Result of FASTA (omim) for
pFN21AE5641
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5641, 583 aa
1>>>pF1KE5641 583 - 583 aa - 583 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2345+/-0.000482; mu= 19.6844+/- 0.030
mean_var=90.8779+/-18.399, 0's: 0 Z-trim(110.0): 421 B-trim: 59 in 1/49
Lambda= 0.134538
statistics sampled from 17806 (18271) to 17806 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.587), E-opt: 0.2 (0.214), width: 16
Scan time: 8.880
The best scores are: opt bits E(85289)
NP_002824 (OMIM: 600768) tyrosine-protein phosphat ( 593) 3908 769.7 0
NP_001193768 (OMIM: 176891,600263) receptor-type t (1448) 657 139.0 1e-31
XP_005250576 (OMIM: 176891,600263) PREDICTED: rece (2308) 657 139.2 1.4e-31
NP_001193767 (OMIM: 176891,600263) receptor-type t (1455) 638 135.4 1.3e-30
XP_016867966 (OMIM: 176891,600263) PREDICTED: rece (2301) 638 135.6 1.8e-30
NP_002842 (OMIM: 176891,600263) receptor-type tyro (2315) 638 135.6 1.8e-30
XP_016862453 (OMIM: 176886) PREDICTED: receptor-ty (1329) 592 126.4 5.9e-28
XP_005265410 (OMIM: 176886) PREDICTED: receptor-ty (1416) 592 126.4 6.2e-28
NP_002832 (OMIM: 176886) receptor-type tyrosine-pr (1445) 592 126.4 6.3e-28
XP_016862452 (OMIM: 176886) PREDICTED: receptor-ty (1456) 592 126.4 6.3e-28
XP_016862451 (OMIM: 176886) PREDICTED: receptor-ty (1458) 592 126.4 6.3e-28
XP_016862450 (OMIM: 176886) PREDICTED: receptor-ty (1485) 592 126.4 6.4e-28
XP_011534671 (OMIM: 603271) PREDICTED: tyrosine-pr ( 970) 589 125.7 7.1e-28
XP_016876428 (OMIM: 603271) PREDICTED: tyrosine-pr ( 970) 589 125.7 7.1e-28
XP_016876427 (OMIM: 603271) PREDICTED: tyrosine-pr (1051) 589 125.7 7.5e-28
XP_006720074 (OMIM: 603271) PREDICTED: tyrosine-pr (1051) 589 125.7 7.5e-28
XP_011534670 (OMIM: 603271) PREDICTED: tyrosine-pr (1051) 589 125.7 7.5e-28
XP_005267344 (OMIM: 603271) PREDICTED: tyrosine-pr (1174) 589 125.8 8.1e-28
NP_008970 (OMIM: 603271) tyrosine-protein phosphat (1174) 589 125.8 8.1e-28
XP_011534669 (OMIM: 603271) PREDICTED: tyrosine-pr (1174) 589 125.8 8.1e-28
XP_016857430 (OMIM: 603155,613611) PREDICTED: tyro (1187) 564 120.9 2.4e-26
NP_005392 (OMIM: 603155,613611) tyrosine-protein p (1187) 564 120.9 2.4e-26
XP_011526460 (OMIM: 601576) PREDICTED: receptor-ty (1157) 518 112.0 1.1e-23
XP_005259667 (OMIM: 601576) PREDICTED: receptor-ty (1497) 518 112.1 1.4e-23
XP_005259666 (OMIM: 601576) PREDICTED: receptor-ty (1501) 518 112.1 1.4e-23
NP_570923 (OMIM: 601576) receptor-type tyrosine-pr (1501) 518 112.1 1.4e-23
XP_016882565 (OMIM: 601576) PREDICTED: receptor-ty (1505) 518 112.1 1.4e-23
NP_570925 (OMIM: 601576) receptor-type tyrosine-pr (1505) 518 112.1 1.4e-23
XP_016882564 (OMIM: 601576) PREDICTED: receptor-ty (1517) 518 112.1 1.4e-23
XP_011526459 (OMIM: 601576) PREDICTED: receptor-ty (1517) 518 112.1 1.4e-23
XP_016882563 (OMIM: 601576) PREDICTED: receptor-ty (1521) 518 112.1 1.4e-23
XP_016882562 (OMIM: 601576) PREDICTED: receptor-ty (1697) 518 112.1 1.5e-23
XP_005259664 (OMIM: 601576) PREDICTED: receptor-ty (1906) 518 112.2 1.6e-23
NP_570924 (OMIM: 601576) receptor-type tyrosine-pr (1910) 518 112.2 1.6e-23
XP_016882561 (OMIM: 601576) PREDICTED: receptor-ty (1910) 518 112.2 1.6e-23
XP_005259663 (OMIM: 601576) PREDICTED: receptor-ty (1910) 518 112.2 1.6e-23
XP_016882560 (OMIM: 601576) PREDICTED: receptor-ty (1919) 518 112.2 1.6e-23
XP_016882559 (OMIM: 601576) PREDICTED: receptor-ty (1923) 518 112.2 1.6e-23
XP_016882558 (OMIM: 601576) PREDICTED: receptor-ty (1930) 518 112.2 1.6e-23
