Result of FASTA (omim) for
pFN21AE5842
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5842, 1872 aa
1>>>pF1KE5842 1872 - 1872 aa - 1872 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9777+/-0.000358; mu= 13.5885+/- 0.023
mean_var=174.3545+/-35.579, 0's: 0 Z-trim(120.0): 267 B-trim: 703 in 1/56
Lambda= 0.097131
statistics sampled from 34291 (34622) to 34291 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.406), width: 16
Scan time: 19.520
The best scores are: opt bits E(85289)
NP_620278 (OMIM: 300966,313650,314250) transcripti (1872) 12580 1776.4 0
XP_005262354 (OMIM: 300966,313650,314250) PREDICTE (1906) 11395 1610.3 0
NP_004597 (OMIM: 300966,313650,314250) transcripti (1893) 11376 1607.7 0
NP_001273003 (OMIM: 300966,313650,314250) transcri (1895) 11362 1605.7 0
XP_006724745 (OMIM: 300966,313650,314250) PREDICTE (1800) 10191 1441.6 0
XP_005262352 (OMIM: 300966,313650,314250) PREDICTE (1927) 10191 1441.6 0
XP_005262353 (OMIM: 300966,313650,314250) PREDICTE (1926) 10174 1439.2 0
NP_722516 (OMIM: 607798) transcription initiation (1826) 9783 1384.4 0
XP_005262357 (OMIM: 300966,313650,314250) PREDICTE ( 999) 5499 783.9 0
NP_001276975 (OMIM: 607576) cat eye syndrome criti (1300) 274 51.8 5.2e-05
XP_011544434 (OMIM: 607576) PREDICTED: cat eye syn (1409) 274 51.9 5.5e-05
XP_011544431 (OMIM: 607576) PREDICTED: cat eye syn (1436) 274 51.9 5.6e-05
XP_016884274 (OMIM: 607576) PREDICTED: cat eye syn (1463) 274 51.9 5.7e-05
NP_001276976 (OMIM: 607576) cat eye syndrome criti (1464) 274 51.9 5.7e-05
XP_011544430 (OMIM: 607576) PREDICTED: cat eye syn (1436) 258 49.6 0.00027
XP_016879937 (OMIM: 602301) PREDICTED: histone ace ( 476) 241 46.9 0.00059
XP_006721881 (OMIM: 602301) PREDICTED: histone ace ( 477) 241 46.9 0.00059
NP_066564 (OMIM: 602301) histone acetyltransferase ( 837) 241 47.1 0.00091
XP_006721880 (OMIM: 602301) PREDICTED: histone ace ( 838) 241 47.1 0.00091
NP_001278915 (OMIM: 601540) bromodomain-containing ( 681) 225 44.7 0.0037
NP_001186385 (OMIM: 601540) bromodomain-containing ( 754) 225 44.8 0.004
NP_005095 (OMIM: 601540) bromodomain-containing pr ( 801) 225 44.8 0.0042
NP_001106653 (OMIM: 601540) bromodomain-containing ( 801) 225 44.8 0.0042
NP_001186384 (OMIM: 601540) bromodomain-containing ( 836) 225 44.8 0.0043
XP_016870654 (OMIM: 601541) PREDICTED: bromodomain ( 725) 218 43.8 0.0076
XP_011517354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 218 43.8 0.0076
XP_006717354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 218 43.8 0.0076
NP_031397 (OMIM: 601541) bromodomain-containing pr ( 726) 218 43.8 0.0076
XP_016883269 (OMIM: 615713) PREDICTED: protein kin ( 909) 219 44.0 0.0082
XP_016883268 (OMIM: 615713) PREDICTED: protein kin ( 917) 219 44.0 0.0083
XP_016883267 (OMIM: 615713) PREDICTED: protein kin ( 992) 219 44.0 0.0088
NP_001268700 (OMIM: 615713) protein kinase C-bindi (1054) 219 44.0 0.0092
XP_016862913 (OMIM: 602303) PREDICTED: histone ace ( 735) 216 43.5 0.0094
XP_016862912 (OMIM: 602303) PREDICTED: histone ace ( 735) 216 43.5 0.0094
NP_001268710 (OMIM: 615713) protein kinase C-bindi (1088) 219 44.1 0.0095
NP_001268705 (OMIM: 615713) protein kinase C-bindi (1107) 219 44.1 0.0096
XP_016883266 (OMIM: 615713) PREDICTED: protein kin (1118) 219 44.1 0.0097
XP_016883265 (OMIM: 615713) PREDICTED: protein kin (1126) 219 44.1 0.0097
NP_001268713 (OMIM: 615713) protein kinase C-bindi (1134) 219 44.1 0.0098
NP_898869 (OMIM: 615713) protein kinase C-binding (1135) 219 44.1 0.0098
NP_001268711 (OMIM: 615713) protein kinase C-bindi (1136) 219 44.1 0.0098
XP_016883264 (OMIM: 615713) PREDICTED: protein kin (1143) 219 44.1 0.0098
XP_016883263 (OMIM: 615713) PREDICTED: protein kin (1146) 219 44.1 0.0099
XP_016883262 (OMIM: 615713) PREDICTED: protein kin (1147) 219 44.1 0.0099
NP_036540 (OMIM: 615713) protein kinase C-binding (1160) 219 44.1 0.01
XP_016883261 (OMIM: 615713) PREDICTED: protein kin (1161) 219 44.1 0.01
XP_016883259 (OMIM: 615713) PREDICTED: protein kin (1161) 219 44.1 0.01
XP_016883260 (OMIM: 615713) PREDICTED: protein kin (1161) 219 44.1 0.01
NP_001268706 (OMIM: 615713) protein kinase C-bindi (1163) 219 44.1 0.01
>>NP_620278 (OMIM: 300966,313650,314250) transcription i (1872 aa)
initn: 12580 init1: 12580 opt: 12580 Z-score: 9528.4 bits: 1776.4 E(85289): 0
Smith-Waterman score: 12580; 100.0% identity (100.0% similar) in 1872 aa overlap (1-1872:1-1872)
10 20 30 40 50 60
pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE5 EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE5 ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE5 VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE5 SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE5 AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE5 EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE5 SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE5 EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE5 SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE5 KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE5 KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE5 TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE5 PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE5 SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE5 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE5 KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE5 AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE5 PEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 PEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSA
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE5 IQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 IQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISY
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE5 GSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 GSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFH
1810 1820 1830 1840 1850 1860
1870
pF1KE5 SIAGDSDLDSDE
::::::::::::
NP_620 SIAGDSDLDSDE
1870
>>XP_005262354 (OMIM: 300966,313650,314250) PREDICTED: t (1906 aa)
initn: 12566 init1: 11359 opt: 11395 Z-score: 8630.8 bits: 1610.3 E(85289): 0
Smith-Waterman score: 12488; 98.2% identity (98.2% similar) in 1904 aa overlap (1-1870:1-1904)
10 20 30 40 50 60
pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE5 EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE5 ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE5 VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE5 SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE5 AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE5 EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE5 SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE5 EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE5 SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE5 KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE5 KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE5 TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE5 PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE5 SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE5 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE5 KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE5 AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT
1630 1640 1650 1660 1670 1680
1690 1700
pF1KE5 PEKQVTQ----------------------------------EGEDGDGDLADEEEGTVQQ
::::::: :::::::::::::::::::
XP_005 PEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAPEGEDGDGDLADEEEGTVQQ
1690 1700 1710 1720 1730 1740
1710 1720 1730 1740 1750 1760
pF1KE5 PQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQ
1750 1760 1770 1780 1790 1800
1770 1780 1790 1800 1810 1820
pF1KE5 ENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVS
1810 1820 1830 1840 1850 1860
1830 1840 1850 1860 1870
pF1KE5 EEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
1870 1880 1890 1900
>>NP_004597 (OMIM: 300966,313650,314250) transcription i (1893 aa)
initn: 11376 init1: 11376 opt: 11376 Z-score: 8616.5 bits: 1607.7 E(85289): 0
Smith-Waterman score: 12528; 98.9% identity (98.9% similar) in 1893 aa overlap (1-1872:1-1893)
10 20 30 40 50 60
pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
130 140 150 160 170
pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG---
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210
pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
::::::::::::::::::::::::::::::::::::::::::
NP_004 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KE5 RDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMS
1690 1700 1710 1720 1730 1740
1720 1730 1740 1750 1760 1770
pF1KE5 EGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESM
1750 1760 1770 1780 1790 1800
1780 1790 1800 1810 1820 1830
pF1KE5 MSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRS
1810 1820 1830 1840 1850 1860
1840 1850 1860 1870
pF1KE5 GPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
:::::::::::::::::::::::::::::::::
NP_004 GPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
1870 1880 1890
>>NP_001273003 (OMIM: 300966,313650,314250) transcriptio (1895 aa)
initn: 9889 init1: 9889 opt: 11362 Z-score: 8605.9 bits: 1605.7 E(85289): 0
Smith-Waterman score: 12514; 98.8% identity (98.8% similar) in 1895 aa overlap (1-1872:1-1895)
10 20 30 40 50 60
pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
