Result of FASTA (omim) for
pFN21AE6287
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6287, 296 aa
1>>>pF1KE6287 296 - 296 aa - 296 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.3340+/-0.000436; mu= 21.1030+/- 0.027
mean_var=65.9762+/-13.725, 0's: 0 Z-trim(110.5): 32 B-trim: 0 in 0/49
Lambda= 0.157899
statistics sampled from 18798 (18830) to 18798 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.57), E-opt: 0.2 (0.221), width: 16
Scan time: 5.260
The best scores are: opt bits E(85289)
NP_001306596 (OMIM: 249270,603941) thiamine transp ( 296) 1933 449.3 4e-126
NP_008927 (OMIM: 249270,603941) thiamine transport ( 497) 1479 346.2 7.8e-95
XP_005246931 (OMIM: 606152,607483) PREDICTED: thia ( 492) 767 184.0 5.2e-46
XP_011510235 (OMIM: 606152,607483) PREDICTED: thia ( 496) 767 184.0 5.2e-46
NP_079519 (OMIM: 606152,607483) thiamine transport ( 496) 767 184.0 5.2e-46
XP_011510234 (OMIM: 606152,607483) PREDICTED: thia ( 496) 767 184.0 5.2e-46
XP_011510233 (OMIM: 606152,607483) PREDICTED: thia ( 508) 767 184.0 5.3e-46
XP_016860523 (OMIM: 606152,607483) PREDICTED: thia ( 564) 767 184.0 5.7e-46
XP_016860522 (OMIM: 606152,607483) PREDICTED: thia ( 564) 767 184.0 5.7e-46
XP_016860521 (OMIM: 606152,607483) PREDICTED: thia ( 564) 767 184.0 5.7e-46
XP_016860520 (OMIM: 606152,607483) PREDICTED: thia ( 569) 767 184.0 5.8e-46
XP_016860519 (OMIM: 606152,607483) PREDICTED: thia ( 576) 767 184.0 5.8e-46
XP_011528011 (OMIM: 600424) PREDICTED: folate tran ( 473) 578 140.9 4.6e-33
XP_005261221 (OMIM: 600424) PREDICTED: folate tran ( 473) 578 140.9 4.6e-33
XP_011528008 (OMIM: 600424) PREDICTED: folate tran ( 545) 578 141.0 5.1e-33
NP_001192136 (OMIM: 600424) folate transporter 1 i ( 551) 578 141.0 5.1e-33
NP_919231 (OMIM: 600424) folate transporter 1 isof ( 591) 578 141.0 5.4e-33
XP_011528006 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33
XP_011528004 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33
XP_011528003 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33
XP_011528002 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33
XP_011528005 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33
XP_011528000 (OMIM: 600424) PREDICTED: folate tran ( 613) 578 141.0 5.5e-33
XP_016883932 (OMIM: 600424) PREDICTED: folate tran ( 659) 578 141.0 5.8e-33
XP_011527998 (OMIM: 600424) PREDICTED: folate tran ( 688) 578 141.1 6e-33
XP_016883935 (OMIM: 600424) PREDICTED: folate tran ( 489) 508 125.0 3e-28
NP_001192135 (OMIM: 600424) folate transporter 1 i ( 489) 508 125.0 3e-28
XP_016883934 (OMIM: 600424) PREDICTED: folate tran ( 541) 508 125.0 3.2e-28
XP_016883933 (OMIM: 600424) PREDICTED: folate tran ( 586) 508 125.0 3.4e-28
>>NP_001306596 (OMIM: 249270,603941) thiamine transporte (296 aa)
initn: 1933 init1: 1933 opt: 1933 Z-score: 2385.2 bits: 449.3 E(85289): 4e-126
Smith-Waterman score: 1933; 100.0% identity (100.0% similar) in 296 aa overlap (1-296:1-296)
10 20 30 40 50 60
pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 KVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLI
190 200 210 220 230 240
250 260 270 280 290
pF1KE6 VVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSSQVTTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSSQVTTS
250 260 270 280 290
>>NP_008927 (OMIM: 249270,603941) thiamine transporter 1 (497 aa)
initn: 1479 init1: 1479 opt: 1479 Z-score: 1823.5 bits: 346.2 E(85289): 7.8e-95
Smith-Waterman score: 1479; 99.1% identity (99.6% similar) in 231 aa overlap (66-296:267-497)
40 50 60 70 80 90
pF1KE6 LLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLL
:. :::::::::::::::::::::::::::
NP_008 IVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLL
240 250 260 270 280 290
100 110 120 130 140 150
pF1KE6 CWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 CWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKI
300 310 320 330 340 350
160 170 180 190 200 210
pF1KE6 SWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 SWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLS
360 370 380 390 400 410
220 230 240 250 260 270
pF1KE6 MERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAV
420 430 440 450 460 470
280 290
pF1KE6 SVMKKCRKLEDPQSSSQVTTS
:::::::::::::::::::::
NP_008 SVMKKCRKLEDPQSSSQVTTS
480 490
>--
initn: 494 init1: 459 opt: 486 Z-score: 601.0 bits: 120.0 E(85289): 9.8e-27
Smith-Waterman score: 486; 44.8% identity (64.2% similar) in 232 aa overlap (1-223:1-217)
10 20 30 40 50 60
pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
:::::::: . . .:. :: :: . :. : . : :: :::
NP_008 DKNLTEREVFNE-----IYPVWT-----YSYLVLL-FPVFLATDYLRYKPVV-LLQGL--
70 80 90 100
130 140 150 160 170
pF1KE6 KVMPSRYAAIYNGGVEAVSTL---LGAVAVFAVGYIKISWSTWGE-MTLSLFSLLIAAAV
... . . .: :. :.. : : ... ..: . .:. : .. : .:..
