Result of FASTA (omim) for
pFN21AE6208
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6208, 193 aa
1>>>pF1KE6208 193 - 193 aa - 193 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9155+/-0.000385; mu= 15.0478+/- 0.024
mean_var=60.0014+/-12.086, 0's: 0 Z-trim(111.4): 42 B-trim: 251 in 1/49
Lambda= 0.165575
statistics sampled from 19908 (19950) to 19908 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.613), E-opt: 0.2 (0.234), width: 16
Scan time: 4.460
The best scores are: opt bits E(85289)
NP_005820 (OMIM: 602416) AP-3 complex subunit sigm ( 193) 1263 310.0 1.5e-84
NP_001275 (OMIM: 601507) AP-3 complex subunit sigm ( 193) 1089 268.5 4.8e-72
NP_001002924 (OMIM: 601507) AP-3 complex subunit s ( 171) 964 238.6 4.3e-63
NP_001305022 (OMIM: 601507) AP-3 complex subunit s ( 162) 873 216.8 1.4e-56
XP_016864513 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 873 217.0 2.1e-56
XP_011541438 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 873 217.0 2.1e-56
NP_001305023 (OMIM: 601507) AP-3 complex subunit s ( 157) 685 171.9 4.6e-43
NP_001305019 (OMIM: 601507) AP-3 complex subunit s ( 125) 567 143.7 1.2e-34
NP_001305020 (OMIM: 601507) AP-3 complex subunit s ( 169) 527 134.2 1.1e-31
XP_016864514 (OMIM: 601507) PREDICTED: AP-3 comple ( 238) 527 134.3 1.5e-31
XP_016885415 (OMIM: 300629) PREDICTED: AP-1 comple ( 189) 354 92.9 3.4e-19
NP_001274 (OMIM: 603531,609313) AP-1 complex subun ( 158) 353 92.6 3.4e-19
XP_016885414 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 354 92.9 3.6e-19
XP_011543901 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 354 92.9 3.6e-19
NP_004060 (OMIM: 600740,602242) AP-2 complex subun ( 142) 352 92.3 3.7e-19
NP_001288007 (OMIM: 600740,602242) AP-2 complex su ( 156) 350 91.9 5.6e-19
NP_001259000 (OMIM: 300629) AP-1 complex subunit s ( 160) 350 91.9 5.7e-19
NP_001034658 (OMIM: 615781,616106) AP-1 complex su ( 154) 349 91.6 6.5e-19
NP_003907 (OMIM: 300629) AP-1 complex subunit sigm ( 157) 349 91.7 6.6e-19
XP_005274671 (OMIM: 300629) PREDICTED: AP-1 comple ( 195) 349 91.7 7.9e-19
NP_001288010 (OMIM: 600740,602242) AP-2 complex su ( 144) 345 90.7 1.2e-18
NP_001288005 (OMIM: 600740,602242) AP-2 complex su ( 158) 345 90.7 1.3e-18
XP_011524726 (OMIM: 600740,602242) PREDICTED: AP-2 ( 158) 343 90.2 1.8e-18
XP_011524725 (OMIM: 600740,602242) PREDICTED: AP-2 ( 172) 343 90.2 1.9e-18
NP_001241657 (OMIM: 607243,614067) AP-4 complex su ( 144) 340 89.5 2.7e-18
NP_001121598 (OMIM: 607243,614067) AP-4 complex su ( 144) 340 89.5 2.7e-18
NP_001241658 (OMIM: 607243,614067) AP-4 complex su ( 144) 340 89.5 2.7e-18
NP_001241656 (OMIM: 607243,614067) AP-4 complex su ( 149) 236 64.6 8.5e-11
NP_009008 (OMIM: 607243,614067) AP-4 complex subun ( 159) 236 64.7 9e-11
XP_011534673 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 236 64.7 9e-11
XP_005267350 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 236 64.7 9e-11
XP_011534674 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 236 64.7 9e-11
XP_011508902 (OMIM: 615781,616106) PREDICTED: AP-1 ( 108) 222 61.2 6.6e-10
NP_001241655 (OMIM: 607243,614067) AP-4 complex su ( 135) 214 59.4 3e-09
NP_057513 (OMIM: 615526) coatomer subunit zeta-2 [ ( 210) 188 53.3 3.2e-07
NP_001258664 (OMIM: 615472) coatomer subunit zeta- ( 160) 166 47.9 9.7e-06
NP_057141 (OMIM: 615472) coatomer subunit zeta-1 i ( 177) 166 48.0 1.1e-05
XP_016874486 (OMIM: 615472) PREDICTED: coatomer su ( 180) 166 48.0 1.1e-05
NP_001258665 (OMIM: 615472) coatomer subunit zeta- ( 185) 166 48.0 1.1e-05
NP_067586 (OMIM: 600740,602242) AP-2 complex subun ( 104) 153 44.7 5.9e-05
NP_001258663 (OMIM: 615472) coatomer subunit zeta- ( 154) 133 40.0 0.0022
>>NP_005820 (OMIM: 602416) AP-3 complex subunit sigma-2 (193 aa)
initn: 1263 init1: 1263 opt: 1263 Z-score: 1639.0 bits: 310.0 E(85289): 1.5e-84
Smith-Waterman score: 1263; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193)
10 20 30 40 50 60
pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG
130 140 150 160 170 180
190
pF1KE6 DLNIKVPNLSQFV
:::::::::::::
NP_005 DLNIKVPNLSQFV
190
>>NP_001275 (OMIM: 601507) AP-3 complex subunit sigma-1 (193 aa)
initn: 1107 init1: 1089 opt: 1089 Z-score: 1414.4 bits: 268.5 E(85289): 4.8e-72
Smith-Waterman score: 1089; 84.4% identity (94.8% similar) in 192 aa overlap (1-192:1-192)
10 20 30 40 50 60
pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD
