 220
pF1KE6 NMPSKLHIVDL--SNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEIT
..:. :.. : ..:....: .. :: .: .: . ::.. .. . ::.: .:...:
XP_016 DLPGT-HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLT
250 260 270 280 290 300
230 240 250 260 270
pF1KE6 LYNNRWSCDHKQNITYLLKWM--METKAHVIGTPCS--TQISSL--KEHNMYPTPSGFTS
:: : :: .: .. .:. . .. .: : :. :. .. .: :: .. :
XP_016 ARNNPWFCD--CSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNM-----NLLS
310 320 330 340 350
280 290 300 310 320 330
pF1KE6 SLFTVSGMQTVDTINSL-SVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPY
:. :. : : .::: . .::. :. : : : . .
XP_016 CPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSY-----------TPPTPTTSKLPTI
360 370 380 390 400
340 350 360 370 380 390
pF1KE6 PEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMP
:. . : .. . :.::. :..::. : : : :. ..:
XP_016 PDWDGRERVTPPISERIQLSIHF----VNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGG
410 420 430 440 450 460
400 410 420 430 440
pF1KE6 QQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV
XP_016 IVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSN
470 480 490 500 510 520
>>XP_016876620 (OMIM: 604807) PREDICTED: leucine-rich re (660 aa)
initn: 190 init1: 106 opt: 252 Z-score: 231.0 bits: 52.5 E(85289): 3.9e-06
Smith-Waterman score: 255; 26.3% identity (55.5% similar) in 319 aa overlap (79-383:160-453)
50 60 70 80 90 100
pF1KE6 LPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAAN
.:. : .:.:.: :.:. :: .: .. . .
XP_016 AQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDE
130 140 150 160 170 180
110 120 130 140 150 160
pF1KE6 NNIKLLDKSDTAYQ--WNLKYLDVSKNMLEKVVLIKNT---LRSLEVLNLSSNKLWTVPT
: : .. :: :.: .:. : :. :.: . . ..: : .:. ... :.: :
XP_016 NRIAVI--SDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP
190 200 210 220 230 240
170 180 190 200 210 220
pF1KE6 NMPSKLHIVDL--SNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEIT
..:. :.. : ..:....: .. :: .: .: . ::.. .. . ::.: .:...:
XP_016 DLPGT-HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLT
250 260 270 280 290 300
230 240 250 260 270
pF1KE6 LYNNRWSCDHKQNITYLLKWM--METKAHVIGTPCS--TQISSL--KEHNMYPTPSGFTS
:: : :: .: .. .:. . .. .: : :. :. .. .: :: .. :
XP_016 ARNNPWFCD--CSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNM-----NLLS
310 320 330 340 350
280 290 300 310 320 330
pF1KE6 SLFTVSGMQTVDTINSL-SVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPY
:. :. : : .::: . .::. :. : : : . .
XP_016 CPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSY-----------TPPTPTTSKLPTI
360 370 380 390 400
340 350 360 370 380 390
pF1KE6 PEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMP
:. . : .. . :.::. :..::. : : : :. ..:
XP_016 PDWDGRERVTPPISERIQLSIHF----VNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGG
410 420 430 440 450 460
400 410 420 430 440
pF1KE6 QQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV
XP_016 IVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSN
470 480 490 500 510 520
>>XP_005267547 (OMIM: 604807) PREDICTED: leucine-rich re (660 aa)
initn: 190 init1: 106 opt: 252 Z-score: 231.0 bits: 52.5 E(85289): 3.9e-06
Smith-Waterman score: 255; 26.3% identity (55.5% similar) in 319 aa overlap (79-383:160-453)
50 60 70 80 90 100
pF1KE6 LPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAAN
.:. : .:.:.: :.:. :: .: .. . .
XP_005 AQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDE
130 140 150 160 170 180
110 120 130 140 150 160
pF1KE6 NNIKLLDKSDTAYQ--WNLKYLDVSKNMLEKVVLIKNT---LRSLEVLNLSSNKLWTVPT
: : .. :: :.: .:. : :. :.: . . ..: : .:. ... :.: :
XP_005 NRIAVI--SDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP
190 200 210 220 230 240
170 180 190 200 210 220
pF1KE6 NMPSKLHIVDL--SNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEIT
..:. :.. : ..:....: .. :: .: .: . ::.. .. . ::.: .:...:
XP_005 DLPGT-HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLT
250 260 270 280 290 300
230 240 250 260 270
pF1KE6 LYNNRWSCDHKQNITYLLKWM--METKAHVIGTPCS--TQISSL--KEHNMYPTPSGFTS
:: : :: .: .. .:. . .. .: : :. :. .. .: :: .. :
XP_005 ARNNPWFCD--CSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNM-----NLLS
310 320 330 340 350
280 290 300 310 320 330
pF1KE6 SLFTVSGMQTVDTINSL-SVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPY
:. :. : : .::: . .::. :. : : : . .
XP_005 CPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSY-----------TPPTPTTSKLPTI
360 370 380 390 400
340 350 360 370 380 390
pF1KE6 PEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMP
:. . : .. . :.::. :..::. : : : :. ..:
XP_005 PDWDGRERVTPPISERIQLSIHF----VNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGG
410 420 430 440 450 460
400 410 420 430 440
pF1KE6 QQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV
XP_005 IVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSN
470 480 490 500 510 520
440 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:09:12 2016 done: Tue Nov 8 12:09:13 2016
Total Scan time: 7.970 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]