Result of FASTA (omim) for
pFN21AE5676
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5676, 579 aa
1>>>pF1KE5676 579 - 579 aa - 579 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2671+/-0.000522; mu= 14.5904+/- 0.032
mean_var=155.4899+/-29.938, 0's: 0 Z-trim(113.3): 218 B-trim: 125 in 1/50
Lambda= 0.102854
statistics sampled from 22261 (22552) to 22261 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.264), width: 16
Scan time: 7.300
The best scores are: opt bits E(85289)
XP_011542782 (OMIM: 601533) PREDICTED: disintegrin ( 579) 4117 623.9 4.3e-178
XP_005273525 (OMIM: 601533) PREDICTED: disintegrin ( 705) 2990 456.8 1.1e-127
XP_011542781 (OMIM: 601533) PREDICTED: disintegrin ( 609) 2930 447.8 4.7e-125
NP_001265042 (OMIM: 601533) disintegrin and metall ( 716) 1803 280.7 1.1e-74
NP_001455 (OMIM: 601533) disintegrin and metallopr ( 735) 1803 280.7 1.2e-74
NP_001265043 (OMIM: 601533) disintegrin and metall ( 672) 1801 280.3 1.3e-74
XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801) 780 128.9 6.1e-29
NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819) 780 128.9 6.2e-29
XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821) 780 128.9 6.2e-29
XP_016870955 (OMIM: 602267) PREDICTED: disintegrin ( 779) 672 112.9 4e-24
NP_001157961 (OMIM: 602267) disintegrin and metall ( 742) 671 112.7 4.3e-24
NP_001100 (OMIM: 602267) disintegrin and metallopr ( 824) 671 112.8 4.6e-24
XP_011537419 (OMIM: 602267) PREDICTED: disintegrin ( 863) 671 112.8 4.7e-24
XP_016870954 (OMIM: 602267) PREDICTED: disintegrin ( 889) 671 112.8 4.8e-24
XP_011542673 (OMIM: 606188) PREDICTED: disintegrin ( 522) 654 110.0 2e-23
XP_011542672 (OMIM: 606188) PREDICTED: disintegrin ( 542) 654 110.0 2e-23
XP_011542671 (OMIM: 606188) PREDICTED: disintegrin ( 673) 654 110.1 2.3e-23
XP_016868465 (OMIM: 606188) PREDICTED: disintegrin ( 715) 654 110.2 2.4e-23
XP_006716337 (OMIM: 606188) PREDICTED: disintegrin ( 728) 654 110.2 2.4e-23
XP_011542670 (OMIM: 606188) PREDICTED: disintegrin ( 728) 654 110.2 2.4e-23
XP_016868464 (OMIM: 606188) PREDICTED: disintegrin ( 732) 654 110.2 2.4e-23
XP_005273437 (OMIM: 606188) PREDICTED: disintegrin ( 736) 654 110.2 2.4e-23
XP_016868463 (OMIM: 606188) PREDICTED: disintegrin ( 741) 654 110.2 2.5e-23
XP_011542669 (OMIM: 606188) PREDICTED: disintegrin ( 746) 654 110.2 2.5e-23
NP_001291280 (OMIM: 606188) disintegrin and metall ( 754) 654 110.2 2.5e-23
XP_006716336 (OMIM: 606188) PREDICTED: disintegrin ( 767) 654 110.2 2.5e-23
NP_055080 (OMIM: 606188) disintegrin and metallopr ( 775) 654 110.2 2.5e-23
NP_003808 (OMIM: 607310) disintegrin and metallopr ( 754) 646 109.0 5.7e-23
XP_016869432 (OMIM: 607310) PREDICTED: disintegrin ( 755) 646 109.0 5.7e-23
NP_003804 (OMIM: 603713) disintegrin and metallopr ( 722) 645 108.8 6.1e-23
XP_005273439 (OMIM: 606188) PREDICTED: disintegrin ( 621) 625 105.8 4.3e-22
NP_001275904 (OMIM: 602714) disintegrin and metall ( 735) 622 105.4 6.6e-22
NP_001275903 (OMIM: 602714) disintegrin and metall ( 737) 622 105.4 6.6e-22
NP_067673 (OMIM: 602714) disintegrin and metallopr ( 738) 622 105.4 6.6e-22
XP_016872194 (OMIM: 602714) PREDICTED: disintegrin ( 753) 622 105.5 6.7e-22
NP_001275902 (OMIM: 602714) disintegrin and metall ( 906) 622 105.6 7.5e-22
NP_003465 (OMIM: 602714) disintegrin and metallopr ( 909) 622 105.6 7.5e-22
XP_011532984 (OMIM: 603640) PREDICTED: disintegrin ( 651) 601 102.3 5.3e-21
XP_016865498 (OMIM: 603640) PREDICTED: disintegrin ( 651) 601 102.3 5.3e-21
NP_150377 (OMIM: 603640) disintegrin and metallopr ( 918) 601 102.4 6.6e-21
XP_005266060 (OMIM: 603640) PREDICTED: disintegrin ( 955) 601 102.5 6.7e-21
NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787) 597 101.8 9e-21
XP_011527670 (OMIM: 607114) PREDICTED: disintegrin ( 800) 597 101.8 9.1e-21
XP_011527675 (OMIM: 607114) PREDICTED: disintegrin ( 492) 589 100.3 1.5e-20
NP_001248395 (OMIM: 605548) disintegrin and metall ( 633) 590 100.6 1.6e-20
NP_001265056 (OMIM: 604778) disintegrin and metall ( 820) 591 100.9 1.7e-20
NP_001124176 (OMIM: 604778) disintegrin and metall ( 820) 591 100.9 1.7e-20
NP_055084 (OMIM: 604778) disintegrin and metallopr ( 820) 591 100.9 1.7e-20
NP_001265055 (OMIM: 604778) disintegrin and metall ( 820) 591 100.9 1.7e-20
XP_011529858 (OMIM: 604778) PREDICTED: disintegrin ( 820) 591 100.9 1.7e-20
