Result of FASTA (omim) for
pFN21AE5449
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5449, 335 aa
1>>>pF1KE5449 335 - 335 aa - 335 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.5941+/-0.00037; mu= 1.6952+/- 0.023
mean_var=205.3053+/-41.308, 0's: 0 Z-trim(119.9): 8 B-trim: 53 in 1/57
Lambda= 0.089511
statistics sampled from 34360 (34368) to 34360 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.403), width: 16
Scan time: 8.170
The best scores are: opt bits E(85289)
NP_001257906 (OMIM: 616434) IST1 homolog isoform d ( 335) 2197 296.0 7.7e-80
NP_001257904 (OMIM: 616434) IST1 homolog isoform a ( 366) 1685 229.9 6.6e-60
NP_001257905 (OMIM: 616434) IST1 homolog isoform c ( 379) 1685 229.9 6.8e-60
NP_055576 (OMIM: 616434) IST1 homolog isoform b [H ( 360) 1673 228.3 1.9e-59
NP_001257907 (OMIM: 616434) IST1 homolog isoform e ( 218) 760 110.2 4e-24
NP_001257908 (OMIM: 616434) IST1 homolog isoform e ( 218) 760 110.2 4e-24
>>NP_001257906 (OMIM: 616434) IST1 homolog isoform d [Ho (335 aa)
initn: 2197 init1: 2197 opt: 2197 Z-score: 1554.3 bits: 296.0 E(85289): 7.7e-80
Smith-Waterman score: 2197; 100.0% identity (100.0% similar) in 335 aa overlap (1-335:1-335)
10 20 30 40 50 60
pF1KE5 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 ANTPFSYPLPKGPVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANTPFSYPLPKGPVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSV
250 260 270 280 290 300
310 320 330
pF1KE5 PDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
:::::::::::::::::::::::::::::::::::
NP_001 PDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
310 320 330
>>NP_001257904 (OMIM: 616434) IST1 homolog isoform a [Ho (366 aa)
initn: 1762 init1: 1670 opt: 1685 Z-score: 1196.5 bits: 229.9 E(85289): 6.6e-60
Smith-Waterman score: 2125; 91.5% identity (91.5% similar) in 366 aa overlap (1-335:1-366)
10 20 30 40 50 60
pF1KE5 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS
190 200 210 220 230 240
250 260
pF1KE5 ANTPFSYPLPKGP-------------------------------VDDINADKNISSAQIV
::::::::::::: ::::::::::::::::
NP_001 ANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIV
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE5 GPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFE
310 320 330 340 350 360
330
pF1KE5 ELKKKT
::::::
NP_001 ELKKKT
>>NP_001257905 (OMIM: 616434) IST1 homolog isoform c [Ho (379 aa)
initn: 1762 init1: 1670 opt: 1685 Z-score: 1196.3 bits: 229.9 E(85289): 6.8e-60
Smith-Waterman score: 2125; 91.5% identity (91.5% similar) in 366 aa overlap (1-335:14-379)
10 20 30 40
pF1KE5 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAG
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVFKLKTKEEQHSMLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 KDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAA
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 PRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLI
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE5 EIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGT
190 200 210 220 230 240
230 240 250
pF1KE5 VPMPMPMPMPMPSANTPFSYPLPKGP-------------------------------VDD
:::::::::::::::::::::::::: :::
NP_001 VPMPMPMPMPMPSANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDD
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE5 INADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSAS
310 320 330 340 350 360
320 330
pF1KE5 EDIDFDDLSRRFEELKKKT
:::::::::::::::::::
NP_001 EDIDFDDLSRRFEELKKKT
370
>>NP_055576 (OMIM: 616434) IST1 homolog isoform b [Homo (360 aa)
initn: 1762 init1: 1670 opt: 1673 Z-score: 1188.2 bits: 228.3 E(85289): 1.9e-59
Smith-Waterman score: 1673; 89.1% identity (94.6% similar) in 294 aa overlap (1-294:1-287)
10 20 30 40 50 60
pF1KE5 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 ANTPFSYPLPKGPVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSV
::::::::::::: .:.:. ... : :. .: ..:. : .:....:
NP_055 ANTPFSYPLPKGP-SDFNGLP-MGTYQAF-PNIHPP---QIPATPP-SYESMTLMLIRIS
250 260 270 280 290
310 320 330
pF1KE5 PDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
NP_055 LLHRLLVLDPSQKPLQSFLPDLQITMTTLSYQSCHLCQTHYQLHLLVPAPQHLKTLTLMI
300 310 320 330 340 350
>>NP_001257907 (OMIM: 616434) IST1 homolog isoform e [Ho (218 aa)
initn: 837 init1: 745 opt: 760 Z-score: 554.0 bits: 110.2 E(85289): 4e-24
Smith-Waterman score: 1200; 85.8% identity (85.8% similar) in 218 aa overlap (149-335:1-218)
120 130 140 150 160 170
pF1KE5 IVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYE
::::::::::::::::::::::::::::::
NP_001 MHKLSVEAPPKILVERYLIEIAKNYNVPYE
10 20 30
180 190 200 210 220 230
pF1KE5 PDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM
40 50 60 70 80 90
240 250 260
pF1KE5 PSANTPFSYPLPKGP-------------------------------VDDINADKNISSAQ
::::::::::::::: ::::::::::::::
NP_001 PSANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQ
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE5 IVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRR
160 170 180 190 200 210
330
pF1KE5 FEELKKKT
::::::::
NP_001 FEELKKKT
>>NP_001257908 (OMIM: 616434) IST1 homolog isoform e [Ho (218 aa)
initn: 837 init1: 745 opt: 760 Z-score: 554.0 bits: 110.2 E(85289): 4e-24
Smith-Waterman score: 1200; 85.8% identity (85.8% similar) in 218 aa overlap (149-335:1-218)
120 130 140 150 160 170
pF1KE5 IVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYE
::::::::::::::::::::::::::::::
NP_001 MHKLSVEAPPKILVERYLIEIAKNYNVPYE
10 20 30
180 190 200 210 220 230
pF1KE5 PDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM
40 50 60 70 80 90
240 250 260
pF1KE5 PSANTPFSYPLPKGP-------------------------------VDDINADKNISSAQ
::::::::::::::: ::::::::::::::
NP_001 PSANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQ
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE5 IVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRR
160 170 180 190 200 210
330
pF1KE5 FEELKKKT
::::::::
NP_001 FEELKKKT
335 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 00:52:41 2016 done: Tue Nov 8 00:52:42 2016
Total Scan time: 8.170 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]