Result of FASTA (omim) for
pFN21AE6326
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6326, 430 aa
1>>>pF1KE6326 430 - 430 aa - 430 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1182+/-0.000395; mu= 18.2035+/- 0.025
mean_var=61.3211+/-12.062, 0's: 0 Z-trim(111.0): 66 B-trim: 26 in 1/54
Lambda= 0.163783
statistics sampled from 19414 (19483) to 19414 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.228), width: 16
Scan time: 6.140
The best scores are: opt bits E(85289)
NP_001599 (OMIM: 609576) long-chain specific acyl- ( 430) 2867 686.3 4.1e-197
XP_005246574 (OMIM: 609576) PREDICTED: long-chain ( 409) 2699 646.6 3.5e-185
XP_016859444 (OMIM: 609576) PREDICTED: long-chain ( 289) 1911 460.3 2.9e-129
XP_016877645 (OMIM: 243500,607036) PREDICTED: isov ( 407) 821 202.8 1.3e-51
NP_002216 (OMIM: 243500,607036) isovaleryl-CoA deh ( 426) 814 201.2 4.3e-51
NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA ( 396) 756 187.4 5.5e-47
XP_016877643 (OMIM: 243500,607036) PREDICTED: isov ( 436) 755 187.2 7e-47
XP_016877641 (OMIM: 243500,607036) PREDICTED: isov ( 455) 755 187.2 7.2e-47
NP_001600 (OMIM: 600301,610006) short/branched cha ( 432) 744 184.6 4.2e-46
NP_000008 (OMIM: 201470,606885) short-chain specif ( 412) 735 182.5 1.8e-45
XP_006720555 (OMIM: 243500,607036) PREDICTED: isov ( 447) 733 182.0 2.6e-45
XP_005254407 (OMIM: 243500,607036) PREDICTED: isov ( 487) 729 181.1 5.4e-45
NP_000007 (OMIM: 201450,607008) medium-chain speci ( 421) 725 180.1 9.2e-45
NP_001120800 (OMIM: 201450,607008) medium-chain sp ( 425) 725 180.1 9.3e-45
NP_001272971 (OMIM: 201450,607008) medium-chain sp ( 385) 723 179.6 1.2e-44
NP_055199 (OMIM: 604773,611283) isobutyryl-CoA deh ( 415) 689 171.6 3.3e-42
XP_016877640 (OMIM: 243500,607036) PREDICTED: isov ( 476) 674 168.1 4.3e-41
XP_016877639 (OMIM: 243500,607036) PREDICTED: isov ( 478) 674 168.1 4.3e-41
XP_016877638 (OMIM: 243500,607036) PREDICTED: isov ( 516) 670 167.2 8.9e-41
XP_006720558 (OMIM: 243500,607036) PREDICTED: isov ( 347) 666 166.1 1.2e-40
XP_016877644 (OMIM: 243500,607036) PREDICTED: isov ( 418) 665 166.0 1.7e-40
XP_016877642 (OMIM: 243500,607036) PREDICTED: isov ( 447) 665 166.0 1.8e-40
NP_001317103 (OMIM: 600301,610006) short/branched ( 330) 645 161.2 3.7e-39
XP_016873032 (OMIM: 604773,611283) PREDICTED: isob ( 434) 640 160.1 1.1e-38
XP_011541052 (OMIM: 604773,611283) PREDICTED: isob ( 451) 640 160.1 1.1e-38
XP_016873031 (OMIM: 604773,611283) PREDICTED: isob ( 451) 640 160.1 1.1e-38
NP_001272972 (OMIM: 201450,607008) medium-chain sp ( 454) 625 156.5 1.3e-37
XP_016877646 (OMIM: 243500,607036) PREDICTED: isov ( 376) 607 152.2 2.1e-36
NP_001289483 (OMIM: 201470,606885) short-chain spe ( 408) 588 147.8 5e-35
XP_016873036 (OMIM: 604773,611283) PREDICTED: isob ( 317) 579 145.6 1.8e-34
NP_054768 (OMIM: 611103,611126) acyl-CoA dehydroge ( 621) 575 144.8 6e-34
NP_001257377 (OMIM: 201475,609575) very long-chain ( 579) 565 142.4 2.9e-33
NP_001029031 (OMIM: 201475,609575) very long-chain ( 633) 565 142.4 3.1e-33
NP_000009 (OMIM: 201475,609575) very long-chain sp ( 655) 565 142.4 3.2e-33
XP_006721579 (OMIM: 201475,609575) PREDICTED: very ( 662) 565 142.4 3.2e-33
NP_001257376 (OMIM: 201475,609575) very long-chain ( 678) 565 142.4 3.3e-33
XP_016873034 (OMIM: 604773,611283) PREDICTED: isob ( 391) 560 141.1 4.7e-33
XP_016873033 (OMIM: 604773,611283) PREDICTED: isob ( 391) 560 141.1 4.7e-33
XP_011522132 (OMIM: 201475,609575) PREDICTED: very ( 621) 557 140.5 1.1e-32
