Result of FASTA (omim) for
pFN21AE5270
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5270, 208 aa
1>>>pF1KE5270 208 - 208 aa - 208 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9697+/-0.000305; mu= 10.9974+/- 0.019
mean_var=92.7907+/-18.172, 0's: 0 Z-trim(119.2): 74 B-trim: 192 in 2/51
Lambda= 0.133144
statistics sampled from 32825 (32906) to 32825 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.386), width: 16
Scan time: 5.990
The best scores are: opt bits E(85289)
NP_001936 (OMIM: 126150) proheparin-binding EGF-li ( 208) 1389 276.2 2.7e-74
NP_001648 (OMIM: 104640) amphiregulin preproprotei ( 252) 281 63.4 3.7e-10
NP_001720 (OMIM: 600345) probetacellulin isoform 1 ( 178) 178 43.5 0.00025
XP_011530513 (OMIM: 600345) PREDICTED: probetacell ( 178) 178 43.5 0.00025
NP_001093161 (OMIM: 190170) protransforming growth ( 159) 171 42.1 0.00058
NP_003227 (OMIM: 190170) protransforming growth fa ( 160) 171 42.1 0.00058
NP_001295088 (OMIM: 190170) protransforming growth ( 165) 171 42.2 0.0006
NP_001295087 (OMIM: 190170) protransforming growth ( 166) 171 42.2 0.0006
XP_016859228 (OMIM: 605734) PREDICTED: tomoregulin ( 337) 168 41.8 0.0016
NP_001292063 (OMIM: 605734) tomoregulin-2 isoform ( 346) 168 41.8 0.0016
XP_011509192 (OMIM: 605734) PREDICTED: tomoregulin ( 365) 168 41.8 0.0017
NP_057276 (OMIM: 605734) tomoregulin-2 isoform 1 p ( 374) 168 41.8 0.0017
NP_001153468 (OMIM: 142445,603013) pro-neuregulin- ( 308) 161 40.4 0.0037
NP_003683 (OMIM: 603421) tomoregulin-1 precursor [ ( 380) 162 40.7 0.0039
NP_039254 (OMIM: 142445,603013) pro-neuregulin-1, ( 462) 161 40.5 0.0051
XP_016868860 (OMIM: 142445,603013) PREDICTED: pro- ( 469) 161 40.5 0.0052
XP_016868859 (OMIM: 142445,603013) PREDICTED: pro- ( 486) 161 40.6 0.0053
XP_005273543 (OMIM: 142445,603013) PREDICTED: pro- ( 695) 162 40.8 0.0062
NP_039258 (OMIM: 142445,603013) pro-neuregulin-1, ( 640) 161 40.6 0.0067
XP_016868854 (OMIM: 142445,603013) PREDICTED: pro- ( 647) 161 40.6 0.0067
>>NP_001936 (OMIM: 126150) proheparin-binding EGF-like g (208 aa)
initn: 1389 init1: 1389 opt: 1389 Z-score: 1454.9 bits: 276.2 E(85289): 2.7e-74
Smith-Waterman score: 1389; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208)
10 20 30 40 50 60
pF1KE5 MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 VRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 CKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVG
130 140 150 160 170 180
190 200
pF1KE5 LLMFRYHRRGGYDVENEEKVKLGMTNSH
::::::::::::::::::::::::::::
NP_001 LLMFRYHRRGGYDVENEEKVKLGMTNSH
190 200
>>NP_001648 (OMIM: 104640) amphiregulin preproprotein [H (252 aa)
initn: 259 init1: 195 opt: 281 Z-score: 303.5 bits: 63.4 E(85289): 3.7e-10
Smith-Waterman score: 281; 34.5% identity (60.8% similar) in 148 aa overlap (70-208:100-247)
40 50 60 70 80 90
pF1KE5 PDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKP--QALATPNKEEHGKRKKK
: .:: :: . . : .. :::::
NP_001 PSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENTSDKPKRKKK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 GKGLGK------KRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVE
: :: :..:: ....:::::::::...:.: .: :. : :::: :. ..
