Result of FASTA (omim) for
pFN21AE5729
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5729, 640 aa
1>>>pF1KE5729 640 - 640 aa - 640 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5326+/-0.000391; mu= 14.8155+/- 0.025
mean_var=114.5845+/-23.414, 0's: 0 Z-trim(115.3): 45 B-trim: 0 in 0/51
Lambda= 0.119815
statistics sampled from 25574 (25619) to 25574 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.3), width: 16
Scan time: 8.460
The best scores are: opt bits E(85289)
NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640) 4436 778.1 0
XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646) 4436 778.1 0
XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651) 4436 778.2 0
XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659) 4436 778.2 0
XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623) 2388 424.1 7.2e-118
NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649) 1301 236.2 2.7e-61
NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669) 1207 220.0 2.2e-56
NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692) 1207 220.0 2.2e-56
NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728) 1207 220.0 2.3e-56
XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 858 159.7 3e-38
XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 858 159.7 3e-38
XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696) 858 159.7 3.2e-38
XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704) 858 159.7 3.2e-38
XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732) 858 159.7 3.3e-38
XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736) 858 159.7 3.4e-38
XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749) 858 159.7 3.4e-38
XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757) 858 159.7 3.4e-38
XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760) 858 159.7 3.4e-38
XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764) 858 159.7 3.5e-38
XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795) 858 159.7 3.6e-38
NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802) 858 159.7 3.6e-38
XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810) 858 159.7 3.6e-38
XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816) 858 159.7 3.6e-38
XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827) 858 159.7 3.7e-38
XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846) 858 159.8 3.7e-38
XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851) 858 159.8 3.8e-38
XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859) 858 159.8 3.8e-38
XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 858 159.8 3.9e-38
XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 858 159.8 3.9e-38
NP_064423 (OMIM: 602866) acid-sensing ion channel ( 574) 381 77.2 1.8e-13
NP_064717 (OMIM: 611741) acid-sensing ion channel ( 549) 376 76.3 3.2e-13
NP_064718 (OMIM: 611741) acid-sensing ion channel ( 543) 367 74.7 9.4e-13
NP_004760 (OMIM: 611741) acid-sensing ion channel ( 531) 366 74.6 1e-12
XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 304 63.8 1.6e-09
NP_059115 (OMIM: 616693) acid-sensing ion channel ( 505) 304 63.8 1.7e-09
NP_001085 (OMIM: 601784) acid-sensing ion channel ( 512) 227 50.5 1.7e-05
NP_899233 (OMIM: 601784) acid-sensing ion channel ( 563) 227 50.6 1.9e-05
NP_001086 (OMIM: 602866) acid-sensing ion channel ( 528) 208 47.2 0.00017
XP_011536654 (OMIM: 602866) PREDICTED: acid-sensin ( 529) 208 47.2 0.00017
XP_011536653 (OMIM: 602866) PREDICTED: acid-sensin ( 559) 208 47.3 0.00018
XP_011536652 (OMIM: 602866) PREDICTED: acid-sensin ( 560) 208 47.3 0.00018
NP_001243759 (OMIM: 602866) acid-sensing ion chann ( 562) 208 47.3 0.00018
NP_878267 (OMIM: 606715) acid-sensing ion channel ( 647) 208 47.3 0.0002
XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320) 194 44.7 0.00062
NP_061144 (OMIM: 606715) acid-sensing ion channel ( 666) 196 45.2 0.00087
>>NP_000327 (OMIM: 177200,211400,264350,600760) amilorid (640 aa)
initn: 4436 init1: 4436 opt: 4436 Z-score: 4150.2 bits: 778.1 E(85289): 0
Smith-Waterman score: 4436; 99.8% identity (99.8% similar) in 640 aa overlap (1-640:1-640)
10 20 30 40 50 60
pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPKKKAMWFLLTLLFA
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
NP_000 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELME
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSAS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 EKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 PGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 CTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 PDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 QSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 GEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPN
550 560 570 580 590 600
610 620 630 640
pF1KE5 TGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
::::::::::::::::::::::::::::::::::::::::
NP_000 TGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
610 620 630 640
>>XP_011544216 (OMIM: 177200,211400,264350,600760) PREDI (646 aa)
initn: 4436 init1: 4436 opt: 4436 Z-score: 4150.1 bits: 778.1 E(85289): 0
Smith-Waterman score: 4436; 99.8% identity (99.8% similar) in 640 aa overlap (1-640:7-646)
10 20 30 40 50
pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPKKKAMWFL
:::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_011 MTVGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 LTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 LDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 TSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 LVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 LKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRM
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 GEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKY
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 CNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHV
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 LSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSV
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE5 LCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDT
550 560 570 580 590 600
600 610 620 630 640
pF1KE5 APRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
610 620 630 640
>>XP_011544215 (OMIM: 177200,211400,264350,600760) PREDI (651 aa)
initn: 4436 init1: 4436 opt: 4436 Z-score: 4150.1 bits: 778.2 E(85289): 0
Smith-Waterman score: 4436; 99.8% identity (99.8% similar) in 640 aa overlap (1-640:12-651)
10 20 30 40
pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPKKK
:::::::::::::::::::::::::::::::::::::::: ::::::::
XP_011 MGKPGHREGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 AMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 HLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGD
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE5 NHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQ
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE5 VPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE5 GTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVD
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE5 KLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLP
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE5 RGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASED
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE5 WIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFW
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE5 MGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFG
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE5 FQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
610 620 630 640 650
>>XP_016879014 (OMIM: 177200,211400,264350,600760) PREDI (659 aa)
initn: 4436 init1: 4436 opt: 4436 Z-score: 4150.0 bits: 778.2 E(85289): 0
Smith-Waterman score: 4436; 99.8% identity (99.8% similar) in 640 aa overlap (1-640:20-659)
10 20 30 40
pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRT
::::::::::::::::::::::::::::::::::::::::
XP_016 MVKQSWTQQHQETTLTGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 ICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNAS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 PFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHP
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE5 MVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE5 QATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTE
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE5 KALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE5 TSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNC
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE5 GHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMAD
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE5 WPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSN
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE5 LGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAEL
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE5 VEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
610 620 630 640 650
>>XP_016879015 (OMIM: 177200,211400,264350,600760) PREDI (623 aa)
initn: 4173 init1: 2387 opt: 2388 Z-score: 2237.1 bits: 424.1 E(85289): 7.2e-118
Smith-Waterman score: 4105; 94.2% identity (94.2% similar) in 640 aa overlap (1-640:20-623)
10 20 30 40
pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRT
::::::::::::::::::::::::::::::::::::::::
XP_016 MVKQSWTQQHQETTLTGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 ICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNAS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 PFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHP
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE5 MVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE5 QATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTE
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE5 KALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE5 TSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNC
::::::: :::::::::::::::::
XP_016 TSIGVLV------------------------------------ACLRSCFQDHMIRNCNC
370 380
410 420 430 440 450 460
pF1KE5 GHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMAD
390 400 410 420 430 440
470 480 490 500 510 520
pF1KE5 WPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSN
450 460 470 480 490 500
530 540 550 560 570 580
pF1KE5 LGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAEL
510 520 530 540 550 560
590 600 610 620 630 640
pF1KE5 VEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
570 580 590 600 610 620
>>NP_001030 (OMIM: 177200,264350,600761,613071) amilorid (649 aa)
initn: 1191 init1: 546 opt: 1301 Z-score: 1221.4 bits: 236.2 E(85289): 2.7e-61
Smith-Waterman score: 1467; 36.5% identity (69.4% similar) in 627 aa overlap (17-626:19-633)
10 20 30 40 50
pF1KE5 MHVKKYLLKGLHRLQKGP-GYTYKELLVWYCDNTNTHGPKR-TICEGPKKKAMWFLLT
:: . : :::. ::: :::::: .: .. .: .. .:. .:
NP_001 MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 LLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLD
: .::. :: .... .. . ::::..: :. .::::::::: .:.::: ..::: ::.
NP_001 LTAVALILWQCALLVFSF--YTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLE
70 80 90 100 110
120 130 140 150 160
pF1KE5 ELMEAVLERILA-PELSHANATRNLNFSI-------WNHT-PLVLIDERNPHHPMVLDLF
. . .:. . . :: . ... : :. ..: ::...:. .. . :.:
NP_001 QETREALKSLYGFPESRKRREAESWN-SVSEGKQPRFSHRIPLLIFDQ--DEKGKARDFF
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 GDNHNGLTSS---SASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQAT
. . .: .::. . ....::: . ..:. .:.:. .:. ::: :.
