Result of FASTA (omim) for
pFN21AE6227
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6227, 219 aa
1>>>pF1KE6227 219 - 219 aa - 219 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7590+/-0.000419; mu= 16.8943+/- 0.026
mean_var=64.7865+/-13.393, 0's: 0 Z-trim(110.0): 40 B-trim: 89 in 1/51
Lambda= 0.159343
statistics sampled from 18260 (18289) to 18260 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.214), width: 16
Scan time: 4.000
The best scores are: opt bits E(85289)
NP_872354 (OMIM: 609427,610265) tetraspan membrane ( 219) 1489 351.1 8.2e-97
XP_005250384 (OMIM: 609719) PREDICTED: lipoma HMGI ( 232) 1069 254.6 1e-67
NP_945351 (OMIM: 609719) lipoma HMGIC fusion partn ( 236) 1066 253.9 1.6e-67
NP_940962 (OMIM: 610240) lipoma HMGIC fusion partn ( 247) 994 237.4 1.6e-62
XP_016861848 (OMIM: 610240) PREDICTED: lipoma HMGI ( 247) 994 237.4 1.6e-62
XP_016861849 (OMIM: 610240) PREDICTED: lipoma HMGI ( 138) 653 158.8 4.1e-39
NP_005771 (OMIM: 606710) lipoma HMGIC fusion partn ( 200) 278 72.7 4.9e-13
XP_011533163 (OMIM: 606710) PREDICTED: lipoma HMGI ( 200) 278 72.7 4.9e-13
XP_006714578 (OMIM: 609718) PREDICTED: lipoma HMGI ( 228) 242 64.5 1.7e-10
NP_005770 (OMIM: 609718) lipoma HMGIC fusion partn ( 228) 242 64.5 1.7e-10
XP_011529246 (OMIM: 300566) PREDICTED: lipoma HMGI ( 220) 231 61.9 9.4e-10
NP_835469 (OMIM: 300566) lipoma HMGIC fusion partn ( 220) 231 61.9 9.4e-10
XP_011529245 (OMIM: 300566) PREDICTED: lipoma HMGI ( 243) 231 62.0 1e-09
XP_016884974 (OMIM: 300566) PREDICTED: lipoma HMGI ( 243) 231 62.0 1e-09
>>NP_872354 (OMIM: 609427,610265) tetraspan membrane pro (219 aa)
initn: 1489 init1: 1489 opt: 1489 Z-score: 1859.1 bits: 351.1 E(85289): 8.2e-97
Smith-Waterman score: 1489; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219)
10 20 30 40 50 60
pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 YFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 YFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 CNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 CNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFM
130 140 150 160 170 180
190 200 210
pF1KE6 LAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV
:::::::::::::::::::::::::::::::::::::::
NP_872 LAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV
190 200 210
>>XP_005250384 (OMIM: 609719) PREDICTED: lipoma HMGIC fu (232 aa)
initn: 1082 init1: 1066 opt: 1069 Z-score: 1336.9 bits: 254.6 E(85289): 1e-67
Smith-Waterman score: 1069; 66.5% identity (90.7% similar) in 215 aa overlap (4-218:15-229)
10 20 30 40
pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYW
.::::::::.:::::::::::.::.:. .::::... .. ::::::
XP_005 MPGAAAAAAAAAAAMLPAQEAAKLYHTNYVRNSRAIGVLWAIFTICFAIVNVVCFIQPYW
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 IGDSVNTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALGMFLII
:::.:.:::::::::: ::.:: .: :: :.:. :::..:: :::.: ::..:.:.:::
XP_005 IGDGVDTPQAGYFGLFHYCIGNGFSRELTCRGSFTDFSTLPSGAFKAASFFIGLSMMLII
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE6 GSIICFSLFFICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYT
. ::::.:::.:::::::::::::::..:. :..::...::::::.::.:::::.: :::
XP_005 ACIICFTLFFFCNTATVYKICAWMQLTSAACLVLGCMIFPDGWDSDEVKRMCGEKTDKYT
130 140 150 160 170 180
170 180 190 200 210
pF1KE6 LGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV
:: :..:::..:::..: ::::::::::::: :::.:. .. ::.. ..
