Result of FASTA (omim) for
pFN21AE5678
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5678, 471 aa
1>>>pF1KE5678 471 - 471 aa - 471 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.7487+/-0.000588; mu= -13.6838+/- 0.035
mean_var=750.8242+/-170.797, 0's: 0 Z-trim(112.9): 641 B-trim: 1129 in 1/57
Lambda= 0.046806
statistics sampled from 21349 (22021) to 21349 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.258), width: 16
Scan time: 7.680
The best scores are: opt bits E(85289)
NP_003659 (OMIM: 606723) MAP kinase-activated prot ( 471) 3137 228.4 3.3e-59
NP_620777 (OMIM: 606723) MAP kinase-activated prot ( 473) 3123 227.5 6.3e-59
XP_016875614 (OMIM: 606723) PREDICTED: MAP kinase- ( 405) 2714 199.8 1.2e-50
XP_016875620 (OMIM: 606723) PREDICTED: MAP kinase- ( 378) 2521 186.7 9.7e-47
XP_016875618 (OMIM: 606723) PREDICTED: MAP kinase- ( 380) 2507 185.7 1.9e-46
XP_016875619 (OMIM: 606723) PREDICTED: MAP kinase- ( 380) 2507 185.7 1.9e-46
XP_016875616 (OMIM: 606723) PREDICTED: MAP kinase- ( 386) 2435 180.9 5.5e-45
XP_016875617 (OMIM: 606723) PREDICTED: MAP kinase- ( 386) 2435 180.9 5.5e-45
XP_016875615 (OMIM: 606723) PREDICTED: MAP kinase- ( 402) 2284 170.7 6.6e-42
XP_016875626 (OMIM: 606723) PREDICTED: MAP kinase- ( 291) 1945 147.6 4.3e-35
XP_016875625 (OMIM: 606723) PREDICTED: MAP kinase- ( 297) 1873 142.8 1.3e-33
XP_016875621 (OMIM: 606723) PREDICTED: MAP kinase- ( 299) 1859 141.8 2.4e-33
XP_016875623 (OMIM: 606723) PREDICTED: MAP kinase- ( 299) 1859 141.8 2.4e-33
XP_016875624 (OMIM: 606723) PREDICTED: MAP kinase- ( 299) 1859 141.8 2.4e-33
XP_016875622 (OMIM: 606723) PREDICTED: MAP kinase- ( 299) 1859 141.8 2.4e-33
XP_016875628 (OMIM: 606723) PREDICTED: MAP kinase- ( 238) 1579 122.8 1.1e-27
XP_016875627 (OMIM: 606723) PREDICTED: MAP kinase- ( 246) 1493 117.0 6e-26
NP_951009 (OMIM: 605069) MAP kinase-interacting se ( 465) 545 53.4 1.6e-06
NP_060042 (OMIM: 605069) MAP kinase-interacting se ( 414) 533 52.5 2.6e-06
XP_016858145 (OMIM: 606724) PREDICTED: MAP kinase- ( 412) 527 52.1 3.5e-06
XP_016858144 (OMIM: 606724) PREDICTED: MAP kinase- ( 412) 527 52.1 3.5e-06
XP_006711066 (OMIM: 606724) PREDICTED: MAP kinase- ( 418) 527 52.1 3.5e-06
XP_006711064 (OMIM: 606724) PREDICTED: MAP kinase- ( 418) 527 52.1 3.5e-06
XP_006711065 (OMIM: 606724) PREDICTED: MAP kinase- ( 418) 527 52.1 3.5e-06
XP_006711063 (OMIM: 606724) PREDICTED: MAP kinase- ( 424) 527 52.1 3.5e-06
NP_001129025 (OMIM: 606724) MAP kinase-interacting ( 424) 527 52.1 3.5e-06
NP_116584 (OMIM: 602006) MAP kinase-activated prot ( 400) 526 52.0 3.6e-06
NP_004750 (OMIM: 602006) MAP kinase-activated prot ( 370) 525 51.9 3.6e-06
XP_005273410 (OMIM: 602006) PREDICTED: MAP kinase- ( 371) 525 51.9 3.6e-06
XP_006711069 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 517 51.3 5.2e-06
XP_006711072 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 517 51.3 5.2e-06
XP_006711070 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 517 51.3 5.2e-06
XP_016858146 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 517 51.3 5.2e-06
XP_016858142 (OMIM: 606724) PREDICTED: MAP kinase- ( 427) 517 51.4 5.6e-06
XP_016858143 (OMIM: 606724) PREDICTED: MAP kinase- ( 427) 517 51.4 5.6e-06
XP_016858141 (OMIM: 606724) PREDICTED: MAP kinase- ( 427) 517 51.4 5.6e-06
NP_001230855 (OMIM: 602130,617111) MAP kinase-acti ( 382) 513 51.1 6.4e-06
NP_001230854 (OMIM: 602130,617111) MAP kinase-acti ( 382) 513 51.1 6.4e-06
NP_004626 (OMIM: 602130,617111) MAP kinase-activat ( 382) 513 51.1 6.4e-06
XP_016858152 (OMIM: 606724) PREDICTED: MAP kinase- ( 335) 505 50.5 8.7e-06
XP_016858149 (OMIM: 606724) PREDICTED: MAP kinase- ( 341) 505 50.5 8.7e-06
XP_016858151 (OMIM: 606724) PREDICTED: MAP kinase- ( 341) 505 50.5 8.7e-06
XP_016858150 (OMIM: 606724) PREDICTED: MAP kinase- ( 341) 505 50.5 8.7e-06
NP_945324 (OMIM: 606724) MAP kinase-interacting se ( 347) 505 50.5 8.8e-06
XP_016858148 (OMIM: 606724) PREDICTED: MAP kinase- ( 347) 505 50.5 8.8e-06
XP_016858154 (OMIM: 606724) PREDICTED: MAP kinase- ( 292) 495 49.7 1.3e-05
XP_016858147 (OMIM: 606724) PREDICTED: MAP kinase- ( 350) 495 49.8 1.4e-05
XP_006711076 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 482 48.9 2.5e-05
XP_016858153 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 482 48.9 2.5e-05
XP_006711077 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 482 48.9 2.5e-05
>>NP_003659 (OMIM: 606723) MAP kinase-activated protein (471 aa)
initn: 3137 init1: 3137 opt: 3137 Z-score: 1184.0 bits: 228.4 E(85289): 3.3e-59
Smith-Waterman score: 3137; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)
10 20 30 40 50 60