XP_016882557 (OMIM: 601576) PREDICTED: receptor-ty (1935) 518 112.2 1.6e-23
XP_005259657 (OMIM: 601576) PREDICTED: receptor-ty (1935) 518 112.2 1.6e-23
XP_016882555 (OMIM: 601576) PREDICTED: receptor-ty (1939) 518 112.2 1.6e-23
XP_016882556 (OMIM: 601576) PREDICTED: receptor-ty (1939) 518 112.2 1.6e-23
XP_016882554 (OMIM: 601576) PREDICTED: receptor-ty (1939) 518 112.2 1.6e-23
NP_002841 (OMIM: 601576) receptor-type tyrosine-pr (1948) 518 112.2 1.6e-23
XP_016857436 (OMIM: 179590,616001) PREDICTED: rece (1618) 517 111.9 1.6e-23
NP_001316068 (OMIM: 179590,616001) receptor-type t (1623) 517 111.9 1.6e-23
XP_016857438 (OMIM: 179590,616001) PREDICTED: rece (1623) 517 111.9 1.6e-23
XP_016857435 (OMIM: 179590,616001) PREDICTED: rece (1627) 517 111.9 1.6e-23
NP_001316066 (OMIM: 179590,616001) receptor-type t (1629) 517 111.9 1.6e-23
>>NP_002824 (OMIM: 600768) tyrosine-protein phosphatase (593 aa)
initn: 3908 init1: 3908 opt: 3908 Z-score: 4105.8 bits: 769.7 E(85289): 0
Smith-Waterman score: 3908; 99.7% identity (99.8% similar) in 583 aa overlap (1-583:11-593)
10 20 30 40 50
pF1KE5 MAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYADFELDLGKKVLNLLKGAFP
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_002 KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 IDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
NP_002 IDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT
490 500 510 520 530 540
540 550 560 570 580
pF1KE5 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
550 560 570 580 590
>>NP_001193768 (OMIM: 176891,600263) receptor-type tyros (1448 aa)
initn: 616 init1: 291 opt: 657 Z-score: 690.6 bits: 139.0 E(85289): 1e-31
Smith-Waterman score: 657; 38.0% identity (67.0% similar) in 303 aa overlap (275-563:838-1124)
250 260 270 280 290 300
pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRRE
:. :... .: . . ..:. ::.:...
NP_001 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFEEVQSC
810 820 830 840 850 860
310 320 330 340 350
pF1KE5 N-PVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINASFMDGYKQ
. .: : : : : .:::: .. :..::::.. ..:. ::::::...:::..
NP_001 TVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINANYVDGYNR
870 880 890 900 910 920
360 370 380 390 400 410
pF1KE5 KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGF
.:::..::::..: .::: :.::..: :::: : . : ::::: :::: :. ..:
NP_001 PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSEEYGN
930 940 950 960 970 980
420 430 440 450 460 470
pF1KE5 LTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGVPSSAASL
. ::. .:. . .: .. ..::. . :: : ::.... .:::.::: . .
NP_001 FLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPV
990 1000 1010 1020 1030 1040
480 490 500 510 520 530
pF1KE5 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT
. :.: . . ::. :.:::::::.:::::. :: : :... ::
NP_001 LTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT
1050 1060 1070 1080 1090
540 550 560 570 580
pF1KE5 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
.:.: ....:.:: . .:: ::: : . ...:
NP_001 VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPA
1100 1110 1120 1130 1140 1150
NP_001 GKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYI
1160 1170 1180 1190 1200 1210
>--
initn: 371 init1: 179 opt: 383 Z-score: 403.2 bits: 85.9 E(85289): 1e-15
Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:1173-1413)
280 290 300 310 320 330
pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK
. ... : :::: ... ....:: ...
