Result of FASTA (omim) for
pFN21AE5619
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5619, 481 aa
1>>>pF1KE5619 481 - 481 aa - 481 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4489+/-0.000402; mu= 17.9573+/- 0.025
mean_var=76.1033+/-15.264, 0's: 0 Z-trim(112.7): 26 B-trim: 1084 in 1/49
Lambda= 0.147019
statistics sampled from 21661 (21676) to 21661 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.254), width: 16
Scan time: 7.000
The best scores are: opt bits E(85289)
NP_112597 (OMIM: 616283,617051) tRNA pseudouridine ( 481) 3241 697.1 2.8e-200
XP_005271744 (OMIM: 616283,617051) PREDICTED: tRNA ( 382) 2435 526.1 6.7e-149
NP_001258914 (OMIM: 616283,617051) tRNA pseudourid ( 273) 1879 408.1 1.6e-113
XP_005271745 (OMIM: 616283,617051) PREDICTED: tRNA ( 176) 1059 234.0 2.6e-61
NP_001002020 (OMIM: 600462,608109) tRNA pseudourid ( 399) 165 44.6 0.0006
NP_001002019 (OMIM: 600462,608109) tRNA pseudourid ( 399) 165 44.6 0.0006
NP_079491 (OMIM: 600462,608109) tRNA pseudouridine ( 427) 165 44.6 0.00064
>>NP_112597 (OMIM: 616283,617051) tRNA pseudouridine(38/ (481 aa)
initn: 3241 init1: 3241 opt: 3241 Z-score: 3716.7 bits: 697.1 E(85289): 2.8e-200
Smith-Waterman score: 3241; 99.6% identity (100.0% similar) in 481 aa overlap (1-481:1-481)
10 20 30 40 50 60
pF1KE5 MADNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSSGAGKTKRAFDFSAH
:::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::
NP_112 MADNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSAGAGKTKRAFDFSAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 GRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 GRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 VSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 EPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 EPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 ILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 ILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 ELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVKTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 ELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVKTH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 MLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 QGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEDNTNLETPTKRVCVDTEIKSI
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
NP_112 QGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEENTNLETPTKRVCVDTEIKSI
430 440 450 460 470 480
pF1KE5 I
:
NP_112 I
>>XP_005271744 (OMIM: 616283,617051) PREDICTED: tRNA pse (382 aa)
initn: 2428 init1: 2428 opt: 2435 Z-score: 2794.2 bits: 526.1 E(85289): 6.7e-149
Smith-Waterman score: 2435; 97.8% identity (99.4% similar) in 363 aa overlap (119-481:20-382)
90 100 110 120 130 140
pF1KE5 IEEKLFEALTKTRLVESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSEDFNVK
.:... .::::::::::::::::::::::
XP_005 MRARAPAQKTHSDSFLSRKRGAAGCRKVISLDLRSQFPRGRDSEDFNVK
10 20 30 40
150 160 170 180 190 200
pF1KE5 EEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADLDIVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADLDIVT
50 60 70 80 90 100
210 220 230 240 250 260
pF1KE5 MDYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQLVGQSPGEGRWQEPFQLCQFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQLVGQSPGEGRWQEPFQLCQFE
110 120 130 140 150 160
270 280 290 300 310 320
pF1KE5 VTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVEFPLVLYDCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVEFPLVLYDCK
170 180 190 200 210 220
330 340 350 360 370 380
pF1KE5 FENVKWIYDQEAQEFNITHLQQLWANHAVKTHMLYSMLQGLDTVPVPCGIGPKMDGMTEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FENVKWIYDQEAQEFNITHLQQLWANHAVKTHMLYSMLQGLDTVPVPCGIGPKMDGMTEW
230 240 250 260 270 280
390 400 410 420 430 440
