Result of FASTA (omim) for
pFN21AE6251
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6251, 264 aa
1>>>pF1KE6251 264 - 264 aa - 264 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1240+/-0.00038; mu= 15.9863+/- 0.024
mean_var=65.7336+/-13.558, 0's: 0 Z-trim(112.8): 311 B-trim: 164 in 1/50
Lambda= 0.158190
statistics sampled from 21512 (21830) to 21512 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.256), width: 16
Scan time: 5.440
The best scores are: opt bits E(85289)
NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 1794 418.1 7.9e-117
NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 722 173.5 3.5e-43
NP_001919 (OMIM: 134350,613912) complement factor ( 253) 628 152.0 9.8e-37
NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 628 152.0 1e-36
NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 571 139.0 8.2e-33
NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 566 137.9 1.9e-32
NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 561 136.7 4e-32
NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 555 135.4 9.9e-32
NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 553 135.0 1.6e-31
NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 533 130.3 3.3e-30
NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 533 130.3 3.3e-30
NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 533 130.4 3.6e-30
NP_001639 (OMIM: 176820) prostate-specific antigen ( 261) 520 127.4 2.6e-29
NP_001264010 (OMIM: 610601) kallikrein-15 isoform ( 255) 516 126.5 4.9e-29
XP_011525387 (OMIM: 610601) PREDICTED: kallikrein- ( 255) 516 126.5 4.9e-29
XP_006723328 (OMIM: 610601) PREDICTED: kallikrein- ( 256) 516 126.5 4.9e-29
NP_059979 (OMIM: 610601) kallikrein-15 isoform 4 p ( 256) 516 126.5 4.9e-29
NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 509 124.9 1.4e-28
NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 509 124.9 1.4e-28
NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 509 124.9 1.5e-28
NP_005542 (OMIM: 147960) kallikrein-2 isoform 1 pr ( 261) 509 124.9 1.5e-28
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 510 125.2 1.9e-28
NP_001519 (OMIM: 604552) hepatocyte growth factor ( 655) 512 125.8 2e-28
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 510 125.3 2e-28
NP_001284368 (OMIM: 604552) hepatocyte growth fact ( 662) 512 125.8 2e-28
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 510 125.3 2e-28
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 495 121.7 1.7e-27
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 495 121.8 2.2e-27
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 492 121.2 3.5e-27
NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 483 118.9 8.8e-27
NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 483 119.0 1e-26
NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 483 119.1 1.3e-26
NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 483 119.1 1.3e-26
NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 483 119.1 1.4e-26
NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 483 119.1 1.4e-26
NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 483 119.1 1.4e-26
NP_001171131 (OMIM: 188050,603924,616535) hyaluron ( 534) 484 119.4 1.4e-26
NP_004123 (OMIM: 188050,603924,616535) hyaluronan- ( 560) 484 119.4 1.5e-26
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 482 118.9 1.9e-26
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 482 118.9 2e-26
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 482 118.9 2e-26
XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 471 116.4 9.6e-26
XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 471 116.4 9.6e-26
XP_011534985 (OMIM: 116831) PREDICTED: granzyme H ( 212) 467 115.2 9.7e-26
XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 471 116.4 1e-25
XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 471 116.4 1e-25
XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 471 116.4 1e-25
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 465 114.9 1.7e-25
NP_001290343 (OMIM: 167800,601564) trypsin-2 isofo ( 261) 463 114.4 2.2e-25
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 469 116.1 2.6e-25
>>NP_002095 (OMIM: 600784) granzyme K precursor [Homo sa (264 aa)
initn: 1794 init1: 1794 opt: 1794 Z-score: 2218.4 bits: 418.1 E(85289): 7.9e-117
Smith-Waterman score: 1794; 100.0% identity (100.0% similar) in 264 aa overlap (1-264:1-264)
10 20 30 40 50 60
pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 KLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 CNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 CNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKP
190 200 210 220 230 240
250 260
pF1KE6 GIYTLLTKKYQTWIKSNLVPPHTN
::::::::::::::::::::::::
NP_002 GIYTLLTKKYQTWIKSNLVPPHTN
250 260
>>NP_006135 (OMIM: 140050) granzyme A precursor [Homo sa (262 aa)
initn: 720 init1: 405 opt: 722 Z-score: 896.2 bits: 173.5 E(85289): 3.5e-43
Smith-Waterman score: 722; 45.1% identity (73.8% similar) in 237 aa overlap (21-254:25-254)
10 20 30 40 50
pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVL
:: .::::.::.:::::.:. .. . .:.:.:
NP_006 MRNSYRFLASSLSVVVSLLLIPEDVC--EKIIGGNEVTPHSRPYMVLLSLDRKTICAGAL
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 IDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSND
: .::::::::. .. :.:::::....: .:: . .:: .:. . .:
NP_006 IAKDWVLTAAHCNL----NKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGD
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 IMLVKLQTAAKLNKHVKMLHIRSK-TSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTV
. :..: ::.::.: .::. .: ... :: :.:.::: : .: :::::::..:.