NP_001 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS
1150 1160 1170 1180 1190 1200
340 350 360 370 380 390
pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG
::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. .
NP_001 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA
1210 1220 1230 1240 1250 1260
400 410 420 430 440 450
pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF
. . ::: .:: : . :: .. :. ... .: .. .. :.. .: ::
NP_001 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF
1270 1280 1290 1300 1310
460 470 480 490 500 510
pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG
: .::. : : . .... :.... .: : :..:: : .:
NP_001 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG
1320 1330 1340 1350 1360
520 530 540 550 560 570
pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS
:::.: . :::. ....:.:... . .: . ::: : ::.::
NP_001 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP
1370 1380 1390 1400 1410 1420
580
pF1KE5 GQNLLAVESQ
NP_001 STSLDSNGAALPDGNIAESLESLV
1430 1440
>>XP_005250576 (OMIM: 176891,600263) PREDICTED: receptor (2308 aa)
initn: 616 init1: 291 opt: 657 Z-score: 688.0 bits: 139.2 E(85289): 1.4e-31
Smith-Waterman score: 657; 38.0% identity (67.0% similar) in 303 aa overlap (275-563:1698-1984)
250 260 270 280 290 300
pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRRE
:. :... .: . . ..:. ::.:...
XP_005 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFEEVQSC
1670 1680 1690 1700 1710 1720
310 320 330 340 350
pF1KE5 N-PVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINASFMDGYKQ
. .: : : : : .:::: .. :..::::.. ..:. ::::::...:::..
XP_005 TVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINANYVDGYNR
1730 1740 1750 1760 1770 1780
360 370 380 390 400 410
pF1KE5 KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGF
.:::..::::..: .::: :.::..: :::: : . : ::::: :::: :. ..:
XP_005 PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSEEYGN
1790 1800 1810 1820 1830 1840
420 430 440 450 460 470
pF1KE5 LTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGVPSSAASL
. ::. .:. . .: .. ..::. . :: : ::.... .:::.::: . .
XP_005 FLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPV
1850 1860 1870 1880 1890 1900
480 490 500 510 520 530
pF1KE5 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT
. :.: . . ::. :.:::::::.:::::. :: : :... ::
XP_005 LTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT
1910 1920 1930 1940 1950
540 550 560 570 580
pF1KE5 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
.:.: ....:.:: . .:: ::: : . ...:
XP_005 VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPA
1960 1970 1980 1990 2000 2010
XP_005 GKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYI
2020 2030 2040 2050 2060 2070
>--
initn: 371 init1: 179 opt: 383 Z-score: 400.6 bits: 86.1 E(85289): 1.4e-15
Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:2033-2273)
280 290 300 310 320 330
pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK
. ... : :::: ... ....:: ...
XP_005 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS
2010 2020 2030 2040 2050 2060
340 350 360 370 380 390
pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG
::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. .
XP_005 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA
2070 2080 2090 2100 2110 2120
400 410 420 430 440 450
pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF
. . ::: .:: : . :: .. :. ... .: .. .. :.. .: ::
XP_005 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF
2130 2140 2150 2160 2170
460 470 480 490 500 510
pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG
: .::. : : . .... :.... .: : :..:: : .:
XP_005 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG
2180 2190 2200 2210 2220
520 530 540 550 560 570
pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS
:::.: . :::. ....:.:... . .: . ::: : ::.::
XP_005 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP
2230 2240 2250 2260 2270 2280
580
pF1KE5 GQNLLAVESQ
XP_005 STSLDSNGAALPDGNIAESLESLV
2290 2300
>>NP_001193767 (OMIM: 176891,600263) receptor-type tyros (1455 aa)
initn: 616 init1: 291 opt: 638 Z-score: 670.6 bits: 135.4 E(85289): 1.3e-30
Smith-Waterman score: 640; 37.1% identity (65.2% similar) in 310 aa overlap (275-563:838-1131)
250 260 270 280 290 300
pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRR-
:. :... .: . . ..:. ::.: ...
