Result of FASTA (omim) for
pFN21AE5221
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5221, 259 aa
1>>>pF1KE5221 259 - 259 aa - 259 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6646+/-0.000361; mu= 12.1316+/- 0.022
mean_var=65.3492+/-13.396, 0's: 0 Z-trim(112.8): 26 B-trim: 0 in 0/49
Lambda= 0.158655
statistics sampled from 21917 (21936) to 21917 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.629), E-opt: 0.2 (0.257), width: 16
Scan time: 5.380
The best scores are: opt bits E(85289)
NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-d ( 259) 1813 423.8 1.5e-118
NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 186) 1171 276.8 1.9e-74
NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-ster ( 254) 806 193.3 3.6e-49
NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 212) 762 183.2 3.3e-46
XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-ox ( 169) 649 157.3 1.6e-38
XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-ox ( 180) 646 156.7 2.8e-38
NP_612510 (OMIM: 610057,614020) very-long-chain en ( 308) 204 55.6 1.3e-07
NP_001308099 (OMIM: 610057,614020) very-long-chain ( 323) 204 55.6 1.3e-07
XP_011526744 (OMIM: 610057,614020) PREDICTED: very ( 329) 204 55.6 1.4e-07
XP_006723008 (OMIM: 610057,614020) PREDICTED: very ( 341) 204 55.6 1.4e-07
XP_005265824 (OMIM: 611715,612379,612713) PREDICTE ( 207) 191 52.5 7e-07
XP_016864090 (OMIM: 611715,612379,612713) PREDICTE ( 273) 165 46.6 5.6e-05
NP_078868 (OMIM: 611715,612379,612713) polyprenol ( 318) 165 46.6 6.4e-05
XP_005265823 (OMIM: 611715,612379,612713) PREDICTE ( 273) 151 43.4 0.00051
>>NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-dehyd (259 aa)
initn: 1813 init1: 1813 opt: 1813 Z-score: 2249.4 bits: 423.8 E(85289): 1.5e-118
Smith-Waterman score: 1813; 100.0% identity (100.0% similar) in 259 aa overlap (1-259:1-259)
10 20 30 40 50 60
pF1KE5 MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
190 200 210 220 230 240
250
pF1KE5 LRKFEEYPKFRKIIIPFLF
:::::::::::::::::::
NP_001 LRKFEEYPKFRKIIIPFLF
250
>>NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (186 aa)
initn: 1171 init1: 1171 opt: 1171 Z-score: 1457.5 bits: 276.8 E(85289): 1.9e-74
Smith-Waterman score: 1171; 100.0% identity (100.0% similar) in 162 aa overlap (98-259:25-186)
70 80 90 100 110 120
pF1KE5 LYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCN
::::::::::::::::::::::::::::::
NP_001 MTLPWRTWSEWKQITSFTVFPALLRCLIYPFLMRGGKPMPLLACTMAIMFCTCN
10 20 30 40 50
130 140 150 160 170 180
pF1KE5 GYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPR
60 70 80 90 100 110
190 200 210 220 230 240
pF1KE5 GGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEY
120 130 140 150 160 170
250
pF1KE5 PKFRKIIIPFLF
::::::::::::
NP_001 PKFRKIIIPFLF
180
>>NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-steroid (254 aa)
initn: 772 init1: 608 opt: 806 Z-score: 1003.8 bits: 193.3 E(85289): 3.6e-49
Smith-Waterman score: 806; 52.7% identity (74.3% similar) in 226 aa overlap (36-259:31-254)
10 20 30 40 50 60
pF1KE5 GVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRH--ALPSHRLRVPARAAWVVQELPS
: ::.: .: :.:::::: .:::::
NP_000 MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMF
.:.: : . : . :. .::..: .:: :: ..: .: :: .:.: . . :
NP_000 FAVPAGILARQPLS-LFGPPGTVLLGLFCLHYFHRTFVYSLLNRG-RPYPAILILRGTAF
70 80 90 100 110
130 140 150 160 170 180
pF1KE5 CTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGY
:: :: ::. :: .:: : : : :: :: .: :.. :: ::::::.:::.:::::. .:
NP_000 CTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISY
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 KIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRK
.::.:::: ::..::..:::.:: :::::.::. . :::::..:::. :: .::..::.
