Result of FASTA (omim) for
pFN21AE5645
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5645, 480 aa
1>>>pF1KE5645 480 - 480 aa - 480 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5960+/-0.000344; mu= 7.1210+/- 0.022
mean_var=119.3318+/-24.242, 0's: 0 Z-trim(118.4): 61 B-trim: 289 in 1/49
Lambda= 0.117408
statistics sampled from 31252 (31313) to 31252 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.367), width: 16
Scan time: 7.850
The best scores are: opt bits E(85289)
NP_001193631 (OMIM: 604585) nuclear autoantigen Sp ( 480) 3213 555.2 1.5e-157
NP_001193630 (OMIM: 604585) nuclear autoantigen Sp ( 688) 3195 552.2 1.7e-156
NP_003104 (OMIM: 604585) nuclear autoantigen Sp-10 ( 879) 3195 552.2 2.1e-156
NP_001073860 (OMIM: 604585) nuclear autoantigen Sp ( 885) 3195 552.2 2.1e-156
NP_001193633 (OMIM: 604585) nuclear autoantigen Sp ( 445) 2962 512.6 8.7e-145
NP_001193632 (OMIM: 604585) nuclear autoantigen Sp ( 452) 2934 507.9 2.4e-143
XP_005246312 (OMIM: 608602) PREDICTED: nuclear bod ( 817) 480 92.3 5.4e-18
XP_016858732 (OMIM: 608602) PREDICTED: nuclear bod ( 830) 479 92.2 6.1e-18
XP_005246309 (OMIM: 608602) PREDICTED: nuclear bod ( 864) 479 92.2 6.4e-18
XP_016858734 (OMIM: 608602) PREDICTED: nuclear bod ( 814) 478 92.0 6.8e-18
NP_001265382 (OMIM: 608602) nuclear body protein S ( 753) 477 91.8 7.1e-18
XP_011508820 (OMIM: 608602) PREDICTED: nuclear bod ( 847) 469 90.5 2e-17
XP_011508819 (OMIM: 608602) PREDICTED: nuclear bod ( 847) 469 90.5 2e-17
XP_011508818 (OMIM: 608602) PREDICTED: nuclear bod ( 858) 469 90.5 2e-17
XP_016858741 (OMIM: 608602) PREDICTED: nuclear bod ( 756) 468 90.3 2.1e-17
NP_009168 (OMIM: 608602) nuclear body protein SP14 ( 867) 469 90.5 2.1e-17
XP_006712286 (OMIM: 608602) PREDICTED: nuclear bod ( 867) 469 90.5 2.1e-17
XP_016858737 (OMIM: 608602) PREDICTED: nuclear bod ( 803) 465 89.8 3.1e-17
XP_011508817 (OMIM: 608602) PREDICTED: nuclear bod ( 861) 465 89.8 3.3e-17
XP_016858728 (OMIM: 608602) PREDICTED: nuclear bod ( 858) 463 89.5 4.1e-17
XP_005246313 (OMIM: 608602) PREDICTED: nuclear bod ( 806) 460 88.9 5.6e-17
XP_005246311 (OMIM: 608602) PREDICTED: nuclear bod ( 833) 460 88.9 5.7e-17
NP_001265380 (OMIM: 608602) nuclear body protein S ( 840) 460 88.9 5.8e-17
XP_016858730 (OMIM: 608602) PREDICTED: nuclear bod ( 834) 454 87.9 1.2e-16
XP_011508821 (OMIM: 608602) PREDICTED: nuclear bod ( 840) 454 87.9 1.2e-16
XP_016858740 (OMIM: 608602) PREDICTED: nuclear bod ( 760) 453 87.7 1.2e-16
XP_016858739 (OMIM: 608602) PREDICTED: nuclear bod ( 777) 453 87.7 1.2e-16
XP_016858738 (OMIM: 608602) PREDICTED: nuclear bod ( 780) 453 87.7 1.2e-16
XP_016858736 (OMIM: 608602) PREDICTED: nuclear bod ( 804) 453 87.8 1.3e-16
NP_001265381 (OMIM: 608602) nuclear body protein S ( 807) 453 87.8 1.3e-16