130 140 150 160 170
pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG---
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210
pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
::::::::::::::::::::::::::::::::::::::::::
NP_001 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQ--PPDLYDTNTSLS
:::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_001 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQAKPPDLYDTNTSLS
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KE5 MSRDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSRDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLL
1690 1700 1710 1720 1730 1740
1720 1730 1740 1750 1760 1770
pF1KE5 MSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEE
1750 1760 1770 1780 1790 1800
1780 1790 1800 1810 1820 1830
pF1KE5 SMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQ
1810 1820 1830 1840 1850 1860
1840 1850 1860 1870
pF1KE5 RSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
:::::::::::::::::::::::::::::::::::
NP_001 RSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
1870 1880 1890
>>XP_006724745 (OMIM: 300966,313650,314250) PREDICTED: t (1800 aa)
initn: 11362 init1: 10155 opt: 10191 Z-score: 7719.4 bits: 1441.6 E(85289): 0
Smith-Waterman score: 11613; 96.9% identity (96.9% similar) in 1798 aa overlap (128-1870:1-1798)
100 110 120 130 140 150
pF1KE5 EGWVRSTEDAVDYSDINEVAEDESRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMP
::::::::::::::::::::::::::::::
XP_006 MGSLQPLCHSDYDEDDYDADCEDIDCKLMP
10 20 30
160 170 180 190
pF1KE5 PPPPPPGPMKKDKDQDSITG---------------------EKVDFSSSSDSESEMGPQE
:::::::::::::::::::: :::::::::::::::::::
XP_006 PPPPPPGPMKKDKDQDSITGVSENGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQE
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE5 ATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWR
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE5 SARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAP
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE5 VESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPV
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE5 IKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGW
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE5 LPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLE
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE5 PPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNM
400 410 420 430 440 450
560 570 580 590 600 610
pF1KE5 SQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFH
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE5 RPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDG
520 530 540 550 560 570
680 690 700 710 720 730
pF1KE5 DLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHP
580 590 600 610 620 630
740 750 760 770 780 790
pF1KE5 GQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNS
640 650 660 670 680 690
800 810 820 830 840 850
pF1KE5 KRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTG
700 710 720 730 740 750
860 870 880 890 900 910
pF1KE5 MDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENE
760 770 780 790 800 810
920 930 940 950 960 970
pF1KE5 EDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQK
820 830 840 850 860 870
980 990 1000 1010 1020 1030
pF1KE5 DDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ
880 890 900 910 920 930
1040 1050 1060 1070 1080 1090
pF1KE5 ARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSD
940 950 960 970 980 990
1100 1110 1120 1130 1140 1150
pF1KE5 FEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSL
1000 1010 1020 1030 1040 1050
1160 1170 1180 1190 1200 1210
pF1KE5 NSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQH
1060 1070 1080 1090 1100 1110
1220 1230 1240 1250 1260 1270
pF1KE5 REEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 REEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTN
1120 1130 1140 1150 1160 1170
1280 1290 1300 1310 1320 1330
pF1KE5 KFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEV
1180 1190 1200 1210 1220 1230
1340 1350 1360 1370 1380 1390
pF1KE5 RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDM
1240 1250 1260 1270 1280 1290
1400 1410 1420 1430 1440 1450
pF1KE5 RDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNS
1300 1310 1320 1330 1340 1350
1460 1470 1480 1490 1500 1510
pF1KE5 ATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVT
1360 1370 1380 1390 1400 1410
1520 1530 1540 1550 1560 1570
pF1KE5 QKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLIL
1420 1430 1440 1450 1460 1470
1580 1590 1600 1610 1620 1630
pF1KE5 ANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDP
1480 1490 1500 1510 1520 1530
1640 1650 1660 1670 1680
pF1KE5 MTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQ---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLG
1540 1550 1560 1570 1580 1590
1690 1700 1710 1720
pF1KE5 -------------------------EGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGE
:::::::::::::::::::::::::::::::::::
XP_006 EEDSDVDIEGYDDEEEDGKPKTPAPEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGE
1600 1610 1620 1630 1640 1650
1730 1740 1750 1760 1770 1780
pF1KE5 DDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSY
1660 1670 1680 1690 1700 1710
1790 1800 1810 1820 1830 1840
pF1KE5 EGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPS
1720 1730 1740 1750 1760 1770
1850 1860 1870
pF1KE5 VLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
::::::::::::::::::::::::::::
XP_006 VLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
1780 1790 1800
>>XP_005262352 (OMIM: 300966,313650,314250) PREDICTED: t (1927 aa)
initn: 11362 init1: 10155 opt: 10191 Z-score: 7719.0 bits: 1441.6 E(85289): 0
Smith-Waterman score: 12436; 97.1% identity (97.1% similar) in 1925 aa overlap (1-1870:1-1925)
10 20 30 40 50 60
pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
130 140 150 160 170
pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG---
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210
pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
::::::::::::::::::::::::::::::::::::::::::
XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
1630 1640 1650 1660 1670 1680
1660 1670 1680
pF1KE5 RDASVFQDESNMSVLDIPSATPEKQVTQ--------------------------------
::::::::::::::::::::::::::::
XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP
1690 1700 1710 1720 1730 1740
1690 1700 1710 1720 1730 1740
pF1KE5 --EGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE
1750 1760 1770 1780 1790 1800
1750 1760 1770 1780 1790 1800
pF1KE5 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE
1810 1820 1830 1840 1850 1860
1810 1820 1830 1840 1850 1860
pF1KE5 PDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGD
1870 1880 1890 1900 1910 1920
1870
pF1KE5 SDLDSDE
:::::
XP_005 SDLDSDE
>>XP_005262353 (OMIM: 300966,313650,314250) PREDICTED: t (1926 aa)
initn: 8057 init1: 6536 opt: 10174 Z-score: 7706.1 bits: 1439.2 E(85289): 0
Smith-Waterman score: 12433; 97.1% identity (97.1% similar) in 1927 aa overlap (1-1872:1-1926)
10 20 30 40 50 60
pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
130 140 150 160 170
pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG---
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210
pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
::::::::::::::::::::::::::::::::::::::::::
XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
:::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_005 EREEQERKELQRMLLA-GSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1150 1160 1170 1180 1190
1180 1190 1200 1210 1220 1230
pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1200 1210 1220 1230 1240 1250
1240 1250 1260 1270 1280 1290
pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1260 1270 1280 1290 1300 1310
1300 1310 1320 1330 1340 1350
pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1320 1330 1340 1350 1360 1370
1360 1370 1380 1390 1400 1410
pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1380 1390 1400 1410 1420 1430
1420 1430 1440 1450 1460 1470
pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1440 1450 1460 1470 1480 1490
1480 1490 1500 1510 1520 1530
pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1500 1510 1520 1530 1540 1550
1540 1550 1560 1570 1580 1590
pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1560 1570 1580 1590 1600 1610
1600 1610 1620 1630 1640 1650
pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
1620 1630 1640 1650 1660 1670
1660 1670 1680
pF1KE5 RDASVFQDESNMSVLDIPSATPEKQVTQ--------------------------------
::::::::::::::::::::::::::::
XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP
1680 1690 1700 1710 1720 1730
1690 1700 1710 1720 1730 1740
pF1KE5 --EGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE
1740 1750 1760 1770 1780 1790
1750 1760 1770 1780 1790 1800
pF1KE5 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE
1800 1810 1820 1830 1840 1850
1810 1820 1830 1840 1850 1860
pF1KE5 PDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGD
1860 1870 1880 1890 1900 1910
1870
pF1KE5 SDLDSDE
:::::::
XP_005 SDLDSDE
1920
>>NP_722516 (OMIM: 607798) transcription initiation fact (1826 aa)
initn: 11044 init1: 9207 opt: 9783 Z-score: 7410.3 bits: 1384.4 E(85289): 0
Smith-Waterman score: 11200; 92.2% identity (95.7% similar) in 1819 aa overlap (1-1769:1-1817)