NP_001 GGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTH
130 140 150 160 170 180
160 170 180 190 200
pF1KE5 NRLYTYDHTTILAVVAVVLSSVCLLVI-VGLLMFRYHRRGGYDVENEEKVKLGMTNSH
. . . ::..:. .:.: : .. : ...: . :. : ::. :: . :..
NP_001 SMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVH
190 200 210 220 230 240
NP_001 AIA
250
>>NP_001720 (OMIM: 600345) probetacellulin isoform 1 pre (178 aa)
initn: 161 init1: 161 opt: 178 Z-score: 198.7 bits: 43.5 E(85289): 0.00025
Smith-Waterman score: 178; 32.0% identity (66.7% similar) in 75 aa overlap (108-181:69-138)
80 90 100 110 120 130
pF1KE5 SKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPG
: ..:: .::.:.:..: ..:::.: :
NP_001 PETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEG
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE5 YHGERCHGLSLPVENRLYTY-DHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVEN
: : ::. ..: .: :. ::.. ... : .....:.
NP_001 YIGARCERVDL-----FYLRGDRGQILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKK
100 110 120 130 140 150
200
pF1KE5 EEKVKLGMTNSH
NP_001 KEEEMETLGKDITPINEDIEETNIA
160 170
>>XP_011530513 (OMIM: 600345) PREDICTED: probetacellulin (178 aa)
initn: 161 init1: 161 opt: 178 Z-score: 198.7 bits: 43.5 E(85289): 0.00025
Smith-Waterman score: 178; 32.0% identity (66.7% similar) in 75 aa overlap (108-181:69-138)
80 90 100 110 120 130
pF1KE5 SKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPG
: ..:: .::.:.:..: ..:::.: :
XP_011 PETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEG
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE5 YHGERCHGLSLPVENRLYTY-DHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVEN
: : ::. ..: .: :. ::.. ... : .....:.
XP_011 YIGARCERVDL-----FYLRGDRGQILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKK
100 110 120 130 140 150
200
pF1KE5 EEKVKLGMTNSH
XP_011 KEEEMETLGKDITPINEDIEETNIA
160 170
>>NP_001093161 (OMIM: 190170) protransforming growth fac (159 aa)
initn: 158 init1: 143 opt: 171 Z-score: 192.1 bits: 42.1 E(85289): 0.00058
Smith-Waterman score: 171; 31.8% identity (57.6% similar) in 85 aa overlap (106-187:44-128)
80 90 100 110 120 130
pF1KE5 LSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICH
. : .. .::.:: :... . :.:.::
NP_001 GIVLAACQALENSTSPLSDPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCH
20 30 40 50 60 70
140 150 160 170 180 190
pF1KE5 PGYHGERC-HGLSLPVENRLYTYDHTTILAVVAVVLSSVCLL--VIVGLLMFRYHRRGGY
:: : :: :. : : . : :.::..: .: .. :.. . : :
NP_001 SGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCR
80 90 100 110 120 130
200
pF1KE5 DVENEEKVKLGMTNSH
NP_001 ALICRHEKPSALLKGRTACCHSETVV
140 150
>>NP_003227 (OMIM: 190170) protransforming growth factor (160 aa)
initn: 158 init1: 143 opt: 171 Z-score: 192.1 bits: 42.1 E(85289): 0.00058
Smith-Waterman score: 171; 31.8% identity (57.6% similar) in 85 aa overlap (106-187:45-129)
80 90 100 110 120 130
pF1KE5 LSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICH
. : .. .::.:: :... . :.:.::
NP_003 IVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCH
20 30 40 50 60 70
140 150 160 170 180 190
pF1KE5 PGYHGERC-HGLSLPVENRLYTYDHTTILAVVAVVLSSVCLL--VIVGLLMFRYHRRGGY
:: : :: :. : : . : :.::..: .: .. :.. . : :