NP_000 RIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKM
180 190 200 210 220 230
250
pF1KE5 FEEYPKFRKIIIPFLF
::.::: :: .:::.:
NP_000 FEDYPKSRKALIPFIF
240 250
>>NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (212 aa)
initn: 761 init1: 761 opt: 762 Z-score: 950.7 bits: 183.2 E(85289): 3.3e-46
Smith-Waterman score: 762; 91.6% identity (95.0% similar) in 119 aa overlap (142-259:94-212)
120 130 140 150 160 170
pF1KE5 MPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDW-VTDPRFLIGFGLWLTGMLINIHSDH
:..: .. ::::::::::::::::::
NP_001 PGWCRSCPRWPCRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIHSDH
70 80 90 100 110 120
180 190 200 210 220 230
pF1KE5 ILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLS
130 140 150 160 170 180
240 250
pF1KE5 GRAKEHHEWYLRKFEEYPKFRKIIIPFLF
:::::::::::::::::::::::::::::
NP_001 GRAKEHHEWYLRKFEEYPKFRKIIIPFLF
190 200 210
>>XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (169 aa)
initn: 625 init1: 608 opt: 649 Z-score: 812.5 bits: 157.3 E(85289): 1.6e-38
Smith-Waterman score: 649; 55.8% identity (78.5% similar) in 163 aa overlap (97-259:8-169)
70 80 90 100 110 120
pF1KE5 PLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTC
.: ..: .: :: .:.: . . :::
XP_011 MRSWSLTYRTFVYSLLNRG-RPYPAILILRGTAFCTG
10 20 30
130 140 150 160 170 180
pF1KE5 NGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIP
:: ::. :: .:: : : : :: :: .: :.. :: ::::::.:::.:::::. .:.::
XP_011 NGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIP
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE5 RGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEE
.:::: ::..::..:::.:: :::::.::. . :::::..:::. :: .::..::. ::.
XP_011 QGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFED
100 110 120 130 140 150
250
pF1KE5 YPKFRKIIIPFLF
::: :: .:::.:
XP_011 YPKSRKALIPFIF
160
>>XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (180 aa)
initn: 625 init1: 608 opt: 646 Z-score: 808.3 bits: 156.7 E(85289): 2.8e-38
Smith-Waterman score: 648; 51.3% identity (74.3% similar) in 187 aa overlap (73-259:3-180)
50 60 70 80 90 100
pF1KE5 LPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIY
:.. :: .: .: :. . . ..:
XP_011 MTSQGMPR--TANHCQKLGTL------KTFVY
10 20
110 120 130 140 150 160
pF1KE5 PFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGM
.: :: .:.: . . ::: :: ::. :: .:: : : : :: :: .: :.. ::
XP_011 SLLNRG-RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGM
30 40 50 60 70 80
170 180 190 200 210 220
pF1KE5 LINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFA
::::::.:::.:::::. .:.::.:::: ::..::..:::.:: :::::.::. . :::
XP_011 GINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFA
90 100 110 120 130 140
230 240 250
pF1KE5 FFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
::..:::. :: .::..::. ::.::: :: .:::.:
XP_011 FFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
150 160 170 180
>>NP_612510 (OMIM: 610057,614020) very-long-chain enoyl- (308 aa)
initn: 225 init1: 163 opt: 204 Z-score: 257.8 bits: 55.6 E(85289): 1.3e-07
Smith-Waterman score: 205; 28.7% identity (52.8% similar) in 178 aa overlap (94-259:137-308)
70 80 90 100 110 120
pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGK-PMPLLACTMAIM
:: .: : :. : .. ::: .
NP_612 FRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN-----I
110 120 130 140 150 160
130 140 150 160 170
pF1KE5 FCTCNGYL-----QSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRK
: .:. : .. :..: .:. . ....... .: :. ::.::
NP_612 FKNCTYYWGFAAWMAYYINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRP
170 180 190 200 210 220
180 190 200 210 220 230
pF1KE5 PGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSG
:. ::: :: :. :: :. : :.:. . . : :.. : ..
