Result of FASTA (omim) for
pFN21AE6253
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6253, 214 aa
1>>>pF1KE6253 214 - 214 aa - 214 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.5495+/-0.000326; mu= 18.1823+/- 0.020
mean_var=59.1444+/-11.917, 0's: 0 Z-trim(115.0): 42 B-trim: 738 in 1/53
Lambda= 0.166770
statistics sampled from 25057 (25102) to 25057 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.672), E-opt: 0.2 (0.294), width: 16
Scan time: 5.980
The best scores are: opt bits E(85289)
NP_006129 (OMIM: 606498) membrane-spanning 4-domai ( 214) 1418 349.0 3.4e-96
XP_011543665 (OMIM: 606498) PREDICTED: membrane-sp ( 154) 1032 256.0 2.4e-68
NP_001026979 (OMIM: 606498) membrane-spanning 4-do ( 168) 757 189.9 2.1e-48
NP_001026836 (OMIM: 606498) membrane-spanning 4-do ( 91) 587 148.8 2.7e-36
XP_016873398 (OMIM: 606547) PREDICTED: membrane-sp ( 220) 315 83.6 2.7e-16
NP_076926 (OMIM: 606547) membrane-spanning 4-domai ( 220) 315 83.6 2.7e-16
NP_683876 (OMIM: 606547) membrane-spanning 4-domai ( 239) 315 83.7 2.9e-16
NP_076434 (OMIM: 606499) membrane-spanning 4-domai ( 200) 260 70.4 2.4e-12
NP_000130 (OMIM: 147050,147138) high affinity immu ( 244) 250 68.0 1.5e-11
XP_011543152 (OMIM: 147050,147138) PREDICTED: high ( 244) 250 68.0 1.5e-11
XP_005273903 (OMIM: 147050,147138) PREDICTED: high ( 251) 250 68.0 1.5e-11
NP_113645 (OMIM: 606549) membrane-spanning 4-domai ( 250) 245 66.8 3.5e-11
NP_060186 (OMIM: 606550) membrane-spanning 4-domai ( 267) 225 62.0 1e-09
XP_011543419 (OMIM: 606550) PREDICTED: membrane-sp ( 267) 225 62.0 1e-09
XP_016872851 (OMIM: 147050,147138) PREDICTED: high ( 204) 213 59.1 6.2e-09
NP_690590 (OMIM: 606548) membrane-spanning 4-domai ( 178) 199 55.6 5.8e-08
XP_016854968 (OMIM: 608401) PREDICTED: putative me ( 180) 197 55.2 8.1e-08
NP_071744 (OMIM: 606548) membrane-spanning 4-domai ( 225) 198 55.5 8.1e-08
NP_690591 (OMIM: 606548) membrane-spanning 4-domai ( 248) 198 55.5 8.8e-08
NP_001234928 (OMIM: 606548) membrane-spanning 4-do ( 253) 198 55.5 8.9e-08
NP_001317204 (OMIM: 606548) membrane-spanning 4-do ( 276) 198 55.6 9.5e-08
XP_005274234 (OMIM: 606548) PREDICTED: membrane-sp ( 276) 198 55.6 9.5e-08
XP_011506612 (OMIM: 608401) PREDICTED: putative me ( 229) 197 55.3 9.7e-08
XP_016874130 (OMIM: 608401) PREDICTED: putative me ( 180) 191 53.7 2.2e-07
XP_011543718 (OMIM: 608401) PREDICTED: putative me ( 229) 191 53.8 2.6e-07
NP_996822 (OMIM: 606502) membrane-spanning 4-domai ( 240) 189 53.3 3.8e-07
NP_067024 (OMIM: 606502) membrane-spanning 4-domai ( 240) 189 53.3 3.8e-07
NP_001230195 (OMIM: 606547) membrane-spanning 4-do ( 186) 167 48.0 1.2e-05
XP_016873614 (OMIM: 606548) PREDICTED: membrane-sp ( 145) 149 43.5 0.00021
XP_011543511 (OMIM: 606548) PREDICTED: membrane-sp ( 148) 149 43.6 0.00021
NP_690605 (OMIM: 112210,613495) B-lymphocyte antig ( 297) 137 40.9 0.0026
NP_068769 (OMIM: 112210,613495) B-lymphocyte antig ( 297) 137 40.9 0.0026
>>NP_006129 (OMIM: 606498) membrane-spanning 4-domains s (214 aa)
initn: 1418 init1: 1418 opt: 1418 Z-score: 1848.0 bits: 349.0 E(85289): 3.4e-96
Smith-Waterman score: 1418; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214)
10 20 30 40 50 60
pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL
130 140 150 160 170 180
190 200 210
pF1KE6 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV
::::::::::::::::::::::::::::::::::
NP_006 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV
190 200 210
>>XP_011543665 (OMIM: 606498) PREDICTED: membrane-spanni (154 aa)
initn: 1032 init1: 1032 opt: 1032 Z-score: 1348.0 bits: 256.0 E(85289): 2.4e-68
Smith-Waterman score: 1032; 100.0% identity (100.0% similar) in 154 aa overlap (61-214:1-154)
