Result of FASTA (omim) for
pFN21AE5673
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5673, 543 aa
1>>>pF1KE5673 543 - 543 aa - 543 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6318+/-0.000432; mu= 22.3726+/- 0.027
mean_var=63.6648+/-13.285, 0's: 0 Z-trim(109.8): 31 B-trim: 99 in 1/50
Lambda= 0.160740
statistics sampled from 18010 (18030) to 18010 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.211), width: 16
Scan time: 9.420
The best scores are: opt bits E(85289)
NP_000051 (OMIM: 253260,609019) biotinidase isofor ( 543) 3746 878.0 0
NP_001268652 (OMIM: 253260,609019) biotinidase iso ( 545) 3658 857.6 0
NP_001268653 (OMIM: 253260,609019) biotinidase iso ( 545) 3652 856.2 0
NP_001268654 (OMIM: 253260,609019) biotinidase iso ( 523) 3608 846.0 0
XP_011532343 (OMIM: 253260,609019) PREDICTED: biot ( 523) 3608 846.0 0
XP_016862577 (OMIM: 253260,609019) PREDICTED: biot ( 523) 3608 846.0 0
NP_001310511 (OMIM: 253260,609019) biotinidase iso ( 523) 3608 846.0 0
NP_001268655 (OMIM: 253260,609019) biotinidase iso ( 179) 1054 253.3 4.6e-67
NP_004657 (OMIM: 603570) pantetheinase precursor [ ( 513) 995 240.0 1.3e-62
XP_011534533 (OMIM: 603571) PREDICTED: vascular no ( 459) 990 238.8 2.7e-62
XP_016866896 (OMIM: 603571) PREDICTED: vascular no ( 520) 990 238.9 3e-62
NP_004656 (OMIM: 603571) vascular non-inflammatory ( 520) 990 238.9 3e-62
XP_006715656 (OMIM: 603571) PREDICTED: vascular no ( 467) 920 222.6 2.1e-57
NP_511043 (OMIM: 603571) vascular non-inflammatory ( 467) 920 222.6 2.1e-57
NP_001229279 (OMIM: 603571) vascular non-inflammat ( 299) 539 134.1 6.1e-31
NP_001278632 (OMIM: 606592) vascular non-inflammat ( 243) 364 93.4 8.6e-19
NP_001278631 (OMIM: 606592) vascular non-inflammat ( 243) 364 93.4 8.6e-19
XP_016866897 (OMIM: 603571) PREDICTED: vascular no ( 282) 203 56.1 1.7e-07
XP_016866898 (OMIM: 603571) PREDICTED: vascular no ( 282) 203 56.1 1.7e-07
>>NP_000051 (OMIM: 253260,609019) biotinidase isoform 3 (543 aa)
initn: 3746 init1: 3746 opt: 3746 Z-score: 4692.3 bits: 878.0 E(85289): 0
Smith-Waterman score: 3746; 100.0% identity (100.0% similar) in 543 aa overlap (1-543:1-543)
10 20 30 40 50 60
pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
490 500 510 520 530 540
pF1KE5 ERD
:::
NP_000 ERD
>>NP_001268652 (OMIM: 253260,609019) biotinidase isoform (545 aa)
initn: 3658 init1: 3658 opt: 3658 Z-score: 4582.0 bits: 857.6 E(85289): 0
Smith-Waterman score: 3658; 99.8% identity (100.0% similar) in 531 aa overlap (13-543:15-545)
10 20 30 40 50
pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYY
.:::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPEGGGTSRRLLPMQSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 VAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 NFTRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFTRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 CHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 RFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLA
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 ANVHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANVHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 SKFLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKFLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVC
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 SNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEA
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 TGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGR
490 500 510 520 530 540
540
pF1KE5 LYERD
:::::
NP_001 LYERD
>>NP_001268653 (OMIM: 253260,609019) biotinidase isoform (545 aa)
initn: 3652 init1: 3652 opt: 3652 Z-score: 4574.5 bits: 856.2 E(85289): 0
Smith-Waterman score: 3652; 99.8% identity (100.0% similar) in 530 aa overlap (14-543:16-545)
10 20 30 40 50
pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYY
.::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARKETQLIIKMNHLARFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 VAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 NFTRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFTRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 CHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 RFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLA
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 ANVHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANVHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 SKFLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKFLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVC
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 SNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEA
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 TGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGR
490 500 510 520 530 540
540
pF1KE5 LYERD
:::::
NP_001 LYERD
>>NP_001268654 (OMIM: 253260,609019) biotinidase isoform (523 aa)
initn: 3608 init1: 3608 opt: 3608 Z-score: 4519.6 bits: 846.0 E(85289): 0
Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 523 aa overlap (21-543:1-523)
10 20 30 40 50 60
pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
::::::::::::::::::::::::::::::::::::::::
NP_001 MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
10 20 30 40
70 80 90 100 110 120
pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
470 480 490 500 510 520
pF1KE5 ERD
:::
NP_001 ERD
>>XP_011532343 (OMIM: 253260,609019) PREDICTED: biotinid (523 aa)
initn: 3608 init1: 3608 opt: 3608 Z-score: 4519.6 bits: 846.0 E(85289): 0
Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 523 aa overlap (21-543:1-523)
10 20 30 40 50 60
pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
::::::::::::::::::::::::::::::::::::::::
XP_011 MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
10 20 30 40
70 80 90 100 110 120
pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
470 480 490 500 510 520
pF1KE5 ERD
:::
XP_011 ERD
>>XP_016862577 (OMIM: 253260,609019) PREDICTED: biotinid (523 aa)
initn: 3608 init1: 3608 opt: 3608 Z-score: 4519.6 bits: 846.0 E(85289): 0
Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 523 aa overlap (21-543:1-523)
10 20 30 40 50 60
pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
::::::::::::::::::::::::::::::::::::::::
XP_016 MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
10 20 30 40
70 80 90 100 110 120
pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
470 480 490 500 510 520
pF1KE5 ERD
:::
XP_016 ERD
>>NP_001310511 (OMIM: 253260,609019) biotinidase isoform (523 aa)
initn: 3608 init1: 3608 opt: 3608 Z-score: 4519.6 bits: 846.0 E(85289): 0
Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 523 aa overlap (21-543:1-523)
10 20 30 40 50 60
pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
::::::::::::::::::::::::::::::::::::::::
NP_001 MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
10 20 30 40
70 80 90 100 110 120
pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
470 480 490 500 510 520
pF1KE5 ERD
:::
NP_001 ERD
>>NP_001268655 (OMIM: 253260,609019) biotinidase isoform (179 aa)
initn: 1046 init1: 1046 opt: 1054 Z-score: 1324.9 bits: 253.3 E(85289): 4.6e-67
Smith-Waterman score: 1054; 93.5% identity (95.9% similar) in 170 aa overlap (1-167:1-170)
10 20 30 40 50 60
pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
70 80 90 100 110 120
130 140 150 160 170
pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQR--LSCMAI-RGDMFLVANLGTKE
::::::::::::::::::::::::::::::::::. :: . . :::.
NP_001 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVIPAFFLSRLRVHRGDLSQGPEAVTC
130 140 150 160 170
180 190 200 210 220 230
pF1KE5 PCHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFA
>>NP_004657 (OMIM: 603570) pantetheinase precursor [Homo (513 aa)
initn: 1146 init1: 611 opt: 995 Z-score: 1244.9 bits: 240.0 E(85289): 1.3e-62
Smith-Waterman score: 1323; 43.1% identity (72.0% similar) in 490 aa overlap (58-543:25-483)
30 40 50 60 70 80
pF1KE5 LALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQEALELMN
..:::::: .:: :. .::.::: :::
NP_004 MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMN
10 20 30 40 50
90 100 110 120 130 140
pF1KE5 QNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRWNPCLEPH
.:::: : . .::.. ..::: :::.:.:.::.: :.::.:. .:.:.: : :: . .
NP_004 RNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEV-NWIPCNNRN
60 70 80 90 100 110
150 160 170 180 190 200
pF1KE5 RFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVFSNNGTLV
::..: : .::::.: .....:::.: :.:: .:::.:: :::::.::.:::...: ::
NP_004 RFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLV
120 130 140 150 160 170
210 220 230 240 250 260
pF1KE5 DRYRKHNLYF-EAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRDYKVKHV
::.:.::.. : :.:: . ...::.: : : ::::::::::: :::. ...:..: .
