Result of FASTA (ccds) for
pFN21AE5363
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5363, 299 aa
1>>>pF1KE5363 299 - 299 aa - 299 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6037+/-0.000728; mu= 11.2674+/- 0.044
mean_var=139.0076+/-26.718, 0's: 0 Z-trim(115.2): 26 B-trim: 52 in 1/49
Lambda= 0.108781
statistics sampled from 15717 (15739) to 15717 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.808), E-opt: 0.2 (0.483), width: 16
Scan time: 2.910
The best scores are: opt bits E(32554)
CCDS47296.1 SPRY4 gene_id:81848|Hs108|chr5 ( 299) 2170 351.2 5.5e-97
CCDS4274.1 SPRY4 gene_id:81848|Hs108|chr5 ( 322) 2170 351.2 5.8e-97
CCDS9463.1 SPRY2 gene_id:10253|Hs108|chr13 ( 315) 830 140.9 1.2e-33
CCDS3731.1 SPRY1 gene_id:10252|Hs108|chr4 ( 319) 825 140.2 2e-33
CCDS14769.4 SPRY3 gene_id:10251|Hs108|chrX ( 288) 769 131.3 8.2e-31
CCDS14769.4 SPRY3 gene_id:10251|Hs108|chrY ( 288) 769 131.3 8.2e-31
>>CCDS47296.1 SPRY4 gene_id:81848|Hs108|chr5 (299 aa)
initn: 2170 init1: 2170 opt: 2170 Z-score: 1854.7 bits: 351.2 E(32554): 5.5e-97
Smith-Waterman score: 2170; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299)
10 20 30 40 50 60
pF1KE5 MEPPIPQSAPLTPNSVMVQPLLDSRMSHSRLQHPLTILPIDQVKTSHVENDYIDNPSLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 MEPPIPQSAPLTPNSVMVQPLLDSRMSHSRLQHPLTILPIDQVKTSHVENDYIDNPSLAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 TTGPKRTRGGAPELAPTPARCDQDVTHHWISFSGRPSSVSSSSSTSSDQRLLDHMAPPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 TTGPKRTRGGAPELAPTPARCDQDVTHHWISFSGRPSSVSSSSSTSSDQRLLDHMAPPPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ADQASPRAVRIQPKVVHCQPLDLKGPAVPPELDKHFLLCEACGKCKCKECASPRTLPSCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ADQASPRAVRIQPKVVHCQPLDLKGPAVPPELDKHFLLCEACGKCKCKECASPRTLPSCW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 VCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSCSRSNCCARWSFMGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 VCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSCSRSNCCARWSFMGA
190 200 210 220 230 240
250 260 270 280 290
pF1KE5 LSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKHTNSVICKAASGDAKTSRPDKPF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKHTNSVICKAASGDAKTSRPDKPF
250 260 270 280 290
>>CCDS4274.1 SPRY4 gene_id:81848|Hs108|chr5 (322 aa)
initn: 2170 init1: 2170 opt: 2170 Z-score: 1854.3 bits: 351.2 E(32554): 5.8e-97
Smith-Waterman score: 2170; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:24-322)
10 20 30
pF1KE5 MEPPIPQSAPLTPNSVMVQPLLDSRMSHSRLQHPLTI
:::::::::::::::::::::::::::::::::::::
CCDS42 MLSPLPTGPLEACFSVQSRTSSPMEPPIPQSAPLTPNSVMVQPLLDSRMSHSRLQHPLTI
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 LPIDQVKTSHVENDYIDNPSLALTTGPKRTRGGAPELAPTPARCDQDVTHHWISFSGRPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 LPIDQVKTSHVENDYIDNPSLALTTGPKRTRGGAPELAPTPARCDQDVTHHWISFSGRPS
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 SVSSSSSTSSDQRLLDHMAPPPVADQASPRAVRIQPKVVHCQPLDLKGPAVPPELDKHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 SVSSSSSTSSDQRLLDHMAPPPVADQASPRAVRIQPKVVHCQPLDLKGPAVPPELDKHFL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 LCEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 LCEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEG
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 SCADHPCSCSRSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 SCADHPCSCSRSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKH
250 260 270 280 290 300
280 290
pF1KE5 TNSVICKAASGDAKTSRPDKPF
::::::::::::::::::::::
CCDS42 TNSVICKAASGDAKTSRPDKPF
310 320
>>CCDS9463.1 SPRY2 gene_id:10253|Hs108|chr13 (315 aa)
initn: 838 init1: 401 opt: 830 Z-score: 717.9 bits: 140.9 E(32554): 1.2e-33
Smith-Waterman score: 854; 45.5% identity (68.1% similar) in 279 aa overlap (31-287:34-305)
10 20 30 40 50
pF1KE5 MEPPIPQSAPLTPNSVMVQPLLDSRMSHSRLQHPLTILPIDQVKTSHVENDYIDNPSLA-
: . . .: .::... . :.: ..:...