NP_006 LKLLQLTEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTH-NSASWSDTLREVNITI
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 LSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHE--
..::.::....:: .: : .:::::. .: .:::.::::.::.:.:::....: : :
NP_006 IDRKVCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENK
180 190 200 210 220 230
240 250 260
pF1KE6 CGVATKPGIYTLLTKKYQTWIKSNLVPPHTN
:: ::.: ::.::. .::
NP_006 CGDPRGPGVYILLSKKHLNWIIMTIKGAV
240 250 260
>>NP_001919 (OMIM: 134350,613912) complement factor D is (253 aa)
initn: 429 init1: 224 opt: 628 Z-score: 780.5 bits: 152.0 E(85289): 9.8e-37
Smith-Waterman score: 628; 42.7% identity (69.2% similar) in 234 aa overlap (27-258:26-252)
10 20 30 40 50 60
pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ
:.::.:. :.::.:::.: .: :.:::::. :
NP_001 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQ
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLV
:::.:::: . :. :.:::::::. : ::. .. . .: : ..:..:.
NP_001 WVLSAAHCLEDAADGKVQ-VLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLL
60 70 80 90 100 110
130 140 150 160 170
pF1KE6 KLQTAAKLNKHVKMLHI-RSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRK
.:. : :. :. : : .. :: : :.::: .. . :: :.:..: . ::.:
NP_001 QLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRP-DSLQHVLLPVLDRA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 LCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIV-SGGHECGVAT
:: .....: ::. ..:: ....:::::::::::.: ::....: ::.. ::
NP_001 TCNRRTHHDGA--ITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK
180 190 200 210 220 230
240 250 260
pF1KE6 KPGIYTLLTKKYQTWIKSNLVPPHTN
:::::: ... : .:: : :
NP_001 KPGIYTRVAS-YAAWIDSVLA
240 250
>>NP_001304264 (OMIM: 134350,613912) complement factor D (260 aa)
initn: 412 init1: 224 opt: 628 Z-score: 780.3 bits: 152.0 E(85289): 1e-36
Smith-Waterman score: 628; 42.7% identity (69.2% similar) in 234 aa overlap (27-258:33-259)
10 20 30 40 50
pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVL
:.::.:. :.::.:::.: .: :.:::::
NP_001 SWERLAVLVLLGAAACGEEAWAWAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 IDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSND
. ::::.:::: . :. :.:::::::. : ::. .. . .: : ..:
NP_001 VAEQWVLSAAHCLEDAADGKVQ-VLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 IMLVKLQTAAKLNKHVKMLHI-RSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTV
..:..:. : :. :. : : .. :: : :.::: .. . :: :.:..: . :
NP_001 LLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRP-DSLQHVLLPV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 LSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIV-SGGHEC
:.: :: .....: ::. ..:: ....:::::::::::.: ::....: ::.. :
NP_001 LDRATCNRRTHHDGA--ITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVC
190 200 210 220 230
240 250 260
pF1KE6 GVATKPGIYTLLTKKYQTWIKSNLVPPHTN
: :::::: ... : .:: : :
NP_001 GNRKKPGIYTRVAS-YAAWIDSVLA
240 250 260
>>NP_005308 (OMIM: 600311) granzyme M isoform 1 prepropr (257 aa)
initn: 446 init1: 272 opt: 571 Z-score: 710.1 bits: 139.0 E(85289): 8.2e-33
Smith-Waterman score: 571; 40.2% identity (66.9% similar) in 254 aa overlap (8-255:7-250)
10 20 30 40 50 60
pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ
::. : .:: . :. .::::.:: :::::.:::.: .: :.:::::. :.
