Result of FASTA (omim) for
pFN21AE6257
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6257, 247 aa
1>>>pF1KE6257 247 - 247 aa - 247 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1085+/-0.000429; mu= 14.9828+/- 0.026
mean_var=62.5542+/-13.373, 0's: 0 Z-trim(110.4): 27 B-trim: 747 in 1/56
Lambda= 0.162161
statistics sampled from 18717 (18732) to 18717 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.22), width: 16
Scan time: 4.580
The best scores are: opt bits E(85289)
NP_057106 (OMIM: 607629) gamma-secretase subunit A ( 247) 1609 385.3 5.6e-107
NP_001071096 (OMIM: 607629) gamma-secretase subuni ( 265) 1598 382.7 3.5e-106
NP_112591 (OMIM: 607630) gamma-secretase subunit A ( 257) 1005 244.0 2e-64
NP_001230700 (OMIM: 607629) gamma-secretase subuni ( 190) 999 242.5 4.1e-64
XP_016856906 (OMIM: 607629) PREDICTED: gamma-secre ( 208) 988 239.9 2.6e-63
XP_011520407 (OMIM: 607630) PREDICTED: gamma-secre ( 235) 863 210.7 1.8e-54
NP_001230701 (OMIM: 607629) gamma-secretase subuni ( 195) 837 204.6 1.1e-52
NP_001139118 (OMIM: 607630) gamma-secretase subuni ( 216) 486 122.5 6.1e-28
>>NP_057106 (OMIM: 607629) gamma-secretase subunit APH-1 (247 aa)
initn: 1609 init1: 1609 opt: 1609 Z-score: 2041.7 bits: 385.3 E(85289): 5.6e-107
Smith-Waterman score: 1609; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:1-247)
10 20 30 40 50 60
pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
190 200 210 220 230 240
pF1KE6 RSLLCKD
:::::::
NP_057 RSLLCKD
>>NP_001071096 (OMIM: 607629) gamma-secretase subunit AP (265 aa)
initn: 1598 init1: 1598 opt: 1598 Z-score: 2027.3 bits: 382.7 E(85289): 3.5e-106
Smith-Waterman score: 1598; 99.6% identity (100.0% similar) in 246 aa overlap (1-246:1-246)
10 20 30 40 50 60
pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
190 200 210 220 230 240
pF1KE6 RSLLCKD
:::::.
NP_001 RSLLCRRQEDSRVMVYSALRIPPED
250 260
>>NP_112591 (OMIM: 607630) gamma-secretase subunit APH-1 (257 aa)
initn: 978 init1: 536 opt: 1005 Z-score: 1277.7 bits: 244.0 E(85289): 2e-64
Smith-Waterman score: 1005; 59.1% identity (83.0% similar) in 247 aa overlap (1-247:1-246)
10 20 30 40 50 60
pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
: :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. .
NP_112 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
: .:. : :::::: ::: .::.::::::::::::.::: :.. :.. :.: .:::
NP_112 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINP-GETAPSMRLLAYV
70 80 90 100 110
130 140 150 160 170 180
pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
:::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::
NP_112 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
.::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
NP_112 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK
180 190 200 210 220 230
pF1KE6 RSLLCKD
:::.:
NP_112 LCLLCQDKNFLLYNQRSR
240 250
>>NP_001230700 (OMIM: 607629) gamma-secretase subunit AP (190 aa)
initn: 1233 init1: 999 opt: 999 Z-score: 1272.1 bits: 242.5 E(85289): 4.1e-64
Smith-Waterman score: 1123; 76.9% identity (76.9% similar) in 247 aa overlap (1-247:1-190)
10 20 30 40 50 60
pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
::::::::::::::::::::::::::::::::::::::
NP_001 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG----------------------
10 20 30
70 80 90 100 110 120
pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
:::::::::::::::::::::::::
NP_001 -----------------------------------KADEGLASLSEDGRSPISIRQMAYV
40 50 60
130 140 150 160 170 180
pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
130 140 150 160 170 180
pF1KE6 RSLLCKD
:::::::
NP_001 RSLLCKD
190
>>XP_016856906 (OMIM: 607629) PREDICTED: gamma-secretase (208 aa)
initn: 1222 init1: 988 opt: 988 Z-score: 1257.6 bits: 239.9 E(85289): 2.6e-63
Smith-Waterman score: 1112; 76.4% identity (76.8% similar) in 246 aa overlap (1-246:1-189)
10 20 30 40 50 60
pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
::::::::::::::::::::::::::::::::::::::
XP_016 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG----------------------
10 20 30
70 80 90 100 110 120
pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
:::::::::::::::::::::::::
XP_016 -----------------------------------KADEGLASLSEDGRSPISIRQMAYV
40 50 60
130 140 150 160 170 180
pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
130 140 150 160 170 180
pF1KE6 RSLLCKD
:::::.
