Result of FASTA (omim) for
pFN21AE5332
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5332, 290 aa
1>>>pF1KE5332 290 - 290 aa - 290 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2635+/-0.000499; mu= 10.3545+/- 0.031
mean_var=125.0104+/-26.495, 0's: 0 Z-trim(111.0): 215 B-trim: 338 in 2/52
Lambda= 0.114710
statistics sampled from 19195 (19498) to 19195 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.598), E-opt: 0.2 (0.229), width: 16
Scan time: 5.780
The best scores are: opt bits E(85289)
NP_054862 (OMIM: 605402) programmed cell death 1 l ( 290) 1903 326.7 3.3e-89
NP_001300958 (OMIM: 605402) programmed cell death ( 245) 1486 257.6 1.7e-68
NP_001254635 (OMIM: 605402) programmed cell death ( 176) 1049 185.1 8.1e-47
NP_079516 (OMIM: 605715) CD276 antigen isoform b p ( 316) 416 80.6 4.2e-15
NP_001316557 (OMIM: 605715) CD276 antigen isoform ( 316) 416 80.6 4.2e-15
NP_001316558 (OMIM: 605715) CD276 antigen isoform ( 388) 412 80.0 7.8e-15
XP_011520397 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 412 80.2 9.8e-15
NP_001019907 (OMIM: 605715) CD276 antigen isoform ( 534) 412 80.2 9.8e-15
XP_011520398 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 412 80.2 9.8e-15
XP_016878127 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 412 80.2 9.8e-15
XP_005254757 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 412 80.2 9.8e-15
NP_079515 (OMIM: 605723) programmed cell death 1 l ( 273) 366 72.3 1.2e-12
XP_005251657 (OMIM: 605723) PREDICTED: programmed ( 283) 366 72.3 1.2e-12
NP_078902 (OMIM: 608162) V-set domain-containing T ( 282) 241 51.6 2e-06
XP_016857824 (OMIM: 608162) PREDICTED: V-set domai ( 287) 241 51.6 2.1e-06
XP_011540445 (OMIM: 608162) PREDICTED: V-set domai ( 332) 241 51.7 2.3e-06
NP_001723 (OMIM: 601610) butyrophilin subfamily 1 ( 526) 243 52.2 2.5e-06
XP_005249397 (OMIM: 601610) PREDICTED: butyrophili ( 626) 243 52.3 2.9e-06
NP_008820 (OMIM: 601020) T-lymphocyte activation a ( 323) 202 45.2 0.0002
NP_787058 (OMIM: 601020) T-lymphocyte activation a ( 329) 202 45.2 0.0002
XP_011512570 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026
XP_011512569 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026
XP_006715042 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026
XP_006715044 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026
XP_006715043 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026
NP_001184163 (OMIM: 613590) butyrophilin subfamily ( 330) 199 44.7 0.00028
NP_510961 (OMIM: 613590) butyrophilin subfamily 2 ( 334) 199 44.7 0.00028
NP_008980 (OMIM: 613590) butyrophilin subfamily 2 ( 527) 199 44.9 0.0004
NP_001184167 (OMIM: 613591) butyrophilin subfamily ( 336) 194 43.9 0.00051
XP_016865658 (OMIM: 613591) PREDICTED: butyrophili ( 353) 194 43.9 0.00053
XP_016865657 (OMIM: 613591) PREDICTED: butyrophili ( 353) 194 43.9 0.00053
XP_006715018 (OMIM: 613591) PREDICTED: butyrophili ( 353) 194 43.9 0.00053
NP_008926 (OMIM: 613591) butyrophilin subfamily 2 ( 523) 194 44.1 0.0007
NP_001184166 (OMIM: 613591) butyrophilin subfamily ( 523) 194 44.1 0.0007
XP_006715016 (OMIM: 613591) PREDICTED: butyrophili ( 523) 194 44.1 0.0007
XP_011512530 (OMIM: 613591) PREDICTED: butyrophili ( 523) 194 44.1 0.0007
XP_005248854 (OMIM: 613591) PREDICTED: butyrophili ( 523) 194 44.1 0.0007
NP_005182 (OMIM: 112203) T-lymphocyte activation a ( 288) 190 43.2 0.00072
NP_001240778 (OMIM: 608162) V-set domain-containin ( 187) 187 42.5 0.00074
XP_006715045 (OMIM: 613594) PREDICTED: butyrophili ( 297) 188 42.9 0.00092
XP_011512571 (OMIM: 613594) PREDICTED: butyrophili ( 297) 188 42.9 0.00092
XP_016865702 (OMIM: 613594) PREDICTED: butyrophili ( 297) 188 42.9 0.00092
XP_016863009 (OMIM: 112203) PREDICTED: T-lymphocyt ( 249) 186 42.5 0.001
NP_001184177 (OMIM: 613594) butyrophilin subfamily ( 311) 185 42.4 0.0013
XP_005248884 (OMIM: 613594) PREDICTED: butyrophili ( 334) 185 42.4 0.0014