>>XP_011542782 (OMIM: 601533) PREDICTED: disintegrin and (579 aa)
initn: 4117 init1: 4117 opt: 4117 Z-score: 3318.3 bits: 623.9 E(85289): 4.3e-178
Smith-Waterman score: 4117; 100.0% identity (100.0% similar) in 579 aa overlap (1-579:1-579)
10 20 30 40 50 60
pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 KSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 CAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICID
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 GVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIAVE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 FASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 ASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFF
490 500 510 520 530 540
550 560 570
pF1KE5 IIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
:::::::::::::::::::::::::::::::::::::::
XP_011 IIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
550 560 570
>>XP_005273525 (OMIM: 601533) PREDICTED: disintegrin and (705 aa)
initn: 2988 init1: 2988 opt: 2990 Z-score: 2413.5 bits: 456.8 E(85289): 1.1e-127
Smith-Waterman score: 3220; 79.4% identity (79.4% similar) in 611 aa overlap (95-579:95-705)
70 80 90 100 110 120
pF1KE5 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS
::::::::::::::::::::::::::::::
XP_005 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS
70 80 90 100 110 120
130 140 150 160 170
pF1KE5 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVE-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHV
130 140 150 160 170 180
pF1KE5 ------------------------------------------------------------
XP_005 IVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEAN
190 200 210 220 230 240
pF1KE5 -----------------------------------------------------HPRTISL
:::::::
XP_005 ELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISL
250 260 270 280 290 300
180 190 200 210 220 230
pF1KE5 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS
310 320 330 340 350 360
240 250 260 270 280 290
pF1KE5 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG
370 380 390 400 410 420
300 310 320 330 340 350
pF1KE5 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC
430 440 450 460 470 480
360 370 380 390 400 410
pF1KE5 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIA
490 500 510 520 530 540
420 430 440 450 460 470
pF1KE5 VEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH
550 560 570 580 590 600
480 490 500 510 520 530
pF1KE5 CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIP
610 620 630 640 650 660
540 550 560 570
pF1KE5 FFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
:::::::::::::::::::::::::::::::::::::::::
XP_005 FFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
670 680 690 700
>--
initn: 635 init1: 635 opt: 635 Z-score: 524.9 bits: 107.4 E(85289): 1.7e-22
Smith-Waterman score: 635; 100.0% identity (100.0% similar) in 94 aa overlap (1-94:1-94)
10 20 30 40 50 60
pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
::::::::::::::::::::::::::::::::::
XP_005 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES
XP_005 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYI
130 140 150 160 170 180
>>XP_011542781 (OMIM: 601533) PREDICTED: disintegrin and (609 aa)
initn: 2903 init1: 2903 opt: 2930 Z-score: 2366.2 bits: 447.8 E(85289): 4.7e-125
Smith-Waterman score: 4047; 95.1% identity (95.1% similar) in 609 aa overlap (1-579:1-609)
10 20 30 40 50 60
pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 KSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 CAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICID
310 320 330 340 350 360
370 380 390 400 410
pF1KE5 GVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEAD--------
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLI
370 380 390 400 410 420
420 430 440 450
pF1KE5 ----------------------GHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRC
::::::::::::::::::::::::::::::::::::::
XP_011 CKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRC
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE5 VSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAI
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE5 PARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQ
550 560 570 580 590 600
pF1KE5 PESESEPKG
:::::::::
XP_011 PESESEPKG