NP_001 TGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYM
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE5 NIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKAL
::.:::: .. ..::: .:.....:.: . :. :::: . .: .:::: :: .: :
NP_001 NIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETIL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE5 PSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSI
.. :.:.::..:: :..:.: :::.:..:.....:.: :::..: : .. :::
NP_001 STSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSI
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE5 GVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHY
:. . . ...:::: :: .::.::..:.: :..::.: ::.:::: .:...:.:..:
NP_001 GMHLTESFKLSEPYSQCTEDGSDVPIRNIY---NAAYSLQICLHSCFQTKMVEKCGCAQY
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE5 LYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISMADWP
::: . .::: .. :.: .:: .:. . .:.: : ..:::.:. .. .: :.:.::
NP_001 SQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWP
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE5 SEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLG
: .:: :.. ::. .. ...: :.. ..:: :.....: :.: :: ::.: ::::.:
NP_001 SVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFG
480 490 500 510 520 530
530 540 550 560 570 580
pF1KE5 GQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPP-PTVAELV
::.:.::. ::.:.:: ::. .: .....: . . .. : .:: : . .
NP_001 GQLGLWMSCSVVCVIE----IIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSP
540 550 560 570 580
590 600 610 620 630 640
pF1KE5 EAHTNFGFQ-PDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
... : ... : : .. : . .::::::.:..:::.
NP_001 QGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDE
590 600 610 620 630 640
NP_001 L
>>NP_001029 (OMIM: 264350,600228,613021) amiloride-sensi (669 aa)
initn: 1123 init1: 448 opt: 1207 Z-score: 1133.4 bits: 220.0 E(85289): 2.2e-56
Smith-Waterman score: 1227; 32.4% identity (65.6% similar) in 620 aa overlap (21-627:54-651)
10 20 30 40
pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPK--K
.:.::. ..:.::. :: : .: . :
NP_001 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE5 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI
:.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .:
NP_001 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE5 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV
:. :..::.. : .: . .. .. . . :.: .. : : : : :
NP_001 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPP--
150 160 170 180 190
170 180 190 200 210 220
pF1KE5 LDLFGDNHNGLTSSSASEKI--CNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
: . ..:: .. . . :....::. :...: .....:...:. ::: .
NP_001 ---HGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE5 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT
. ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: .
NP_001 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE5 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT
. :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :.
NP_001 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE5 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN
::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:.
NP_001 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG
380 390 400 410 420 430
410 420 430 440 450
pF1KE5 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM
:.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... ..
NP_001 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY
440 450 460 470 480 490
460 470 480 490 500 510
pF1KE5 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL
. ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: ::
NP_001 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL
500 510 520 530 540
520 530 540 550 560 570
pF1KE5 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV
::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: :
NP_001 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE5 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG
: . . : : : . :: :: : .::: : .: .:
NP_001 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS
610 620 630 640 650 660
640
pF1KE5 DAI
NP_001 STCPLGGP
>>NP_001153047 (OMIM: 264350,600228,613021) amiloride-se (692 aa)
initn: 1123 init1: 448 opt: 1207 Z-score: 1133.2 bits: 220.0 E(85289): 2.2e-56
Smith-Waterman score: 1227; 32.4% identity (65.6% similar) in 620 aa overlap (21-627:77-674)
10 20 30 40
pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPK--K
.:.::. ..:.::. :: : .: . :
NP_001 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK
50 60 70 80 90 100
50 60 70 80 90 100
pF1KE5 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI
:.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .:
NP_001 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI
110 120 130 140 150 160
110 120 130 140 150 160
pF1KE5 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV
:. :..::.. : .: . .. .. . . :.: .. : : : : :
NP_001 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPP--
170 180 190 200 210 220
170 180 190 200 210 220
pF1KE5 LDLFGDNHNGLTSSSASEKI--CNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
: . ..:: .. . . :....::. :...: .....:...:. ::: .
NP_001 ---HGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF
230 240 250 260 270
230 240 250 260 270 280
pF1KE5 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT
. ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: .
NP_001 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE5 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT
. :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :.
NP_001 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV
340 350 360 370 380 390
350 360 370 380 390 400
pF1KE5 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN
::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:.
NP_001 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG
400 410 420 430 440 450
410 420 430 440 450
pF1KE5 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM
:.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... ..