XP_016865700 (OMIM: 613594) PREDICTED: butyrophili ( 334) 185 42.4 0.0014
NP_001184175 (OMIM: 613594) butyrophilin subfamily ( 334) 185 42.4 0.0014
NP_001184176 (OMIM: 613594) butyrophilin subfamily ( 334) 185 42.4 0.0014
XP_016865701 (OMIM: 613594) PREDICTED: butyrophili ( 334) 185 42.4 0.0014
NP_008978 (OMIM: 613594) butyrophilin subfamily 3 ( 334) 185 42.4 0.0014
>>NP_054862 (OMIM: 605402) programmed cell death 1 ligan (290 aa)
initn: 1903 init1: 1903 opt: 1903 Z-score: 1722.5 bits: 326.7 E(85289): 3.3e-89
Smith-Waterman score: 1903; 100.0% identity (100.0% similar) in 290 aa overlap (1-290:1-290)
10 20 30 40 50 60
pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
190 200 210 220 230 240
250 260 270 280 290
pF1KE5 LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
250 260 270 280 290
>>NP_001300958 (OMIM: 605402) programmed cell death 1 li (245 aa)
initn: 1486 init1: 1486 opt: 1486 Z-score: 1350.5 bits: 257.6 E(85289): 1.7e-68
Smith-Waterman score: 1486; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227)
10 20 30 40 50 60
pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPGNILNVSIKICLT
190 200 210 220 230 240
250 260 270 280 290
pF1KE5 LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
NP_001 LSPST
>>NP_001254635 (OMIM: 605402) programmed cell death 1 li (176 aa)
initn: 1049 init1: 1049 opt: 1049 Z-score: 961.5 bits: 185.1 E(85289): 8.1e-47
Smith-Waterman score: 1049; 99.4% identity (100.0% similar) in 161 aa overlap (130-290:16-176)
100 110 120 130 140 150
pF1KE5 QITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEG
.:::::::::::::::::::::::::::::
NP_001 MRIFAVFIFMTYWHLLNAPYNKINQRILVVDPVTSEHELTCQAEG
10 20 30 40
160 170 180 190 200 210
pF1KE5 YPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEEN
50 60 70 80 90 100
220 230 240 250 260 270
pF1KE5 HTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNS
110 120 130 140 150 160
280 290
pF1KE5 KKQSDTHLEET
:::::::::::
NP_001 KKQSDTHLEET
170
>>NP_079516 (OMIM: 605715) CD276 antigen isoform b precu (316 aa)
initn: 311 init1: 180 opt: 416 Z-score: 392.1 bits: 80.6 E(85289): 4.2e-15
Smith-Waterman score: 416; 30.2% identity (59.3% similar) in 285 aa overlap (13-288:22-300)
10 20 30 40 50
pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL
: : .:. : ::.: :. :.. :. :.: : ..:
NP_079 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG
: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : :
NP_079 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG
70 80 90 100 110
120 130 140 150 160
pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA
. :..: ....: :::.: :. . : :: .::.. .:::.:
NP_079 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGYPEA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAE
::.: ... :.:..::.. :. ::.: :.::. .: . : : ... .
NP_079 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE5 LVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ-
..: :.. ::. : :.. :. : :::.:. . . . .. : .: ... .
NP_079 VTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGEGEG
240 250 260 270 280 290
290
pF1KE5 SDTHLEET
: : :.
NP_079 SKTALQPLKHSDSKEDDGQEIA
300 310
>>NP_001316557 (OMIM: 605715) CD276 antigen isoform b pr (316 aa)
initn: 311 init1: 180 opt: 416 Z-score: 392.1 bits: 80.6 E(85289): 4.2e-15
Smith-Waterman score: 416; 30.2% identity (59.3% similar) in 285 aa overlap (13-288:22-300)
10 20 30 40 50
pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL
: : .:. : ::.: :. :.. :. :.: : ..:
NP_001 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG
: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : :
NP_001 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG
70 80 90 100 110
120 130 140 150 160
pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA
. :..: ....: :::.: :. . : :: .::.. .:::.:
NP_001 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGYPEA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAE
::.: ... :.:..::.. :. ::.: :.::. .: . : : ... .