>>NP_001265042 (OMIM: 601533) disintegrin and metallopro (716 aa)
initn: 2341 init1: 1774 opt: 1803 Z-score: 1461.6 bits: 280.7 E(85289): 1.1e-74
Smith-Waterman score: 3331; 78.6% identity (78.6% similar) in 641 aa overlap (76-579:76-716)
50 60 70 80 90 100
pF1KE5 SYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSV
::::::::::::::::::::::::::::::
NP_001 SYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSV
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE5 VMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSF
110 120 130 140 150 160
170
pF1KE5 KLQSVE------------------------------------------------------
::::::
NP_001 KLQSVEYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEAN
170 180 190 200 210 220
pF1KE5 -----------------------------------------------------HPRTISL
:::::::
NP_001 ELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISL
230 240 250 260 270 280
180 190 200 210 220 230
pF1KE5 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS
290 300 310 320 330 340
240 250 260 270 280 290
pF1KE5 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG
350 360 370 380 390 400
300 310 320 330 340 350
pF1KE5 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC
410 420 430 440 450 460
360 370 380 390 400 410
pF1KE5 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEAD------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGK
470 480 490 500 510 520
420 430 440
pF1KE5 ------------------------GHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQ
::::::::::::::::::::::::::::::::::::
NP_001 LICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQ
530 540 550 560 570 580
450 460 470 480 490 500
pF1KE5 RCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPV
590 600 610 620 630 640
510 520 530 540 550 560
pF1KE5 AIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD
650 660 670 680 690 700
570
pF1KE5 EQPESESEPKG
:::::::::::
NP_001 EQPESESEPKG
710
>--
initn: 492 init1: 492 opt: 492 Z-score: 410.2 bits: 86.1 E(85289): 4.1e-16
Smith-Waterman score: 492; 100.0% identity (100.0% similar) in 75 aa overlap (1-75:1-75)
10 20 30 40 50 60
pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
:::::::::::::::
NP_001 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
70 80 90 100 110 120
>>NP_001455 (OMIM: 601533) disintegrin and metalloprotei (735 aa)
initn: 2339 init1: 1774 opt: 1803 Z-score: 1461.4 bits: 280.7 E(85289): 1.2e-74
Smith-Waterman score: 3150; 75.7% identity (75.7% similar) in 641 aa overlap (95-579:95-735)
70 80 90 100 110 120
pF1KE5 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS
::::::::::::::::::::::::::::::
NP_001 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS
70 80 90 100 110 120
130 140 150 160 170
pF1KE5 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVE-------------
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHV
130 140 150 160 170 180
pF1KE5 ------------------------------------------------------------
NP_001 IVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEAN
190 200 210 220 230 240
pF1KE5 -----------------------------------------------------HPRTISL
:::::::
NP_001 ELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISL
250 260 270 280 290 300
180 190 200 210 220 230
pF1KE5 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS
310 320 330 340 350 360
240 250 260 270 280 290
pF1KE5 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG
370 380 390 400 410 420
300 310 320 330 340 350
pF1KE5 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC
430 440 450 460 470 480
360 370 380 390 400 410
pF1KE5 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEAD------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGK
490 500 510 520 530 540
420 430 440
pF1KE5 ------------------------GHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQ
::::::::::::::::::::::::::::::::::::
NP_001 LICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQ
550 560 570 580 590 600
450 460 470 480 490 500
pF1KE5 RCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPV
610 620 630 640 650 660
510 520 530 540 550 560
pF1KE5 AIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD
670 680 690 700 710 720
570
pF1KE5 EQPESESEPKG
:::::::::::
NP_001 EQPESESEPKG
730
>--
initn: 635 init1: 635 opt: 635 Z-score: 524.7 bits: 107.4 E(85289): 1.7e-22