NP_008 SLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE6 Y---IMDTVGNIWVCYASYVVFR--IIYMLLITIATFQIAANLSMERYALVFGVNTFIAL
. ...:.: : :.. .: .: . ...: : .: : : . .: :
NP_008 VGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVA-FAVAWFLPMPQKSLFFHHIPSTCQ
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS
NP_008 RVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWND
230 240 250 260 270 280
>>XP_005246931 (OMIM: 606152,607483) PREDICTED: thiamine (492 aa)
initn: 747 init1: 747 opt: 767 Z-score: 947.0 bits: 184.0 E(85289): 5.2e-46
Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:249-468)
50 60 70 80 90
pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS
::. . : . : : .:. ::::. :. ::
XP_005 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS
.:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:.
XP_005 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER
::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..::
XP_005 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER
340 350 360 370 380 390
220 230 240 250 260 270
pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM
::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. .
XP_005 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT
400 410 420 430 440 450
280 290
pF1KE6 KKCRKLEDPQSSSQVTTS
. .. .: ::
XP_005 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
460 470 480 490
>>XP_011510235 (OMIM: 606152,607483) PREDICTED: thiamine (496 aa)
initn: 918 init1: 747 opt: 767 Z-score: 947.0 bits: 184.0 E(85289): 5.2e-46
Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:253-472)
50 60 70 80 90
pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS
::. . : . : : .:. ::::. :. ::
XP_011 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS
230 240 250 260 270 280
100 110 120 130 140 150
pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS
.:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:.
XP_011 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD
290 300 310 320 330 340
160 170 180 190 200 210
pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER
::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..::
XP_011 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER
350 360 370 380 390 400
220 230 240 250 260 270
pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM
::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. .
XP_011 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT
410 420 430 440 450 460
280 290
pF1KE6 KKCRKLEDPQSSSQVTTS
. .. .: ::
XP_011 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
470 480 490
>--
initn: 227 init1: 185 opt: 206 Z-score: 256.3 bits: 56.2 E(85289): 1.5e-07
Smith-Waterman score: 206; 26.6% identity (53.7% similar) in 203 aa overlap (30-223:12-199)
10 20 30 40 50 60
pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
:. ::..:: .:::. .::::::: ::: ::
XP_011 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP
10 20 30 40
70 80 90 100 110 120
pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
::::: : . :... .. :. ..:. .. : ::.
XP_011 DKNLTSAE------------ITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGI--
50 60 70 80
130 140 150 160 170
pF1KE6 KVMPSRYAAIYNGGV---EAVSTLLGAVAVFAVGYIKISWSTWGE---MTLSLFSLLIAA
. . . ... :: ..: . : :.. :.: .:. . . .: . ..
XP_011 SFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTL
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE6 AVYIMDTV-GNIWVCYA--SYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIAL
:.: .: ... : : :: . .: . ...: : .. : : . .. :
XP_011 AAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVA-FLFSLFLPMPKKSMFFHAKPSREI
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS
XP_011 KKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQ
210 220 230 240 250 260
>>NP_079519 (OMIM: 606152,607483) thiamine transporter 2 (496 aa)
initn: 918 init1: 747 opt: 767 Z-score: 947.0 bits: 184.0 E(85289): 5.2e-46
Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:253-472)
50 60 70 80 90
pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS
::. . : . : : .:. ::::. :. ::
NP_079 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS
230 240 250 260 270 280
100 110 120 130 140 150
pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS
.:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:.
NP_079 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD
290 300 310 320 330 340
160 170 180 190 200 210
pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER
::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..::
NP_079 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER
350 360 370 380 390 400
220 230 240 250 260 270
pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM
::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. .
