Result of FASTA (omim) for
pFN21AE5652
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5652, 505 aa
1>>>pF1KE5652 505 - 505 aa - 505 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6557+/-0.000442; mu= 16.2299+/- 0.027
mean_var=72.0308+/-14.192, 0's: 0 Z-trim(110.9): 169 B-trim: 436 in 1/53
Lambda= 0.151118
statistics sampled from 19135 (19308) to 19135 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.587), E-opt: 0.2 (0.226), width: 16
Scan time: 5.600
The best scores are: opt bits E(85289)
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 3375 745.5 8.1e-215
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 3091 683.6 3.4e-196
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 2949 652.6 6.5e-187
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1864 416.1 1.2e-115
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1841 411.1 4e-114
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 1841 411.1 4e-114
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1841 411.1 4e-114
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 1702 380.8 5.2e-105
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1620 363.0 1.5e-99
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 1595 357.4 5.2e-98
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 1428 321.1 5.3e-87
XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370) 1410 317.1 5.7e-86
XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370) 1410 317.1 5.7e-86
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1392 313.2 9.8e-85
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1392 313.2 9.8e-85
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 1345 302.9 1.3e-81
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 1327 299.0 1.9e-80
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 1300 293.1 1.2e-78
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 1292 291.4 3.7e-78
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 1292 291.4 3.8e-78
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 1292 291.4 3.8e-78
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 1292 291.4 4.1e-78
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 1291 291.2 4.4e-78
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 1285 289.9 1.2e-77
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 1279 288.6 2.9e-77
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 1279 288.6 2.9e-77
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 1261 284.6 4.2e-76
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 1261 284.6 4.2e-76
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 1220 275.7 2.2e-73
XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331) 1215 274.5 3.3e-73
XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331) 1215 274.5 3.3e-73
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 1204 272.2 2.6e-72
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 1198 270.9 6.6e-72
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 1164 263.5 1e-69
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 1164 263.5 1e-69
XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 1079 245.0 3.8e-64
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 1020 232.1 2.8e-60
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 1014 230.8 6.6e-60
NP_001243502 (OMIM: 118504,188890,600513) neuronal ( 451) 978 222.9 1.5e-57
XP_016883114 (OMIM: 118504,188890,600513) PREDICTE ( 451) 978 222.9 1.5e-57
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 960 219.0 2e-56
XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329) 915 209.1 1.6e-53
XP_011519494 (OMIM: 118509) PREDICTED: neuronal ac ( 316) 900 205.8 1.5e-52
XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412) 870 199.4 1.7e-50
NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 870 199.4 1.7e-50
XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401) 863 197.8 4.9e-50
XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440) 862 197.6 6.1e-50
XP_016877371 (OMIM: 118511,612001) PREDICTED: neur ( 441) 862 197.6 6.1e-50
XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332) 761 175.5 2e-43
XP_016877370 (OMIM: 118505,612052) PREDICTED: neur ( 245) 753 173.7 5.3e-43
>>NP_000734 (OMIM: 118503,612052) neuronal acetylcholine (505 aa)
initn: 3375 init1: 3375 opt: 3375 Z-score: 3977.6 bits: 745.5 E(85289): 8.1e-215
Smith-Waterman score: 3375; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505)
10 20 30 40 50 60
pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL
430 440 450 460 470 480
490 500
pF1KE5 WVFTLVCILGTAGLFLQPLMAREDA
:::::::::::::::::::::::::
NP_000 WVFTLVCILGTAGLFLQPLMAREDA
490 500
>>NP_001160166 (OMIM: 118503,612052) neuronal acetylchol (489 aa)
initn: 3091 init1: 3091 opt: 3091 Z-score: 3643.2 bits: 683.6 E(85289): 3.4e-196