pF1KE5 GNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQGLESRIQHFVRRGRIEHPHLFHEEETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQGLESRIQHFVRRGRIEHPHLFHEEETK
290 300 310 320 330 340
450 460 470 480
pF1KE5 AKRDCNDTLEEDNTNLETPTKRVCVDTEIKSII
:::::::::::.:::::::::::::::::::::
XP_005 AKRDCNDTLEEENTNLETPTKRVCVDTEIKSII
350 360 370 380
>>NP_001258914 (OMIM: 616283,617051) tRNA pseudouridine( (273 aa)
initn: 1879 init1: 1879 opt: 1879 Z-score: 2159.0 bits: 408.1 E(85289): 1.6e-113
Smith-Waterman score: 1879; 99.6% identity (100.0% similar) in 273 aa overlap (209-481:1-273)
180 190 200 210 220 230
pF1KE5 PVEPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQ
::::::::::::::::::::::::::::::
NP_001 MDYAAQKYVGTHDFRNLCKMDVANGVINFQ
10 20 30
240 250 260 270 280 290
pF1KE5 RTILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEI
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE5 IDELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVK
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE5 THMLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THMLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRP
160 170 180 190 200 210
420 430 440 450 460 470
pF1KE5 KCQGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEDNTNLETPTKRVCVDTEIK
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_001 KCQGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEENTNLETPTKRVCVDTEIK
220 230 240 250 260 270
480
pF1KE5 SII
:::
NP_001 SII
>>XP_005271745 (OMIM: 616283,617051) PREDICTED: tRNA pse (176 aa)
initn: 1059 init1: 1059 opt: 1059 Z-score: 1221.7 bits: 234.0 E(85289): 2.6e-61
Smith-Waterman score: 1059; 98.8% identity (99.4% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KE5 MADNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSSGAGKTKRAFDFSAH
:: ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::
XP_005 MAYNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSAGAGKTKRAFDFSAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 GRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPV
::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRYGCRISSSLI
130 140 150 160 170
190 200 210 220 230 240
pF1KE5 EPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRT
>>NP_001002020 (OMIM: 600462,608109) tRNA pseudouridine (399 aa)
initn: 280 init1: 108 opt: 165 Z-score: 191.8 bits: 44.6 E(85289): 0.0006
Smith-Waterman score: 270; 25.4% identity (53.5% similar) in 342 aa overlap (62-374:55-368)
40 50 60 70 80
pF1KE5 QAKNKEDSNIRENSSGAGKTKRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNN--TI
.:...: .:: : ::.:. . .... ::
NP_001 AGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTI
30 40 50 60 70 80
90 100 110 120 130 140
pF1KE5 EEKLFEALTKTRLV-----ESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSED
:. : ::... . :. . ...::.:::::::: :::.:: . .:
NP_001 EDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLI-------DD
90 100 110 120 130
150 160 170 180 190 200
pF1KE5 FNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADL
. :. : .: :: ::::. : .:... : ::: :..: .
NP_001 --ILEKIN--------SH-----LPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAF
140 150 160 170 180
210 220 230 240 250
pF1KE5 DIVTMDYAAQKY-VGTHDFRNLCKMDVA-NGVINFQRTILSAQVQLVGQSPGEGRW----
: . : .... .... .. . .:. ::. . : :.:. :.
NP_001 AHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFH----NFTSQKGPQDPSACRYILEM
190 200 210 220 230
260 270 280 290 300
pF1KE5 --QEPF-----QLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKN--P
.::: .. ..: ::.:..::.: :.... : .:. .... . :: :
NP_001 YCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE5 QKPQYSMAVE-FPLVLYDCKFEN------VKWIYDQEAQEFNITHLQQLWANHAVKTHML
. : ....: . :. .: : . : :: . . .... . .
NP_001 KAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWA--QEEGKVAAFKEEHIYPTIIGTERDE
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE5 YSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQG
:: : :.:.:.