NP_001 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE5 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL
. ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: ::
NP_001 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE5 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV
::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: :
NP_001 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV
580 590 600 610 620
580 590 600 610 620 630
pF1KE5 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG
: . . : : : . :: :: : .::: : .: .:
NP_001 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS
630 640 650 660 670 680
640
pF1KE5 DAI
NP_001 STCPLGGP
690
>>NP_001153048 (OMIM: 264350,600228,613021) amiloride-se (728 aa)
initn: 1123 init1: 448 opt: 1207 Z-score: 1132.9 bits: 220.0 E(85289): 2.3e-56
Smith-Waterman score: 1227; 32.4% identity (65.6% similar) in 620 aa overlap (21-627:113-710)
10 20 30 40
pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPK--K
.:.::. ..:.::. :: : .: . :
NP_001 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE5 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI
:.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .:
NP_001 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI
150 160 170 180 190 200
110 120 130 140 150 160
pF1KE5 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV
:. :..::.. : .: . .. .. . . :.: .. : : : : :
NP_001 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPP--
210 220 230 240 250
170 180 190 200 210 220
pF1KE5 LDLFGDNHNGLTSSSASEKI--CNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
: . ..:: .. . . :....::. :...: .....:...:. ::: .
NP_001 ---HGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF
260 270 280 290 300 310
230 240 250 260 270 280
pF1KE5 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT
. ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: .
NP_001 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN
320 330 340 350 360 370
290 300 310 320 330 340
pF1KE5 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT
. :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :.
NP_001 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV
380 390 400 410 420 430
350 360 370 380 390 400
pF1KE5 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN
::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:.
NP_001 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG
440 450 460 470 480
410 420 430 440 450
pF1KE5 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM
:.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... ..
NP_001 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY
490 500 510 520 530 540
460 470 480 490 500 510
pF1KE5 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL
. ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: ::
NP_001 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE5 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV
::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: :
NP_001 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE5 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG
: . . : : : . :: :: : .::: : .: .:
NP_001 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS
670 680 690 700 710 720
640
pF1KE5 DAI
NP_001 STCPLGGP
>>XP_011540234 (OMIM: 601328) PREDICTED: amiloride-sensi (638 aa)
initn: 920 init1: 346 opt: 858 Z-score: 807.7 bits: 159.7 E(85289): 3e-38
Smith-Waterman score: 1035; 29.9% identity (61.4% similar) in 606 aa overlap (21-614:55-616)
10 20 30 40
pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTIC-EGPK-K
...:::...: :.. :: : .: .: . :
XP_011 AQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLK
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE5 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI
. : ::.: . .::: :.... . : ...:: . .: ::.:...: . : .
XP_011 TTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPV
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE5 KHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFG
. :. :::. . .. . .::.. :. :. .. : : .:.. . :
XP_011 LRHLELLDEFARENIDSLYNVNLSKGRAA--LSATVPRHEPPFHLDRE-------IRLQR
150 160 170 180 190
170 180 190 200 210 220
pF1KE5 DNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFA
.:.: .. ....:::. . .: .:..::.. :. .:: .. ..:.:
XP_011 LSHSG-------SRV------RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILA
200 210 220 230 240
230 240 250 260 270 280
pF1KE5 QVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSA
.: : . : : ...:.: . . :. :.: .. .: ::.:: . : .
XP_011 LLPAAWEDSHGSQDG-HFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQ-----
250 260 270 280 290
290 300 310 320 330 340
pF1KE5 NPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVL
:: :. :.: . :. ..:.:.. ::.:.:.: . ::. ... . :::..:..
XP_011 RPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIR
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE5 VDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYP
:...:.: ::. ::..: : :. . .::.:. :::: ::::. :...:.::.::.:
XP_011 EDEVHRLGSPYGHCTAGGEGVEVELL---HNTSYTRQACLVSCFQQLMVETCSCGYYLHP
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE5 LPRGEKYCNNRDFPDWAHCYSDLQMSV-AQRETCIGMCKESCNDTQYKMTISMADWPSEA
:: : .::.. : :.::. : ... ..: : . : . : .. .:.. . . :::
XP_011 LPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAK
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE5 SEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQF
: : . .:. :. . .:....:.:: .::.:::..::. . .. ::: .:.
XP_011 SAGWTLATLG-EQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLC
480 490 500 510 520 530
530 540 550 560 570 580
pF1KE5 GFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHT
..:.:.::: :.:. :...: . . :: .. : ::: :. : :
XP_011 SLWFGASVLSLLELLELLLD---ASALTLVLGGR--RLRRAWFSWPRASP-------ASG
540 550 560 570 580
590 600 610 620 630
pF1KE5 NFGFQPDTAPRSPNTG-----PYPSEQALP---IPGTPPPNYDSLRLQPLDVIESDSEGD
...:... : .: : :: :: .::
XP_011 ASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
590 600 610 620 630
640
pF1KE5 AI
640 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:08:52 2016 done: Tue Nov 8 06:08:53 2016
Total Scan time: 8.460 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]