Smith-Waterman score: 635; 100.0% identity (100.0% similar) in 94 aa overlap (1-94:1-94)
10 20 30 40 50 60
pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
::::::::::::::::::::::::::::::::::
NP_001 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES
NP_001 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYI
130 140 150 160 170 180
>>NP_001265043 (OMIM: 601533) disintegrin and metallopro (672 aa)
initn: 2118 init1: 1753 opt: 1801 Z-score: 1460.3 bits: 280.3 E(85289): 1.3e-74
Smith-Waterman score: 2909; 74.0% identity (74.0% similar) in 611 aa overlap (95-579:95-672)
70 80 90 100 110 120
pF1KE5 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS
::::::::::::::::::::::::::::::
NP_001 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS
70 80 90 100 110 120
130 140 150 160 170
pF1KE5 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVE-------------
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHV
130 140 150 160 170 180
pF1KE5 ------------------------------------------------------------
NP_001 IVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEAN
190 200 210 220 230 240
pF1KE5 -----------------------------------------------------HPRTISL
:::::::
NP_001 ELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISL
250 260 270 280 290 300
180 190 200 210 220 230
pF1KE5 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS
310 320 330 340 350 360
240 250 260 270 280 290
pF1KE5 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG
370 380 390 400 410 420
300 310 320 330 340 350
pF1KE5 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC
430 440 450 460 470 480
360 370 380 390 400 410
pF1KE5 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIA
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCE--------
490 500 510 520 530
420 430 440 450 460 470
pF1KE5 VEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH
:::::::::::::::::::::::::::::::::::
NP_001 -------------------------VCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH
540 550 560 570
480 490 500 510 520 530
pF1KE5 CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIP
580 590 600 610 620 630
540 550 560 570
pF1KE5 FFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
:::::::::::::::::::::::::::::::::::::::::
NP_001 FFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
640 650 660 670
>--
initn: 635 init1: 635 opt: 635 Z-score: 525.2 bits: 107.3 E(85289): 1.6e-22
Smith-Waterman score: 635; 100.0% identity (100.0% similar) in 94 aa overlap (1-94:1-94)
10 20 30 40 50 60
pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
::::::::::::::::::::::::::::::::::
NP_001 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES
NP_001 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYI
130 140 150 160 170 180
>>XP_011542984 (OMIM: 602713,612775) PREDICTED: disinteg (801 aa)
initn: 1253 init1: 464 opt: 780 Z-score: 640.6 bits: 128.9 E(85289): 6.1e-29
Smith-Waterman score: 980; 34.2% identity (62.3% similar) in 438 aa overlap (176-577:318-732)
150 160 170 180 190 200
pF1KE5 KKADVSLYNEKDIESRDLSFKLQSVEHPRTISLESLAVILAQLLSLSMGITYDDINKCQC
:..:..: :.:. :. ..:...:: :.:
XP_011 KKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSC
290 300 310 320 330 340
210 220 230 240 250 260
pF1KE5 SGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAK
.. :::: : :: . ::.:: ::: .. .. ..:: : :. : .. . :::
XP_011 GAKSCIMNSGA---SGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPS-CGNKL
350 360 370 380 390 400
270 280 290 300 310 320
pF1KE5 LEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEE
..::::::::: ..: : . ::. .::..:. ..:: : ::..: :. .:: . :
XP_011 VDAGEECDCGTPKECEL--DPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE
410 420 430 440 450 460
330 340 350 360 370 380
pF1KE5 CDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSEC
::.:::::::: : . ..:.:.:: :. : .:.:. : :: ::.... .:..:
XP_011 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC
470 480 490 500 510 520
390 400 410 420 430
pF1KE5 YSHLNSKTDVSGNCGISDSGYTQCEADGHLC---------------IAVEFASDHADSQK
. ..::: : ::::.: . : .: . . :: :. . . . . :
XP_011 FIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTK
530 540 550 560 570 580
440 450 460 470
pF1KE5 MW---------------IKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDK-CNDRGVCNNK
: ...::.::..:.::: .::..: :.::: ..: :. .::::..