NP_005 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPK
10 20 30 40 50
70 80 90 100 110
pF1KE6 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQ-SNDIML
:::::::: . . . .::: :.: .. :..:: : : : ::. :
NP_005 WVLTAAHCLAQ--RMAQLRLVLGLHTL---DSPGLTFHIKAAIQHPRYKPVPALENDLAL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 VKLQTAAKLNKHVKMLHIRSKTSL-RSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSR
..:. .: .. .. : . :: .. .::.:...::: : . : : .:::. . ::.
NP_005 LQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGG-RLSRVLRELDLQVLDT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 KLCNSQSYYNGDPFITKDMVC-AGDAKGQKDSCKGDSGGPLIC-KG-VFHAIVS-GGHEC
..::.. ..::. .. .::: :.:.: : :::::::::.: :: :. ...: ... :
NP_005 RMCNNSRFWNGS--LSPSMVCLAADSKDQAP-CKGDSGGPLVCGKGRVLAGVLSFSSRVC
180 190 200 210 220 230
240 250 260
pF1KE6 GVATKPGIYTLLTKKYQTWIKSNLVPPHTN
:: . : .. : .::.
NP_005 TDIFKPPVATAVAP-YVSWIRKVTGRSA
240 250
>>NP_056411 (OMIM: 605505) kallikrein-13 precursor [Homo (277 aa)
initn: 555 init1: 172 opt: 566 Z-score: 703.5 bits: 137.9 E(85289): 1.9e-32
Smith-Waterman score: 566; 38.3% identity (66.4% similar) in 235 aa overlap (29-258:38-262)
10 20 30 40 50
pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLID
:: :::.:..:.. :. .:::::.
NP_056 IASLTLALSGGVSQESSKVLNTNGTSGFLPGGYTCFPHSQPWQAALLVQGRLLCGGVLVH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 PQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDP----QS
:.:::::::: . : : :: :.:.. ::..:. :. . :: . .: ..
NP_056 PKWVLTAAHCLKEGLK-----VYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 NDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVT
.::::..::. ..:. ... : . .. : :: :.:.:::.: .. ::. ...
NP_056 HDIMLLELQSPVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 VLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVS-GGHE
. : . : .. : : :: .:.::: .: ::::.:::::::.:. ....::: :
NP_056 LRSDEEC--RQVYPGK--ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFP
190 200 210 220 230
240 250 260
pF1KE6 CGVATKPGIYTLLTKKYQTWIKSNLVPPHTN
:: .::.:: ... : ::. ..
NP_056 CGQPDRPGVYTRVSR-YVLWIRETIRKYETQQQKWLKGPQ
240 250 260 270
>>NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 prepro (260 aa)
initn: 401 init1: 171 opt: 561 Z-score: 697.7 bits: 136.7 E(85289): 4e-32
Smith-Waterman score: 561; 38.6% identity (68.1% similar) in 254 aa overlap (9-255:13-253)
10 20 30 40 50
pF1KE6 MTKFSSFSLFFLIVG-AYMTHVCFNME-IIGGKEVSPHSRPFMASIQYGGHHVCGG
.:.:..: :. : . . ..::.: .:::.:..:.. : . .:::
NP_009 MGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 VLIDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIP---FSRVTSD
::. .:::::::: : . :: :: :::..... .: . . . :: .. .
NP_009 VLVGGNWVLTAAHC-----KKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVE
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 PQSNDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGA-TDPDSLRPSDTLRE
...:.::..:. :.:...:: . . .. . . : :: :.:::. :.: : :::
NP_009 DHNHDLMLLQLRDQASLGSKVKPISLADHCT-QPGQKCTVSGWGTVTSPRENFP-DTLNC
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 VTVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSG
. : .. .: : .. : :. :: :::::..:: :.:.:::::::.: :....:.:
NP_009 AEVKIFPQKKC--EDAYPGQ--ITDGMVCAGSSKGA-DTCQGDSGGPLVCDGALQGITSW
180 190 200 210 220
240 250 260
pF1KE6 GHE-CGVATKPGIYTLLTKKYQTWIKSNLVPPHTN
: . :: . :::.:: . . : :::
NP_009 GSDPCGRSDKPGVYTNICR-YLDWIKKIIGSKG
230 240 250 260
>>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa)
initn: 371 init1: 139 opt: 555 Z-score: 690.7 bits: 135.4 E(85289): 9.9e-32
Smith-Waterman score: 555; 37.9% identity (68.8% similar) in 253 aa overlap (10-258:4-243)
10 20 30 40 50
pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQY---GGHHVCGGVLI
:.:... .: . :::::.:..:::::.:: .:. ... :::.:.