Smith-Waterman score: 3091; 99.8% identity (99.8% similar) in 465 aa overlap (1-465:1-465)
10 20 30 40 50 60
pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL
::::::::::::::::::::::::::::::::::::::::::: :
NP_001 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEEQKAQEIQQLKRKEKST
430 440 450 460 470 480
490 500
pF1KE5 WVFTLVCILGTAGLFLQPLMAREDA
NP_001 ETSDQEPGL
>>XP_006720445 (OMIM: 118503,612052) PREDICTED: neuronal (438 aa)
initn: 2949 init1: 2949 opt: 2949 Z-score: 3476.6 bits: 652.6 E(85289): 6.5e-187
Smith-Waterman score: 2949; 100.0% identity (100.0% similar) in 438 aa overlap (68-505:1-438)
40 50 60 70 80 90
pF1KE5 LFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLK
::::::::::::::::::::::::::::::
XP_006 MSQLVKVDEVNQIMETNLWLKQIWNDYKLK
10 20 30
100 110 120 130 140 150
pF1KE5 WNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKS
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE5 SCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKH
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE5 DIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCI
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE5 SVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHT
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE5 MPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPC
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE5 QDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKA
340 350 360 370 380 390
460 470 480 490 500
pF1KE5 QNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
400 410 420 430
>>NP_004189 (OMIM: 606888) neuronal acetylcholine recept (494 aa)
initn: 2175 init1: 1832 opt: 1864 Z-score: 2197.4 bits: 416.1 E(85289): 1.2e-115
Smith-Waterman score: 2191; 67.9% identity (85.4% similar) in 471 aa overlap (35-500:34-488)
10 20 30 40 50 60
pF1KE5 PLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHF
:.:::..:: ::..:::: :::::: .::
NP_004 SKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 EVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLY
::...::..::::::::::::::..:::::::.:.: .: : : .::::.::::::::::
NP_004 EVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 NNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDK
:::::::::. ::::::::.: .:: ::::::::: .:.:.::::.:::..:::::.:::
NP_004 NNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 AKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFY
:.:::..:::.....:.::..:: :: : ::::::::::::::: :::::.::::::.::
NP_004 AEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 TINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLI
:::::::::.::::::::::::::::::::::::::::::::::::::::::::::.::.
NP_004 TINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 GEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRP---TS
::::::::::::::::.::::::.::::::::::: :::::::.:::.:..: : :
NP_004 GEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTR
310 320 330 340 350 360
370 380 390 400 410
pF1KE5 NEGNAQKPRPLYGAELSNLNCFSRAESKG--CKEGYPCQDGMCGYCHHRRIKISNFSANL
. :. :: : .: .:: ..: : . : .::. :: :.
NP_004 GTGSDAVPRGL-----------ARRPAKGKLASHGEPRHLKECFHCHK-----SNELATS
370 380 390 400
420 430 440 450 460 470
pF1KE5 TRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIF
: : . .. :. : :::....:.::..::::::..::.::..:::::::::.::.:
NP_004 KRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVF
410 420 430 440 450 460
480 490 500
pF1KE5 LWVFTLVCILGTAGLFLQPLMAREDA
:::: .::..::::::::::.
NP_004 LWVFIIVCVFGTAGLFLQPLLGNTGKS
470 480 490
>>XP_011542690 (OMIM: 118502,610353) PREDICTED: neuronal (529 aa)
initn: 1864 init1: 1602 opt: 1841 Z-score: 2169.8 bits: 411.1 E(85289): 4e-114
Smith-Waterman score: 1842; 56.7% identity (76.1% similar) in 506 aa overlap (14-501:33-526)
10 20 30
pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL
::: : : :.: .:.: ::
XP_011 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW
:..::. ::. ::: :.:: ::..: .:..::. ::: ::.: ::.:::: :.::::.:
XP_011 FKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRW
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS
::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.:::
XP_011 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD
:.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : ..
XP_011 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS
::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.:::::
XP_011 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM
::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.::::
XP_011 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM
310 320 330 340 350 360
340 350 360 370 380
pF1KE5 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK
: ::. ..:. .:: ..:.:: . : : : ::.. : :..
XP_011 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE5 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI
:. : .:.. : : ..:. ...:.:. . : ::....:.