XP_011 CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSN
590 600 610 620 630 640
480 490 500 510 520 530
pF1KE5 KHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFF
:.::: .. ::.: ... :::.::: : ... .. . . ::
XP_011 KNCHCENGWAPPNCETKGY---GGSVDSG-----------PTYNEMNTALRDGLLVF-FF
650 660 670 680
540 550 560 570
pF1KE5 LFIPFFIIFCVLIAIMVKVNFQR---KKWRTEDYSSD--EQPESESEPKG
:..: .: :... .. . .. : .: :.. : :: .: . .:
XP_011 LIVP--LIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTP
690 700 710 720 730 740
XP_011 PREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
750 760 770 780 790 800
>--
initn: 340 init1: 286 opt: 345 Z-score: 291.7 bits: 64.4 E(85289): 1.6e-09
Smith-Waterman score: 345; 35.2% identity (63.7% similar) in 193 aa overlap (13-198:15-203)
10 20 30 40 50
pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEG---IESQASYKIVIEGKP
:... :...: .: .: .. .:. .:.:: : :::
XP_011 MSLGKRLRDETFAAGFQQTSHLSSY--EIITPWRLTRERREAPRPYSKQVSYVIQAEGKE
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 YTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGL
. ..: . :..::..: ::.:. : . ..:: :::.::.:: .: . .: : ::
XP_011 HIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 RGVLQFENVSYGIEPLESSVGFEHVIYQVK--HKKADVSLYNEKDIESRDLSFKLQSVEH
::.:..::.:::::::..: :::.::.. .:. ..::::.. . : . :
XP_011 RGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKE--TAKDEEEEP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 PR-TISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFE
: : :. ..: : . . :. :
XP_011 PSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLN
180 190 200 210 220 230
>>NP_003807 (OMIM: 602713,612775) disintegrin and metall (819 aa)
initn: 1253 init1: 464 opt: 780 Z-score: 640.5 bits: 128.9 E(85289): 6.2e-29
Smith-Waterman score: 980; 34.2% identity (62.3% similar) in 438 aa overlap (176-577:336-750)
150 160 170 180 190 200
pF1KE5 KKADVSLYNEKDIESRDLSFKLQSVEHPRTISLESLAVILAQLLSLSMGITYDDINKCQC
:..:..: :.:. :. ..:...:: :.:
NP_003 KKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSC
310 320 330 340 350 360
210 220 230 240 250 260
pF1KE5 SGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAK
.. :::: : :: . ::.:: ::: .. .. ..:: : :. : .. . :::
NP_003 GAKSCIMNSGA---SGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPS-CGNKL
370 380 390 400 410 420
270 280 290 300 310 320
pF1KE5 LEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEE
..::::::::: ..: : . ::. .::..:. ..:: : ::..: :. .:: . :
NP_003 VDAGEECDCGTPKECEL--DPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE
430 440 450 460 470
330 340 350 360 370 380
pF1KE5 CDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSEC
::.:::::::: : . ..:.:.:: :. : .:.:. : :: ::.... .:..:
NP_003 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC
480 490 500 510 520 530
390 400 410 420 430
pF1KE5 YSHLNSKTDVSGNCGISDSGYTQCEADGHLC---------------IAVEFASDHADSQK
. ..::: : ::::.: . : .: . . :: :. . . . . :
NP_003 FIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTK
540 550 560 570 580 590
440 450 460 470
pF1KE5 MW---------------IKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDK-CNDRGVCNNK
: ...::.::..:.::: .::..: :.::: ..: :. .::::..