XP_005 LGACSVRWAYILAIIGILDALILSFLAFVLGNRQDSLMAEELKAENKDDGNA
190 200 210 220 230
>>NP_945351 (OMIM: 609719) lipoma HMGIC fusion partner-l (236 aa)
initn: 1081 init1: 1063 opt: 1066 Z-score: 1333.1 bits: 253.9 E(85289): 1.6e-67
Smith-Waterman score: 1066; 67.8% identity (91.0% similar) in 211 aa overlap (4-214:15-225)
10 20 30 40
pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYW
.::::::::.:::::::::::.::.:. .::::... .. ::::::
NP_945 MPGAAAAAAAAAAAMLPAQEAAKLYHTNYVRNSRAIGVLWAIFTICFAIVNVVCFIQPYW
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 IGDSVNTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALGMFLII
:::.:.:::::::::: ::.:: .: :: :.:. :::..:: :::.: ::..:.:.:::
NP_945 IGDGVDTPQAGYFGLFHYCIGNGFSRELTCRGSFTDFSTLPSGAFKAASFFIGLSMMLII
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE6 GSIICFSLFFICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYT
. ::::.:::.:::::::::::::::..:. :..::...::::::.::.:::::.: :::
NP_945 ACIICFTLFFFCNTATVYKICAWMQLTSAACLVLGCMIFPDGWDSDEVKRMCGEKTDKYT
130 140 150 160 170 180
170 180 190 200 210
pF1KE6 LGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV
:: :..:::..:::..: ::::::::::::: :::.:. .. ::.
NP_945 LGACSVRWAYILAIIGILDALILSFLAFVLGNRQDSLMAEELKAENKVLLSQYSLE
190 200 210 220 230
>>NP_940962 (OMIM: 610240) lipoma HMGIC fusion partner-l (247 aa)
initn: 989 init1: 649 opt: 994 Z-score: 1243.4 bits: 237.4 E(85289): 1.6e-62
Smith-Waterman score: 994; 61.8% identity (84.8% similar) in 217 aa overlap (4-219:1-217)
10 20 30 40 50 60
pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG
.::.:::.:.:: .:.:::::.::.:. .::::... ...::::::.::::.::. :
NP_940 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPG
10 20 30 40 50
70 80 90 100 110
pF1KE6 YFGLFSYCVGNVLSS-ELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFF
::::: ::::. :.. :: :.:. :::.::: :::.: ::: :.: ::.: : ::::::
NP_940 YFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 ICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAF
.::::::::::::::: :: :..::...:::::. .: ::: .::::.:: :..:::.
NP_940 FCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAY
120 130 140 150 160 170
180 190 200 210
pF1KE6 MLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV
.:::..: .:::::::::::: :: :: .. : .. . :
NP_940 ILAIIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVL
180 190 200 210 220 230
NP_940 PCPVAHSQGP
240
>>XP_016861848 (OMIM: 610240) PREDICTED: lipoma HMGIC fu (247 aa)
initn: 989 init1: 649 opt: 994 Z-score: 1243.4 bits: 237.4 E(85289): 1.6e-62
Smith-Waterman score: 994; 61.8% identity (84.8% similar) in 217 aa overlap (4-219:1-217)
10 20 30 40 50 60
pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG
.::.:::.:.:: .:.:::::.::.:. .::::... ...::::::.::::.::. :
XP_016 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPG
10 20 30 40 50
70 80 90 100 110
pF1KE6 YFGLFSYCVGNVLSS-ELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFF
::::: ::::. :.. :: :.:. :::.::: :::.: ::: :.: ::.: : ::::::
XP_016 YFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 ICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAF
.::::::::::::::: :: :..::...:::::. .: ::: .::::.:: :..:::.