::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: ::::::
NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL
:::::::::::::::::::::::::::::::::::::::::::::::::::.:::: ::
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG
:.:::::::::::::::.::.:::.:::::.::..:::::::::::.::::::::::::
NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
130 140 150 160 170 180
190
pF1KE6 DLNIKVPNLSQFV
:..:::::: .:
NP_001 DISIKVPNLPSFK
190
>>NP_001002924 (OMIM: 601507) AP-3 complex subunit sigma (171 aa)
initn: 975 init1: 957 opt: 964 Z-score: 1253.8 bits: 238.6 E(85289): 4.3e-63
Smith-Waterman score: 964; 86.3% identity (95.8% similar) in 168 aa overlap (25-192:3-170)
10 20 30 40 50 60
pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD
:. ::::.::::::: :::.:.::::::: ::::::
NP_001 MSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30
70 80 90 100 110 120
pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL
:::::::::::::::::::::::::::::::::::::::::::::::::::.:::: ::
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG
:.:::::::::::::::.::.:::.:::::.::..:::::::::::.::::::::::::
NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
100 110 120 130 140 150
190
pF1KE6 DLNIKVPNLSQFV
:..:::::: .:
NP_001 DISIKVPNLPSFK
160 170
>>NP_001305022 (OMIM: 601507) AP-3 complex subunit sigma (162 aa)
initn: 870 init1: 870 opt: 873 Z-score: 1136.6 bits: 216.8 E(85289): 1.4e-56
Smith-Waterman score: 873; 82.3% identity (91.8% similar) in 158 aa overlap (1-158:1-158)
10 20 30 40 50 60
pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD
::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: ::::::
NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL
:::::::::::::::::::::::::::::::::::::::::::::::::::.:::: ::
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG
:.:::::::::::::::.::.:::.::::: . .:
NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSETFIFQSPRQDR
130 140 150 160
190
pF1KE6 DLNIKVPNLSQFV
>>XP_016864513 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa)
initn: 870 init1: 870 opt: 873 Z-score: 1133.6 bits: 217.0 E(85289): 2.1e-56
Smith-Waterman score: 873; 82.3% identity (91.8% similar) in 158 aa overlap (1-158:101-258)
10 20 30
pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQ
::.:::.::::::::: .::: . :. :::
XP_016 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ
80 90 100 110 120 130
40 50 60 70 80 90
pF1KE6 IVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLI
:.::::::: :::.:.::::::: :::::: :::::::::::::::::::::::::::::
XP_016 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI
140 150 160 170 180 190
100 110 120 130 140 150
pF1KE6 QVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKS
::::::::::::::::::::::.:::: :: :.:::::::::::::::.::.:::.::::
XP_016 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS
200 210 220 230 240 250
160 170 180 190
pF1KE6 EGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV
: . .:
XP_016 ETFIFQSPRQDR
260
>>XP_011541438 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa)
initn: 870 init1: 870 opt: 873 Z-score: 1133.6 bits: 217.0 E(85289): 2.1e-56
Smith-Waterman score: 873; 82.3% identity (91.8% similar) in 158 aa overlap (1-158:101-258)
10 20 30
pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQ
::.:::.::::::::: .::: . :. :::
XP_011 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ
80 90 100 110 120 130
40 50 60 70 80 90
pF1KE6 IVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLI
:.::::::: :::.:.::::::: :::::: :::::::::::::::::::::::::::::
XP_011 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI
140 150 160 170 180 190
100 110 120 130 140 150
pF1KE6 QVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKS
::::::::::::::::::::::.:::: :: :.:::::::::::::::.::.:::.::::
XP_011 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS
200 210 220 230 240 250
160 170 180 190
pF1KE6 EGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV
: . .:
XP_011 ETFIFQSPRQDR
260
>>NP_001305023 (OMIM: 601507) AP-3 complex subunit sigma (157 aa)
initn: 891 init1: 685 opt: 685 Z-score: 894.1 bits: 171.9 E(85289): 4.6e-43
Smith-Waterman score: 821; 68.8% identity (77.1% similar) in 192 aa overlap (1-192:1-156)
10 20 30 40 50 60
pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD
::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: ::::::
NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL
:::::::::::::::::::::::::::::::::::::::::::::::::::.::.