XP_011522131 (OMIM: 201475,609575) PREDICTED: very ( 628) 557 140.5 1.1e-32
XP_016873035 (OMIM: 604773,611283) PREDICTED: isob ( 353) 530 134.0 5.9e-31
XP_016861753 (OMIM: 611103,611126) PREDICTED: acyl ( 537) 493 125.4 3.6e-28
XP_016877647 (OMIM: 243500,607036) PREDICTED: isov ( 308) 468 119.3 1.4e-26
NP_000150 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 438) 451 115.4 2.9e-25
XP_011526201 (OMIM: 231670,608801) PREDICTED: glut ( 446) 430 110.4 9.3e-24
NP_039663 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 428) 424 109.0 2.4e-23
XP_016882069 (OMIM: 231670,608801) PREDICTED: glut ( 442) 424 109.0 2.5e-23
XP_006722784 (OMIM: 231670,608801) PREDICTED: glut ( 442) 424 109.0 2.5e-23
XP_011526202 (OMIM: 231670,608801) PREDICTED: glut ( 443) 424 109.0 2.5e-23
NP_001272973 (OMIM: 201450,607008) medium-chain sp ( 232) 398 102.7 1e-21
>>NP_001599 (OMIM: 609576) long-chain specific acyl-CoA (430 aa)
initn: 2867 init1: 2867 opt: 2867 Z-score: 3659.8 bits: 686.3 E(85289): 4.1e-197
Smith-Waterman score: 2867; 100.0% identity (100.0% similar) in 430 aa overlap (1-430:1-430)
10 20 30 40 50 60
pF1KE6 MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE
370 380 390 400 410 420
430
pF1KE6 LIAREIVFDK
::::::::::
NP_001 LIAREIVFDK
430
>>XP_005246574 (OMIM: 609576) PREDICTED: long-chain spec (409 aa)
initn: 2697 init1: 2697 opt: 2699 Z-score: 3445.6 bits: 646.6 E(85289): 3.5e-185
Smith-Waterman score: 2699; 99.0% identity (99.3% similar) in 409 aa overlap (22-430:1-409)
10 20 30 40 50 60
pF1KE6 MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF
. : ::::::::::::::::::::::::::::::::::
XP_005 MTALVCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF
10 20 30
70 80 90 100 110 120
pF1KE6 RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE6 WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE6 LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE6 GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE6 SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE6 DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE
340 350 360 370 380 390
430
pF1KE6 LIAREIVFDK
::::::::::
XP_005 LIAREIVFDK
400
>>XP_016859444 (OMIM: 609576) PREDICTED: long-chain spec (289 aa)
initn: 1911 init1: 1911 opt: 1911 Z-score: 2441.6 bits: 460.3 E(85289): 2.9e-129
Smith-Waterman score: 1911; 100.0% identity (100.0% similar) in 289 aa overlap (142-430:1-289)
120 130 140 150 160 170
pF1KE6 GDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIA
::::::::::::::::::::::::::::::
XP_016 MSYITNHGSEEQIKHFIPQMTAGKCIGAIA
10 20 30
180 190 200 210 220 230
pF1KE6 MTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGIS
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE6 LFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQE
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE6 RLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNC
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE6 LQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIY
220 230 240 250 260 270
420 430
pF1KE6 GGTNEIMKELIAREIVFDK
:::::::::::::::::::
XP_016 GGTNEIMKELIAREIVFDK
280
>>XP_016877645 (OMIM: 243500,607036) PREDICTED: isovaler (407 aa)
initn: 812 init1: 680 opt: 821 Z-score: 1047.4 bits: 202.8 E(85289): 1.3e-51
Smith-Waterman score: 821; 34.9% identity (69.8% similar) in 384 aa overlap (53-429:26-405)
30 40 50 60 70 80
pF1KE6 PAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKA
..::. .:... ::.::.. :. .: ...