XP_016 FCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAY
120 130 140 150 160 170
180 190 200 210
pF1KE6 MLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV
.:::..: .:::::::::::: :: :: .. : .. . :
XP_016 ILAIIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVL
180 190 200 210 220 230
XP_016 PCPVAHSQGP
240
>>XP_016861849 (OMIM: 610240) PREDICTED: lipoma HMGIC fu (138 aa)
initn: 648 init1: 354 opt: 653 Z-score: 823.2 bits: 158.8 E(85289): 4.1e-39
Smith-Waterman score: 653; 65.9% identity (87.4% similar) in 135 aa overlap (4-137:1-135)
10 20 30 40 50 60
pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG
.::.:::.:.:: .:.:::::.::.:. .::::... ...::::::.::::.::. :
XP_016 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPG
10 20 30 40 50
70 80 90 100 110
pF1KE6 YFGLFSYCVGNVLSS-ELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFF
::::: ::::. :.. :: :.:. :::.::: :::.: ::: :.: ::.: : ::::::
XP_016 YFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 ICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAF
.::::::::::::::: :
XP_016 FCNTATVYKICAWMQLLAGGM
120 130
>>NP_005771 (OMIM: 606710) lipoma HMGIC fusion partner p (200 aa)
initn: 275 init1: 182 opt: 278 Z-score: 355.1 bits: 72.7 E(85289): 4.9e-13
Smith-Waterman score: 282; 30.3% identity (60.5% similar) in 195 aa overlap (26-203:9-195)
10 20 30 40 50
pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLT-ICFSVLVMALFIQPYWI-GDSVNTPQ
::.:. :. .: .. ...:. :::. :.... :
NP_005 MASSLTCTGVIWALLSFLCAATSCVGFFM-PYWLWGSQLGKPV
10 20 30 40
60 70 80 90 100 110
pF1KE6 AGYFGLFSYCVGNVL--SSELI-----CKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGS
. :: : : : : ... : : .:..::: .. . ..:: :..
NP_005 S--FGTFRRCSYPVHDESRQMMVMVEEC-GRYASFQGIPSAEWRICTIVTGLGCGLLL--
50 60 70 80 90
120 130 140 150 160
pF1KE6 IICFSLFFICNTA-----TVYKICAWMQLAAATGLMIG--CLVYPDGWDSSEVRRMCGEQ
.. .. .. : .. :: .. . .:. . ::.:: : .:: :::: :::. ::
NP_005 LVALTALMGCCVSDLISRTVGRVAGGIQFLG--GLLIGAGCALYPLGWDSEEVRQTCGYT
100 110 120 130 140 150
170 180 190 200 210
pF1KE6 TGKYTLGHCTIRWAFMLAILSIGDALIL-SFLAFVLGYRQDKLLPDDYKADGTEEV
.:.. ::.: : ::.. . . :..: ..:: : .:
NP_005 SGQFDLGKCEIGWAYYCTGAGATAAMLLCTWLACFSGKKQKHYPY
160 170 180 190 200
>>XP_011533163 (OMIM: 606710) PREDICTED: lipoma HMGIC fu (200 aa)
initn: 275 init1: 182 opt: 278 Z-score: 355.1 bits: 72.7 E(85289): 4.9e-13
Smith-Waterman score: 282; 30.3% identity (60.5% similar) in 195 aa overlap (26-203:9-195)
10 20 30 40 50
pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLT-ICFSVLVMALFIQPYWI-GDSVNTPQ
::.:. :. .: .. ...:. :::. :.... :
XP_011 MASSLTCTGVIWALLSFLCAATSCVGFFM-PYWLWGSQLGKPV
10 20 30 40
60 70 80 90 100 110
pF1KE6 AGYFGLFSYCVGNVL--SSELI-----CKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGS
. :: : : : : ... : : .:..::: .. . ..:: :..