NP_001 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE5 LVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ-
..: :.. ::. : :.. :. : :::.:. . . . .. : .: ... .
NP_001 VTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGEGEG
240 250 260 270 280 290
290
pF1KE5 SDTHLEET
: : :.
NP_001 SKTALQPLKHSDSKEDDGQEIA
300 310
>>NP_001316558 (OMIM: 605715) CD276 antigen isoform c [H (388 aa)
initn: 312 init1: 180 opt: 412 Z-score: 387.3 bits: 80.0 E(85289): 7.8e-15
Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:100-372)
10 20 30 40
pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ
: : ::.: :. :.. :..:.: :
NP_001 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG
70 80 90 100 110 120
50 60 70 80 90 100
pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ
..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :..
NP_001 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA
130 140 150 160 170 180
110 120 130 140 150 160
pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY
: : . :..: ....: :::.: :. . : :: .::.. .::
NP_001 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY
190 200 210 220 230 240
170 180 190 200 210 220
pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH
:.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ...
NP_001 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA
250 260 270 280 290 300
230 240 250 260 270 280
pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK
. ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ...
NP_001 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE
310 320 330 340 350 360
290
pF1KE5 KQ-SDTHLEET
. : : :.
NP_001 GEGSKTALQPLKHSDSKEDDGQEIA
370 380
>>XP_011520397 (OMIM: 605715) PREDICTED: CD276 antigen i (534 aa)
initn: 443 init1: 180 opt: 412 Z-score: 385.6 bits: 80.2 E(85289): 9.8e-15
Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:246-518)
10 20 30 40
pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ
: : ::.: :. :.. :..:.: :
XP_011 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG
220 230 240 250 260 270
50 60 70 80 90 100
pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ
..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :..
XP_011 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA
280 290 300 310 320 330
110 120 130 140 150 160
pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY
: : . :..: ....: :::.: :. . : :: .::.. .::
XP_011 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY
340 350 360 370 380
170 180 190 200 210 220
pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH
:.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ...
XP_011 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA
390 400 410 420 430 440
230 240 250 260 270 280
pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK
. ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ...
XP_011 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE
450 460 470 480 490 500
290
pF1KE5 KQ-SDTHLEET
. : : :.
XP_011 GEGSKTALQPLKHSDSKEDDGQEIA
510 520 530
>--
initn: 247 init1: 145 opt: 374 Z-score: 351.6 bits: 73.9 E(85289): 7.6e-13
Smith-Waterman score: 374; 31.6% identity (60.0% similar) in 225 aa overlap (13-228:22-240)
10 20 30 40 50
pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL
: : .:. : ::.: :. :.. :. :.: : ..:
XP_011 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG
: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : :
XP_011 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG
70 80 90 100 110
120 130 140 150 160
pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA
. :..: ....: :::.: :. . : :: .::.. .:::.:
XP_011 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYQGYPEA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRR-LDPEENHTA
::.: ... :.:..::.. :. ::.: : ::. .: . : : . .. :..
XP_011 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE5 ELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ
. :.
XP_011 VTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLV
240 250 260 270 280 290
>>NP_001019907 (OMIM: 605715) CD276 antigen isoform a pr (534 aa)
initn: 443 init1: 180 opt: 412 Z-score: 385.6 bits: 80.2 E(85289): 9.8e-15
Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:246-518)
10 20 30 40
pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ
: : ::.: :. :.. :..:.: :
NP_001 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG
220 230 240 250 260 270
50 60 70 80 90 100
pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ
..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :..
NP_001 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA
280 290 300 310 320 330
110 120 130 140 150 160
pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY
: : . :..: ....: :::.: :. . : :: .::.. .::
NP_001 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY
340 350 360 370 380
170 180 190 200 210 220
pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH
:.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ...
NP_001 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA
390 400 410 420 430 440
230 240 250 260 270 280
pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK
. ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ...
NP_001 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE
450 460 470 480 490 500
290
pF1KE5 KQ-SDTHLEET
. : : :.