XP_016 MVFWWRIGQATYRLWHKGPQSVCSSLTPEQAELRQTMAKFLQEHLAPKAQEIDRS
10 20 30 40 50
90 100 110 120 130
pF1KE6 GEVS--REVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAY-SNCSGPGFSIHSG
.: . :: :.. :. :.::.. . :: : ..: :: . :. : ... ::.
XP_016 NEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSN
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE6 IVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNG
. .. .. .:.: : ....:.. .:. :::.::.::.::::. ..: .:.: :. .::::
XP_016 LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNG
120 130 140 150 160 170
200 210 220 230 240 250
pF1KE6 SKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTA
.: .:.:: .::.:: : :. : ..::. :.::.:: :: ..:: :.:.....:
XP_016 NKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTC
180 190 200 210 220 230
260 270 280 290 300 310
pF1KE6 ELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKA
::.::: ..::. .::.:::: : .:. : :::..: .. . ....: :.. :.:
XP_016 ELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREA
240 250 260 270 280 290
320 330 340 350 360 370
pF1KE6 FGKTVAHLQTVQHKLAELKTHICVTRAFVDN----CLQLHEAKRLDSATACMAKYWASEL
::. ..:.: .: :.:.. :.. . : .: : : . : . . : : . . ...:
XP_016 FGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAK-DCAGVIL---YSAEC
300 310 320 330 340 350
380 390 400 410 420 430
pF1KE6 QNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK
..:: : .: :: ::. ..:... ::.. : .::.:. . .:.: . :
XP_016 ATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
360 370 380 390 400
>>NP_002216 (OMIM: 243500,607036) isovaleryl-CoA dehydro (426 aa)
initn: 787 init1: 680 opt: 814 Z-score: 1038.2 bits: 201.2 E(85289): 4.3e-51
Smith-Waterman score: 814; 34.9% identity (69.5% similar) in 384 aa overlap (53-429:45-424)
30 40 50 60 70 80
pF1KE6 PAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKA
.: :. .:... ::.::.. :. .: ...
NP_002 VASWRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRS
20 30 40 50 60 70
90 100 110 120 130
pF1KE6 GEVS--REVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAY-SNCSGPGFSIHSG
.: . :: :.. :. :.::.. . :: : ..: :: . :. : ... ::.
NP_002 NEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSN
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE6 IVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNG
. .. .. .:.: : ....:.. .:. :::.::.::.::::. ..: .:.: :. .::::
NP_002 LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNG
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE6 SKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTA
.: .:.:: .::.:: : :. : ..::. :.::.:: :: ..:: :.:.....:
NP_002 NKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTC
200 210 220 230 240 250
260 270 280 290 300 310
pF1KE6 ELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKA
::.::: ..::. .::.:::: : .:. : :::..: .. . ....: :.. :.:
NP_002 ELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREA
260 270 280 290 300 310
320 330 340 350 360 370
pF1KE6 FGKTVAHLQTVQHKLAELKTHICVTRAFVDN----CLQLHEAKRLDSATACMAKYWASEL
::. ..:.: .: :.:.. :.. . : .: : : . : . . : : . . ...:
NP_002 FGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAK-DCAGVIL---YSAEC
320 330 340 350 360 370
380 390 400 410 420 430
pF1KE6 QNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK
..:: : .: :: ::. ..:... ::.. : .::.:. . .:.: . :
NP_002 ATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
380 390 400 410 420
>>NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA dehy (396 aa)
initn: 746 init1: 680 opt: 756 Z-score: 964.6 bits: 187.4 E(85289): 5.5e-47
Smith-Waterman score: 756; 35.3% identity (68.9% similar) in 351 aa overlap (84-429:48-394)
60 70 80 90 100 110
pF1KE6 SPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGD
: .: :.. :. :.::.. . :: :
NP_001 WRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQEFWKQLGNLGVLGITAPVQYGGSGLG
20 30 40 50 60 70
120 130 140 150 160 170
pF1KE6 LYSAAIVWEEQAY-SNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAM
..: :: . :. : ... ::.. .. .. .:.: : ....:.. .:. :::.::
NP_001 YLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAM
80 90 100 110 120 130
180 190 200 210 220 230
pF1KE6 TEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISL
.::.::::. ..: .:.: :. .::::.: .:.:: .::.:: : :. : ..::.