NP_219 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILV
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 DPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDI
..:::::::: :.: .:.::::.....: ..: . .:. :: . ::::
NP_219 RKDFVLTAAHCQ-----GSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDI
60 70 80 90 100
120 130 140 150 160 170
pF1KE6 MLVKLQTAAKLNKHVKMLHI-RSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVL
::..:. :: . :. :.. ::.... : :.:.::: .. ..: . ::.:: .::
NP_219 MLLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTL--ATTLQEVLLTV-
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE6 SRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGV
.: :. . ..:. . .:.:: : . . ::::::::.:: : ..:.: :.. :
NP_219 -QKDCQCERLFHGN-YSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKG-
170 180 190 200 210 220
240 250 260
pF1KE6 ATKPGIYTLLTKKYQTWIKSNLVPPHTN
: ::.: . .... ::: ..
NP_219 -TPPGVY-IKVSHFLPWIKRTMKRL
230 240
>>NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 precur (305 aa)
initn: 441 init1: 171 opt: 553 Z-score: 686.8 bits: 135.0 E(85289): 1.6e-31
Smith-Waterman score: 553; 39.6% identity (68.9% similar) in 235 aa overlap (26-255:77-298)
10 20 30 40 50
pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGV
...::.: .:::.:..:.. : . .::::
NP_653 QWPSQPSHCPRGWRSNPLPPAAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGV
50 60 70 80 90 100
60 70 80 90 100 110
pF1KE6 LIDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIP---FSRVTSDP
:. .:::::::: : . :: :: :::..... .: . . . :: .. .
NP_653 LVGGNWVLTAAHC-----KKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVED
110 120 130 140 150 160
120 130 140 150 160 170
pF1KE6 QSNDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGA-TDPDSLRPSDTLREV
...:.::..:. :.:...:: . . .. . . : :: :.:::. :.: : ::: .
NP_653 HNHDLMLLQLRDQASLGSKVKPISLADHCT-QPGQKCTVSGWGTVTSPRENFP-DTLNCA
170 180 190 200 210
180 190 200 210 220 230
pF1KE6 TVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGG
: .. .: : .. : :. :: :::::..:: :.:.:::::::.: :....:.: :
NP_653 EVKIFPQKKC--EDAYPGQ--ITDGMVCAGSSKGA-DTCQGDSGGPLVCDGALQGITSWG
220 230 240 250 260 270
240 250 260
pF1KE6 HE-CGVATKPGIYTLLTKKYQTWIKSNLVPPHTN
. :: . :::.:: . . : :::
NP_653 SDPCGRSDKPGVYTNICR-YLDWIKKIIGSKG
280 290 300
>>NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 precu (250 aa)
initn: 476 init1: 180 opt: 533 Z-score: 663.4 bits: 130.3 E(85289): 3.3e-30
Smith-Waterman score: 533; 37.8% identity (67.6% similar) in 238 aa overlap (27-258:22-247)
10 20 30 40 50 60
pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ
:: : : .:::.:..:.. . .::..:: :.
NP_006 MRILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPR
10 20 30 40 50
70 80 90 100 110
pF1KE6 WVLTAAHC-QYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPF----SRVTSDPQSN
:.:::::: . :. : :: :.:.:.:. .:: . .: . . . . :
NP_006 WLLTAAHCLKPRYI------VHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRN
60 70 80 90 100
120 130 140 150 160 170
pF1KE6 DIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTV
::::::. . .... :. : . :. . .::.: ..:::.:. .:: ::: ...:.
NP_006 DIMLVKMASPVSITWAVRPLTLSSRC-VTAGTSCLISGWGSTSSPQLRLPHTLRCANITI
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE6 LSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHE-C
. .. : .. : :. :: ::::. .: ::::.:::::::.:. ...:.: :.. :
NP_006 IEHQKC--ENAYPGN--ITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPC
170 180 190 200 210 220
240 250 260
pF1KE6 GVATKPGIYTLLTKKYQTWIKSNLVPPHTN
... :::.:: . : : ::. ..
NP_006 AITRKPGVYTKVCK-YVDWIQETMKNN
230 240 250
264 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:28:29 2016 done: Tue Nov 8 11:28:30 2016
Total Scan time: 5.440 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]