NP_001 GEGSKTALQPLKHSDSKEDDGQEIA
510 520 530
>--
initn: 247 init1: 145 opt: 374 Z-score: 351.6 bits: 73.9 E(85289): 7.6e-13
Smith-Waterman score: 374; 31.6% identity (60.0% similar) in 225 aa overlap (13-228:22-240)
10 20 30 40 50
pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL
: : .:. : ::.: :. :.. :. :.: : ..:
NP_001 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG
: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : :
NP_001 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG
70 80 90 100 110
120 130 140 150 160
pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA
. :..: ....: :::.: :. . : :: .::.. .:::.:
NP_001 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYQGYPEA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRR-LDPEENHTA
::.: ... :.:..::.. :. ::.: : ::. .: . : : . .. :..
NP_001 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE5 ELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ
. :.
NP_001 VTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLV
240 250 260 270 280 290
>>XP_011520398 (OMIM: 605715) PREDICTED: CD276 antigen i (534 aa)
initn: 443 init1: 180 opt: 412 Z-score: 385.6 bits: 80.2 E(85289): 9.8e-15
Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:246-518)
10 20 30 40
pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ
: : ::.: :. :.. :..:.: :
XP_011 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG
220 230 240 250 260 270
50 60 70 80 90 100
pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ
..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :..
XP_011 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA
280 290 300 310 320 330
110 120 130 140 150 160
pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY
: : . :..: ....: :::.: :. . : :: .::.. .::
XP_011 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY
340 350 360 370 380
170 180 190 200 210 220
pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH
:.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ...
XP_011 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA
390 400 410 420 430 440
230 240 250 260 270 280
pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK
. ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ...
XP_011 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE
450 460 470 480 490 500
290
pF1KE5 KQ-SDTHLEET
. : : :.
XP_011 GEGSKTALQPLKHSDSKEDDGQEIA
510 520 530
>--
initn: 247 init1: 145 opt: 374 Z-score: 351.6 bits: 73.9 E(85289): 7.6e-13
Smith-Waterman score: 374; 31.6% identity (60.0% similar) in 225 aa overlap (13-228:22-240)
10 20 30 40 50
pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL
: : .:. : ::.: :. :.. :. :.: : ..:
XP_011 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG
: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : :
XP_011 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG
70 80 90 100 110
120 130 140 150 160
pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA
. :..: ....: :::.: :. . : :: .::.. .:::.:
XP_011 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYQGYPEA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRR-LDPEENHTA
::.: ... :.:..::.. :. ::.: : ::. .: . : : . .. :..
XP_011 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE5 ELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ
. :.
XP_011 VTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLV
240 250 260 270 280 290
>>XP_016878127 (OMIM: 605715) PREDICTED: CD276 antigen i (534 aa)
initn: 443 init1: 180 opt: 412 Z-score: 385.6 bits: 80.2 E(85289): 9.8e-15
Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:246-518)
10 20 30 40
pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ
: : ::.: :. :.. :..:.: :
XP_016 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG
220 230 240 250 260 270
50 60 70 80 90 100
pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ
..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :..
XP_016 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA
280 290 300 310 320 330
110 120 130 140 150 160
pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY
: : . :..: ....: :::.: :. . : :: .::.. .::
XP_016 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY
340 350 360 370 380
170 180 190 200 210 220
pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH
:.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ...
XP_016 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA
390 400 410 420 430 440
230 240 250 260 270 280
pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK
. ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ...
XP_016 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE
450 460 470 480 490 500
290
pF1KE5 KQ-SDTHLEET
. : : :.
XP_016 GEGSKTALQPLKHSDSKEDDGQEIA
510 520 530
>--
initn: 247 init1: 145 opt: 374 Z-score: 351.6 bits: 73.9 E(85289): 7.6e-13
Smith-Waterman score: 374; 31.6% identity (60.0% similar) in 225 aa overlap (13-228:22-240)
10 20 30 40 50
pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL
: : .:. : ::.: :. :.. :. :.: : ..:
XP_016 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG
: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : :
XP_016 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG
70 80 90 100 110
120 130 140 150 160
pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA
. :..: ....: :::.: :. . : :: .::.. .:::.:
XP_016 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYQGYPEA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRR-LDPEENHTA
::.: ... :.:..::.. :. ::.: : ::. .: . : : . .. :..
XP_016 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE5 ELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ
. :.
XP_016 VTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLV
240 250 260 270 280 290
290 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 23:51:29 2016 done: Mon Nov 7 23:51:30 2016
Total Scan time: 5.780 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]