XP_011 S--FGTFRRCSYPVHDESRQMMVMVEEC-GRYASFQGIPSAEWRICTIVTGLGCGLLL--
50 60 70 80 90
120 130 140 150 160
pF1KE6 IICFSLFFICNTA-----TVYKICAWMQLAAATGLMIG--CLVYPDGWDSSEVRRMCGEQ
.. .. .. : .. :: .. . .:. . ::.:: : .:: :::: :::. ::
XP_011 LVALTALMGCCVSDLISRTVGRVAGGIQFLG--GLLIGAGCALYPLGWDSEEVRQTCGYT
100 110 120 130 140 150
170 180 190 200 210
pF1KE6 TGKYTLGHCTIRWAFMLAILSIGDALIL-SFLAFVLGYRQDKLLPDDYKADGTEEV
.:.. ::.: : ::.. . . :..: ..:: : .:
XP_011 SGQFDLGKCEIGWAYYCTGAGATAAMLLCTWLACFSGKKQKHYPY
160 170 180 190 200
>>XP_006714578 (OMIM: 609718) PREDICTED: lipoma HMGIC fu (228 aa)
initn: 147 init1: 130 opt: 242 Z-score: 309.6 bits: 64.5 E(85289): 1.7e-10
Smith-Waterman score: 242; 24.5% identity (56.5% similar) in 184 aa overlap (45-218:44-220)
20 30 40 50 60 70
pF1KE6 HTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAGYFGLFSYCVGNV--
..: : . : .:... :. :
XP_006 TLLSIVVAFAELIAFMSADWLIGKARSRGGVEPAGPGGGSPEPYHPTLGIYARCIRNPGV
20 30 40 50 60 70
80 90 100 110 120
pF1KE6 --LSSELICKGGPL--DFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFFICNTA----
.. . .: :: .:. : : .... .:.:.:.: :. . :.: .: .
XP_006 QHFQRDTLC--GPYAESFGEIASGFWQATAIFLAVGIF-ILCMVALVSVFTMCVQSIMKK
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE6 TVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFMLAIL
.....:. .: :. :..: ..:: :: ... .::. .. : : :.. :::. ::
XP_006 SIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAI-
140 150 160 170 180
190 200 210
pF1KE6 SIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV
. .:.:. :.. . . .: . ::
XP_006 ---GGTVLTFICAVFSAQAEIATSSDKVQEEIEEGKNLICLL
190 200 210 220
>>NP_005770 (OMIM: 609718) lipoma HMGIC fusion partner-l (228 aa)
initn: 147 init1: 130 opt: 242 Z-score: 309.6 bits: 64.5 E(85289): 1.7e-10
Smith-Waterman score: 242; 24.5% identity (56.5% similar) in 184 aa overlap (45-218:44-220)
20 30 40 50 60 70
pF1KE6 HTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAGYFGLFSYCVGNV--
..: : . : .:... :. :
NP_005 TLLSIVVAFAELIAFMSADWLIGKARSRGGVEPAGPGGGSPEPYHPTLGIYARCIRNPGV
20 30 40 50 60 70
80 90 100 110 120
pF1KE6 --LSSELICKGGPL--DFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFFICNTA----
.. . .: :: .:. : : .... .:.:.:.: :. . :.: .: .
NP_005 QHFQRDTLC--GPYAESFGEIASGFWQATAIFLAVGIF-ILCMVALVSVFTMCVQSIMKK
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE6 TVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFMLAIL
.....:. .: :. :..: ..:: :: ... .::. .. : : :.. :::. ::
NP_005 SIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAI-
140 150 160 170 180
190 200 210
pF1KE6 SIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV
. .:.:. :.. . . .: . ::
NP_005 ---GGTVLTFICAVFSAQAEIATSSDKVQEEIEEGKNLICLL
190 200 210 220
219 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:15:57 2016 done: Tue Nov 8 11:15:58 2016
Total Scan time: 4.000 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]