NP_004 ARYHKQNLFMGENQFNVPKEPEIVTFNTTF-GSFGIFTCFDILFHDPAVTLVKDFHVDTI
180 190 200 210 220 230
270 280 290 300 310 320
pF1KE5 VYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESFWYH-DM
:.:::::: :: :.:.:...:.:... .: ::.:.:.: ::::::..: : .: ::
NP_004 VFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDM
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE5 ENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPYCEKDAQEVHCDEATK
.. ...:...:. .. :::: ... : :. . :: .
NP_004 KTEEGKLLLSQL---------------DSHPSHSA---VVNWTSY----ASSI---EALS
300 310 320
390 400 410 420 430 440
pF1KE5 WNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYE-RPTLSKELYALGVFD
.. :.. ...:.::.: . : : ::.. :::.: :. .. .:.::::.::
NP_004 ---SGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFD
330 340 350 360 370 380
450 460 470 480 490 500
pF1KE5 GLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFE-FHLWGNFSTSYIFPLFLTSG
:::::.: ::.:.:.:..: ...:::. :. :: : : :.:.:.:.:: : :
NP_004 GLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSE
390 400 410 420 430 440
510 520 530 540
pF1KE5 MTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD
: .: .. .: .. . :. ..:..:.:::::.:
NP_004 NQL-APGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIV
450 460 470 480 490 500
NP_004 IAPIVCSLSW
510
>>XP_011534533 (OMIM: 603571) PREDICTED: vascular non-in (459 aa)
initn: 921 init1: 381 opt: 990 Z-score: 1239.3 bits: 238.8 E(85289): 2.7e-62
Smith-Waterman score: 1184; 41.3% identity (71.4% similar) in 455 aa overlap (58-506:26-451)
30 40 50 60 70 80
pF1KE5 LALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQEALELMN
..:::::: :: . . .:...::.:::
XP_011 MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETPVSQEDALNLMN
10 20 30 40 50
90 100 110 120 130 140
pF1KE5 QNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRWNPCLEPH
.:.:: : . ::.. ..::: :::...:..::: ...:.:. .:.::: : :: .::
XP_011 ENIDILETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQV-NWIPCQDPH
60 70 80 90 100 110
150 160 170 180 190 200
pF1KE5 RFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVFSNNGTLV
::. : : ::::.: ......:::: :.::.: : :: .: .:.:::::....: ::
XP_011 RFGHTPVQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQYNTNVVYNTEGKLV
120 130 140 150 160 170
210 220 230 240 250 260
pF1KE5 DRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRDYKVKHVV
::.:..:: : :.:: : .:.::.: : :::::::::::.:.::.. ...:..: ..
XP_011 ARYHKYHLYSEPQFNVPEKPELVTFNTAF-GRFGIFTCFDIFFYDPGVTLVKDFHVDTIL
180 190 200 210 220 230
270 280 290 300 310 320
pF1KE5 YPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESFWYH-DME
.:::::: ::::.:::...:.:...:.:.:.::.:: :.::::::..: :: ::.
XP_011 FPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMK
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE5 NPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPY-CEKDAQEVHCDEATK
. ..:....: ..:.. .. .:.. . ... .: :. .:.
XP_011 TELGKLLLSEVDSHPLSSLAYPTAVNWN--AYATTIK-----PFPVQKN-----------
300 310 320 330
390 400 410 420 430 440
pF1KE5 WNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKE---LYALGV
::.. . :.:... .. . : : ::.. :::.: :. :.:: .:.::.
XP_011 -------TFRGFISRDGFNFTELFENAGNLTVCQKELCCHLSYR--MLQKEENEVYVLGA
340 350 360 370 380
450 460 470 480 490 500
pF1KE5 FDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFE-FHLWGNFSTSYIFPLFLT
: ::: . : :::.:..: .. :::. . :. :: : : :.:.: :.:: :
XP_011 FTGLHGRRRREYWQVCTLLKCKTTNLTTCGRPVETASTRFEMFSLSGTFGTEYVFPEVLL
390 400 410 420 430 440
510 520 530 540
pF1KE5 SGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD
. . :
XP_011 TEIHLSPGKFEQT
450
543 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:12:28 2016 done: Tue Nov 8 04:12:29 2016
Total Scan time: 9.420 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]