CCDS94 RAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVP
10 20 30 40 50 60
60 70 80 90
pF1KE5 ---LTTGP------KRTR-GGAPELAPTP----------ARCDQDVTHHWISFSGRPSSV
: .: :. : : :: : :: . . .: ..: :.
CCDS94 RPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSSARAPLSRSISTVSSGSRSSTR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 SSSSSTSSDQRLL-DHMAPPPVADQASPRAVRIQPKVVHCQPLDLKGPAVPPELDKHFLL
.:.::.::.:::: . .. :::: .:.::: . .: .:: : .: :
CCDS94 TSTSSSSSEQRLLGSSFSSGPVADGI----IRVQPKS-ELKPGELK-PLSKEDLGLHAYR
130 140 150 160 170
160 170 180 190 200 210
pF1KE5 CEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGS
:: :::::::::. :: ::: :.:...::::::....::::.: :.:.::::.: ::: .
CCDS94 CEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSN-DDEDN
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE5 CADHPCSCSRSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKHT
:::.:::::.:.::.::: ::..:. :::: ::::: ::.:: : :::. :::::::..
CCDS94 CADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNS
240 250 260 270 280 290
280 290
pF1KE5 NSVICKAASGDAKTSRPDKPF
:.: ::. .
CCDS94 NTVCCKVPTVPPRNFEKPT
300 310
>>CCDS3731.1 SPRY1 gene_id:10252|Hs108|chr4 (319 aa)
initn: 889 init1: 726 opt: 825 Z-score: 713.6 bits: 140.2 E(32554): 2e-33
Smith-Waterman score: 894; 44.7% identity (68.8% similar) in 311 aa overlap (6-287:3-309)
10 20 30 40 50
pF1KE5 MEPPIPQSAPLTPNSVMV--QPLLDSR--MSHSRLQHPLTILPIDQVKTSHVENDYIDNP
::. . .:..: :: :::: ... : .: .:: .::.:. . :.: ..:
CCDS37 MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIRGSNEYTEGP
10 20 30 40 50
60 70 80 90
pF1KE5 SL----ALTTGPKRTRGG-APELAPTPARCDQDVTH-----HWI-------------SFS
:. : :.:.. . . :. : . . . : : . . .
CCDS37 SVVKRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRSTST
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE5 GRPSSVSSSSSTSSDQRLLDHMAPP--PVADQASPRAVRIQPKVVHCQPLDLKGPAVPPE
: .: .:.::.::.: :: . .:: :: . : ::.: ::: . . :::: .. .
CCDS37 GSAASSGSNSSASSEQGLLGR-SPPTRPVPGHRSERAIRTQPKQLIVD--DLKG-SLKED
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE5 LDKHFLLCEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCT
: .: ..:: :::::: ::..::::::: .::..:::::...:.::::::::.::::::.
CCDS37 LTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCS
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE5 NEDDEGSCADHPCSCSRSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRP
:.:. : .:.:::::.:.::.:. :::.:. ::::::: :: ::.:: .: :: ..::
CCDS37 NDDEGDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRP
240 250 260 270 280 290
280 290
pF1KE5 GCRCKHTNSVICKAASGDAKTSRPDKPF
:::::..:.: :: :
CCDS37 GCRCKNSNTVYCKLESCPSRGQGKPS
300 310
>>CCDS14769.4 SPRY3 gene_id:10251|Hs108|chrX (288 aa)
initn: 796 init1: 379 opt: 769 Z-score: 666.6 bits: 131.3 E(32554): 8.2e-31
Smith-Waterman score: 819; 46.2% identity (70.5% similar) in 275 aa overlap (37-290:12-278)
10 20 30 40 50 60
pF1KE5 QSAPLTPNSVMVQPLLDSRMSHSRLQHPLTILPIDQVKTSHVENDYIDNP----SLALTT
::::.:....:. :::.. : . ::..