NP_001 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEF
810 820 830 840 850 860
310 320 330 340 350
pF1KE5 -------ENPVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINAS
.: : : : : .:::: .. :..::::.. ..:. ::::::.
NP_001 YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINAN
870 880 890 900 910 920
360 370 380 390 400 410
pF1KE5 FMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKD
..:::.. .:::..::::..: .::: :.::..: :::: : . : ::::: :::: :
NP_001 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--AD
930 940 950 960 970 980
420 430 440 450 460
pF1KE5 SRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGV
. ..: . ::. .:. . .: .. ..::. . :: : ::.... .:::.::
NP_001 GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGV
990 1000 1010 1020 1030 1040
470 480 490 500 510 520
pF1KE5 PSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLA
: . .. :.: . . ::. :.:::::::.:::::. :: :
NP_001 PEYSLPVLTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQ
1050 1060 1070 1080 1090
530 540 550 560 570 580
pF1KE5 QLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
:... ::.:.: ....:.:: . .:: ::: : . ...:
NP_001 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNA
1100 1110 1120 1130 1140 1150
NP_001 LLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS
1160 1170 1180 1190 1200 1210
>--
initn: 371 init1: 179 opt: 383 Z-score: 403.1 bits: 85.9 E(85289): 1e-15
Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:1180-1420)
280 290 300 310 320 330
pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK
. ... : :::: ... ....:: ...
NP_001 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS
1150 1160 1170 1180 1190 1200
340 350 360 370 380 390
pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG
::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. .
NP_001 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA
1210 1220 1230 1240 1250 1260
400 410 420 430 440 450
pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF
. . ::: .:: : . :: .. :. ... .: .. .. :.. .: ::
NP_001 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF
1270 1280 1290 1300 1310 1320
460 470 480 490 500 510
pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG
: .::. : : . .... :.... .: : :..:: : .:
NP_001 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG
1330 1340 1350 1360 1370
520 530 540 550 560 570
pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS
:::.: . :::. ....:.:... . .: . ::: : ::.::
NP_001 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP
1380 1390 1400 1410 1420 1430
580
pF1KE5 GQNLLAVESQ
NP_001 STSLDSNGAALPDGNIAESLESLV
1440 1450
>>XP_016867966 (OMIM: 176891,600263) PREDICTED: receptor (2301 aa)
initn: 616 init1: 291 opt: 638 Z-score: 668.1 bits: 135.6 E(85289): 1.8e-30
Smith-Waterman score: 640; 37.1% identity (65.2% similar) in 310 aa overlap (275-563:1684-1977)
250 260 270 280 290 300
pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRR-
:. :... .: . . ..:. ::.: ...
XP_016 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEF
1660 1670 1680 1690 1700 1710
310 320 330 340 350
pF1KE5 -------ENPVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINAS
.: : : : : .:::: .. :..::::.. ..:. ::::::.
XP_016 YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINAN
1720 1730 1740 1750 1760 1770
360 370 380 390 400 410
pF1KE5 FMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKD
..:::.. .:::..::::..: .::: :.::..: :::: : . : ::::: :::: :
XP_016 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--AD
1780 1790 1800 1810 1820 1830
420 430 440 450 460
pF1KE5 SRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGV
. ..: . ::. .:. . .: .. ..::. . :: : ::.... .:::.::
XP_016 GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGV
1840 1850 1860 1870 1880 1890
470 480 490 500 510 520
pF1KE5 PSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLA
: . .. :.: . . ::. :.:::::::.:::::. :: :
XP_016 PEYSLPVLTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQ
1900 1910 1920 1930
530 540 550 560 570 580
pF1KE5 QLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
:... ::.:.: ....:.:: . .:: ::: : . ...:
XP_016 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNA
1940 1950 1960 1970 1980 1990
XP_016 LLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS
2000 2010 2020 2030 2040 2050
>--
initn: 371 init1: 179 opt: 383 Z-score: 400.6 bits: 86.1 E(85289): 1.4e-15
Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:2026-2266)
280 290 300 310 320 330
pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK
. ... : :::: ... ....:: ...
XP_016 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS
2000 2010 2020 2030 2040 2050
340 350 360 370 380 390
pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG
::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. .
