Result of FASTA (omim) for
pFN21AE5750
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5750, 692 aa
1>>>pF1KE5750 692 - 692 aa - 692 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2962+/-0.000336; mu= 11.2621+/- 0.021
mean_var=168.4362+/-32.659, 0's: 0 Z-trim(121.1): 218 B-trim: 130 in 1/59
Lambda= 0.098823
statistics sampled from 36942 (37195) to 36942 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.766), E-opt: 0.2 (0.436), width: 16
Scan time: 12.250
The best scores are: opt bits E(85289)
NP_001269376 (OMIM: 607114) disintegrin and metall ( 812) 3264 477.9 6.6e-134
XP_006723702 (OMIM: 607114) PREDICTED: disintegrin ( 825) 3264 477.9 6.6e-134
XP_011527675 (OMIM: 607114) PREDICTED: disintegrin ( 492) 3252 476.0 1.5e-133
XP_011527669 (OMIM: 607114) PREDICTED: disintegrin ( 812) 3252 476.2 2.1e-133
NP_079496 (OMIM: 607114) disintegrin and metallopr ( 813) 3252 476.2 2.1e-133
XP_006723703 (OMIM: 607114) PREDICTED: disintegrin ( 823) 3252 476.2 2.2e-133
XP_011527668 (OMIM: 607114) PREDICTED: disintegrin ( 825) 3252 476.2 2.2e-133
XP_005260900 (OMIM: 607114) PREDICTED: disintegrin ( 826) 3252 476.2 2.2e-133
NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787) 1907 284.4 1.1e-75
XP_011527670 (OMIM: 607114) PREDICTED: disintegrin ( 800) 1907 284.4 1.1e-75
XP_016883570 (OMIM: 607114) PREDICTED: disintegrin ( 547) 1891 282.0 4.2e-75
XP_016865498 (OMIM: 603640) PREDICTED: disintegrin ( 651) 1352 205.2 6.4e-52
XP_011532984 (OMIM: 603640) PREDICTED: disintegrin ( 651) 1352 205.2 6.4e-52
NP_150377 (OMIM: 603640) disintegrin and metallopr ( 918) 1352 205.4 8.2e-52
XP_005266060 (OMIM: 603640) PREDICTED: disintegrin ( 955) 1352 205.4 8.4e-52
XP_016872195 (OMIM: 602714) PREDICTED: disintegrin ( 520) 1209 184.7 7.5e-46
XP_016872194 (OMIM: 602714) PREDICTED: disintegrin ( 753) 1209 184.9 9.8e-46
NP_001275902 (OMIM: 602714) disintegrin and metall ( 906) 1209 185.0 1.1e-45
NP_003465 (OMIM: 602714) disintegrin and metallopr ( 909) 1209 185.0 1.1e-45
NP_001275904 (OMIM: 602714) disintegrin and metall ( 735) 1174 179.9 3e-44
NP_067673 (OMIM: 602714) disintegrin and metallopr ( 738) 1174 179.9 3.1e-44
NP_001275903 (OMIM: 602714) disintegrin and metall ( 737) 1169 179.2 5e-44
XP_011527672 (OMIM: 607114) PREDICTED: disintegrin ( 635) 1148 176.1 3.6e-43
XP_016883572 (OMIM: 607114) PREDICTED: disintegrin ( 396) 1111 170.7 9.9e-42
XP_016883571 (OMIM: 607114) PREDICTED: disintegrin ( 435) 1111 170.7 1.1e-41
XP_006723707 (OMIM: 607114) PREDICTED: disintegrin ( 489) 1111 170.7 1.1e-41
XP_016883569 (OMIM: 607114) PREDICTED: disintegrin ( 560) 1111 170.8 1.3e-41
XP_011527673 (OMIM: 607114) PREDICTED: disintegrin ( 560) 1111 170.8 1.3e-41
NP_997079 (OMIM: 605548) disintegrin and metallopr ( 862) 1110 170.8 1.9e-41
NP_997078 (OMIM: 605548) disintegrin and metallopr ( 838) 1105 170.1 3.1e-41
NP_997077 (OMIM: 605548) disintegrin and metallopr ( 839) 1105 170.1 3.1e-41
NP_997080 (OMIM: 605548) disintegrin and metallopr ( 863) 1099 169.3 5.7e-41
NP_003806 (OMIM: 605548) disintegrin and metallopr ( 814) 1073 165.5 7.1e-40
NP_001248393 (OMIM: 605548) disintegrin and metall ( 824) 1073 165.5 7.2e-40
NP_997074 (OMIM: 605548) disintegrin and metallopr ( 772) 1059 163.5 2.7e-39
NP_001248394 (OMIM: 605548) disintegrin and metall ( 796) 1057 163.2 3.4e-39
XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801) 988 153.4 3.1e-36
NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819) 988 153.4 3.2e-36
XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821) 988 153.4 3.2e-36
NP_068566 (OMIM: 604779) disintegrin and metallopr ( 790) 919 143.6 2.8e-33
NP_003804 (OMIM: 603713) disintegrin and metallopr ( 722) 911 142.4 5.8e-33
NP_003805 (OMIM: 603712) disintegrin and metallopr ( 776) 873 137.0 2.6e-31
XP_005268208 (OMIM: 603712) PREDICTED: disintegrin ( 776) 873 137.0 2.6e-31
NP_001248395 (OMIM: 605548) disintegrin and metall ( 633) 860 135.1 8.2e-31
NP_001124177 (OMIM: 604778) disintegrin and metall ( 820) 854 134.3 1.8e-30
NP_001265055 (OMIM: 604778) disintegrin and metall ( 820) 854 134.3 1.8e-30
NP_055084 (OMIM: 604778) disintegrin and metallopr ( 820) 854 134.3 1.8e-30
XP_011529859 (OMIM: 604778) PREDICTED: disintegrin ( 820) 854 134.3 1.8e-30
NP_001124176 (OMIM: 604778) disintegrin and metall ( 820) 854 134.3 1.8e-30
XP_011529863 (OMIM: 604778) PREDICTED: disintegrin ( 820) 854 134.3 1.8e-30
>>NP_001269376 (OMIM: 607114) disintegrin and metallopro (812 aa)
initn: 3264 init1: 3264 opt: 3264 Z-score: 2525.1 bits: 477.9 E(85289): 6.6e-134
Smith-Waterman score: 4280; 83.4% identity (83.4% similar) in 724 aa overlap (89-692:89-812)
60 70 80 90 100 110
pF1KE5 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG
::::::::::::::::::::::::::::::
NP_001 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
180 190 200 210 220 230
240 250 260 270
pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR----------------------------
