Result of FASTA (omim) for
pFN21AE4581
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4581, 805 aa
1>>>pF1KE4581 805 - 805 aa - 805 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0204+/-0.000402; mu= 22.8196+/- 0.025
mean_var=73.8392+/-15.230, 0's: 0 Z-trim(112.3): 47 B-trim: 35 in 1/49
Lambda= 0.149256
statistics sampled from 21163 (21210) to 21163 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.605), E-opt: 0.2 (0.249), width: 16
Scan time: 10.400
The best scores are: opt bits E(85289)
NP_001278 (OMIM: 166600,602727,611490) H(+)/Cl(-) ( 805) 5294 1150.0 0
XP_011520656 (OMIM: 166600,602727,611490) PREDICTE ( 747) 4900 1065.1 0
NP_001107803 (OMIM: 166600,602727,611490) H(+)/Cl( ( 781) 4817 1047.2 0
NP_001277 (OMIM: 602726) chloride transport protei ( 869) 1146 256.8 3e-67
NP_001243888 (OMIM: 602726) chloride transport pro ( 847) 1095 245.8 5.9e-64
NP_000076 (OMIM: 602023,607364,613090) chloride ch ( 687) 566 131.8 9.8e-30
NP_001036169 (OMIM: 602024,613090) chloride channe ( 686) 539 126.0 5.5e-28
NP_004061 (OMIM: 602024,613090) chloride channel p ( 687) 539 126.0 5.5e-28
NP_001244068 (OMIM: 602024,613090) chloride channe ( 644) 530 124.0 2e-27
NP_000075 (OMIM: 300008,300009,300554,308990,31046 ( 746) 478 112.9 5.3e-24
NP_001269092 (OMIM: 300008,300009,300554,308990,31 ( 766) 478 112.9 5.4e-24
NP_001121370 (OMIM: 300008,300009,300554,308990,31 ( 816) 478 112.9 5.7e-24
NP_001121371 (OMIM: 300008,300009,300554,308990,31 ( 816) 478 112.9 5.7e-24
XP_016884747 (OMIM: 300008,300009,300554,308990,31 ( 820) 478 112.9 5.7e-24
XP_016884746 (OMIM: 300008,300009,300554,308990,31 ( 820) 478 112.9 5.7e-24
XP_011510703 (OMIM: 600570,607628,615651) PREDICTE ( 835) 478 112.9 5.8e-24
XP_006713552 (OMIM: 600570,607628,615651) PREDICTE ( 863) 478 113.0 5.9e-24
NP_001164560 (OMIM: 600570,607628,615651) chloride ( 869) 478 113.0 5.9e-24
NP_004357 (OMIM: 600570,607628,615651) chloride ch ( 898) 478 113.0 6.1e-24
NP_001230303 (OMIM: 600580) H(+)/Cl(-) exchange tr ( 791) 464 109.9 4.5e-23
NP_001820 (OMIM: 600580) H(+)/Cl(-) exchange trans ( 818) 464 109.9 4.6e-23
XP_011529888 (OMIM: 600580) PREDICTED: H(+)/Cl(-) ( 831) 464 109.9 4.6e-23
XP_005262783 (OMIM: 600580) PREDICTED: H(+)/Cl(-) ( 839) 464 109.9 4.7e-23
NP_776297 (OMIM: 600580) H(+)/Cl(-) exchange trans ( 866) 464 109.9 4.8e-23
NP_001164559 (OMIM: 600570,607628,615651) chloride ( 854) 461 109.3 7.4e-23
NP_001243873 (OMIM: 300114,302910) H(+)/Cl(-) exch ( 666) 452 107.3 2.4e-22
NP_001821 (OMIM: 300114,302910) H(+)/Cl(-) exchang ( 760) 452 107.3 2.6e-22
XP_016867229 (OMIM: 118425,160800,255700) PREDICTE ( 838) 404 97.0 3.6e-19
XP_016867228 (OMIM: 118425,160800,255700) PREDICTE ( 846) 402 96.6 4.9e-19
NP_000074 (OMIM: 118425,160800,255700) chloride ch ( 988) 384 92.8 8.1e-18
NP_001159417 (OMIM: 602023,607364,613090) chloride ( 517) 376 90.8 1.6e-17
NP_001164558 (OMIM: 600570,607628,615651) chloride ( 881) 358 87.1 3.6e-16
NP_001230301 (OMIM: 600580) H(+)/Cl(-) exchange tr ( 791) 305 75.7 9e-13
XP_006713553 (OMIM: 600570,607628,615651) PREDICTE ( 512) 270 68.0 1.2e-10
XP_011514084 (OMIM: 118425,160800,255700) PREDICTE ( 570) 269 67.8 1.5e-10
>>NP_001278 (OMIM: 166600,602727,611490) H(+)/Cl(-) exch (805 aa)
initn: 5294 init1: 5294 opt: 5294 Z-score: 6156.1 bits: 1150.0 E(85289): 0
Smith-Waterman score: 5294; 100.0% identity (100.0% similar) in 805 aa overlap (1-805:1-805)
10 20 30 40 50 60
pF1KE4 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
730 740 750 760 770 780
790 800
pF1KE4 LVTRKDLARYRLGKRGLEELSLAQT
:::::::::::::::::::::::::
NP_001 LVTRKDLARYRLGKRGLEELSLAQT
790 800
>>XP_011520656 (OMIM: 166600,602727,611490) PREDICTED: H (747 aa)
initn: 4900 init1: 4900 opt: 4900 Z-score: 5698.0 bits: 1065.1 E(85289): 0
Smith-Waterman score: 4900; 100.0% identity (100.0% similar) in 747 aa overlap (59-805:1-747)
30 40 50 60 70 80
pF1KE4 RPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEK
::::::::::::::::::::::::::::::
XP_011 MSSVELDDELLDPDMDPPHPFPKEIPHNEK
10 20 30
90 100 110 120 130 140
pF1KE4 LLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVV
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE4 ENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQ
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE4 IKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTS
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE4 LKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIF
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE4 FASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVL
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE4 GAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSY
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE4 PLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLT
400 410 420 430 440 450
510 520 530 540 550 560
pF1KE4 VSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTV
460 470 480 490 500 510
570 580 590 600 610 620
pF1KE4 IMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAR
520 530 540 550 560 570
630 640 650 660 670 680
pF1KE4 EVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLL
580 590 600 610 620 630
690 700 710 720 730 740
pF1KE4 KHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTV
640 650 660 670 680 690
750 760 770 780 790 800
pF1KE4 PQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT
700 710 720 730 740
>>NP_001107803 (OMIM: 166600,602727,611490) H(+)/Cl(-) e (781 aa)
initn: 5122 init1: 4817 opt: 4817 Z-score: 5601.1 bits: 1047.2 E(85289): 0
Smith-Waterman score: 5078; 97.0% identity (97.0% similar) in 805 aa overlap (1-805:1-781)
10 20 30 40 50 60
pF1KE4 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQ-------------
10 20 30 40
70 80 90 100 110 120
pF1KE4 SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----------DMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
50 60 70 80 90
130 140 150 160 170 180
pF1KE4 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE4 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE4 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE4 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE4 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE4 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE4 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE4 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE4 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
700 710 720 730 740 750
790 800
pF1KE4 LVTRKDLARYRLGKRGLEELSLAQT
:::::::::::::::::::::::::
NP_001 LVTRKDLARYRLGKRGLEELSLAQT
760 770 780
>>NP_001277 (OMIM: 602726) chloride transport protein 6 (869 aa)
initn: 1701 init1: 704 opt: 1146 Z-score: 1328.4 bits: 256.8 E(85289): 3e-67
Smith-Waterman score: 1815; 43.3% identity (71.3% similar) in 732 aa overlap (86-784:40-756)
60 70 80 90 100 110
pF1KE4 VGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRIN
.: : ::::::: :. .:: . ..
NP_001 CCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMD
10 20 30 40 50 60
120 130 140 150 160 170
pF1KE4 HTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFS
. : : .:.. ::. ::::. :.:. :. .. ::. :.. .... ..:: :..:
NP_001 NKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALS
70 80 90 100 110 120
180 190 200 210 220 230
pF1KE4 LLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVI
:: .: .::...:..: .:::::::::::..::.:::::.: .:::.::. :: ::.
NP_001 LLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVL
130 140 150 160 170 180
240 250 260 270 280 290
pF1KE4 LSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAA
.::.::: :::::::::::::..::. : .: ::.. : ::: : .:::::::::::
NP_001 FSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAA
190 200 210 220 230 240
300 310 320 330 340 350
pF1KE4 GVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLS-IYHGNMWDLSS
::.::::::.::.:::::::.::::: :::...: :: .:::::: : : :. ...
