Result of FASTA (omim) for
pFN21AE5635
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5635, 527 aa
1>>>pF1KE5635 527 - 527 aa - 527 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0090+/-0.000411; mu= 14.9729+/- 0.026
mean_var=84.1352+/-16.755, 0's: 0 Z-trim(112.0): 31 B-trim: 0 in 0/54
Lambda= 0.139825
statistics sampled from 20773 (20802) to 20773 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.244), width: 16
Scan time: 8.640
The best scores are: opt bits E(85289)
NP_997657 (OMIM: 601934) COP9 signalosome complex ( 527) 3424 701.0 2.2e-201
NP_001308019 (OMIM: 601934) COP9 signalosome compl ( 555) 3424 701.1 2.3e-201
NP_001308018 (OMIM: 601934) COP9 signalosome compl ( 559) 3406 697.4 2.8e-200
NP_001308020 (OMIM: 601934) COP9 signalosome compl ( 554) 3405 697.2 3.3e-200
XP_005256410 (OMIM: 601934) PREDICTED: COP9 signal ( 581) 3275 671.0 2.7e-192
XP_005256407 (OMIM: 601934) PREDICTED: COP9 signal ( 585) 3257 667.4 3.3e-191
XP_016880014 (OMIM: 601934) PREDICTED: COP9 signal ( 580) 3256 667.2 3.8e-191
NP_001308021 (OMIM: 601934) COP9 signalosome compl ( 487) 3101 635.9 8.4e-182
NP_004118 (OMIM: 601934) COP9 signalosome complex ( 491) 3083 632.2 1.1e-180
NP_001317468 (OMIM: 601934) COP9 signalosome compl ( 486) 3082 632.0 1.2e-180
NP_001308022 (OMIM: 601934) COP9 signalosome compl ( 471) 3065 628.6 1.3e-179
NP_001317470 (OMIM: 601934) COP9 signalosome compl ( 490) 3064 628.4 1.5e-179
XP_016880023 (OMIM: 601934) PREDICTED: COP9 signal ( 475) 3047 625.0 1.6e-178
XP_016880024 (OMIM: 601934) PREDICTED: COP9 signal ( 470) 3046 624.8 1.8e-178
XP_016880015 (OMIM: 601934) PREDICTED: COP9 signal ( 474) 3028 621.1 2.2e-177
XP_005256417 (OMIM: 601934) PREDICTED: COP9 signal ( 513) 2952 605.8 9.8e-173
XP_005256416 (OMIM: 601934) PREDICTED: COP9 signal ( 517) 2934 602.2 1.2e-171
XP_016880016 (OMIM: 601934) PREDICTED: COP9 signal ( 512) 2933 602.0 1.4e-171
XP_011521872 (OMIM: 601934) PREDICTED: COP9 signal ( 497) 2916 598.6 1.5e-170
XP_016880019 (OMIM: 601934) PREDICTED: COP9 signal ( 497) 2916 598.6 1.5e-170
XP_011521871 (OMIM: 601934) PREDICTED: COP9 signal ( 501) 2898 594.9 1.8e-169
XP_016880017 (OMIM: 601934) PREDICTED: COP9 signal ( 501) 2898 594.9 1.8e-169
XP_016880020 (OMIM: 601934) PREDICTED: COP9 signal ( 496) 2897 594.7 2.1e-169
XP_016880018 (OMIM: 601934) PREDICTED: COP9 signal ( 500) 2879 591.1 2.6e-168
XP_016880013 (OMIM: 601934) PREDICTED: COP9 signal ( 500) 2879 591.1 2.6e-168
>>NP_997657 (OMIM: 601934) COP9 signalosome complex subu (527 aa)
initn: 3424 init1: 3424 opt: 3424 Z-score: 3736.5 bits: 701.0 E(85289): 2.2e-201
Smith-Waterman score: 3424; 100.0% identity (100.0% similar) in 527 aa overlap (1-527:1-527)
10 20 30 40 50 60
pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 VDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 VDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 FVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 FVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 VIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 QAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 QAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 QVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 QVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 DMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 DMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGK
430 440 450 460 470 480
490 500 510 520
pF1KE5 EFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM
:::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM
490 500 510 520
>>NP_001308019 (OMIM: 601934) COP9 signalosome complex s (555 aa)
initn: 3424 init1: 3424 opt: 3424 Z-score: 3736.2 bits: 701.1 E(85289): 2.3e-201
Smith-Waterman score: 3424; 100.0% identity (100.0% similar) in 527 aa overlap (1-527:29-555)
10 20 30
pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
::::::::::::::::::::::::::::::::
NP_001 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE5 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE5 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE5 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQG
490 500 510 520 530 540
520
pF1KE5 ELTPANSQSRMSTNM
:::::::::::::::
NP_001 ELTPANSQSRMSTNM
550
>>NP_001308018 (OMIM: 601934) COP9 signalosome complex s (559 aa)
initn: 2503 init1: 2503 opt: 3406 Z-score: 3716.5 bits: 697.4 E(85289): 2.8e-200
Smith-Waterman score: 3406; 99.2% identity (99.2% similar) in 531 aa overlap (1-527:29-559)
10 20 30
pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
::::::::::::::::::::::::::::::::
NP_001 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
70 80 90 100 110 120
100 110 120 130 140
pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATR----ELQNA