::::::::::::::::::::::::::::::::
NP_001 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA
240 250 260 270 280 290
pF1KE5 ------------------------------------------------------------
NP_001 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD
300 310 320 330 340 350
280 290
pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::
NP_001 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
360 370 380 390 400 410
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
420 430 440 450 460 470
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
600 610 620 630 640 650
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
660 670 680 690 700 710
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
720 730 740 750 760 770
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW
::::::::::::::::::::::::::::::::::
NP_001 PENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW
780 790 800 810
>--
initn: 613 init1: 613 opt: 613 Z-score: 482.5 bits: 100.0 E(85289): 3.9e-20
Smith-Waterman score: 613; 100.0% identity (100.0% similar) in 88 aa overlap (1-88:1-88)
10 20 30 40 50 60
pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
::::::::::::::::::::::::::::
NP_001 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
70 80 90 100 110 120
>>XP_006723702 (OMIM: 607114) PREDICTED: disintegrin and (825 aa)
initn: 4041 init1: 3264 opt: 3264 Z-score: 2525.0 bits: 477.9 E(85289): 6.6e-134
Smith-Waterman score: 4145; 81.6% identity (81.6% similar) in 724 aa overlap (102-692:102-825)
80 90 100 110
pF1KE5 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCHYQG
:::::::::: :::::::
XP_006 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQG
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
140 150 160 170 180 190
180 190 200 210 220 230
pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
200 210 220 230 240 250
240 250 260 270
pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR----------------------------
::::::::::::::::::::::::::::::::
XP_006 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA
260 270 280 290 300 310
pF1KE5 ------------------------------------------------------------
XP_006 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD
320 330 340 350 360 370
280 290
pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::
XP_006 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
380 390 400 410 420 430
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
440 450 460 470 480 490
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
500 510 520 530 540 550
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
560 570 580 590 600 610
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
620 630 640 650 660 670
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
680 690 700 710 720 730
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
740 750 760 770 780 790
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW
::::::::::::::::::::::::::::::::::
XP_006 PENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW
800 810 820
>--
initn: 712 init1: 712 opt: 712 Z-score: 558.6 bits: 114.1 E(85289): 2.2e-24
Smith-Waterman score: 712; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101)
10 20 30 40 50 60
pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
:::::::::::::::::::::::::::::::::::::::::
XP_006 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG
XP_006 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF
130 140 150 160 170 180
>>XP_011527675 (OMIM: 607114) PREDICTED: disintegrin and (492 aa)
initn: 3250 init1: 3175 opt: 3252 Z-score: 2518.7 bits: 476.0 E(85289): 1.5e-133
Smith-Waterman score: 3252; 99.8% identity (99.8% similar) in 425 aa overlap (269-692:68-492)
240 250 260 270 280 290
pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::::
XP_011 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
160 170 180 190 200 210
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
220 230 240 250 260 270
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
280 290 300 310 320 330
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
340 350 360 370 380 390
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
400 410 420 430 440 450
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW
::::::::::::::::::::::: :::::::::::
XP_011 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
460 470 480 490
>>XP_011527669 (OMIM: 607114) PREDICTED: disintegrin and (812 aa)
initn: 3825 init1: 3175 opt: 3252 Z-score: 2515.9 bits: 476.2 E(85289): 2.1e-133
Smith-Waterman score: 4268; 83.3% identity (83.3% similar) in 725 aa overlap (89-692:88-812)
60 70 80 90 100 110
pF1KE5 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG
::::::::::::::::::::::::::::::
XP_011 EPVSKPDMGLVALEAEGQELLLELEKNQLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
180 190 200 210 220 230
240 250 260 270
pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR----------------------------
::::::::::::::::::::::::::::::::
XP_011 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA
240 250 260 270 280 290
pF1KE5 ------------------------------------------------------------
XP_011 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD
300 310 320 330 340 350
280 290
pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::
XP_011 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
360 370 380 390 400 410
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
420 430 440 450 460 470
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
600 610 620 630 640 650
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
660 670 680 690 700 710
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
720 730 740 750 760 770
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW
::::::::::::::::::::::: :::::::::::
XP_011 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
780 790 800 810
>--
initn: 620 init1: 589 opt: 589 Z-score: 464.0 bits: 96.5 E(85289): 4.2e-19
Smith-Waterman score: 589; 97.7% identity (98.9% similar) in 87 aa overlap (1-87:1-87)
10 20 30 40 50 60
pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
::::::::::::::::::::::::. :
XP_011 SKPDMGLVALEAEGQELLLELEKNQLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVR
70 80 90 100 110 120
>>NP_079496 (OMIM: 607114) disintegrin and metalloprotei (813 aa)
initn: 3250 init1: 3175 opt: 3252 Z-score: 2515.8 bits: 476.2 E(85289): 2.1e-133
Smith-Waterman score: 4268; 83.3% identity (83.3% similar) in 725 aa overlap (89-692:89-813)
60 70 80 90 100 110
pF1KE5 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG
::::::::::::::::::::::::::::::
NP_079 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
180 190 200 210 220 230
240 250 260 270
pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR----------------------------
::::::::::::::::::::::::::::::::
NP_079 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA
240 250 260 270 280 290
pF1KE5 ------------------------------------------------------------
NP_079 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD
300 310 320 330 340 350
280 290
pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::
NP_079 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
360 370 380 390 400 410
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
420 430 440 450 460 470
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
600 610 620 630 640 650
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
660 670 680 690 700 710
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
720 730 740 750 760 770
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW
::::::::::::::::::::::: :::::::::::
NP_079 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
780 790 800 810
>--
initn: 613 init1: 613 opt: 613 Z-score: 482.4 bits: 100.0 E(85289): 3.9e-20
Smith-Waterman score: 613; 100.0% identity (100.0% similar) in 88 aa overlap (1-88:1-88)
10 20 30 40 50 60
pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
::::::::::::::::::::::::::::
NP_079 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
70 80 90 100 110 120
>>XP_006723703 (OMIM: 607114) PREDICTED: disintegrin and (823 aa)
initn: 4027 init1: 3175 opt: 3252 Z-score: 2515.8 bits: 476.2 E(85289): 2.2e-133
Smith-Waterman score: 4165; 81.9% identity (81.9% similar) in 725 aa overlap (99-692:99-823)
70 80 90 100 110
pF1KE5 ALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCH
::::::::::::: ::::
XP_006 ALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCH
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 YQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTW
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 KGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQ
190 200 210 220 230 240
240 250 260 270
pF1KE5 RLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSR-------------------------
:::::::::::::::::::::::::::::::::::
XP_006 RLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPH
250 260 270 280 290 300
pF1KE5 ------------------------------------------------------------
XP_006 DSAQLLTGRAFQGATVGLAPVEGMCRAESSGGDHSELPIGAAATMAHEIGHSLGLSHDPD
310 320 330 340 350 360
280 290
pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::
XP_006 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
370 380 390 400 410 420
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
430 440 450 460 470 480
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
490 500 510 520 530 540
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
550 560 570 580 590 600
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
610 620 630 640 650 660
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
670 680 690 700 710 720
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
730 740 750 760 770 780
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW
::::::::::::::::::::::: :::::::::::
XP_006 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
790 800 810 820
>--
initn: 686 init1: 686 opt: 686 Z-score: 538.6 bits: 110.4 E(85289): 2.9e-23
Smith-Waterman score: 686; 100.0% identity (100.0% similar) in 98 aa overlap (1-98:1-98)
10 20 30 40 50 60
pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
::::::::::::::::::::::::::::::::::::::
XP_006 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG
XP_006 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF
130 140 150 160 170 180
>>XP_011527668 (OMIM: 607114) PREDICTED: disintegrin and (825 aa)
initn: 4003 init1: 3175 opt: 3252 Z-score: 2515.8 bits: 476.2 E(85289): 2.2e-133
Smith-Waterman score: 4133; 81.5% identity (81.5% similar) in 725 aa overlap (102-692:101-825)
80 90 100 110
pF1KE5 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCHYQG
:::::::::: :::::::
XP_011 EAEGQELLLELEKNQLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQG
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
140 150 160 170 180 190
180 190 200 210 220 230
pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
200 210 220 230 240 250
240 250 260 270
pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR----------------------------
::::::::::::::::::::::::::::::::
XP_011 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA
260 270 280 290 300 310
pF1KE5 ------------------------------------------------------------
XP_011 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD
320 330 340 350 360 370
280 290
pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::
XP_011 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
380 390 400 410 420 430
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
440 450 460 470 480 490
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
500 510 520 530 540 550
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
560 570 580 590 600 610
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
620 630 640 650 660 670
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
680 690 700 710 720 730
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
740 750 760 770 780 790
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW
::::::::::::::::::::::: :::::::::::
XP_011 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
800 810 820
>--
initn: 620 init1: 589 opt: 684 Z-score: 537.1 bits: 110.1 E(85289): 3.5e-23
Smith-Waterman score: 684; 98.0% identity (99.0% similar) in 101 aa overlap (1-101:1-100)
10 20 30 40 50 60
pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
::::::::::::::::::::::::. :::::::::::::::
XP_011 SKPDMGLVALEAEGQELLLELEKNQ-LLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD
70 80 90 100 110
130 140 150 160 170 180
pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG
XP_011 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF
120 130 140 150 160 170
>>XP_005260900 (OMIM: 607114) PREDICTED: disintegrin and (826 aa)
initn: 4027 init1: 3175 opt: 3252 Z-score: 2515.8 bits: 476.2 E(85289): 2.2e-133
Smith-Waterman score: 4133; 81.5% identity (81.5% similar) in 725 aa overlap (102-692:102-826)
80 90 100 110
pF1KE5 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCHYQG
:::::::::: :::::::
XP_005 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQG
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
140 150 160 170 180 190
180 190 200 210 220 230
pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
200 210 220 230 240 250
240 250 260 270
pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR----------------------------
::::::::::::::::::::::::::::::::
XP_005 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA
260 270 280 290 300 310
pF1KE5 ------------------------------------------------------------
XP_005 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD
320 330 340 350 360 370
280 290
pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::
XP_005 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
380 390 400 410 420 430
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
440 450 460 470 480 490
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
500 510 520 530 540 550
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
560 570 580 590 600 610
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
620 630 640 650 660 670
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
680 690 700 710 720 730
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
740 750 760 770 780 790
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW
::::::::::::::::::::::: :::::::::::
XP_005 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
800 810 820
>--
initn: 712 init1: 712 opt: 712 Z-score: 558.6 bits: 114.1 E(85289): 2.2e-24
Smith-Waterman score: 712; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101)
10 20 30 40 50 60
pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
:::::::::::::::::::::::::::::::::::::::::