NP_079 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT
410 420 430 440 450 460
280 290
pF1KE6 KKCRKLEDPQSSSQVTTS
. .. .: ::
NP_079 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
470 480 490
>--
initn: 227 init1: 185 opt: 206 Z-score: 256.3 bits: 56.2 E(85289): 1.5e-07
Smith-Waterman score: 206; 26.6% identity (53.7% similar) in 203 aa overlap (30-223:12-199)
10 20 30 40 50 60
pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
:. ::..:: .:::. .::::::: ::: ::
NP_079 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP
10 20 30 40
70 80 90 100 110 120
pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
::::: : . :... .. :. ..:. .. : ::.
NP_079 DKNLTSAE------------ITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGI--
50 60 70 80
130 140 150 160 170
pF1KE6 KVMPSRYAAIYNGGV---EAVSTLLGAVAVFAVGYIKISWSTWGE---MTLSLFSLLIAA
. . . ... :: ..: . : :.. :.: .:. . . .: . ..
NP_079 SFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTL
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE6 AVYIMDTV-GNIWVCYA--SYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIAL
:.: .: ... : : :: . .: . ...: : .. : : . .. :
NP_079 AAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVA-FLFSLFLPMPKKSMFFHAKPSREI
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS
NP_079 KKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQ
210 220 230 240 250 260
>>XP_011510234 (OMIM: 606152,607483) PREDICTED: thiamine (496 aa)
initn: 918 init1: 747 opt: 767 Z-score: 947.0 bits: 184.0 E(85289): 5.2e-46
Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:253-472)
50 60 70 80 90
pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS
::. . : . : : .:. ::::. :. ::
XP_011 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS
230 240 250 260 270 280
100 110 120 130 140 150
pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS
.:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:.
XP_011 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD
290 300 310 320 330 340
160 170 180 190 200 210
pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER
::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..::
XP_011 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER
350 360 370 380 390 400
220 230 240 250 260 270
pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM
::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. .
XP_011 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT
410 420 430 440 450 460
280 290
pF1KE6 KKCRKLEDPQSSSQVTTS
. .. .: ::
XP_011 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
470 480 490
>--
initn: 227 init1: 185 opt: 206 Z-score: 256.3 bits: 56.2 E(85289): 1.5e-07
Smith-Waterman score: 206; 26.6% identity (53.7% similar) in 203 aa overlap (30-223:12-199)
10 20 30 40 50 60
pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
:. ::..:: .:::. .::::::: ::: ::
XP_011 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP
10 20 30 40
70 80 90 100 110 120
pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
::::: : . :... .. :. ..:. .. : ::.
XP_011 DKNLTSAE------------ITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGI--
50 60 70 80
130 140 150 160 170
pF1KE6 KVMPSRYAAIYNGGV---EAVSTLLGAVAVFAVGYIKISWSTWGE---MTLSLFSLLIAA
. . . ... :: ..: . : :.. :.: .:. . . .: . ..
XP_011 SFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTL
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE6 AVYIMDTV-GNIWVCYA--SYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIAL
:.: .: ... : : :: . .: . ...: : .. : : . .. :
XP_011 AAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVA-FLFSLFLPMPKKSMFFHAKPSREI
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS
XP_011 KKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQ
210 220 230 240 250 260
>>XP_011510233 (OMIM: 606152,607483) PREDICTED: thiamine (508 aa)
initn: 918 init1: 747 opt: 767 Z-score: 946.8 bits: 184.0 E(85289): 5.3e-46
Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:265-484)
50 60 70 80 90
pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS
::. . : . : : .:. ::::. :. ::
XP_011 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS
240 250 260 270 280 290
100 110 120 130 140 150
pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS
.:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:.
XP_011 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD
300 310 320 330 340 350
160 170 180 190 200 210
pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER
::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..::
XP_011 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER
360 370 380 390 400 410
220 230 240 250 260 270
pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM
::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. .
XP_011 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT
420 430 440 450 460 470
280 290
pF1KE6 KKCRKLEDPQSSSQVTTS
. .. .: ::
XP_011 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
480 490 500
>--
initn: 227 init1: 185 opt: 206 Z-score: 256.2 bits: 56.2 E(85289): 1.6e-07
Smith-Waterman score: 206; 26.6% identity (53.7% similar) in 203 aa overlap (30-223:24-211)
10 20 30 40 50 60
pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
:. ::..:: .:::. .::::::: ::: ::
XP_011 MKGKGKHLAFTAMDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
::::: : . :... .. :. ..:. .. : ::.
XP_011 DKNLTSAE------------ITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGI--
60 70 80 90 100
130 140 150 160 170
pF1KE6 KVMPSRYAAIYNGGV---EAVSTLLGAVAVFAVGYIKISWSTWGE---MTLSLFSLLIAA
. . . ... :: ..: . : :.. :.: .:. . . .: . ..