10 20 30 40 50 60
pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
: ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.:::::::::::::
NP_722 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
:::::::::::::::::::::::::::::: :::::::::.:::::::::::::::::::
NP_722 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE
60 70 80 90 100 110
130 140 150 160 170
pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSIT----
:.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.::
NP_722 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE
120 130 140 150 160 170
180 190 200 210
pF1KE5 -----------------GEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
.::::::: ::::::::::::::::::::::::::::::::::
NP_722 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
:::::::::::::::::::::::.::::::::::::::::::::: ::::::::::::::
NP_722 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
:::::::::::::::::::::::::::.:::::::.::::::::::::.:::::::::::
NP_722 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
:::::::::::::::: :::::::::::::::.:::::::::.::::::::.::::::::
NP_722 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
:::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: :::
NP_722 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_722 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
:::::::::::::::::::::::::::::.::::::::::::::::::::::::.:::::
NP_722 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG
540 550 560 570 580 590
580 590 600 610 620 630
pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::.:: ::::::::::::.:::::::::::::::::::::::::::
NP_722 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_722 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
660 670 680 690 700 710
700 710 720 730 740 750
pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
:::::::::::::::::::::::::::::::::::::::::::.::::::::.:::::::
NP_722 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE
720 730 740 750 760 770
760 770 780 790 800 810
pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
:::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::::
NP_722 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK
780 790 800 810 820 830
820 830 840 850 860 870
pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK
840 850 860 870 880 890
880 890 900 910 920 930
pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
:::::::::::::::.::::::::::::::::::::::::::::::::..::::::::::
NP_722 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI
900 910 920 930 940 950
940 950 960 970 980 990
pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
NP_722 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS
960 970 980 990 1000 1010
1000 1010 1020 1030 1040 1050
pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_722 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ
1020 1030 1040 1050 1060 1070
1060 1070 1080 1090 1100 1110
pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_722 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR
1080 1090 1100 1110 1120 1130
1120 1130 1140 1150 1160 1170
pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
: ::::::::.::::.::::::::::::: :::.:::.:::::.::::::::::::::::
NP_722 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY
1140 1150 1160 1170 1180 1190
1180 1190 1200 1210 1220 1230
pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::.::.:::::::.::::::::::::::::::::::::
NP_722 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE
1200 1210 1220 1230 1240 1250
1240 1250 1260 1270 1280 1290
pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
:::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::
NP_722 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ
1260 1270 1280 1290 1300 1310
1300 1310 1320 1330 1340 1350
pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
:::::::::::::::::::::::::.::::::.. :::::::::::::::::::::::::
NP_722 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG
1320 1330 1340 1350 1360 1370
1360 1370 1380 1390 1400 1410
pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
::::::::: :::::::::::::::::::::::::::::::::.::::::::::::::::
NP_722 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK
1380 1390 1400 1410 1420 1430
1420 1430 1440 1450 1460 1470
pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_722 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1440 1450 1460 1470 1480 1490
1480 1490 1500 1510 1520 1530
pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1500 1510 1520 1530 1540 1550
1540 1550 1560 1570 1580 1590
pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
:::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::.