XP_005 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG
XP_005 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF
130 140 150 160 170 180
>>NP_694882 (OMIM: 607114) disintegrin and metalloprotei (787 aa)
initn: 3047 init1: 1907 opt: 1907 Z-score: 1479.7 bits: 284.4 E(85289): 1.1e-75
Smith-Waterman score: 4010; 79.7% identity (79.7% similar) in 725 aa overlap (89-692:89-787)
60 70 80 90 100 110
pF1KE5 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG
::::::::::::::::::::::::::::::
NP_694 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
180 190 200 210 220 230
240 250 260 270
pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR----------------------------
::::::::::::::::::::::::::::::::
NP_694 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA
240 250 260 270 280 290
pF1KE5 ------------------------------------------------------------
NP_694 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD
300 310 320 330 340 350
280 290
pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::
NP_694 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
360 370 380 390 400 410
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
420 430 440 450 460 470
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
:::::::::::::::::::::::::::::::::::::
NP_694 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRM-----------------------
600 610 620 630
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 ---VCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
640 650 660 670 680 690
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
700 710 720 730 740 750
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW
::::::::::::::::::::::: :::::::::::
NP_694 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
760 770 780
>--
initn: 613 init1: 613 opt: 613 Z-score: 482.6 bits: 99.9 E(85289): 3.8e-20
Smith-Waterman score: 613; 100.0% identity (100.0% similar) in 88 aa overlap (1-88:1-88)
10 20 30 40 50 60
pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
::::::::::::::::::::::::::::
NP_694 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
70 80 90 100 110 120
>>XP_011527670 (OMIM: 607114) PREDICTED: disintegrin and (800 aa)
initn: 2759 init1: 1907 opt: 1907 Z-score: 1479.6 bits: 284.4 E(85289): 1.1e-75
Smith-Waterman score: 3875; 77.9% identity (77.9% similar) in 725 aa overlap (102-692:102-800)
80 90 100 110
pF1KE5 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCHYQG
:::::::::: :::::::
XP_011 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQG
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT
140 150 160 170 180 190
180 190 200 210 220 230
pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL
200 210 220 230 240 250
240 250 260 270
pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR----------------------------
::::::::::::::::::::::::::::::::
XP_011 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA
260 270 280 290 300 310
pF1KE5 ------------------------------------------------------------
XP_011 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD
320 330 340 350 360 370
280 290
pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA
::::::::::::::::::::::::::::
XP_011 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA
380 390 400 410 420 430
300 310 320 330 340 350
pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA
440 450 460 470 480 490
360 370 380 390 400 410
pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP
500 510 520 530 540 550
420 430 440 450 460 470
pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH
560 570 580 590 600 610
480 490 500 510 520 530
pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH
:::::::::::::::::::::::::::::::::::::::
XP_011 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVC---------------------
620 630 640 650
540 550 560 570 580 590
pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 -----NSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA
660 670 680 690 700
600 610 620 630 640 650
pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD
710 720 730 740 750 760
660 670 680 690
pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW
::::::::::::::::::::::: :::::::::::
XP_011 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
770 780 790 800
>--
initn: 712 init1: 712 opt: 712 Z-score: 558.8 bits: 114.1 E(85289): 2.2e-24
Smith-Waterman score: 712; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101)
10 20 30 40 50 60
pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
:::::::::::::::::::::::::::::::::::::::::
XP_011 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG
XP_011 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF
130 140 150 160 170 180
692 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:20:24 2016 done: Tue Nov 8 06:20:26 2016
Total Scan time: 12.250 Total Display time: 0.200
Function used was FASTA [36.3.4 Apr, 2011]