XP_016858735 (OMIM: 608602) PREDICTED: nuclear bod ( 811) 453 87.8 1.3e-16
XP_016858733 (OMIM: 608602) PREDICTED: nuclear bod ( 821) 453 87.8 1.3e-16
XP_016858731 (OMIM: 608602) PREDICTED: nuclear bod ( 832) 453 87.8 1.3e-16
XP_016858729 (OMIM: 608602) PREDICTED: nuclear bod ( 835) 453 87.8 1.3e-16
XP_011508822 (OMIM: 608602) PREDICTED: nuclear bod ( 838) 453 87.8 1.3e-16
XP_005246310 (OMIM: 608602) PREDICTED: nuclear bod ( 841) 453 87.8 1.3e-16
NP_001171944 (OMIM: 235550,604457,607948) sp110 nu ( 555) 423 82.6 3.1e-15
XP_006712552 (OMIM: 235550,604457,607948) PREDICTE ( 648) 423 82.6 3.5e-15
XP_011509393 (OMIM: 235550,604457,607948) PREDICTE ( 672) 423 82.6 3.6e-15
XP_006712550 (OMIM: 235550,604457,607948) PREDICTE ( 695) 423 82.6 3.8e-15
XP_005246582 (OMIM: 235550,604457,607948) PREDICTE ( 719) 423 82.7 3.9e-15
XP_016859457 (OMIM: 235550,604457,607948) PREDICTE ( 745) 423 82.7 4e-15
XP_011509390 (OMIM: 235550,604457,607948) PREDICTE ( 745) 423 82.7 4e-15
XP_011509391 (OMIM: 235550,604457,607948) PREDICTE ( 739) 418 81.8 7.1e-15
NP_004501 (OMIM: 235550,604457,607948) sp110 nucle ( 549) 413 80.9 9.8e-15
NP_004500 (OMIM: 235550,604457,607948) sp110 nucle ( 689) 413 81.0 1.2e-14
NP_536349 (OMIM: 235550,604457,607948) sp110 nucle ( 713) 413 81.0 1.2e-14
XP_016859458 (OMIM: 235550,604457,607948) PREDICTE ( 505) 399 78.5 4.7e-14
XP_011509392 (OMIM: 235550,604457,607948) PREDICTE ( 695) 399 78.6 6.3e-14
XP_016859459 (OMIM: 235550,604457,607948) PREDICTE ( 482) 394 77.7 8.1e-14
>>NP_001193631 (OMIM: 604585) nuclear autoantigen Sp-100 (480 aa)
initn: 3213 init1: 3213 opt: 3213 Z-score: 2949.6 bits: 555.2 E(85289): 1.5e-157
Smith-Waterman score: 3213; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480)
10 20 30 40 50 60
pF1KE5 MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 GALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
430 440 450 460 470 480
>>NP_001193630 (OMIM: 604585) nuclear autoantigen Sp-100 (688 aa)
initn: 3261 init1: 3195 opt: 3195 Z-score: 2930.6 bits: 552.2 E(85289): 1.7e-156
Smith-Waterman score: 3195; 99.6% identity (100.0% similar) in 479 aa overlap (1-479:1-479)
10 20 30 40 50 60
pF1KE5 MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 GALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::..
NP_001 GALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGSQP
430 440 450 460 470 480
NP_001 QEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
490 500 510 520 530 540
>>NP_003104 (OMIM: 604585) nuclear autoantigen Sp-100 is (879 aa)
initn: 3261 init1: 3195 opt: 3195 Z-score: 2928.9 bits: 552.2 E(85289): 2.1e-156
Smith-Waterman score: 3195; 99.6% identity (100.0% similar) in 479 aa overlap (1-479:1-479)
10 20 30 40 50 60
pF1KE5 MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 GALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::..