NP_003 CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSN
600 610 620 630 640 650
480 490 500 510 520 530
pF1KE5 KHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFF
:.::: .. ::.: ... :::.::: : ... .. . . ::
NP_003 KNCHCENGWAPPNCETKGY---GGSVDSG-----------PTYNEMNTALRDGLLVF-FF
660 670 680 690 700
540 550 560 570
pF1KE5 LFIPFFIIFCVLIAIMVKVNFQR---KKWRTEDYSSD--EQPESESEPKG
:..: .: :... .. . .. : .: :.. : :: .: . .:
NP_003 LIVP--LIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTP
710 720 730 740 750 760
NP_003 PREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
770 780 790 800 810
>--
initn: 340 init1: 286 opt: 352 Z-score: 297.2 bits: 65.4 E(85289): 8.1e-10
Smith-Waterman score: 352; 35.2% identity (62.4% similar) in 210 aa overlap (2-198:16-221)
10 20 30 40
pF1KE5 MWRVLFLLSG--LG----GLRMDSNFDSLPVQITVPEKIRSIIKEG
: .:. : : :: :... :...: .: .: .. .:.
NP_003 MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSY--EIITPWRLTRERREA
10 20 30 40 50
50 60 70 80 90
pF1KE5 ---IESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQG
.:.:: : ::: . ..: . :..::..: ::.:. : . ..:: :::.:
NP_003 PRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRG
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE5 YIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVK--HKKADVSLYN
:.:: .: . .: : ::::.:..::.:::::::..: :::.::.. .:. .
NP_003 YVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVS
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE5 EKDIESRDLSFKLQSVEHPR-TISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMN
.::::.. . : . : : : :. ..: : . . :. :
NP_003 NKDIEKE--TAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVR
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE5 PEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECD
NP_003 EEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRR
240 250 260 270 280 290
>>XP_016869431 (OMIM: 602713,612775) PREDICTED: disinteg (821 aa)
initn: 1253 init1: 464 opt: 780 Z-score: 640.5 bits: 128.9 E(85289): 6.2e-29
Smith-Waterman score: 980; 34.2% identity (62.3% similar) in 438 aa overlap (176-577:338-752)
150 160 170 180 190 200
pF1KE5 KKADVSLYNEKDIESRDLSFKLQSVEHPRTISLESLAVILAQLLSLSMGITYDDINKCQC
:..:..: :.:. :. ..:...:: :.:
XP_016 KKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSC
310 320 330 340 350 360
210 220 230 240 250 260
pF1KE5 SGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAK
.. :::: : :: . ::.:: ::: .. .. ..:: : :. : .. . :::
XP_016 GAKSCIMNSGA---SGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPS-CGNKL
370 380 390 400 410 420
270 280 290 300 310 320
pF1KE5 LEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEE
..::::::::: ..: : . ::. .::..:. ..:: : ::..: :. .:: . :
XP_016 VDAGEECDCGTPKECEL--DPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE
430 440 450 460 470 480
330 340 350 360 370 380
pF1KE5 CDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSEC
::.:::::::: : . ..:.:.:: :. : .:.:. : :: ::.... .:..:
XP_016 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC
490 500 510 520 530 540
390 400 410 420 430
pF1KE5 YSHLNSKTDVSGNCGISDSGYTQCEADGHLC---------------IAVEFASDHADSQK
. ..::: : ::::.: . : .: . . :: :. . . . . :
XP_016 FIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTK
550 560 570 580 590 600
440 450 460 470
pF1KE5 MW---------------IKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDK-CNDRGVCNNK
: ...::.::..:.::: .::..: :.::: ..: :. .::::..