XP_016 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA
2060 2070 2080 2090 2100 2110
400 410 420 430 440 450
pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF
. . ::: .:: : . :: .. :. ... .: .. .. :.. .: ::
XP_016 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF
2120 2130 2140 2150 2160 2170
460 470 480 490 500 510
pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG
: .::. : : . .... :.... .: : :..:: : .:
XP_016 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG
2180 2190 2200 2210
520 530 540 550 560 570
pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS
:::.: . :::. ....:.:... . .: . ::: : ::.::
XP_016 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP
2220 2230 2240 2250 2260 2270
580
pF1KE5 GQNLLAVESQ
XP_016 STSLDSNGAALPDGNIAESLESLV
2280 2290 2300
>>NP_002842 (OMIM: 176891,600263) receptor-type tyrosine (2315 aa)
initn: 616 init1: 291 opt: 638 Z-score: 668.1 bits: 135.6 E(85289): 1.8e-30
Smith-Waterman score: 640; 37.1% identity (65.2% similar) in 310 aa overlap (275-563:1698-1991)
250 260 270 280 290 300
pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRR-
:. :... .: . . ..:. ::.: ...
NP_002 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEF
1670 1680 1690 1700 1710 1720
310 320 330 340 350
pF1KE5 -------ENPVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINAS
.: : : : : .:::: .. :..::::.. ..:. ::::::.
NP_002 YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINAN
1730 1740 1750 1760 1770 1780
360 370 380 390 400 410
pF1KE5 FMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKD
..:::.. .:::..::::..: .::: :.::..: :::: : . : ::::: :::: :
NP_002 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--AD
1790 1800 1810 1820 1830 1840
420 430 440 450 460
pF1KE5 SRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGV
. ..: . ::. .:. . .: .. ..::. . :: : ::.... .:::.::
NP_002 GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGV
1850 1860 1870 1880 1890 1900
470 480 490 500 510 520
pF1KE5 PSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLA
: . .. :.: . . ::. :.:::::::.:::::. :: :
NP_002 PEYSLPVLTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQ
1910 1920 1930 1940 1950
530 540 550 560 570 580
pF1KE5 QLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
:... ::.:.: ....:.:: . .:: ::: : . ...:
NP_002 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNA
1960 1970 1980 1990 2000 2010
NP_002 LLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS
2020 2030 2040 2050 2060 2070
>--
initn: 371 init1: 179 opt: 383 Z-score: 400.6 bits: 86.1 E(85289): 1.4e-15
Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:2040-2280)
280 290 300 310 320 330
pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK
. ... : :::: ... ....:: ...
NP_002 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS
2010 2020 2030 2040 2050 2060
340 350 360 370 380 390
pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG
::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. .
NP_002 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA
2070 2080 2090 2100 2110 2120
400 410 420 430 440 450
pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF
. . ::: .:: : . :: .. :. ... .: .. .. :.. .: ::
NP_002 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF
2130 2140 2150 2160 2170 2180
460 470 480 490 500 510
pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG
: .::. : : . .... :.... .: : :..:: : .:
NP_002 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG
2190 2200 2210 2220 2230
520 530 540 550 560 570
pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS
:::.: . :::. ....:.:... . .: . ::: : ::.::
NP_002 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP
2240 2250 2260 2270 2280 2290
580
pF1KE5 GQNLLAVESQ
NP_002 STSLDSNGAALPDGNIAESLESLV
2300 2310
>>XP_016862453 (OMIM: 176886) PREDICTED: receptor-type t (1329 aa)
initn: 629 init1: 307 opt: 592 Z-score: 622.9 bits: 126.4 E(85289): 5.9e-28
Smith-Waterman score: 668; 36.7% identity (64.7% similar) in 343 aa overlap (258-575:690-1015)
230 240 250 260 270 280
pF1KE5 YVKIDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHV-PGP---HAMTIQELVD
: : .. .:. . : : .:. ....:
XP_016 RFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVK
660 670 680 690 700 710
290 300 310 320 330
pF1KE5 YVN---ARQKQGIYEEYEDIRR---ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLT
... . ...:. :..:...: . . . : : : : .:::: .. :..::::
XP_016 HIGELYSNNQHGFSEDFEEVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLR
720 730 740 750 760 770
340 350 360 370 380 390
pF1KE5 KRSGHT--QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE
:. ..:::::...:::.. .:::.:::::..:..::: :.:::.. .::: : .