NP_003 GALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGSQP
430 440 450 460 470 480
NP_003 QEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
490 500 510 520 530 540
>>NP_001073860 (OMIM: 604585) nuclear autoantigen Sp-100 (885 aa)
initn: 3261 init1: 3195 opt: 3195 Z-score: 2928.9 bits: 552.2 E(85289): 2.1e-156
Smith-Waterman score: 3195; 99.6% identity (100.0% similar) in 479 aa overlap (1-479:1-479)
10 20 30 40 50 60
pF1KE5 MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 GALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::..
NP_001 GALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGSQP
430 440 450 460 470 480
NP_001 QEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
490 500 510 520 530 540
>>NP_001193633 (OMIM: 604585) nuclear autoantigen Sp-100 (445 aa)
initn: 2962 init1: 2962 opt: 2962 Z-score: 2720.4 bits: 512.6 E(85289): 8.7e-145
Smith-Waterman score: 2962; 100.0% identity (100.0% similar) in 444 aa overlap (37-480:2-445)
10 20 30 40 50 60
pF1KE5 DLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISN
::::::::::::::::::::::::::::::
NP_001 MMFTEDQGVDDRLLYDIVFKHFKRNKVEISN
10 20 30
70 80 90 100 110 120
pF1KE5 AIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE5 SDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTW
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE5 PPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE5 SCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSK
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE5 VECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPLESNDEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPLESNDEK
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE5 EGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSK
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE5 HGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
400 410 420 430 440
>>NP_001193632 (OMIM: 604585) nuclear autoantigen Sp-100 (452 aa)
initn: 2621 init1: 2621 opt: 2934 Z-score: 2694.6 bits: 507.9 E(85289): 2.4e-143
Smith-Waterman score: 2940; 94.2% identity (94.2% similar) in 480 aa overlap (1-480:1-452)
10 20 30 40 50 60
pF1KE5 MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRN
::::::::::: ::::::::::::::::::::::::
NP_001 MAGGGGDLSTR-------------------------MFTEDQGVDDRLLYDIVFKHFKRN
10 20 30
70 80 90 100 110 120
pF1KE5 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE5 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE5 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE5 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE5 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE5 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE5 GALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GALRSKH---APMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
400 410 420 430 440 450
>>XP_005246312 (OMIM: 608602) PREDICTED: nuclear body pr (817 aa)
initn: 556 init1: 406 opt: 480 Z-score: 444.1 bits: 92.3 E(85289): 5.4e-18
Smith-Waterman score: 483; 33.8% identity (59.1% similar) in 352 aa overlap (40-374:29-357)
10 20 30 40 50 60
pF1KE5 TRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIK
: :...... . .:. :..:::::..::
XP_005 MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENKVEIASAIT
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 KTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDV
. :::: :::::..:...:.: :.. :::::: ::.: :::::::::. :::::: .
XP_005 RPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSELEKTFGWSHLEALFSRI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 NMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTWPPS
:.. :::: .::..:.:: ... ::: .. .. :.: : : : :::
XP_005 NLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRL---LPYGKQENSNACHEMDDI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 GSPSHAGTTPP--ENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTE-
. :..: .. : : :.: . : ::. : : .: .: : . :
XP_005 AVPQEALSSSPRCEPGFSSESC--EQL-ALPKAGGGDAED-----------APSLLPGGG
180 190 200 210 220
250 260 270 280 290 300
pF1KE5 -SCEQIAVQVNNGDAGREMPCPLPCDEESP----EAELHNHG-IQINSCSVRLVDIKKEK
:: ..:.:...:.. .::: :: : : .. :.: . . : :. . :.