CCDS14 MDAAVTDDFQQILPIEQLRSTHASNDYVERPPAPCKQALSS
10 20 30 40
70 80 90 100 110
pF1KE5 GPK---RTRGGAPELAPTP-------ARCDQ--DVTHHWISFSGRPSSVSSSSSTSSDQR
:. .:. . :: : ..: : . .: .: :. ::.: :. :.::::
CCDS14 -PSLIVQTHKSDWSLATMPTSLPRSLSQCHQLQPLPQH-LSQSSIASSMSHST-TASDQR
50 60 70 80 90
120 130 140 150 160
pF1KE5 LLDHMAPPPVADQASPRAVRIQPKV-VHCQPLD-LKGPAVPP--ELDKHFLLCEACGKCK
:: ..: : .. .: :: . :: . ::: : . ..:...:: ::.::
CCDS14 LLASITPSP----SGQSIIRTQPGAGVHPKADGALKGEAEQSAGHPSEHLFICEECGRCK
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE5 CKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSC
: :.. : :::::.:::.:::::..:..::::.: :.:.::::.. ::: .:::.::::
CCDS14 CVPCTAARPLPSCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCST-DDEDNCADEPCSC
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE5 SRSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCK-HTNSVICKA
. :.: .::. :. .:. :::: ::::. ::..: :.::: ::::::::: :::.: :
CCDS14 GPSSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKI
220 230 240 250 260 270
290
pF1KE5 ASGDAKTSRPDKPF
.::.:
CCDS14 SSGSAPFPKAQEKSV
280
>>CCDS14769.4 SPRY3 gene_id:10251|Hs108|chrY (288 aa)
initn: 796 init1: 379 opt: 769 Z-score: 666.6 bits: 131.3 E(32554): 8.2e-31
Smith-Waterman score: 819; 46.2% identity (70.5% similar) in 275 aa overlap (37-290:12-278)
10 20 30 40 50 60
pF1KE5 QSAPLTPNSVMVQPLLDSRMSHSRLQHPLTILPIDQVKTSHVENDYIDNP----SLALTT
::::.:....:. :::.. : . ::..
CCDS14 MDAAVTDDFQQILPIEQLRSTHASNDYVERPPAPCKQALSS
10 20 30 40
70 80 90 100 110
pF1KE5 GPK---RTRGGAPELAPTP-------ARCDQ--DVTHHWISFSGRPSSVSSSSSTSSDQR
:. .:. . :: : ..: : . .: .: :. ::.: :. :.::::
CCDS14 -PSLIVQTHKSDWSLATMPTSLPRSLSQCHQLQPLPQH-LSQSSIASSMSHST-TASDQR
50 60 70 80 90
120 130 140 150 160
pF1KE5 LLDHMAPPPVADQASPRAVRIQPKV-VHCQPLD-LKGPAVPP--ELDKHFLLCEACGKCK
:: ..: : .. .: :: . :: . ::: : . ..:...:: ::.::
CCDS14 LLASITPSP----SGQSIIRTQPGAGVHPKADGALKGEAEQSAGHPSEHLFICEECGRCK
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE5 CKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSC
: :.. : :::::.:::.:::::..:..::::.: :.:.::::.. ::: .:::.::::
CCDS14 CVPCTAARPLPSCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCST-DDEDNCADEPCSC
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE5 SRSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCK-HTNSVICKA
. :.: .::. :. .:. :::: ::::. ::..: :.::: ::::::::: :::.: :
CCDS14 GPSSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKI
220 230 240 250 260 270
290
pF1KE5 ASGDAKTSRPDKPF
.::.:
CCDS14 SSGSAPFPKAQEKSV
280
299 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 00:08:03 2016 done: Tue Nov 8 00:08:03 2016
Total Scan time: 2.910 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]