XP_011 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL
430 440 450 460 470
450 460 470 480 490 500
pF1KE5 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..:
XP_011 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
480 490 500 510 520
>>NP_000733 (OMIM: 118502,610353) neuronal acetylcholine (529 aa)
initn: 1864 init1: 1602 opt: 1841 Z-score: 2169.8 bits: 411.1 E(85289): 4e-114
Smith-Waterman score: 1842; 56.7% identity (76.1% similar) in 506 aa overlap (14-501:33-526)
10 20 30
pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL
::: : : :.: .:.: ::
NP_000 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW
:..::. ::. ::: :.:: ::..: .:..::. ::: ::.: ::.:::: :.::::.:
NP_000 FKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRW
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS
::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.:::
NP_000 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD
:.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : ..
NP_000 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS
::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.:::::
NP_000 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM
::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.::::
NP_000 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM
310 320 330 340 350 360
340 350 360 370 380
pF1KE5 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK
: ::. ..:. .:: ..:.:: . : : : ::.. : :..
NP_000 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE5 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI
:. : .:.. : : ..:. ...:.:. . : ::....:.
NP_000 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL
430 440 450 460 470
450 460 470 480 490 500
pF1KE5 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..:
NP_000 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
480 490 500 510 520
>>XP_006716345 (OMIM: 118502,610353) PREDICTED: neuronal (529 aa)
initn: 1864 init1: 1602 opt: 1841 Z-score: 2169.8 bits: 411.1 E(85289): 4e-114
Smith-Waterman score: 1842; 56.7% identity (76.1% similar) in 506 aa overlap (14-501:33-526)
10 20 30
pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL
::: : : :.: .:.: ::
XP_006 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW
:..::. ::. ::: :.:: ::..: .:..::. ::: ::.: ::.:::: :.::::.:
XP_006 FKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRW
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS
::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.:::
XP_006 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD
:.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : ..
XP_006 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS
::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.:::::
XP_006 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM
::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.::::
XP_006 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM
310 320 330 340 350 360
340 350 360 370 380
pF1KE5 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK
: ::. ..:. .:: ..:.:: . : : : ::.. : :..
XP_006 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE5 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI
:. : .:.. : : ..:. ...:.:. . : ::....:.
XP_006 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL
430 440 450 460 470
450 460 470 480 490 500
pF1KE5 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..:
XP_006 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
480 490 500 510 520
>>NP_001269384 (OMIM: 118502,610353) neuronal acetylchol (514 aa)
initn: 1810 init1: 1464 opt: 1702 Z-score: 2006.3 bits: 380.8 E(85289): 5.2e-105
Smith-Waterman score: 1762; 55.5% identity (73.7% similar) in 506 aa overlap (14-501:33-511)
10 20 30
pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL
::: : : :.: .:.: ::
NP_001 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW
:..::. ::. ::: :.:: ::: ::.: ::.:::: :.::::.:
NP_001 FKHLFRGYNRWARPVPNTSD---------------VDEKNQMMTTNVWLKQEWSDYKLRW
70 80 90 100
100 110 120 130 140 150
pF1KE5 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS
::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.:::
NP_001 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS
110 120 130 140 150 160
160 170 180 190 200 210
pF1KE5 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD
:.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : ..
NP_001 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE5 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS
::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.:::::
NP_001 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE5 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM
::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.::::
NP_001 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM
290 300 310 320 330 340
340 350 360 370 380
pF1KE5 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK
: ::. ..:. .:: ..:.:: . : : : ::.. : :..
NP_001 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR
350 360 370 380 390 400
390 400 410 420 430 440
pF1KE5 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI
:. : .:.. : : ..:. ...:.:. . : ::....:.