NP_001 SEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITA
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE6 FLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQER
:.::.:: :: ..:: :.:.....: ::.::: ..::. .::.:::: : .:. : ::
NP_001 FIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLER
200 210 220 230 240 250
300 310 320 330 340 350
pF1KE6 LLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDN--
:..: .. . ....: :.. :.:::. ..:.: .: :.:.. :.. . : .: :
NP_001 LVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVA
260 270 280 290 300 310
360 370 380 390 400
pF1KE6 --CLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQ
: . : . . : : . . ...: ..:: : .: :: ::. ..:... ::..
NP_001 KACDEGHCTAK-DCAGVIL---YSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLY
320 330 340 350 360 370
410 420 430
pF1KE6 PIYGGTNEIMKELIAREIVFDK
: .::.:. . .:.: . :
NP_001 EIGAGTSEVRRLVIGRAFNADFH
380 390
>>XP_016877643 (OMIM: 243500,607036) PREDICTED: isovaler (436 aa)
initn: 802 init1: 680 opt: 755 Z-score: 962.7 bits: 187.2 E(85289): 7e-47
Smith-Waterman score: 760; 32.9% identity (65.1% similar) in 413 aa overlap (53-429:26-434)
30 40 50 60 70 80
pF1KE6 PAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKA
..::. .:... ::.::.. :. .: ...
XP_016 MVFWWRIGQATYRLWHKGPQSVCSSLTPEQAELRQTMAKFLQEHLAPKAQEIDRS
10 20 30 40 50
90 100 110
pF1KE6 GE-----VSREV--------------------------WEKAGKQGLLGVNIAEHLGGIG
.: :: :: :.. :. :.::.. . :: :
XP_016 NEFKNLRVSWEVRAVGGSQGVGLSCTAAWKSSHSFLEFWKQLGNLGVLGITAPVQYGGSG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 GDLYSAAIVWEEQAY-SNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAI
..: :: . :. : ... ::.. .. .. .:.: : ....:.. .:. :::.
XP_016 LGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGAL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 AMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGI
::.::.::::. ..: .:.: :. .::::.: .:.:: .::.:: : :. : ..::
XP_016 AMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGI
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 SLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQ
. :.::.:: :: ..:: :.:.....: ::.::: ..::. .::.:::: : .:. :
XP_016 TAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE6 ERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDN
:::..: .. . ....: :.. :.:::. ..:.: .: :.:.. :.. . : .: :
XP_016 ERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYN
300 310 320 330 340 350
360 370 380 390 400
pF1KE6 ----CLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDAR
: . : . . : : . . ...: ..:: : .: :: ::. ..:... ::.
XP_016 VAKACDEGHCTAK-DCAGVIL---YSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAK
360 370 380 390 400 410
410 420 430
pF1KE6 VQPIYGGTNEIMKELIAREIVFDK
. : .::.:. . .:.: . :
XP_016 LYEIGAGTSEVRRLVIGRAFNADFH
420 430
>>XP_016877641 (OMIM: 243500,607036) PREDICTED: isovaler (455 aa)
initn: 743 init1: 680 opt: 755 Z-score: 962.4 bits: 187.2 E(85289): 7.2e-47
Smith-Waterman score: 755; 35.1% identity (68.8% similar) in 356 aa overlap (79-429:103-453)
50 60 70 80 90 100
pF1KE6 IRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLG
: :... : :.. :. :.::.. . :
XP_016 RSNEFKNLRVSWEVRAVGGSQGVGLSCTAAW-KSSHSFLEFWKQLGNLGVLGITAPVQYG
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE6 GIGGDLYSAAIVWEEQAY-SNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCI
: : ..: :: . :. : ... ::.. .. .. .:.: : ....:.. .:. :
XP_016 GSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYI
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE6 GAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPA
::.::.::.::::. ..: .:.: :. .::::.: .:.:: .::.:: : :. : .
XP_016 GALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPAS
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE6 HGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKE
.::. :.::.:: :: ..:: :.:.....: ::.::: ..::. .::.:::: : .:.
XP_016 RGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSG
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE6 LPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAF
: :::..: .. . ....: :.. :.:::. ..:.: .: :.:.. :.. . : .