40 50 60 70 80 90
pF1KE6 TSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTG
::::::::::::::::::::::::::::::
XP_011 MILALGVFLGSLQYPYHFQKHFFFFTFYTG
10 20 30
100 110 120 130 140 150
pF1KE6 YPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSL
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE6 RSCHSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSCHSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSP
100 110 120 130 140 150
pF1KE6 PNSV
::::
XP_011 PNSV
>>NP_001026979 (OMIM: 606498) membrane-spanning 4-domain (168 aa)
initn: 1085 init1: 757 opt: 757 Z-score: 989.9 bits: 189.9 E(85289): 2.1e-48
Smith-Waterman score: 997; 78.5% identity (78.5% similar) in 214 aa overlap (1-214:1-168)
10 20 30 40 50 60
pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLG--------
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN
::::::::::::::::::::::
NP_001 --------------------------------------FCSSGTLSVVAGIKPTRTWIQN
60 70
130 140 150 160 170 180
pF1KE6 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL
80 90 100 110 120 130
190 200 210
pF1KE6 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV
::::::::::::::::::::::::::::::::::
NP_001 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV
140 150 160
>>NP_001026836 (OMIM: 606498) membrane-spanning 4-domain (91 aa)
initn: 587 init1: 587 opt: 587 Z-score: 772.5 bits: 148.8 E(85289): 2.7e-36
Smith-Waterman score: 587; 100.0% identity (100.0% similar) in 91 aa overlap (124-214:1-91)
100 110 120 130 140 150
pF1KE6 WGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSC
::::::::::::::::::::::::::::::
NP_001 MNIASATIALVGTAFLSLNIAVNIQSLRSC
10 20 30
160 170 180 190 200 210
pF1KE6 HSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNS
40 50 60 70 80 90
pF1KE6 V
:
NP_001 V
>>XP_016873398 (OMIM: 606547) PREDICTED: membrane-spanni (220 aa)
initn: 349 init1: 172 opt: 315 Z-score: 413.6 bits: 83.6 E(85289): 2.7e-16
Smith-Waterman score: 315; 31.7% identity (64.5% similar) in 186 aa overlap (20-201:12-193)
10 20 30 40 50
pF1KE6 MASHEVDNAELGSASAHGTPGSEAG-PEELNTSVYQP--IDGSPD-YQKAKLQVLGAIQI
::. : :. : .: . : . . :.. .:::..::
XP_016 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQI
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 LNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRT
:.: : :..:. . . . .. .. : :: :::.:.: ::.::..:::. :.
XP_016 LTALMSLSMGITMMCMASNTYGSNP---ISVYIGYTIWGSVMFIISGSLSIAAGIRTTKG
60 70 80 90 100
120 130 140 150 160 170
pF1KE6 WIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSL
...:.::::.:...: : . ....: :. ..: . :. :: :. ..
XP_016 LVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN-CHGTMSILMGLDGM
110 120 130 140 150 160
180 190 200 210
pF1KE6 LLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV
.:.:..::.:...: :. :.. ::
XP_016 VLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV
170 180 190 200 210 220
>>NP_076926 (OMIM: 606547) membrane-spanning 4-domains s (220 aa)
initn: 349 init1: 172 opt: 315 Z-score: 413.6 bits: 83.6 E(85289): 2.7e-16
Smith-Waterman score: 315; 31.7% identity (64.5% similar) in 186 aa overlap (20-201:12-193)
10 20 30 40 50
pF1KE6 MASHEVDNAELGSASAHGTPGSEAG-PEELNTSVYQP--IDGSPD-YQKAKLQVLGAIQI
::. : :. : .: . : . . :.. .:::..::
NP_076 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQI
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 LNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRT
:.: : :..:. . . . .. .. : :: :::.:.: ::.::..:::. :.
NP_076 LTALMSLSMGITMMCMASNTYGSNP---ISVYIGYTIWGSVMFIISGSLSIAAGIRTTKG
60 70 80 90 100
120 130 140 150 160 170
pF1KE6 WIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSL
...:.::::.:...: : . ....: :. ..: . :. :: :. ..