pF1KE5 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA
370 380 390 400 410 420
430 440 450 460 470
pF1KE5 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
430 440 450 460 470
>>NP_620777 (OMIM: 606723) MAP kinase-activated protein (473 aa)
initn: 2813 init1: 2723 opt: 3123 Z-score: 1178.9 bits: 227.5 E(85289): 6.3e-59
Smith-Waterman score: 3123; 99.6% identity (99.6% similar) in 473 aa overlap (1-471:1-473)
10 20 30 40 50 60
pF1KE5 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
310 320 330 340 350 360
370 380 390 400 410
pF1KE5 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAG--ENEDEKLNEVMQ
:::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_620 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQ
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
430 440 450 460 470
>>XP_016875614 (OMIM: 606723) PREDICTED: MAP kinase-acti (405 aa)
initn: 2714 init1: 2714 opt: 2714 Z-score: 1030.3 bits: 199.8 E(85289): 1.2e-50
Smith-Waterman score: 2714; 100.0% identity (100.0% similar) in 405 aa overlap (67-471:1-405)
40 50 60 70 80 90
pF1KE5 RVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRA
::::::::::::::::::::::::::::::
XP_016 MMCATHPNIVQIIEVFANSVQFPHESSPRA
10 20 30
100 110 120 130 140 150
pF1KE5 RLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLF
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE5 KDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPY
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE5 TYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEM
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE5 AKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQ
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE5 LANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDV
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE5 IAQCILPQAGENEDEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAQCILPQAGENEDEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEI
340 350 360 370 380 390
460 470
pF1KE5 VKQVIEEQTTSHESQ
:::::::::::::::
XP_016 VKQVIEEQTTSHESQ
400
>>XP_016875620 (OMIM: 606723) PREDICTED: MAP kinase-acti (378 aa)
initn: 2521 init1: 2521 opt: 2521 Z-score: 960.1 bits: 186.7 E(85289): 9.7e-47
Smith-Waterman score: 2521; 100.0% identity (100.0% similar) in 377 aa overlap (95-471:2-378)
70 80 90 100 110 120
pF1KE5 LHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQ
::::::::::::::::::::::::::::::
XP_016 MRARLLIVMEMMEGGELFHRISQHRHFTEKQ
10 20 30
130 140 150 160 170 180
pF1KE5 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE5 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE5 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE5 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE5 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEAWKYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEAWKYN
280 290 300 310 320 330
430 440 450 460 470
pF1KE5 RECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
340 350 360 370
>>XP_016875618 (OMIM: 606723) PREDICTED: MAP kinase-acti (380 aa)
initn: 2171 init1: 2107 opt: 2507 Z-score: 955.0 bits: 185.7 E(85289): 1.9e-46
Smith-Waterman score: 2507; 99.5% identity (99.5% similar) in 379 aa overlap (95-471:2-380)
70 80 90 100 110 120
pF1KE5 LHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQ
::::::::::::::::::::::::::::::
XP_016 MRARLLIVMEMMEGGELFHRISQHRHFTEKQ
10 20 30
130 140 150 160 170 180
pF1KE5 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE5 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE5 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE5 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE5 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAG--ENEDEKLNEVMQEAWK
:::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWK
280 290 300 310 320 330
430 440 450 460 470
pF1KE5 YNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
340 350 360 370 380
>>XP_016875619 (OMIM: 606723) PREDICTED: MAP kinase-acti (380 aa)
initn: 2171 init1: 2107 opt: 2507 Z-score: 955.0 bits: 185.7 E(85289): 1.9e-46
Smith-Waterman score: 2507; 99.5% identity (99.5% similar) in 379 aa overlap (95-471:2-380)
70 80 90 100 110 120
pF1KE5 LHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQ
::::::::::::::::::::::::::::::
XP_016 MRARLLIVMEMMEGGELFHRISQHRHFTEKQ
10 20 30
130 140 150 160 170 180
pF1KE5 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE5 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE5 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE5 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE5 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAG--ENEDEKLNEVMQEAWK