XP_016 LDLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQY
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE6 VDN----CLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYV
: : : . : . . : : . . ...: ..:: : .: :: ::. ..:...
XP_016 VYNVAKACDEGHCTAK-DCAGVIL---YSAECATQVALDGIQCFGGNGYINDFPMGRFLR
380 390 400 410 420
410 420 430
pF1KE6 DARVQPIYGGTNEIMKELIAREIVFDK
::.. : .::.:. . .:.: . :
XP_016 DAKLYEIGAGTSEVRRLVIGRAFNADFH
430 440 450
>>NP_001600 (OMIM: 600301,610006) short/branched chain s (432 aa)
initn: 733 init1: 407 opt: 744 Z-score: 948.7 bits: 184.6 E(85289): 4.2e-46
Smith-Waterman score: 744; 32.3% identity (64.9% similar) in 436 aa overlap (1-426:4-428)
10 20 30 40 50
pF1KE6 MAARLLRGSLRVLGGHR----APRQLPAARCSHSGGEERLETPSAKKLTDIGIR---
.:.:::::: :.: . . ..: . : .: :. .:. ::.
NP_001 MEGLAVRLLRGS-RLLRRNFLTCLSSWKIPPHVSKSSQSEALLN------ITNNGIHFAP
10 20 30 40 50
60 70 80 90 100
pF1KE6 -RIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGG
. :. :. ....::.:: ::.. : : .. ... . : . .:::.:... . ::
NP_001 LQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGG
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 IGGDLYSAAIVWEEQAYSNCSGPGFS-IHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIG
:... :...: :: : . : : :.. .. . : .::.::: ..::.:. : .:
NP_001 TGASFLSTVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEK-VG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 AIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAH
.. ..: ::::: ..:: : :.:. ..:::::..::.. . . .:.: .. :. ..
NP_001 SFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVD---PTIGY
180 190 200 210 220
230 240 250 260 270 280
pF1KE6 -GISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKE
::. :::. :. :. .:.::.:..: : ::....: . .::. ..:. : .
NP_001 KGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGS
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE6 LPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAF
: . :. :: .. .. :. : :.:.: ::: . .: .::..:.. :.. ..: .
NP_001 LNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLL
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE6 VDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARV
. : .: :: . : ::::.:::. .... :.. :: :: .::. : . ::..
NP_001 TYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKI
350 360 370 380 390 400
410 420 430
pF1KE6 QPIYGGTNEIMKELIAREIVFDK
:: :...:. . ::..:
NP_001 GTIYEGASNIQLNTIAKHIDAEY
410 420 430
>>NP_000008 (OMIM: 201470,606885) short-chain specific a (412 aa)
initn: 659 init1: 415 opt: 735 Z-score: 937.5 bits: 182.5 E(85289): 1.8e-45
Smith-Waterman score: 735; 33.0% identity (65.2% similar) in 397 aa overlap (30-423:10-403)
10 20 30 40 50
pF1KE6 MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPE-HDI
:: .: : : . . . :: :..
NP_000 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQM
10 20 30 40
60 70 80 90 100 110
pF1KE6 FRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAI
. .. : : ..:..: .. .: .: : :::.... :.::: : : . ::
NP_000 LLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE6 VWEEQAYSNCSGPG--FSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGA
. :: . . :.. : .:..... .. : . ::.:: . .. .:.: :: .:..:::
NP_000 AMEEISRG-CASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGN
110 120 130 140 150
180 190 200 210 220 230
pF1KE6 GSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVEN
::: . .:.:. .:..:.:::.:..:.:. .....: : :.. . .::: :::
NP_000 GSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQN--KGISAFLVPM
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE6 GMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIAD
:. :.: :.:.....::.:.::: :.: ...::: . :: :. : . :. ::.
NP_000 PTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIAS
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE6 VAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEA
:.. .. .. . ::...: ::: ...::..: :::.. . .: .. .:..
NP_000 QALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDN
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE6 KRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEI
:. : ::: ::: ...... .:. :: ::. :.: . : :::. :: ::.::
NP_000 KKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEI
340 350 360 370 380 390
420 430
pF1KE6 MKELIAREIVFDK
.. .::
NP_000 QRLVIAGHLLRSYRS
400 410
430 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:07:58 2016 done: Tue Nov 8 12:07:59 2016
Total Scan time: 6.140 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]