NP_001 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL
410 420 430 440 450
450 460 470 480 490 500
pF1KE5 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..:
NP_001 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
460 470 480 490 500 510
>>NP_000735 (OMIM: 118504,188890,600513) neuronal acetyl (627 aa)
initn: 1909 init1: 1592 opt: 1620 Z-score: 1908.3 bits: 363.0 E(85289): 1.5e-99
Smith-Waterman score: 1620; 66.1% identity (83.6% similar) in 360 aa overlap (12-368:11-370)
10 20 30 40 50
pF1KE5 MGSGPLSLPLALSPPRLLLL---LLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVS
: :: :::: :: . : ..::.::...:: ::. :::::.:
NP_000 MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANIS
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 DPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIW
: :...: .:..::. ::: ::.: ::.:.:: :.::::.:.:.:: .. .:.:.. ::
NP_000 DVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIW
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 KPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKF
.::::::::: ::: : ::: : . :.: : ::::.::::.::::.:::: :::::::
NP_000 RPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 GSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYI
:::.::::::::: . : .. :.::::::.:. : : . ::.:: ::::::::.. :
NP_000 GSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVI
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 RRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPST
::::::::::::::::::: ::::::::::.::::.:::::::::::::::.::: ::::
NP_000 RRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPST
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 SLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMT
::::::::::::::::::::::::::::::::.:.: :::::.::. :::...::...:
NP_000 SLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMK
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE5 RPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSA
::. . : ..
NP_000 RPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPG
360 370 380 390 400 410
>--
initn: 324 init1: 278 opt: 284 Z-score: 334.2 bits: 71.7 E(85289): 7.1e-12
Smith-Waterman score: 284; 40.6% identity (66.4% similar) in 128 aa overlap (374-501:508-624)
350 360 370 380 390 400
pF1KE5 TVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCG
:: :.. : : :: . ::. :
NP_000 VEGGVRCRSRSIQYCVPRDDAAPEADGQAAGA-LASRNTHS-AELPPPDQPSPCK---CT
480 490 500 510 520 530
410 420 430 440 450 460
pF1KE5 YCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKE
:... ..: .. :::... ::: . .:...:.:::...::..
NP_000 -CKKEPSSVSPSATVKTRSTKAPPPHL-----PLSPALTRAVEGVQYIADHLKAEDTDFS
540 550 560 570 580
470 480 490 500
pF1KE5 IQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
...:::::::::::::::.: .::.:::.:::: : .:
NP_000 VKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
590 600 610 620
>>NP_001186208 (OMIM: 606888) neuronal acetylcholine rec (479 aa)
initn: 2069 init1: 1563 opt: 1595 Z-score: 1880.7 bits: 357.4 E(85289): 5.2e-98
Smith-Waterman score: 2059; 65.2% identity (82.2% similar) in 471 aa overlap (35-500:34-473)
10 20 30 40 50 60
pF1KE5 PLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHF
:.:::..:: ::..:::: :::::: .::
NP_001 SKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 EVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLY
::...::..: :::::::.:.: .: : : .::::.::::::::::
NP_001 EVAITQLANV---------------IWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLY
70 80 90 100
130 140 150 160 170 180
pF1KE5 NNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDK
:::::::::. ::::::::.: .:: ::::::::: .:.:.::::.:::..:::::.:::
NP_001 NNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDK
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE5 AKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFY
:.:::..:::.....:.::..:: :: : ::::::::::::::: :::::.::::::.::
NP_001 AEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFY
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE5 TINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLI
:::::::::.::::::::::::::::::::::::::::::::::::::::::::::.::.
NP_001 TINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLV
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE5 GEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRP---TS
::::::::::::::::.::::::.::::::::::: :::::::.:::.:..: : :
NP_001 GEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTR
290 300 310 320 330 340
370 380 390 400 410
pF1KE5 NEGNAQKPRPLYGAELSNLNCFSRAESKG--CKEGYPCQDGMCGYCHHRRIKISNFSANL
. :. :: : .: .:: ..: : . : .::. :: :.
NP_001 GTGSDAVPRGL-----------ARRPAKGKLASHGEPRHLKECFHCHK-----SNELATS
350 360 370 380 390
420 430 440 450 460 470
pF1KE5 TRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIF
: : . .. :. : :::....:.::..::::::..::.::..:::::::::.::.:
NP_001 KRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVF
400 410 420 430 440 450
480 490 500
pF1KE5 LWVFTLVCILGTAGLFLQPLMAREDA
:::: .::..::::::::::.
NP_001 LWVFIIVCVFGTAGLFLQPLLGNTGKS
460 470
505 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 10:37:58 2016 done: Tue Nov 8 10:37:59 2016
Total Scan time: 5.600 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]