NP_003 SGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCR
80 90 100 110 120 130
200
pF1KE5 DVENEEKVKLGMTNSH
NP_003 ALICRHEKPSALLKGRTACCHSETVV
140 150 160
>>NP_001295088 (OMIM: 190170) protransforming growth fac (165 aa)
initn: 158 init1: 143 opt: 171 Z-score: 191.9 bits: 42.2 E(85289): 0.0006
Smith-Waterman score: 171; 31.8% identity (57.6% similar) in 85 aa overlap (106-187:50-134)
80 90 100 110 120 130
pF1KE5 LSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICH
. : .. .::.:: :... . :.:.::
NP_001 GIVLAACQALENSTSPLSDPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCH
20 30 40 50 60 70
140 150 160 170 180 190
pF1KE5 PGYHGERC-HGLSLPVENRLYTYDHTTILAVVAVVLSSVCLL--VIVGLLMFRYHRRGGY
:: : :: :. : : . : :.::..: .: .. :.. . : :
NP_001 SGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCR
80 90 100 110 120 130
200
pF1KE5 DVENEEKVKLGMTNSH
NP_001 ALICRHEKPSALLKGRTACCHSETVV
140 150 160
>>NP_001295087 (OMIM: 190170) protransforming growth fac (166 aa)
initn: 158 init1: 143 opt: 171 Z-score: 191.8 bits: 42.2 E(85289): 0.0006
Smith-Waterman score: 171; 31.8% identity (57.6% similar) in 85 aa overlap (106-187:51-135)
80 90 100 110 120 130
pF1KE5 LSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICH
. : .. .::.:: :... . :.:.::
NP_001 IVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCH
30 40 50 60 70 80
140 150 160 170 180 190
pF1KE5 PGYHGERC-HGLSLPVENRLYTYDHTTILAVVAVVLSSVCLL--VIVGLLMFRYHRRGGY
:: : :: :. : : . : :.::..: .: .. :.. . : :
NP_001 SGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCR
90 100 110 120 130 140
200
pF1KE5 DVENEEKVKLGMTNSH
NP_001 ALICRHEKPSALLKGRTACCHSETVV
150 160
>>XP_016859228 (OMIM: 605734) PREDICTED: tomoregulin-2 i (337 aa)
initn: 154 init1: 154 opt: 168 Z-score: 184.3 bits: 41.8 E(85289): 0.0016
Smith-Waterman score: 168; 28.9% identity (67.1% similar) in 76 aa overlap (107-178:255-330)
80 90 100 110 120 130
pF1KE5 SSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHP
:: ..:. ::.::.:.. ... ::: :
XP_016 TTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDA
230 240 250 260 270 280
140 150 160 170 180 190
pF1KE5 GYHGERCHGLSLPVENRL---YTYDHTTILAVVAVV-LSSVCLLVIVGLLMFRYHRRGGY
:: :..:. . : . .... : ::.... .. .:..:.
XP_016 GYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRAKL
290 300 310 320 330
200
pF1KE5 DVENEEKVKLGMTNSH
>>NP_001292063 (OMIM: 605734) tomoregulin-2 isoform 2 pr (346 aa)
initn: 154 init1: 154 opt: 168 Z-score: 184.2 bits: 41.8 E(85289): 0.0016
Smith-Waterman score: 168; 28.9% identity (67.1% similar) in 76 aa overlap (107-178:264-339)
80 90 100 110 120 130
pF1KE5 SSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHP
:: ..:. ::.::.:.. ... ::: :
NP_001 TTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDA
240 250 260 270 280 290
140 150 160 170 180 190
pF1KE5 GYHGERCHGLSLPVENRL---YTYDHTTILAVVAVV-LSSVCLLVIVGLLMFRYHRRGGY
:: :..:. . : . .... : ::.... .. .:..:.
NP_001 GYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRAKL
300 310 320 330 340
200
pF1KE5 DVENEEKVKLGMTNSH
208 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 07:26:05 2016 done: Tue Nov 8 07:26:06 2016
Total Scan time: 5.990 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]