XP_016 PLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLV
780 790 800 810 820 830
400 410 420 430 440
pF1KE5 EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER--QK-----R
: ::::: :::: :.. . .: . :: ... : . :.::. . :: :
XP_016 EKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR
840 850 860 870 880 890
450 460 470 480 490 500
pF1KE5 Q----VTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVV
: : .... .:::.::: : .. :.: :. : .. :: :..:
XP_016 QNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RS------------SAARMPETGPVLV
900 910 920 930 940
510 520 530 540 550 560
pF1KE5 HCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
:::::.:::::. .: : :... .:.::. ....:::: . .:: ::: : . :.::
XP_016 HCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
950 960 970 980 990 1000
570 580
pF1KE5 -FAEKEGMVSSGQNLLAVESQ
. :: :::.:
XP_016 AILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEK
1010 1020 1030 1040 1050 1060
>--
initn: 381 init1: 218 opt: 371 Z-score: 391.0 bits: 83.5 E(85289): 4.8e-15
Smith-Waterman score: 371; 31.3% identity (57.6% similar) in 278 aa overlap (317-582:1059-1319)
290 300 310 320 330 340
pF1KE5 ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTD
: :::: ..: ...:: :. : ::
XP_016 GGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTD
1030 1040 1050 1060 1070 1080
350 360 370 380 390 400
pF1KE5 YINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW
:::::.. :: ..: .: :: :: .: .::: :.:.... .::: . .. . ::
XP_016 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF-VYW
1090 1100 1110 1120 1130 1140
410 420 430 440 450 460
pF1KE5 PLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN-----TEERQKRQVTHFQFLSWPDY
: ...: .: ::: .. . . .. . ::. :.. .: ::: .::.
XP_016 PSREESMNCEAF-TVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP
1150 1160 1170 1180 1190 1200
470 480 490 500 510 520
pF1KE5 GVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDIC
.: : : .... :.... :.. : : .:: : .: .:.:
XP_016 DAPIS--STFELINVIKEE---ALTRDG----------PTIVHDEYGAVSAGMLCALTTL
1210 1220 1230 1240 1250
530 540 550 560 570
pF1KE5 LAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF-AEKE---GMVSSGQN-
:::. ....:::... . .: . ::: : :::.: . . :: : .. .:
XP_016 SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNG
1260 1270 1280 1290 1300 1310
580
pF1KE5 --LLAVESQ
:.: ::
XP_016 AVLIADESDPAESMESLV
1320
>>XP_005265410 (OMIM: 176886) PREDICTED: receptor-type t (1416 aa)
initn: 629 init1: 307 opt: 592 Z-score: 622.5 bits: 126.4 E(85289): 6.2e-28
Smith-Waterman score: 668; 36.7% identity (64.7% similar) in 343 aa overlap (258-575:777-1102)
230 240 250 260 270 280
pF1KE5 YVKIDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHV-PGP---HAMTIQELVD
: : .. .:. . : : .:. ....:
XP_005 LTFVCLILLIAVLVYWRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVK
750 760 770 780 790 800
290 300 310 320 330
pF1KE5 YVN---ARQKQGIYEEYEDIRR---ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLT
... . ...:. :..:...: . . . : : : : .:::: .. :..::::
XP_005 HIGELYSNNQHGFSEDFEEVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLR
810 820 830 840 850 860
340 350 360 370 380 390
pF1KE5 KRSGHT--QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE
:. ..:::::...:::.. .:::.:::::..:..::: :.:::.. .::: : .
XP_005 PLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLV
870 880 890 900 910 920
400 410 420 430 440
pF1KE5 EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER--QK-----R
: ::::: :::: :.. . .: . :: ... : . :.::. . :: :
XP_005 EKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR
930 940 950 960 970 980
450 460 470 480 490 500
pF1KE5 Q----VTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVV
: : .... .:::.::: : .. :.: :. : .. :: :..:
XP_005 QNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RS------------SAARMPETGPVLV
990 1000 1010 1020
510 520 530 540 550 560
pF1KE5 HCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
:::::.:::::. .: : :... .:.::. ....:::: . .:: ::: : . :.::
XP_005 HCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
1030 1040 1050 1060 1070 1080
570 580
pF1KE5 -FAEKEGMVSSGQNLLAVESQ
. :: :::.:
XP_005 AILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEK
1090 1100 1110 1120 1130 1140
>--
initn: 381 init1: 218 opt: 371 Z-score: 390.7 bits: 83.5 E(85289): 5e-15
Smith-Waterman score: 371; 31.3% identity (57.6% similar) in 278 aa overlap (317-582:1146-1406)
290 300 310 320 330 340
pF1KE5 ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTD
: :::: ..: ...:: :. : ::
XP_005 GGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTD
1120 1130 1140 1150 1160 1170
350 360 370 380 390 400
pF1KE5 YINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW
:::::.. :: ..: .: :: :: .: .::: :.:.... .::: . .. . ::
XP_005 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF-VYW
1180 1190 1200 1210 1220 1230
410 420 430 440 450 460
pF1KE5 PLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN-----TEERQKRQVTHFQFLSWPDY
: ...: .: ::: .. . . .. . ::. :.. .: ::: .::.