NP_001 GVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQL
250 260 270 280 290 300
360 370 380 390 400
pF1KE4 PGLINFGRF---DSEKMAY--TIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIH-
:::.:::.: ::.: . : .. :..:::.::.:::.:: :: :. .:.: .:
NP_001 PGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHP
310 320 330 340 350 360
410 420 430 440 450
pF1KE4 RPCL-QVIEAVLVAAVTATVAFVLIYSSRDCQPL----QGGSMSYPLQL-----------
.: : .:.:..::. ::..:.:: . .:. . : :. :. ::.
NP_001 KPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTF
370 380 390 400 410 420
460 470 480 490 500 510
pF1KE4 FCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAG
:: . ::.::. ::: :.....:::. :...:.::.:: ..::.:::::::..: .:
NP_001 FCPNDTYNDMATLFFNPQESAILQLFHQD-GTFSPVTLALFFVLYFLLACWTYGISVPSG
430 440 450 460 470 480
520 530 540 550 560 570
pF1KE4 VFIPSLLIGAAWGRLFGISL-SYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMM
.:.:::: :::.::: . : ::. . :.. : .::.:::: :::.::::.:::::..
NP_001 LFVPSLLCGAAFGRLVANVLKSYIGLGHIYS--GTFALIGAAAFLGGVVRMTISLTVILI
490 500 510 520 530 540
580 590 600 610 620 630
pF1KE4 EATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVM
:.:...:::.:::..::.:: .:: : .:.::.:. :..::.:.::. : .: : ..:
NP_001 ESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIM
550 560 570 580 590 600
640 650 660 670 680 690
pF1KE4 STPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHK
.: . . .. .:..: :. :..:::: . .. ..: : :. : . : .
NP_001 EPNLTYVYPHTRIQSLVSILRTTV--HHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSS
610 620 630 640 650 660
700 710 720 730 740
pF1KE4 VFVERSNLGLVQRRLRLKDFRDAYP--RFPPIQSIHVSQDERECTMDLSEFM-----NPS
... :.. ..: : .... .:: .. . . :....: :: . : .:
NP_001 ILT-RAG----EQRKRSQSMK-SYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPY
670 680 690 700 710
750 760 770 780 790 800
pF1KE4 PYTVPQEASLP--RVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSL
: :... . . :: : .. :.. :.:.: :..:
NP_001 PNLYPDQSPSEDWTMEERFRPLTFHGLIL---RSQLVTLLVRGVCYSESQSSASQPRLSY
720 730 740 750 760 770
pF1KE4 AQT
NP_001 AEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRH
780 790 800 810 820 830
>--
initn: 258 init1: 231 opt: 238 Z-score: 271.7 bits: 61.3 E(85289): 2.1e-08
Smith-Waterman score: 238; 37.6% identity (72.0% similar) in 93 aa overlap (703-795:769-861)
680 690 700 710 720 730
pF1KE4 ARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERE
: :: .. . :::.: :... .. . .
NP_001 LTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPR
740 750 760 770 780 790
740 750 760 770 780 790
pF1KE4 CTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRL
.:.. .:::::.:: .. . .::.:::..::::: ::. ...::..::..:. :
NP_001 MIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFL
800 810 820 830 840 850
800
pF1KE4 GKRGLEELSLAQT
:
NP_001 QARLRQHYQTI
860
>>NP_001243888 (OMIM: 602726) chloride transport protein (847 aa)
initn: 1743 init1: 704 opt: 1095 Z-score: 1269.2 bits: 245.8 E(85289): 5.9e-64
Smith-Waterman score: 1764; 43.4% identity (71.8% similar) in 705 aa overlap (113-784:45-734)
90 100 110 120 130 140
pF1KE4 IPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVAC
: .. : : .:.. ::. ::::.
NP_001 CCCCGERETRTPEELTILGETQEEEDEILPRKDYEKGRRYEAVKWMVVFAIGVCTGLVGL
20 30 40 50 60 70
150 160 170 180 190 200
pF1KE4 FIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAA
:.:. :. .. ::. :.. .... ..:: :..::: .: .::...:..: .::::::
NP_001 FVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAA
80 90 100 110 120 130
210 220 230 240 250 260
pF1KE4 GSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGIS
:::::..::.:::::.: .:::.::. :: ::..::.::: :::::::::::::..::.