NP_001 RSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD
360 370 380 390
>>NP_001002019 (OMIM: 600462,608109) tRNA pseudouridine (399 aa)
initn: 280 init1: 108 opt: 165 Z-score: 191.8 bits: 44.6 E(85289): 0.0006
Smith-Waterman score: 270; 25.4% identity (53.5% similar) in 342 aa overlap (62-374:55-368)
40 50 60 70 80
pF1KE5 QAKNKEDSNIRENSSGAGKTKRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNN--TI
.:...: .:: : ::.:. . .... ::
NP_001 AGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTI
30 40 50 60 70 80
90 100 110 120 130 140
pF1KE5 EEKLFEALTKTRLV-----ESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSED
:. : ::... . :. . ...::.:::::::: :::.:: . .:
NP_001 EDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLI-------DD
90 100 110 120 130
150 160 170 180 190 200
pF1KE5 FNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADL
. :. : .: :: ::::. : .:... : ::: :..: .
NP_001 --ILEKIN--------SH-----LPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAF
140 150 160 170 180
210 220 230 240 250
pF1KE5 DIVTMDYAAQKY-VGTHDFRNLCKMDVA-NGVINFQRTILSAQVQLVGQSPGEGRW----
: . : .... .... .. . .:. ::. . : :.:. :.
NP_001 AHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFH----NFTSQKGPQDPSACRYILEM
190 200 210 220 230
260 270 280 290 300
pF1KE5 --QEPF-----QLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKN--P
.::: .. ..: ::.:..::.: :.... : .:. .... . :: :
NP_001 YCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE5 QKPQYSMAVE-FPLVLYDCKFEN------VKWIYDQEAQEFNITHLQQLWANHAVKTHML
. : ....: . :. .: : . : :: . . .... . .
NP_001 KAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWA--QEEGKVAAFKEEHIYPTIIGTERDE
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE5 YSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQG
:: : :.:.:.
NP_001 RSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD
360 370 380 390
>>NP_079491 (OMIM: 600462,608109) tRNA pseudouridine syn (427 aa)
initn: 253 init1: 108 opt: 165 Z-score: 191.4 bits: 44.6 E(85289): 0.00064
Smith-Waterman score: 270; 25.4% identity (53.5% similar) in 342 aa overlap (62-374:83-396)
40 50 60 70 80
pF1KE5 QAKNKEDSNIRENSSGAGKTKRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNN--TI
.:...: .:: : ::.:. . .... ::
NP_079 AGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTI
60 70 80 90 100 110
90 100 110 120 130 140
pF1KE5 EEKLFEALTKTRLV-----ESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSED
:. : ::... . :. . ...::.:::::::: :::.:: . .:
NP_079 EDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLI-------DD
120 130 140 150 160
150 160 170 180 190 200
pF1KE5 FNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADL
. :. : .: :: ::::. : .:... : ::: :..: .
NP_079 --ILEKIN--------SH-----LPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAF
170 180 190 200 210
210 220 230 240 250
pF1KE5 DIVTMDYAAQKY-VGTHDFRNLCKMDVA-NGVINFQRTILSAQVQLVGQSPGEGRW----
: . : .... .... .. . .:. ::. . : :.:. :.
NP_079 AHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFH----NFTSQKGPQDPSACRYILEM
220 230 240 250 260
260 270 280 290 300
pF1KE5 --QEPF-----QLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKN--P
.::: .. ..: ::.:..::.: :.... : .:. .... . :: :
NP_079 YCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVP
270 280 290 300 310 320
310 320 330 340 350 360
pF1KE5 QKPQYSMAVE-FPLVLYDCKFEN------VKWIYDQEAQEFNITHLQQLWANHAVKTHML
. : ....: . :. .: : . : :: . . .... . .
NP_079 KAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWA--QEEGKVAAFKEEHIYPTIIGTERDE
330 340 350 360 370 380
370 380 390 400 410 420
pF1KE5 YSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQG
:: : :.:.:.
NP_079 RSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD
390 400 410 420
481 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:13:16 2016 done: Tue Nov 8 05:13:17 2016
Total Scan time: 7.000 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]