XP_011 SFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE6 AVYIMDTV-GNIWVCYA--SYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIAL
:.: .: ... : : :: . .: . ...: : .. : : . .. :
XP_011 AAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVA-FLFSLFLPMPKKSMFFHAKPSREI
170 180 190 200 210
240 250 260 270 280 290
pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS
XP_011 KKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQ
220 230 240 250 260 270
>>XP_016860523 (OMIM: 606152,607483) PREDICTED: thiamine (564 aa)
initn: 932 init1: 747 opt: 767 Z-score: 946.3 bits: 184.0 E(85289): 5.7e-46
Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:321-540)
50 60 70 80 90
pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS
::. . : . : : .:. ::::. :. ::
XP_016 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS
300 310 320 330 340 350
100 110 120 130 140 150
pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS
.:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:.
XP_016 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD
360 370 380 390 400 410
160 170 180 190 200 210
pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER
::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..::
XP_016 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER
420 430 440 450 460 470
220 230 240 250 260 270
pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM
::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. .
XP_016 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT
480 490 500 510 520
280 290
pF1KE6 KKCRKLEDPQSSSQVTTS
. .. .: ::
XP_016 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
530 540 550 560
>--
initn: 241 init1: 199 opt: 199 Z-score: 247.0 bits: 54.6 E(85289): 5.1e-07
Smith-Waterman score: 199; 66.7% identity (82.1% similar) in 39 aa overlap (30-68:12-50)
10 20 30 40 50 60
pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
:. ::..:: .:::. .::::::: ::: ::
XP_016 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP
10 20 30 40
70 80 90 100 110 120
pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
::::: :
XP_016 DKNLTSAELLRLKHATIKTTKDRCRVRSNSMNPLGSASRATVDQLTDLPSKEQLSCVVFA
50 60 70 80 90 100
>>XP_016860522 (OMIM: 606152,607483) PREDICTED: thiamine (564 aa)
initn: 932 init1: 747 opt: 767 Z-score: 946.3 bits: 184.0 E(85289): 5.7e-46
Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:321-540)
50 60 70 80 90
pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS
::. . : . : : .:. ::::. :. ::
XP_016 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS
300 310 320 330 340 350
100 110 120 130 140 150
pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS
.:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:.
XP_016 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD
360 370 380 390 400 410
160 170 180 190 200 210
pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER
::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..::
XP_016 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER
420 430 440 450 460 470
220 230 240 250 260 270
pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM
::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. .
XP_016 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT
480 490 500 510 520
280 290
pF1KE6 KKCRKLEDPQSSSQVTTS
. .. .: ::
XP_016 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
530 540 550 560
>--
initn: 241 init1: 199 opt: 199 Z-score: 247.0 bits: 54.6 E(85289): 5.1e-07
Smith-Waterman score: 199; 66.7% identity (82.1% similar) in 39 aa overlap (30-68:12-50)
10 20 30 40 50 60
pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
:. ::..:: .:::. .::::::: ::: ::
XP_016 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP
10 20 30 40
70 80 90 100 110 120
pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
::::: :
XP_016 DKNLTSAELLRLKHATIKTTKDRCRVRSNSMNPLGSASRATVDQLTDLPSKEQLSCVVFA
50 60 70 80 90 100
>>XP_016860521 (OMIM: 606152,607483) PREDICTED: thiamine (564 aa)
initn: 932 init1: 747 opt: 767 Z-score: 946.3 bits: 184.0 E(85289): 5.7e-46
Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:321-540)
50 60 70 80 90
pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS
::. . : . : : .:. ::::. :. ::
XP_016 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS
300 310 320 330 340 350
100 110 120 130 140 150
pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS
.:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:.
XP_016 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD
360 370 380 390 400 410
160 170 180 190 200 210
pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER
::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..::
XP_016 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER
420 430 440 450 460 470
220 230 240 250 260 270
pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM
::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. .
XP_016 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT
480 490 500 510 520
280 290
pF1KE6 KKCRKLEDPQSSSQVTTS
. .. .: ::
XP_016 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
530 540 550 560
>--
initn: 241 init1: 199 opt: 199 Z-score: 247.0 bits: 54.6 E(85289): 5.1e-07
Smith-Waterman score: 199; 66.7% identity (82.1% similar) in 39 aa overlap (30-68:12-50)
10 20 30 40 50 60
pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
:. ::..:: .:::. .::::::: ::: ::
XP_016 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP
10 20 30 40
70 80 90 100 110 120
pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE
::::: :
XP_016 DKNLTSAELLRLKHATIKTTKDRCRVRSNSMNPLGSASRATVDQLTDLPSKEQLSCVVFA
50 60 70 80 90 100
296 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:48:12 2016 done: Tue Nov 8 11:48:13 2016
Total Scan time: 5.260 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]