NP_001 GSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLP
140 150 160 170 180 190
270 280 290 300 310 320
pF1KE4 QGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQF
: .: ::.. : ::: : .:::::::::::::.::::::.::.:::::::.:::::
NP_001 QFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQG
200 210 220 230 240 250
330 340 350 360 370
pF1KE4 LTWRIFFASMISTFTLNFVLS-IYHGNMWDLSSPGLINFGRF---DSEKMAY--TIHEIP
:::...: :: .:::::: : : :. ... :::.:::.: ::.: . : ..
NP_001 LTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLG
260 270 280 290 300 310
380 390 400 410 420 430
pF1KE4 VFIAMGVVGGVLGAVFNALNYWLTMFRIRYIH-RPCL-QVIEAVLVAAVTATVAFVLIYS
:..:::.::.:::.:: :: :. .:.: .: .: : .:.:..::. ::..:.:: .
NP_001 FFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMV
320 330 340 350 360 370
440 450 460 470
pF1KE4 SRDCQPL----QGGSMSYPLQL-----------FCADGEYNSMAAAFFNTPEKSVVSLFH
.:. . : :. :. ::. :: . ::.::. ::: :.....:::
NP_001 LGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFH
380 390 400 410 420 430
480 490 500 510 520 530
pF1KE4 DPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL-SYLTGA
. :...:.::.:: ..::.:::::::..: .:.:.:::: :::.::: . : ::. .
NP_001 QD-GTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLG
440 450 460 470 480 490
540 550 560 570 580 590
pF1KE4 AIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFI
:.. : .::.:::: :::.::::.:::::..:.:...:::.:::..::.:: .:: :
NP_001 HIYS--GTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFN
500 510 520 530 540 550
600 610 620 630 640 650
pF1KE4 EGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNH
.:.::.:. :..::.:.::. : .: : ..: .: . . .. .:..: :. :
NP_001 KGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTV--H
560 570 580 590 600
660 670 680 690 700 710
pF1KE4 NGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYP--
..:::: . .. ..: : :. : . : ..... .. ::. : .... .::
NP_001 HAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGE----QRK-RSQSMK-SYPSS
610 620 630 640 650 660
720 730 740 750 760
pF1KE4 RFPPIQSIHVSQDERECTMDLSEFM-----NPSPYTVPQEASLP--RVFKLFRALGLRHL
.. . . :....: :: . : .: : :... . . :: : .. :
NP_001 ELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGL
670 680 690 700 710 720
770 780 790 800
pF1KE4 VVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT
.. :.:.: :..:
NP_001 IL---RSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIV
730 740 750 760 770
>--
initn: 258 init1: 231 opt: 238 Z-score: 271.9 bits: 61.3 E(85289): 2.1e-08
Smith-Waterman score: 238; 37.6% identity (72.0% similar) in 93 aa overlap (703-795:747-839)
680 690 700 710 720 730
pF1KE4 ARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERE
: :: .. . :::.: :... .. . .
NP_001 LTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPR
720 730 740 750 760 770
740 750 760 770 780 790
pF1KE4 CTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRL
.:.. .:::::.:: .. . .::.:::..::::: ::. ...::..::..:. :
NP_001 MIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFL
780 790 800 810 820 830
800
pF1KE4 GKRGLEELSLAQT
:
NP_001 QARLRQHYQTI
840
>>NP_000076 (OMIM: 602023,607364,613090) chloride channe (687 aa)
initn: 315 init1: 134 opt: 566 Z-score: 654.8 bits: 131.8 E(85289): 9.8e-30
Smith-Waterman score: 620; 25.0% identity (56.5% similar) in 687 aa overlap (127-789:50-675)
100 110 120 130 140 150
pF1KE4 LDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKY
: . .:.: .::.: .:..::.
NP_000 ELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVES------
20 30 40 50 60 70
160 170 180 190 200 210
pF1KE4 RVIKGNIDKFTEKGGLSF-SLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNG
:.... . : : . : :.. .:.: .: . : : ..:::::..: .: :
NP_000 -VVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAG
80 90 100 110 120 130
220 230 240 250 260 270
pF1KE4 VKIPHVVRLKTLVIKVSGVILSVVGG--LAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF
: . . .:.. :: :. ... : : .:: ::..: . ..:: ... :.:.. .