XP_016 RSLLCRRQEDSRVMVYSALRIPPED
190 200
>>XP_011520407 (OMIM: 607630) PREDICTED: gamma-secretase (235 aa)
initn: 836 init1: 456 opt: 863 Z-score: 1098.8 bits: 210.7 E(85289): 1.8e-54
Smith-Waterman score: 863; 62.7% identity (86.1% similar) in 201 aa overlap (1-201:1-200)
10 20 30 40 50 60
pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
: :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. .
XP_011 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
: .:. : :::::: ::: .::.::::::::::::.::: :.. :.. :.: .:::
XP_011 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINP-GETAPSMRLLAYV
70 80 90 100 110
130 140 150 160 170 180
pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
:::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::
XP_011 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
.::.... : .:. .:::.:
XP_011 GCEKKKWGILLIVLLTHLLVSAQVSLENCSFSVTAAWKSCVFQTRHHDWTLFLALV
180 190 200 210 220 230
>>NP_001230701 (OMIM: 607629) gamma-secretase subunit AP (195 aa)
initn: 1071 init1: 837 opt: 837 Z-score: 1067.1 bits: 204.6 E(85289): 1.1e-52
Smith-Waterman score: 933; 67.9% identity (69.5% similar) in 246 aa overlap (1-246:1-176)
10 20 30 40 50 60
pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
::::::::::::::::::::::::::::::::::::::
NP_001 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG----------------------
10 20 30
70 80 90 100 110 120
pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
: .: : . : .
NP_001 -RCSA-----------------------------------LPTTS------------CLI
40 50
130 140 150 160 170 180
pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
60 70 80 90 100 110
190 200 210 220 230 240
pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
120 130 140 150 160 170
pF1KE6 RSLLCKD
:::::.
NP_001 RSLLCRRQEDSRVMVYSALRIPPED
180 190
>>NP_001139118 (OMIM: 607630) gamma-secretase subunit AP (216 aa)
initn: 771 init1: 456 opt: 486 Z-score: 622.6 bits: 122.5 E(85289): 6.1e-28
Smith-Waterman score: 703; 47.0% identity (68.0% similar) in 247 aa overlap (1-247:1-205)
10 20 30 40 50 60
pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
: :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. .
NP_001 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
: .:. : :::::: ::: .::.::::::::::::.::: :.. :.. :.: .::
NP_001 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINP-GETAPSMRLLAY-
70 80 90 100 110
130 140 150 160 170 180
pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
::.: .:::::.:::.::::
NP_001 ----------------------------------------AFMTLVIILLHVFWGIVFFD
120 130
190 200 210 220 230 240
pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
.::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
NP_001 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK
140 150 160 170 180 190
pF1KE6 RSLLCKD
:::.:
NP_001 LCLLCQDKNFLLYNQRSR
200 210
247 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:32:33 2016 done: Tue Nov 8 11:32:34 2016
Total Scan time: 4.580 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]