NP_076 LVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN-CHGTMSILMGLDGM
110 120 130 140 150 160
180 190 200 210
pF1KE6 LLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV
.:.:..::.:...: :. :.. ::
NP_076 VLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV
170 180 190 200 210 220
>>NP_683876 (OMIM: 606547) membrane-spanning 4-domains s (239 aa)
initn: 349 init1: 172 opt: 315 Z-score: 413.1 bits: 83.7 E(85289): 2.9e-16
Smith-Waterman score: 315; 31.7% identity (64.5% similar) in 186 aa overlap (20-201:31-212)
10 20 30 40
pF1KE6 MASHEVDNAELGSASAHGTPGSEAG-PEELNTSVYQP--IDGSPD-YQK
::. : :. : .: . : . . :
NP_683 MHQTYSRHCRPEESTFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 AKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTL
.. .:::..:::.: : :..:. . . . .. .. : :: :::.:.: ::.:
NP_683 GEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNP---ISVYIGYTIWGSVMFIISGSL
70 80 90 100 110
110 120 130 140 150 160
pF1KE6 SVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNY
:..:::. :. ...:.::::.:...: : . ....: :. ..: . :.
NP_683 SIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN-CHG
120 130 140 150 160 170
170 180 190 200 210
pF1KE6 MGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV
:: :. ...:.:..::.:...: :. :.. ::
NP_683 TMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPL
180 190 200 210 220 230
NP_683 NEV
>>NP_076434 (OMIM: 606499) membrane-spanning 4-domains s (200 aa)
initn: 198 init1: 123 opt: 260 Z-score: 342.6 bits: 70.4 E(85289): 2.4e-12
Smith-Waterman score: 260; 28.6% identity (60.2% similar) in 206 aa overlap (11-205:1-198)
10 20 30 40 50
pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPD-------YQKA---KLQV
. :..:: .: . : :...: :. . : :: :...
NP_076 MDSSTAH-SPVFLVFPPEITASEYESTELSATTFSTQSPLQKLFARKMKI
10 20 30 40
60 70 80 90 100
pF1KE6 LGAIQILNAAMILALGV-FLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVA
::.:::: . : ...:: :: .: :: : : : .:::.::.:.: .::.. ...
NP_076 LGTIQILFGIMTFSFGVIFLFTLLKPYPR----FPFIFLSGYPFWGSVLFINSGAFLIAV
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE6 GIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSI
: :.: : : ::. :: :..: .:.... .. . . : : .. . :. . .
NP_076 KRKTTETLIILSRIMNFLSALGAIAGIILLTFGFILDQNYI--CGYSHQNSQ-CKAVTVL
110 120 130 140 150 160
170 180 190 200 210
pF1KE6 SNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV
:.. :. ....:: ... . :... :. ..
NP_076 FLGILITLMTFSIIELFISLPFSILGCHSEDCDCEQCC
170 180 190 200
>>NP_000130 (OMIM: 147050,147138) high affinity immunogl (244 aa)
initn: 187 init1: 152 opt: 250 Z-score: 328.4 bits: 68.0 E(85289): 1.5e-11
Smith-Waterman score: 250; 29.3% identity (61.4% similar) in 184 aa overlap (23-198:27-204)
10 20 30 40 50
pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQ------KAKLQV
: .:.:.... .:: . : . .
NP_000 MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 LGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAG
::. :::.: . : .:. . :. :.. .: .: .:::.:::.:: :: ::...
NP_000 LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISE
70 80 90 100 110
120 130 140 150 160
pF1KE6 IKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQ--SLRSCHSSSESPDLCNYMGS
. . ...:.: : ::. . .: ..: .:. .. ..::.. :. : .:.:
NP_000 RRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETK--C-FMAS
120 130 140 150 160 170
170 180 190 200 210
pF1KE6 ISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV
.:. .: ..:.::.: : ..: :.:
NP_000 FSTEIVVMMLFLTILGLGSAVSLTI--CGAGEELKGNKVPEDRVYEELNIYSATYSELED
180 190 200 210 220 230
>>XP_011543152 (OMIM: 147050,147138) PREDICTED: high aff (244 aa)
initn: 187 init1: 152 opt: 250 Z-score: 328.4 bits: 68.0 E(85289): 1.5e-11
Smith-Waterman score: 250; 29.3% identity (61.4% similar) in 184 aa overlap (23-198:27-204)
10 20 30 40 50
pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQ------KAKLQV
: .:.:.... .:: . : . .
XP_011 MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 LGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAG
::. :::.: . : .:. . :. :.. .: .: .:::.:::.:: :: ::...
XP_011 LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISE
70 80 90 100 110
120 130 140 150 160
pF1KE6 IKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQ--SLRSCHSSSESPDLCNYMGS
. . ...:.: : ::. . .: ..: .:. .. ..::.. :. : .:.:
XP_011 RRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETK--C-FMAS
120 130 140 150 160 170
170 180 190 200 210
pF1KE6 ISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV
.:. .: ..:.::.: : ..: :.:
XP_011 FSTEIVVMMLFLTILGLGSAVSLTI--CGAGEELKGNKVPEDRVYEELNIYSATYSELED
180 190 200 210 220 230
214 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:29:33 2016 done: Tue Nov 8 11:29:34 2016
Total Scan time: 5.980 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]