Result of FASTA (ccds) for
pFN21AE5678
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5678, 471 aa
1>>>pF1KE5678 471 - 471 aa - 471 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.6813+/-0.00143; mu= -21.1017+/- 0.081
mean_var=392.2285+/-90.361, 0's: 0 Z-trim(105.4): 326 B-trim: 0 in 0/53
Lambda= 0.064760
statistics sampled from 8078 (8410) to 8078 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.258), width: 16
Scan time: 2.410
The best scores are: opt bits E(32554)
CCDS44976.1 MAPKAPK5 gene_id:8550|Hs108|chr12 ( 471) 3137 308.3 1.1e-83
CCDS44975.1 MAPKAPK5 gene_id:8550|Hs108|chr12 ( 473) 3123 307.0 2.8e-83
CCDS12080.1 MKNK2 gene_id:2872|Hs108|chr19 ( 465) 545 66.1 8.8e-11
>>CCDS44976.1 MAPKAPK5 gene_id:8550|Hs108|chr12 (471 aa)
initn: 3137 init1: 3137 opt: 3137 Z-score: 1615.8 bits: 308.3 E(32554): 1.1e-83
Smith-Waterman score: 3137; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)
10 20 30 40 50 60
pF1KE5 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA
370 380 390 400 410 420
430 440 450 460 470
pF1KE5 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
430 440 450 460 470
>>CCDS44975.1 MAPKAPK5 gene_id:8550|Hs108|chr12 (473 aa)
initn: 2813 init1: 2723 opt: 3123 Z-score: 1608.7 bits: 307.0 E(32554): 2.8e-83
Smith-Waterman score: 3123; 99.6% identity (99.6% similar) in 473 aa overlap (1-471:1-473)
10 20 30 40 50 60
pF1KE5 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
310 320 330 340 350 360
370 380 390 400 410
pF1KE5 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAG--ENEDEKLNEVMQ
:::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
CCDS44 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQ
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
430 440 450 460 470
>>CCDS12080.1 MKNK2 gene_id:2872|Hs108|chr19 (465 aa)
initn: 539 init1: 226 opt: 545 Z-score: 307.1 bits: 66.1 E(32554): 8.8e-11
Smith-Waterman score: 603; 34.2% identity (64.0% similar) in 339 aa overlap (28-341:90-404)
10 20 30 40 50
pF1KE5 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRP
:: : . :..:.. :....:.::. .:
CCDS12 KKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQP
60 70 80 90 100 110
60 70 80 90 100 110
pF1KE5 ---KAR--NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFH
..: ::.. ..: : :....:: : . . :. .:.: :.:: ..
CCDS12 GHIRSRVFREVEMLYQCQGHRNVLELIEFFEE----------EDRFYLVFEKMRGGSILS
120 130 140 150 160
120 130 140 150 160 170
pF1KE5 RISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGF
.: ..:::.: .:: :....: :: : .::::::::::.: . . .:::.::: .
CCDS12 HIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDL
170 180 190 200 210 220
180 190 200 210 220
pF1KE5 AK----------IDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSC
.. :. .:.:: . :.::.:.:: .:...: :.: :
CCDS12 GSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAF----SEEASI---------YDKRC
230 240 250 260 270
230 240 250 260 270
pF1KE5 DLWSLGVIIYVMLCGYPPFYSKHHS-------RTIP--KDMR-RKIMTGSFEFPEEEWSQ
::::::::.:..: ::::: .. : .. : ..: ..:. :..:::...:..
CCDS12 DLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAH
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE5 ISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQA
:: :::.. ::: ..::. ::.:::... : .:.::. .... .. . . .
CCDS12 ISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGC-APENTLPTPMVLQRNSCAKDLTSF
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE5 HAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEK
:: .: :
CCDS12 AAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSS
400 410 420 430 440 450
471 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:46:55 2016 done: Tue Nov 8 05:46:56 2016
Total Scan time: 2.410 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]