XP_016 CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSN
610 620 630 640 650 660
480 490 500 510 520 530
pF1KE5 KHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFF
:.::: .. ::.: ... :::.::: : ... .. . . ::
XP_016 KNCHCENGWAPPNCETKGY---GGSVDSG-----------PTYNEMNTALRDGLLVF-FF
670 680 690 700
540 550 560 570
pF1KE5 LFIPFFIIFCVLIAIMVKVNFQR---KKWRTEDYSSD--EQPESESEPKG
:..: .: :... .. . .. : .: :.. : :: .: . .:
XP_016 LIVP--LIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTP
710 720 730 740 750 760
XP_016 PREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
770 780 790 800 810 820
>--
initn: 340 init1: 286 opt: 340 Z-score: 287.6 bits: 63.7 E(85289): 2.8e-09
Smith-Waterman score: 340; 39.0% identity (65.4% similar) in 159 aa overlap (44-198:67-223)
20 30 40 50 60 70
pF1KE5 LRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRV
:.:: : ::: . ..: . :..::..: :
XP_016 QQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVV
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE5 YSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLES
:.:. : . ..:: :::.::.:: .: . .: : ::::.:..::.:::::::..
XP_016 YTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQN
100 110 120 130 140 150
140 150 160 170 180
pF1KE5 SVGFEHVIYQVK--HKKADVSLYNEKDIESRDLSFKLQSVEHPR-TISLESLAVILAQLL
: :::.::.. .:. ..::::.. . : . : : : :. ..: :
XP_016 SSHFEHIIYRMDDVYKEPLKCGVSNKDIEKE--TAKDEEEEPPSMTQLLRRRRAVLPQTR
160 170 180 190 200 210
190 200 210 220 230 240
pF1KE5 SLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQP
. . :. :
XP_016 YVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLIN
220 230 240 250 260 270
>>XP_016870955 (OMIM: 602267) PREDICTED: disintegrin and (779 aa)
initn: 725 init1: 251 opt: 672 Z-score: 554.1 bits: 112.9 E(85289): 4e-24
Smith-Waterman score: 672; 30.3% identity (58.1% similar) in 370 aa overlap (181-530:393-745)
160 170 180 190 200
pF1KE5 SLYNEKDIESRDLSFKLQSVEHPRTISLESLAVILAQLLSLSMGITYDD-INKCQCS---
.: .:. .. ..:. .:. .. :.:.
XP_016 GTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERF
370 380 390 400 410 420
210 220 230 240 250 260
pF1KE5 -GAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAK
.. ::: .: : ..::.:: . :. . .: :: : : :. . ::::
XP_016 EAGRCIMAG-SIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGP-VCGNLF
430 440 450 460 470 480
270 280 290 300 310 320
pF1KE5 LEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEE
.: ::.:::: .:: . ::. .::.. :..::.: ::..: ..:::. .
XP_016 VERGEQCDCGPPEDCR---NRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDM
490 500 510 520 530
330 340 350 360 370 380
pF1KE5 CDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSEC
::: :.:.: :::. . ..: ::. . : .:.: . .:: .: . . :
XP_016 CDLEEFCDGRHPECPEDAFQENGTPCSGGY--CYNGACPTLAQQCQAFWGPGGQAAEESC
540 550 560 570 580 590
390 400 410 420 430
pF1KE5 YSHLNSKTDVSGNCGISD-----SGYTQCEADGH-----LCIA-VEFASDHADSQKMW-I
.:. :. .: : : ::.. . .::. : : :. . .
XP_016 FSY-----DILPGCKASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPV
600 610 620 630 640 650
440 450 460 470 480 490
pF1KE5 KDGTSCGSNKVCRNQRCVS-SSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCS-VQ
.:: :: .::: . :: . : . .:.. .:...::::.:..::: :.. :: :. .
XP_016 PEGTRCGPEKVCWKGRCQDLHVYRSSNCSA-QCHNHGVCNHKQECHCHAGWAPPHCAKLL
660 670 680 690 700
500 510 520 530 540 550
pF1KE5 SDLWPGGSIDSGNFPP-VAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIM
... . .. :: .. :: :. ...: .:.:
XP_016 TEVHAAPPRPGALRPPSISSPAAT-EHVVVQSI---RPQRHSRAHSTVAQGHPAKLSNLS
710 720 730 740 750 760
560 570
pF1KE5 VKVNFQRKKWRTEDYSSDEQPESESEPKG
XP_016 LASWECQCKVPGPP
770
579 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:45:34 2016 done: Tue Nov 8 05:45:35 2016
Total Scan time: 7.300 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]