XP_005 PSREESMNCEAF-TVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP
1240 1250 1260 1270 1280 1290
470 480 490 500 510 520
pF1KE5 GVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDIC
.: : : .... :.... :.. : : .:: : .: .:.:
XP_005 DAPIS--STFELINVIKEE---ALTRDG----------PTIVHDEYGAVSAGMLCALTTL
1300 1310 1320 1330
530 540 550 560 570
pF1KE5 LAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF-AEKE---GMVSSGQN-
:::. ....:::... . .: . ::: : :::.: . . :: : .. .:
XP_005 SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNG
1340 1350 1360 1370 1380 1390
580
pF1KE5 --LLAVESQ
:.: ::
XP_005 AVLIADESDPAESMESLV
1400 1410
>>NP_002832 (OMIM: 176886) receptor-type tyrosine-protei (1445 aa)
initn: 629 init1: 307 opt: 592 Z-score: 622.4 bits: 126.4 E(85289): 6.3e-28
Smith-Waterman score: 668; 36.7% identity (64.7% similar) in 343 aa overlap (258-575:806-1131)
230 240 250 260 270 280
pF1KE5 YVKIDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHV-PGP---HAMTIQELVD
: : .. .:. . : : .:. ....:
NP_002 RFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVK
780 790 800 810 820 830
290 300 310 320 330
pF1KE5 YVN---ARQKQGIYEEYEDIRR---ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLT
... . ...:. :..:...: . . . : : : : .:::: .. :..::::
NP_002 HIGELYSNNQHGFSEDFEEVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLR
840 850 860 870 880 890
340 350 360 370 380 390
pF1KE5 KRSGHT--QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE
:. ..:::::...:::.. .:::.:::::..:..::: :.:::.. .::: : .
NP_002 PLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLV
900 910 920 930 940 950
400 410 420 430 440
pF1KE5 EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER--QK-----R
: ::::: :::: :.. . .: . :: ... : . :.::. . :: :
NP_002 EKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR
960 970 980 990 1000 1010
450 460 470 480 490 500
pF1KE5 Q----VTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVV
: : .... .:::.::: : .. :.: :. : .. :: :..:
NP_002 QNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RS------------SAARMPETGPVLV
1020 1030 1040 1050
510 520 530 540 550 560
pF1KE5 HCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
:::::.:::::. .: : :... .:.::. ....:::: . .:: ::: : . :.::
NP_002 HCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
1060 1070 1080 1090 1100 1110
570 580
pF1KE5 -FAEKEGMVSSGQNLLAVESQ
. :: :::.:
NP_002 AILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEK
1120 1130 1140 1150 1160 1170
>--
initn: 381 init1: 218 opt: 371 Z-score: 390.6 bits: 83.5 E(85289): 5.1e-15
Smith-Waterman score: 371; 31.3% identity (57.6% similar) in 278 aa overlap (317-582:1175-1435)
290 300 310 320 330 340
pF1KE5 ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTD
: :::: ..: ...:: :. : ::
NP_002 GGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTD
1150 1160 1170 1180 1190 1200
350 360 370 380 390 400
pF1KE5 YINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW
:::::.. :: ..: .: :: :: .: .::: :.:.... .::: . .. . ::
NP_002 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF-VYW
1210 1220 1230 1240 1250 1260
410 420 430 440 450 460
pF1KE5 PLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN-----TEERQKRQVTHFQFLSWPDY
: ...: .: ::: .. . . .. . ::. :.. .: ::: .::.