::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
NP_001 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLRELQNA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE5 PDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHY
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE5 LDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIA
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE5 EQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIY
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE5 GGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNL
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE5 LLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGL
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE5 ISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPRE
490 500 510 520 530 540
510 520
pF1KE5 GSQGELTPANSQSRMSTNM
:::::::::::::::::::
NP_001 GSQGELTPANSQSRMSTNM
550
>>NP_001308020 (OMIM: 601934) COP9 signalosome complex s (554 aa)
initn: 1773 init1: 1773 opt: 3405 Z-score: 3715.5 bits: 697.2 E(85289): 3.3e-200
Smith-Waterman score: 3405; 99.8% identity (99.8% similar) in 527 aa overlap (1-527:29-554)
10 20 30
pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
::::::::::::::::::::::::::::::::
NP_001 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_001 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAE-RG
250 260 270 280 290
280 290 300 310 320 330
pF1KE5 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE5 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE5 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE5 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQG
480 490 500 510 520 530
520
pF1KE5 ELTPANSQSRMSTNM
:::::::::::::::
NP_001 ELTPANSQSRMSTNM
540 550
>>XP_005256410 (OMIM: 601934) PREDICTED: COP9 signalosom (581 aa)
initn: 3275 init1: 3275 opt: 3275 Z-score: 3573.4 bits: 671.0 E(85289): 2.7e-192
Smith-Waterman score: 3362; 95.3% identity (95.3% similar) in 553 aa overlap (1-527:29-581)
10 20 30
pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
::::::::::::::::::::::::::::::::
XP_005 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE5 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE5 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR
430 440 450 460 470 480
460 470 480 490 500
pF1KE5 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVK---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKVGWLEGGQA
490 500 510 520 530 540
510 520
pF1KE5 -----------------SPPREGSQGELTPANSQSRMSTNM
::::::::::::::::::::::::
XP_005 HGVWGLVAVSCSLSPLQSPPREGSQGELTPANSQSRMSTNM
550 560 570 580
>>XP_005256407 (OMIM: 601934) PREDICTED: COP9 signalosom (585 aa)
initn: 3272 init1: 2354 opt: 3257 Z-score: 3553.8 bits: 667.4 E(85289): 3.3e-191
Smith-Waterman score: 3344; 94.6% identity (94.6% similar) in 557 aa overlap (1-527:29-585)
10 20 30
pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
::::::::::::::::::::::::::::::::
XP_005 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
70 80 90 100 110 120
100 110 120 130 140
pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATR----ELQNA
::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_005 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLRELQNA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE5 PDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHY
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE5 LDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIA
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE5 EQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIY
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE5 GGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNL
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE5 LLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGL
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE5 ISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVK-----
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKVGWLE
490 500 510 520 530 540
510 520
pF1KE5 ---------------------SPPREGSQGELTPANSQSRMSTNM
::::::::::::::::::::::::
XP_005 GGQAHGVWGLVAVSCSLSPLQSPPREGSQGELTPANSQSRMSTNM
550 560 570 580
>>XP_016880014 (OMIM: 601934) PREDICTED: COP9 signalosom (580 aa)
initn: 3255 init1: 1773 opt: 3256 Z-score: 3552.7 bits: 667.2 E(85289): 3.8e-191
Smith-Waterman score: 3343; 95.1% identity (95.1% similar) in 553 aa overlap (1-527:29-580)
10 20 30
pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
::::::::::::::::::::::::::::::::
XP_016 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAE-RG
250 260 270 280 290
280 290 300 310 320 330