XP_005 VSC-KLAIQIDEGES-EEMPKLLPYDTEETFDLKTPQVTNEGEPEKGLC---LLPGEGEE
230 240 250 260 270
310 320 330 340 350
pF1KE5 PFSNSKVECQAQ----ARTHHNQASDIIVISSED----SEGSTDVDEPLEVFISAPRSEP
.. . :... : . . ... .:.: . :. :: : .: .:
XP_005 GSDDCSEMCDGEEPQEASSSLARCGSVSCLSAETFDLKTPQVTNEGEP-EKELSLLPGEG
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE5 VINNDNPLESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEE
..:. : : .: :::. :
XP_005 EEGSDDCSEMCDGEERQEASSSLARRGSVSSELENHPMNEEGESEELASSLLYDNVPGAE
340 350 360 370 380 390
>>XP_016858732 (OMIM: 608602) PREDICTED: nuclear body pr (830 aa)
initn: 556 init1: 406 opt: 479 Z-score: 443.0 bits: 92.2 E(85289): 6.1e-18
Smith-Waterman score: 500; 31.9% identity (54.4% similar) in 439 aa overlap (40-476:29-376)
10 20 30 40 50 60
pF1KE5 TRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIK
: :...... . .:. :..:::::..::
XP_016 MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENKVEIASAIT
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 KTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDV
. :::: :::::..:...:.: :.. :::::: ::.: :::::::::. :::::: .
XP_016 RPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSELEKTFGWSHLEALFSRI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 NMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTWPPS
:.. :::: .::..:.:: ... ::: .. .. :.: : : : :::
XP_016 NLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRL---LPYGKQENSNACHEMDDI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 GSPSHAGTTPP--ENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTES
. :..: .. : : :.: . : ::. : : .: .: : . :. :
XP_016 AVPQEALSSSPRCEPGFSSESC--EQL-ALPKAGGGDAED-----------APSLLPV-S
180 190 200 210 220
250 260 270 280 290 300
pF1KE5 CEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKV
: ..:.:...:.. .::: :: : : :...:. : . .:..
XP_016 C-KLAIQIDEGES-EEMPKLLPYDTEV----LESNGM-----------IDAARTYSTAPG
230 240 250 260
310 320 330 340 350 360
pF1KE5 ECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPLESNDEKE
: :.. . ... . ..:.: . : :.. ... .: .: : :
XP_016 EKQGEEEGRNSPRK-----RNQDKEKYQESPEG--------RDKETFDLKTPQVTN-EGE
270 280 290 300
370 380 390 400 410 420
pF1KE5 GQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKH
... : : : :.: : :: . : : ::::. :
XP_016 PEKGLCLLPGEGEE-------------------GSD-DCSEMCDGEEPQEASSSLARC--
310 320 330 340
430 440 450 460 470 480
pF1KE5 GEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED
: .. :.: :.. .::: ::. :: ::::
XP_016 GSEG--------------------SDDCSEMCDGEERQEASSSLARRGSVSSELENHPMN
350 360 370 380
XP_016 EEGESEELASSLLYDNVPGAEQSAYENEKCSCVMCFSEEVPGSPEARTESDQACGTMDTV
390 400 410 420 430 440
>>XP_005246309 (OMIM: 608602) PREDICTED: nuclear body pr (864 aa)
initn: 556 init1: 406 opt: 479 Z-score: 442.8 bits: 92.2 E(85289): 6.4e-18
Smith-Waterman score: 518; 31.3% identity (55.4% similar) in 451 aa overlap (40-476:29-410)
10 20 30 40 50 60
pF1KE5 TRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIK
: :...... . .:. :..:::::..::
XP_005 MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENKVEIASAIT
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 KTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDV
. :::: :::::..:...:.: :.. :::::: ::.: :::::::::. :::::: .
XP_005 RPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSELEKTFGWSHLEALFSRI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 NMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTWPPS
:.. :::: .::..:.:: ... ::: .. .. :.: : : : :::
XP_005 NLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRL---LPYGKQENSNACHEMDDI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 GSPSHAGTTPP--ENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTES
. :..: .. : : :.: . : ::. : : .: .: : . :. :
XP_005 AVPQEALSSSPRCEPGFSSESC--EQL-ALPKAGGGDAED-----------APSLLPV-S
180 190 200 210 220
250 260 270 280 290 300
pF1KE5 CEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKV
: ..:.:...:.. .::: :: : : :...:. : . .:..