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKA----
70 80 90 100 110
130 140 150 160 170 180
pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG
::..:::::::::::.::::::::::::
NP_001 --------------------------------GLAGAPARAVSAVKNMNLPEIPRNINIG
120 130 140
190
pF1KE6 DLNIKVPNLSQFV
:..:::::: .:
NP_001 DISIKVPNLPSFK
150
>>NP_001305019 (OMIM: 601507) AP-3 complex subunit sigma (125 aa)
initn: 691 init1: 567 opt: 567 Z-score: 743.2 bits: 143.7 E(85289): 1.2e-34
Smith-Waterman score: 567; 85.1% identity (97.0% similar) in 101 aa overlap (92-192:24-124)
70 80 90 100 110 120
pF1KE6 KLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQ
:::::::::::::::::::::.:::: ::
NP_001 MIKAILIFNNHGKPRLSKFYQPYVFVETLDKCFENVCELDLIFHVDKVHNILA
10 20 30 40 50
130 140 150 160 170 180
pF1KE6 EVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIGD
:.:::::::::::::::.::.:::.:::::.::..:::::::::::.:::::::::::::
NP_001 EMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGD
60 70 80 90 100 110
190
pF1KE6 LNIKVPNLSQFV
..:::::: .:
NP_001 ISIKVPNLPSFK
120
>>NP_001305020 (OMIM: 601507) AP-3 complex subunit sigma (169 aa)
initn: 918 init1: 527 opt: 527 Z-score: 689.7 bits: 134.2 E(85289): 1.1e-31
Smith-Waterman score: 869; 72.4% identity (82.3% similar) in 192 aa overlap (1-192:1-168)
10 20 30 40 50 60
pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD
::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: ::::::
NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL
::::::::::::::::::::::::::::::: : ::
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQV------------------------HNIL
70 80 90
130 140 150 160 170 180
pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG
:.:::::::::::::::.::.:::.:::::.::..:::::::::::.::::::::::::
NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
100 110 120 130 140 150
190
pF1KE6 DLNIKVPNLSQFV
:..:::::: .:
NP_001 DISIKVPNLPSFK
160
>>XP_016864514 (OMIM: 601507) PREDICTED: AP-3 complex su (238 aa)
initn: 527 init1: 527 opt: 527 Z-score: 687.5 bits: 134.3 E(85289): 1.5e-31
Smith-Waterman score: 653; 67.7% identity (76.6% similar) in 158 aa overlap (1-158:101-234)
10 20 30
pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQ
::.:::.::::::::: .::: . :. :::
XP_016 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ
80 90 100 110 120 130
40 50 60 70 80 90
pF1KE6 IVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLI
:.::::::: :::.:.::::::: :::::: :::::::::::::::::::::::::::::
XP_016 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI
140 150 160 170 180 190
100 110 120 130 140 150
pF1KE6 QVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKS
:: : :: :.:::::::::::::::.::.:::.::::
XP_016 QV------------------------HNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS
200 210 220
160 170 180 190
pF1KE6 EGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV
: . .:
XP_016 ETFIFQSPRQDR
230
193 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:05:46 2016 done: Tue Nov 8 11:05:47 2016
Total Scan time: 4.460 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]