pF1KE5 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE5 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE5 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR
420 430 440 450 460 470
460 470 480 490 500
pF1KE5 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVK---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKVGWLEGGQA
480 490 500 510 520 530
510 520
pF1KE5 -----------------SPPREGSQGELTPANSQSRMSTNM
::::::::::::::::::::::::
XP_016 HGVWGLVAVSCSLSPLQSPPREGSQGELTPANSQSRMSTNM
540 550 560 570 580
>>NP_001308021 (OMIM: 601934) COP9 signalosome complex s (487 aa)
initn: 3101 init1: 3101 opt: 3101 Z-score: 3384.9 bits: 635.9 E(85289): 8.4e-182
Smith-Waterman score: 3101; 99.8% identity (100.0% similar) in 477 aa overlap (51-527:11-487)
30 40 50 60 70 80
pF1KE5 PHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENP
.:::::::::::::::::::::::::::::
NP_001 MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENP
10 20 30 40
90 100 110 120 130 140
pF1KE5 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE5 ATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE5 HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSK
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE5 AESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELL
230 240 250 260 270 280
330 340 350 360 370 380
pF1KE5 SPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKM
290 300 310 320 330 340
390 400 410 420 430 440
pF1KE5 LDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDEL
350 360 370 380 390 400
450 460 470 480 490 500
pF1KE5 TQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQI
410 420 430 440 450 460
510 520
pF1KE5 HVKSPPREGSQGELTPANSQSRMSTNM
:::::::::::::::::::::::::::
NP_001 HVKSPPREGSQGELTPANSQSRMSTNM
470 480
>>NP_004118 (OMIM: 601934) COP9 signalosome complex subu (491 aa)
initn: 2499 init1: 2499 opt: 3083 Z-score: 3365.2 bits: 632.2 E(85289): 1.1e-180
Smith-Waterman score: 3083; 99.0% identity (99.2% similar) in 481 aa overlap (51-527:11-491)
30 40 50 60 70 80
pF1KE5 PHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENP
.:::::::::::::::::::::::::::::
NP_004 MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENP
10 20 30 40
90 100 110 120 130 140
pF1KE5 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE
50 60 70 80 90 100
150 160 170 180 190
pF1KE5 ATR----ELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKES
::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ATRSSLRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKES
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE5 IRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLS
170 180 190 200 210 220
260 270 280 290 300 310
pF1KE5 YVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDF
230 240 250 260 270 280
320 330 340 350 360 370
pF1KE5 PELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYAS
290 300 310 320 330 340
380 390 400 410 420 430
pF1KE5 CLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAAL
350 360 370 380 390 400
440 450 460 470 480 490
pF1KE5 EDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVL
410 420 430 440 450 460
500 510 520
pF1KE5 RNQIHVKSPPREGSQGELTPANSQSRMSTNM
:::::::::::::::::::::::::::::::
NP_004 RNQIHVKSPPREGSQGELTPANSQSRMSTNM
470 480 490
>>NP_001317468 (OMIM: 601934) COP9 signalosome complex s (486 aa)
initn: 1671 init1: 1647 opt: 3082 Z-score: 3364.2 bits: 632.0 E(85289): 1.2e-180
Smith-Waterman score: 3082; 99.6% identity (99.8% similar) in 477 aa overlap (51-527:11-486)
30 40 50 60 70 80
pF1KE5 PHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENP
.:::::::::::::::::::::::::::::
NP_001 MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENP
10 20 30 40
90 100 110 120 130 140
pF1KE5 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE5 ATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE5 HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSK
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE5 AESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELL
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AESTPEIAE-RGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELL
230 240 250 260 270
330 340 350 360 370 380
pF1KE5 SPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKM
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE5 LDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDEL
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE5 TQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQI
400 410 420 430 440 450
510 520
pF1KE5 HVKSPPREGSQGELTPANSQSRMSTNM
:::::::::::::::::::::::::::
NP_001 HVKSPPREGSQGELTPANSQSRMSTNM
460 470 480
527 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:24:00 2016 done: Tue Nov 8 05:24:02 2016
Total Scan time: 8.640 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]