NP_612 AGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTI
230 240 250 260 270 280
240 250
pF1KE5 RAKEHHEWYLRKFEEYPKFRKIIIPFLF
:: .:. ::..:..:: .: :::::.
NP_612 WAKGKHRSYLKEFRDYPPLRMPIIPFLL
290 300
>>NP_001308099 (OMIM: 610057,614020) very-long-chain eno (323 aa)
initn: 225 init1: 163 opt: 204 Z-score: 257.4 bits: 55.6 E(85289): 1.3e-07
Smith-Waterman score: 205; 28.7% identity (52.8% similar) in 178 aa overlap (94-259:152-323)
70 80 90 100 110 120
pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGK-PMPLLACTMAIM
:: .: : :. : .. ::: .
NP_001 FRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN-----I
130 140 150 160 170
130 140 150 160 170
pF1KE5 FCTCNGYL-----QSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRK
: .:. : .. :..: .:. . ....... .: :. ::.::
NP_001 FKNCTYYWGFAAWMAYYINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRP
180 190 200 210 220 230
180 190 200 210 220 230
pF1KE5 PGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSG
:. ::: :: :. :: :. : :.:. . . : :.. : ..
NP_001 AGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTI
240 250 260 270 280 290
240 250
pF1KE5 RAKEHHEWYLRKFEEYPKFRKIIIPFLF
:: .:. ::..:..:: .: :::::.
NP_001 WAKGKHRSYLKEFRDYPPLRMPIIPFLL
300 310 320
>>XP_011526744 (OMIM: 610057,614020) PREDICTED: very-lon (329 aa)
initn: 225 init1: 163 opt: 204 Z-score: 257.3 bits: 55.6 E(85289): 1.4e-07
Smith-Waterman score: 205; 28.7% identity (52.8% similar) in 178 aa overlap (94-259:158-329)
70 80 90 100 110 120
pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGK-PMPLLACTMAIM
:: .: : :. : .. ::: .
XP_011 FRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN-----I
130 140 150 160 170 180
130 140 150 160 170
pF1KE5 FCTCNGYL-----QSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRK
: .:. : .. :..: .:. . ....... .: :. ::.::
XP_011 FKNCTYYWGFAAWMAYYINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRP
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE5 PGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSG
:. ::: :: :. :: :. : :.:. . . : :.. : ..
XP_011 AGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTI
250 260 270 280 290 300
240 250
pF1KE5 RAKEHHEWYLRKFEEYPKFRKIIIPFLF
:: .:. ::..:..:: .: :::::.
XP_011 WAKGKHRSYLKEFRDYPPLRMPIIPFLL
310 320
>>XP_006723008 (OMIM: 610057,614020) PREDICTED: very-lon (341 aa)
initn: 225 init1: 163 opt: 204 Z-score: 257.1 bits: 55.6 E(85289): 1.4e-07
Smith-Waterman score: 205; 28.7% identity (52.8% similar) in 178 aa overlap (94-259:170-341)
70 80 90 100 110 120
pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGK-PMPLLACTMAIM
:: .: : :. : .. ::: .
XP_006 FRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN-----I
140 150 160 170 180 190
130 140 150 160 170
pF1KE5 FCTCNGYL-----QSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRK
: .:. : .. :..: .:. . ....... .: :. ::.::
XP_006 FKNCTYYWGFAAWMAYYINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRP
200 210 220 230 240 250
180 190 200 210 220 230
pF1KE5 PGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSG
:. ::: :: :. :: :. : :.:. . . : :.. : ..
XP_006 AGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTI
260 270 280 290 300 310
240 250
pF1KE5 RAKEHHEWYLRKFEEYPKFRKIIIPFLF
:: .:. ::..:..:: .: :::::.
XP_006 WAKGKHRSYLKEFRDYPPLRMPIIPFLL
320 330 340
259 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:38:24 2016 done: Mon Nov 7 22:38:25 2016
Total Scan time: 5.380 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]