:::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWK
280 290 300 310 320 330
430 440 450 460 470
pF1KE5 YNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
340 350 360 370 380
>>XP_016875616 (OMIM: 606723) PREDICTED: MAP kinase-acti (386 aa)
initn: 2197 init1: 2107 opt: 2435 Z-score: 928.7 bits: 180.9 E(85289): 5.5e-45
Smith-Waterman score: 2435; 99.5% identity (99.5% similar) in 367 aa overlap (95-459:2-368)
70 80 90 100 110 120
pF1KE5 LHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQ
::::::::::::::::::::::::::::::
XP_016 MRARLLIVMEMMEGGELFHRISQHRHFTEKQ
10 20 30
130 140 150 160 170 180
pF1KE5 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE5 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE5 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE5 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE5 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAG--ENEDEKLNEVMQEAWK
:::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWK
280 290 300 310 320 330
430 440 450 460 470
pF1KE5 YNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::
XP_016 YNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQTACWNSQEAHLSLGSQLP
340 350 360 370 380
>>XP_016875617 (OMIM: 606723) PREDICTED: MAP kinase-acti (386 aa)
initn: 2197 init1: 2107 opt: 2435 Z-score: 928.7 bits: 180.9 E(85289): 5.5e-45
Smith-Waterman score: 2435; 99.5% identity (99.5% similar) in 367 aa overlap (95-459:2-368)
70 80 90 100 110 120
pF1KE5 LHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQ
::::::::::::::::::::::::::::::
XP_016 MRARLLIVMEMMEGGELFHRISQHRHFTEKQ
10 20 30
130 140 150 160 170 180
pF1KE5 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQ
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE5 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE5 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE5 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE5 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAG--ENEDEKLNEVMQEAWK
:::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 LLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWK
280 290 300 310 320 330
430 440 450 460 470
pF1KE5 YNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::
XP_016 YNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQTACWNSQEAHLSLGSQLP
340 350 360 370 380
>>XP_016875615 (OMIM: 606723) PREDICTED: MAP kinase-acti (402 aa)
initn: 2284 init1: 2284 opt: 2284 Z-score: 873.4 bits: 170.7 E(85289): 6.6e-42
Smith-Waterman score: 2529; 85.4% identity (85.4% similar) in 471 aa overlap (1-471:1-402)
10 20 30 40 50 60
pF1KE5 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
::
XP_016 NE----------------------------------------------------------
130 140 150 160 170 180
pF1KE5 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -----------IALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
70 80 90 100 110
190 200 210 220 230 240
pF1KE5 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE5 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
180 190 200 210 220 230
310 320 330 340 350 360
pF1KE5 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
240 250 260 270 280 290
370 380 390 400 410 420
pF1KE5 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA
300 310 320 330 340 350
430 440 450 460 470
pF1KE5 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
360 370 380 390 400
>>XP_016875626 (OMIM: 606723) PREDICTED: MAP kinase-acti (291 aa)
initn: 1945 init1: 1945 opt: 1945 Z-score: 751.0 bits: 147.6 E(85289): 4.3e-35
Smith-Waterman score: 1945; 100.0% identity (100.0% similar) in 291 aa overlap (181-471:1-291)
160 170 180 190 200 210
pF1KE5 PENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIP
::::::::::::::::::::::::::::::
XP_016 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIP
10 20 30
220 230 240 250 260 270
pF1KE5 TSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEW
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE5 SQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQ
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE5 QAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVAL
160 170 180 190 200 210
400 410 420 430 440 450
pF1KE5 EKLRDVIAQCILPQAGENEDEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKLRDVIAQCILPQAGENEDEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDR
220 230 240 250 260 270
460 470
pF1KE5 LKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::
XP_016 LKLAEIVKQVIEEQTTSHESQ
280 290
471 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:46:56 2016 done: Tue Nov 8 05:46:57 2016
Total Scan time: 7.680 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]