NP_002 PSREESMNCEAF-TVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP
1270 1280 1290 1300 1310 1320
470 480 490 500 510 520
pF1KE5 GVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDIC
.: : : .... :.... :.. : : .:: : .: .:.:
NP_002 DAPIS--STFELINVIKEE---ALTRDG----------PTIVHDEYGAVSAGMLCALTTL
1330 1340 1350 1360
530 540 550 560 570
pF1KE5 LAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF-AEKE---GMVSSGQN-
:::. ....:::... . .: . ::: : :::.: . . :: : .. .:
NP_002 SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNG
1370 1380 1390 1400 1410 1420
580
pF1KE5 --LLAVESQ
:.: ::
NP_002 AVLIADESDPAESMESLV
1430 1440
>>XP_016862452 (OMIM: 176886) PREDICTED: receptor-type t (1456 aa)
initn: 629 init1: 307 opt: 592 Z-score: 622.4 bits: 126.4 E(85289): 6.3e-28
Smith-Waterman score: 668; 36.7% identity (64.7% similar) in 343 aa overlap (258-575:817-1142)
230 240 250 260 270 280
pF1KE5 YVKIDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHV-PGP---HAMTIQELVD
: : .. .:. . : : .:. ....:
XP_016 LTFVCLILLIAVLVYWRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVK
790 800 810 820 830 840
290 300 310 320 330
pF1KE5 YVN---ARQKQGIYEEYEDIRR---ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLT
... . ...:. :..:...: . . . : : : : .:::: .. :..::::
XP_016 HIGELYSNNQHGFSEDFEEVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLR
850 860 870 880 890 900
340 350 360 370 380 390
pF1KE5 KRSGHT--QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE
:. ..:::::...:::.. .:::.:::::..:..::: :.:::.. .::: : .
XP_016 PLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLV
910 920 930 940 950 960
400 410 420 430 440
pF1KE5 EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER--QK-----R
: ::::: :::: :.. . .: . :: ... : . :.::. . :: :
XP_016 EKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR
970 980 990 1000 1010 1020
450 460 470 480 490 500
pF1KE5 Q----VTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVV
: : .... .:::.::: : .. :.: :. : .. :: :..:
XP_016 QNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RS------------SAARMPETGPVLV
1030 1040 1050 1060
510 520 530 540 550 560
pF1KE5 HCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
:::::.:::::. .: : :... .:.::. ....:::: . .:: ::: : . :.::
XP_016 HCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
1070 1080 1090 1100 1110 1120
570 580
pF1KE5 -FAEKEGMVSSGQNLLAVESQ
. :: :::.:
XP_016 AILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEK
1130 1140 1150 1160 1170 1180
>--
initn: 381 init1: 218 opt: 371 Z-score: 390.5 bits: 83.5 E(85289): 5.1e-15
Smith-Waterman score: 371; 31.3% identity (57.6% similar) in 278 aa overlap (317-582:1186-1446)
290 300 310 320 330 340
pF1KE5 ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTD
: :::: ..: ...:: :. : ::
XP_016 GGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTD
1160 1170 1180 1190 1200 1210
350 360 370 380 390 400
pF1KE5 YINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW
:::::.. :: ..: .: :: :: .: .::: :.:.... .::: . .. . ::
XP_016 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF-VYW
1220 1230 1240 1250 1260 1270
410 420 430 440 450 460
pF1KE5 PLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN-----TEERQKRQVTHFQFLSWPDY
: ...: .: ::: .. . . .. . ::. :.. .: ::: .::.
XP_016 PSREESMNCEAF-TVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP
1280 1290 1300 1310 1320 1330
470 480 490 500 510 520
pF1KE5 GVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDIC
.: : : .... :.... :.. : : .:: : .: .:.:
XP_016 DAPIS--STFELINVIKEE---ALTRDG----------PTIVHDEYGAVSAGMLCALTTL
1340 1350 1360 1370
530 540 550 560 570
pF1KE5 LAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF-AEKE---GMVSSGQN-
:::. ....:::... . .: . ::: : :::.: . . :: : .. .:
XP_016 SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNG
1380 1390 1400 1410 1420 1430
580
pF1KE5 --LLAVESQ
:.: ::
XP_016 AVLIADESDPAESMESLV
1440 1450
583 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:27:47 2016 done: Tue Nov 8 05:27:48 2016
Total Scan time: 8.880 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]