FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE6325, 435 aa
  1>>>pF1KE6325 435 - 435 aa - 435 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.2289+/-0.000456; mu= 8.1502+/- 0.028
 mean_var=139.3049+/-27.293, 0's: 0 Z-trim(112.7): 41  B-trim: 38 in 1/54
 Lambda= 0.108665
 statistics sampled from 21670 (21707) to 21670 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.255), width:  16
 Scan time:  6.570

The best scores are:                                      opt bits E(85289)
NP_005438 (OMIM: 610383) ras association domain-co ( 435) 2841 457.6 2.9e-128
XP_011537290 (OMIM: 610383) PREDICTED: ras associa ( 414) 2697 435.0 1.8e-121
NP_001073990 (OMIM: 614713) ras association domain ( 507)  352 67.4 9.6e-11


>>NP_005438 (OMIM: 610383) ras association domain-contai  (435 aa)
 initn: 2841 init1: 2841 opt: 2841  Z-score: 2423.6  bits: 457.6 E(85289): 2.9e-128
Smith-Waterman score: 2841; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435)

               10        20        30        40        50        60
pF1KE6 MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 EATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE6 LPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE6 DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE6 SEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE6 DAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE6 AKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHS
              370       380       390       400       410       420

              430     
pF1KE6 QDSETTVGDVVLLST
       :::::::::::::::
NP_005 QDSETTVGDVVLLST
              430     

>>XP_011537290 (OMIM: 610383) PREDICTED: ras association  (414 aa)
 initn: 2697 init1: 2697 opt: 2697  Z-score: 2301.9  bits: 435.0 E(85289): 1.8e-121
Smith-Waterman score: 2697; 100.0% identity (100.0% similar) in 414 aa overlap (22-435:1-414)

               10        20        30        40        50        60
pF1KE6 MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH
                            :::::::::::::::::::::::::::::::::::::::
XP_011                      MDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH
                                    10        20        30         

               70        80        90       100       110       120
pF1KE6 EATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAF
      40        50        60        70        80        90         

              130       140       150       160       170       180
pF1KE6 LPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDR
     100       110       120       130       140       150         

              190       200       210       220       230       240
pF1KE6 DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSF
     160       170       180       190       200       210         

              250       260       270       280       290       300
pF1KE6 SEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINE
     220       230       240       250       260       270         

              310       320       330       340       350       360
pF1KE6 DAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELL
     280       290       300       310       320       330         

              370       380       390       400       410       420
pF1KE6 AKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHS
     340       350       360       370       380       390         

              430     
pF1KE6 QDSETTVGDVVLLST
       :::::::::::::::
XP_011 QDSETTVGDVVLLST
     400       410    

>>NP_001073990 (OMIM: 614713) ras association domain-con  (507 aa)
 initn: 896 init1: 282 opt: 352  Z-score: 313.9  bits: 67.4 E(85289): 9.6e-11
Smith-Waterman score: 695; 34.5% identity (57.3% similar) in 447 aa overlap (22-374:1-447)

               10        20        30        40        50        60
pF1KE6 MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH
                            ::  ::.: ::.::::::: ::..::: .::...:::. 
NP_001                      MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDG
                                    10        20        30         

                                                  70        80     
pF1KE6 EATFGEKR-----------------------------------FLLGKPSDYCIIEKWRG
            ..:                                   .: : :. :::.:::::
NP_001 CRRRRRQRRSRRLGSAGDPHGPGELPEPPNEDDEDDDEALPQGMLCGPPQCYCIVEKWRG
      40        50        60        70        80        90         

          90       100       110       120       130       140     
pF1KE6 SERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKL--WEL
        ::.::  ::::.:: :::.:: :..::::...: ::    :.:::..: . :.    . 
NP_001 FERILPNKTRILRLWAAWGEEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARG
     100       110       120       130       140       150         

           150       160       170                              180
pF1KE6 SPANYMKTLPPDKQKRIVRKTFRKLAKI----KQDTVS-------------------HDR
       .::    ..  .::.:.:::.::::::.    .:.: :                   :. 
NP_001 APARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHES
     160       170       180       190       200       210         

                 190       200       210       220       230       
pF1KE6 ---DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLM
          . :::::::..::::::.:::.:..::: ::.. ::: ::::..  : :::::.::.
NP_001 ASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLV
     220       230       240       250       260       270         

       240               250       260       270                   
pF1KE6 PSFSEVE--------QNLDLQYEENQTLEDLSESDGIEQLEE---------RLKYYRI--
        .  :..        ...  . ::  .   :.       :::         ::.  :.  
NP_001 GAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ
     280       290       300       310       320       330         

        280       290       300       310                320       
pF1KE6 --LIDKLSAEIEKEVKSVCIDINEDAEGEAASELESSN---------LESVKCDLEKSMK
         :...:::::..:...  .   ..  .     :: ..          : :. .:  :. 
NP_001 EELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLY
     340       350       360       370       380       390         

       330       340       350       360       370        380      
pF1KE6 AGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELLAKEFNSLHIS-NKDGCQLKENRAKESE
        ::.... : ...... ::..  . : .: . : . ...:...   ::            
NP_001 IGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPG
     400       410       420       430       440       450         

        390       400       410       420       430     
pF1KE6 VPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHSQDSETTVGDVVLLST
                                                        
NP_001 PQACADMWVDQARGLAKSGPGNDEDSDTGLSSMHSQDSDSLPMCESLV 
     460       470       480       490       500        




435 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Nov  8 12:07:20 2016 done: Tue Nov  8 12:07:21 2016
 Total Scan time:  6.570 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]