Result of FASTA (ccds) for
pFN21AE5739
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5739, 609 aa
1>>>pF1KE5739 609 - 609 aa - 609 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1393+/-0.000806; mu= 7.5653+/- 0.049
mean_var=141.8112+/-29.215, 0's: 0 Z-trim(112.7): 37 B-trim: 159 in 1/54
Lambda= 0.107701
statistics sampled from 13415 (13449) to 13415 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.413), width: 16
Scan time: 2.420
The best scores are: opt bits E(32554)
CCDS34723.1 KMT2E gene_id:55904|Hs108|chr7 (1858) 3881 614.6 3.7e-175
CCDS46741.1 SETD5 gene_id:55209|Hs108|chr3 (1442) 977 163.3 2e-39
CCDS74892.1 SETD5 gene_id:55209|Hs108|chr3 (1344) 780 132.7 3.1e-30
>>CCDS34723.1 KMT2E gene_id:55904|Hs108|chr7 (1858 aa)
initn: 3881 init1: 3881 opt: 3881 Z-score: 3258.1 bits: 614.6 E(32554): 3.7e-175
Smith-Waterman score: 3881; 99.5% identity (99.7% similar) in 578 aa overlap (1-578:1-578)
10 20 30 40 50 60
pF1KE5 MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS34 INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMVSWEASSLGLVTAALHMVIVAAFTWA
::::::::::::::::::::::::::::::::::. :
CCDS34 QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQ
550 560 570 580 590 600
pF1KE5 FTLFFEVSE
CCDS34 ALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTH
610 620 630 640 650 660
>>CCDS46741.1 SETD5 gene_id:55209|Hs108|chr3 (1442 aa)
initn: 1183 init1: 726 opt: 977 Z-score: 821.2 bits: 163.3 E(32554): 2e-39
Smith-Waterman score: 1270; 41.4% identity (63.8% similar) in 594 aa overlap (1-572:1-508)
10 20 30 40 50 60
pF1KE5 MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP
:::.::::: :..::: .:::::.::::::::.: ::: :. :.. : . :::
CCDS46 MSIAIPLGVTTSDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCR---GLP
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR
:: ..: ..... . .: .: . . : .: : :
CCDS46 YA-------------------TIIPRSDLNGLPSP-VEERCGDSPNSEGE-----TVPTW
60 70 80 90
130 140 150 160 170 180
pF1KE5 CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK
: ::...: :... :::: :.... ... :.:::
CCDS46 CPCGLSQD-GFLLNCDKC---------------------------RGMSRGKVIRLHRRK
100 110 120
190 200 210 220 230
pF1KE5 RENMSDGDTSATESGDE--VPVE-LYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQH
..:.: ::.::::: :: : :::: :::::::::: : ... :.:::: :: .
CCDS46 QDNISGGDSSATESWDEELSPSTVLYTATQHTPTSITLT---VRRTKPKKRKKSPEKGRA
130 140 150 160 170 180
240 250 260 270 280 290
pF1KE5 ISKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQ
: :: .:.: : . ..... :::..:. : :.:::: .:::: ::
CCDS46 APKTKK-----------IKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQ
190 200 210 220 230
300 310 320 330 340
pF1KE5 RE-AQRIALR---LGNGNDKKEMNKSDLNTNNLLFKPPVE------SHIQKNKKILKSAK
:.. .:. . .::..: :: .. .. ...::..:::..:.
CCDS46 NALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAAR
240 250 260 270 280 290
350 360 370 380 390 400
pF1KE5 DLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFI
:: :.:::::::: :::.:::.::.:::.:::::::::::.:.:::::::::::.::::
CCDS46 DLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFI
300 310 320 330 340 350
410 420 430 440 450 460
pF1KE5 RRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPE
:::::::::::: : :: ::: ::.. .: : .:.:::::..:.::.::::::: : : .
CCDS46 RRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRN
360 370 380 390 400 410
470 480 490 500 510
pF1KE5 CPVLKRSSESME--------NINS-GYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTN
::. ::. .. : .. . : ::::.:... :: . ..:: . .:
CCDS46 CPIQKRNPNATELPLLPPPPSLPTIGAETRRRKARR-----KELEMEQQN---EASEENN
420 430 440 450 460
520 530 540 550 560 570
pF1KE5 KMKSPETKQRKLSPLRLSVSNNQEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMVSWE
..: :. : ...::...: .:. ::: .: ....:..:. .:
CCDS46 DQQSQEV------PEKVTVSSDHEE--VDNPEEKPEEEKEEVIDDQENLAHSRRTREDRK
470 480 490 500 510
580 590 600
pF1KE5 ASSLGLVTAALHMVIVAAFTWAFTLFFEVSE
CCDS46 VEAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNV
520 530 540 550 560 570
>>CCDS74892.1 SETD5 gene_id:55209|Hs108|chr3 (1344 aa)
initn: 909 init1: 726 opt: 780 Z-score: 656.3 bits: 132.7 E(32554): 3.1e-30
Smith-Waterman score: 1157; 47.1% identity (71.1% similar) in 429 aa overlap (168-572:1-410)
140 150 160 170 180 190
pF1KE5 CSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRKRENMSDGDTSATESGDE
... ... :.:::..:.: ::.::::: ::
CCDS74 MSRGKVIRLHRRKQDNISGGDSSATESWDE
10 20 30
200 210 220 230 240 250
pF1KE5 --VPVE-LYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISKCKK--AFREGSRKS
: :::: :::::::::: : ... :.:::: :: . : :: :::::::::
CCDS74 ELSPSTVLYTATQHTPTSITLT---VRRTKPKKRKKSPEKGRAAPKTKKIKAFREGSRKS
40 50 60 70 80
260 270 280 290 300
pF1KE5 SRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQRE-AQRIALR---LG
:.:.: : . ..... :::..:. : :.:::: .:::: :: :.. .:
CCDS74 LRMKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQNALEQHLHSSKEFVG
90 100 110 120 130 140
310 320 330 340 350 360
pF1KE5 NGNDKKEMNKSDLNTNNLLFKPPVE------SHIQKNKKILKSAKDLPPDALIIEYRGKF
. . .::..: :: .. .. ...::..:::..:.:: :.::::::::
CCDS74 KPTILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKV
150 160 170 180 190 200
370 380 390 400 410 420
pF1KE5 MLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHEIQ
:::.:::.::.:::.:::::::::::.:.:::::::::::.:::::::::::::::: :
CCDS74 MLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIA
210 220 230 240 250 260
430 440 450 460 470
pF1KE5 DGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESME---
:: ::: ::.. .: : .:.:::::..:.::.::::::: : : .::. ::. .. :
CCDS74 DGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNATELPL
270 280 290 300 310 320
480 490 500 510 520 530
pF1KE5 -----NINS-GYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPL
.. . : ::::.:... :: . ..:: . .: ..: :. :
CCDS74 LPPPPSLPTIGAETRRRKARR-----KELEMEQQN---EASEENNDQQSQEV------PE
330 340 350 360 370
540 550 560 570 580 590
pF1KE5 RLSVSNNQEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMVSWEASSLGLVTAALHMVI
...::...: .:. ::: .: ....:..:. .:
CCDS74 KVTVSSDHEE--VDNPEEKPEEEKEEVIDDQENLAHSRRTREDRKVEAIMHAFENLEKRK
380 390 400 410 420 430
600
pF1KE5 VAAFTWAFTLFFEVSE
CCDS74 KRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRR
440 450 460 470 480 490
609 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:15:51 2016 done: Tue Nov 8 06:15:52 2016
Total Scan time: 2.420 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]