XP_005 C-KLAIQIDEGES-EEMPKLLPYDTEV----LESNGM-----------IDAARTYSTAPG
230 240 250 260
310 320 330 340 350 360
pF1KE5 ECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPLESNDEKE
: :.. . ... . ..:.: . : :.. ... .: .: : :
XP_005 EKQGEEEGRNSPRK-----RNQDKEKYQESPEG--------RDKETFDLKTPQVTN-EGE
270 280 290 300
370 380 390 400 410 420
pF1KE5 GQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASS-----GA
... : : : :.: : :: . : : :::: :.
XP_005 PEKGLCLLPGEGEE-------------------GSD-DCSEMCDGEEPQEASSSLARCGS
310 320 330 340
430 440 450 460 470
pF1KE5 LRSKHGEKAPMTSRSTSTWRIPSRKRRF-------SSSDFSDLSNGEELQETCSSSLRRG
. .: . . .... : .. . .:.: :.. .::: ::. :: :::
XP_005 VSCLSAETFDLKTPQVTNEGEPEKELSLLPGEGEEGSDDCSEMCDGEERQEASSSLARRG
350 360 370 380 390 400
480
pF1KE5 SGKED
:
XP_005 SVSSELENHPMNEEGESEELASSLLYDNVPGAEQSAYENEKCSCVMCFSEEVPGSPEART
410 420 430 440 450 460
>>XP_016858734 (OMIM: 608602) PREDICTED: nuclear body pr (814 aa)
initn: 556 init1: 406 opt: 478 Z-score: 442.3 bits: 92.0 E(85289): 6.8e-18
Smith-Waterman score: 490; 34.0% identity (59.7% similar) in 350 aa overlap (40-374:29-354)
10 20 30 40 50 60
pF1KE5 TRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIK
: :...... . .:. :..:::::..::
XP_016 MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENKVEIASAIT
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 KTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDV
. :::: :::::..:...:.: :.. :::::: ::.: :::::::::. :::::: .
XP_016 RPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSELEKTFGWSHLEALFSRI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 NMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTWPPS
:.. :::: .::..:.:: ... ::: .. .. :.: : : : :::
XP_016 NLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRL---LPYGKQENSNACHEMDDI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 GSPSHAGTTPP--ENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTES
. :..: .. : : :.: . : ::. : : .: .: : . :. :
XP_016 AVPQEALSSSPRCEPGFSSESC--EQL-ALPKAGGGDAED-----------APSLLPV-S
180 190 200 210 220
250 260 270 280 290 300
pF1KE5 CEQIAVQVNNGDAGREMPCPLPCDEESP----EAELHNHG-IQINSCSVRLVDIKKEKPF
: ..:.:...:.. .::: :: : : .. :.: . . : :. . :.
XP_016 C-KLAIQIDEGES-EEMPKLLPYDTEETFDLKTPQVTNEGEPEKGLC---LLPGEGEEGS
230 240 250 260 270
310 320 330 340 350
pF1KE5 SNSKVECQAQ----ARTHHNQASDIIVISSED----SEGSTDVDEPLEVFISAPRSEPVI
.. . :... : . . ... .:.: . :. :: : .: .:
XP_016 DDCSEMCDGEEPQEASSSLARCGSVSCLSAETFDLKTPQVTNEGEP-EKELSLLPGEGEE
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE5 NNDNPLESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEA
..:. : : .: :::. :
XP_016 GSDDCSEMCDGEERQEASSSLARRGSVSSELENHPMNEEGESEELASSLLYDNVPGAEQS
340 350 360 370 380 390
480 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:30:11 2016 done: Tue Nov 8 05:30:12 2016
Total Scan time: 7.850 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]