NP_722 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI
1560 1570 1580 1590 1600 1610
1600 1610 1620 1630 1640 1650
pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: :
NP_722 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS
1620 1630 1640 1650 1660 1670
1660 1670 1680 1690
pF1KE5 RDASVFQDESNMSVLDIPSATPEKQVTQ--------------EGED--------------
:::::::::::.::::: .::::::. : :: :
NP_722 RDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPE
1680 1690 1700 1710 1720 1730
1700 1710 1720 1730 1740 1750
pF1KE5 -GDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS
::::::::::::::::.:::::::::.::::::::::::::::::::::::::::::::
NP_722 GGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS
1740 1750 1760 1770 1780 1790
1760 1770 1780 1790 1800 1810
pF1KE5 DVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKS
::: :::::::: :::. .
NP_722 DVGYGGIRPKQPFMLQHASGEHKDGHGK
1800 1810 1820
>>XP_005262357 (OMIM: 300966,313650,314250) PREDICTED: t (999 aa)
initn: 5499 init1: 5499 opt: 5499 Z-score: 4169.6 bits: 783.9 E(85289): 0
Smith-Waterman score: 6651; 97.9% identity (97.9% similar) in 997 aa overlap (1-976:1-997)
10 20 30 40 50 60
pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
130 140 150 160 170
pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG---
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210
pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
::::::::::::::::::::::::::::::::::::::::::
XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
:::::::::::::::::::::::::::::::::::::
XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKVG
970 980 990
1000 1010 1020 1030 1040 1050
pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
>>NP_001276975 (OMIM: 607576) cat eye syndrome critical (1300 aa)
initn: 225 init1: 225 opt: 274 Z-score: 210.9 bits: 51.8 E(85289): 5.2e-05
Smith-Waterman score: 278; 24.1% identity (54.8% similar) in 345 aa overlap (1354-1677:104-435)
1330 1340 1350 1360 1370 1380
pF1KE5 VLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMV
..:.. . :.: . . : .. :.
NP_001 GPGQGTWWLLCQTEEEWRQVTESFRERTSLRERQLYKLLSEDFLPEICNMIAQKGKRPQR
80 90 100 110 120 130
1390 1400 1410 1420 1430 1440
pF1KE5 TLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIIT--RPMDLQTLRENVRKRLYPS
: . . ..: .. . .::: ... :. : : . : . ... .. :
NP_001 TKAELHPRWMSDHLSIKPVKQEETPVLTRIEKQKRKEEEEERQILLAVQKKEQEQML---
140 150 160 170 180 190
1450 1460 1470 1480 1490
pF1KE5 REEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKL-----ARLEKAIN
.:: ...:: :: :. . :. . .. : ..: . ..: : :: .
NP_001 KEERKRELEEKVK--AVEDRAKRRKLREERAWLLAQGKELPPELSHLDPNSPMREEKKTK
200 210 220 230 240
1500 1510 1520 1530 1540 1550
pF1KE5 PLLD-DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRK
:.. ::: .:. .:: . ..: ::::: .::.....:.::..: :::. ...:
NP_001 DLFELDDDFTAMYKVLDVVKAHK-----DSWPFLEPVDESYAPNYYQIIKAPMDISSMEK
250 260 270 280 290 300
1560 1570 1580 1590 1600
pF1KE5 NISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEY--------
... : ..: :..:.. .. : :::: :.::: .... .... ..
NP_001 KLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKHFPGEDGDT
310 320 330 340 350 360
1610 1620 1630 1640 1650 1660
pF1KE5 DEHL-----TQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDA
::.. . :: : ... .. .: :: : : : . . . :: .: :
NP_001 DEEFWIREDEKREKRRSRAGRSGGSHVWTRSRDP--EGSSRKQQP-MENGGKSLPPTRRA
370 380 390 400 410 420
1670 1680 1690 1700 1710 1720
pF1KE5 SVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGE
:... : . :
NP_001 PSSGDDQSSSSTQPPREVGTSNGRGFSHPLHCGGTPSQAPFLNQMRPAVPGTFGPLRGSD
430 440 450 460 470 480
1872 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 03:58:17 2016 done: Tue Nov 8 03:58:20 2016
Total Scan time: 19.520 Total Display time: 1.210
Function used was FASTA [36.3.4 Apr, 2011]