NP_000 VVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEP-
140 150 160 170 180 190
280 290 300 310 320 330
pF1KE4 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI
. ... ... :.::.::...:.:: .:::::.: .: .. . :: :::.
NP_000 ------ENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATC
200 210 220 230 240
340 350 360 370 380 390
pF1KE4 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN
..: . . :....... ..: .: : : . . . :: :.:.: . :.::...
NP_000 GAFMFRL-LAVFNSEQETITSLYKTSF-RVD---VPFDLPEIFFFVALGGLCGILGSAYL
250 260 270 280 290 300
400 410 420 430 440 450
pF1KE4 ALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLF
. . : :: . . . : .. ::.... : . . .. .:. .:
NP_000 FCQRIFFGF-IRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHL-
310 320 330 340 350
460 470 480 490 500
pF1KE4 CADGEYNSMAAAFFNTPEKSVVSLFHDPPGS----YNPL-----TLGLFTLVYFFLACWT
:. ... . :... . :: :.: ::..: .. :.. .
NP_000 --DSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILA
360 370 380 390 400 410
510 520 530 540 550
pF1KE4 YGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD-------PGKYALMGAAAQLG
. . :: :.: .. ::: ::::: .::.. .: : :: ::: :::: ..
NP_000 TTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAA-FS
420 430 440 450 460 470
560 570 580 590 600 610
pF1KE4 GIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--
: : :.: ... .:.:.......:.......:. ... ..:: . ....:.:
NP_000 GAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI
480 490 500 510 520 530
620 630 640 650 660 670
pF1KE4 WEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARL
. :: . ... :. .: : . . .: :. :... .:.:: .:. :
NP_000 LGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVV--TSTDVAKYPLVE---STESQIL
540 550 560 570 580 590
680 690 700 710 720 730
pF1KE4 QGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTM
:.. :.::. :: . : . : ...: .
NP_000 VGIVRRAQLVQALKAEP-----------------------PSWAP--------GHQQCLQ
600 610
740 750 760 770 780 790
pF1KE4 DLSEFMNPS-PYTVP--QEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRL
:. :. : :. :.:: .. .::. :.: : . : .:...:: :. .. .
NP_000 DILAAGCPTEPVTLKLSPETSLHEAHNLFELLNL-HSLFVTSRGRAVGCVSWVEMKKAIS
620 630 640 650 660 670
800
pF1KE4 GKRGLEELSLAQT
NP_000 NLTNPPAPK
680
>>NP_001036169 (OMIM: 602024,613090) chloride channel pr (686 aa)
initn: 313 init1: 130 opt: 539 Z-score: 623.4 bits: 126.0 E(85289): 5.5e-28
Smith-Waterman score: 554; 25.1% identity (56.0% similar) in 705 aa overlap (114-789:39-674)
90 100 110 120 130 140
pF1KE4 PHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACF
... .:: : : . .:.: .::.
NP_001 EGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGE--DWYFLMTLGVLMALVSYA
10 20 30 40 50 60
150 160 170 180 190 200
pF1KE4 IDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAAFVLVGSVIVAFIEPVAA
..... : :.... . : : . : :.. .:.: .: . : : ..
NP_001 MNFAI----GC---VVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG
70 80 90 100 110
210 220 230 240 250 260
pF1KE4 GSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LAVGKEGPMIHSGSVIAAG
:::::..: .: :: . . .:.. :: :. ... : : .:: ::..: . .:::
NP_001 GSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAY
120 130 140 150 160 170
270 280 290 300 310 320
pF1KE4 ISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWN
... :.:.. . . ... ... :.::.::...:.:: .:::::.: .: ..
NP_001 LGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFS
180 190 200 210 220 230
330 340 350 360 370 380
pF1KE4 QFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIA
:: :::. ..: . . :....... ..: .: : : . . . :: :.:
NP_001 VRDYWRGFFAATCGAFIFRL-LAVFNSEQETITSLYKTSF-RVD---VPFDLPEIFFFVA
240 250 260 270 280
390 400 410 420 430
pF1KE4 MGVVGGVLG-AVFNALNYWLTMFRI-RY------IHRPCLQVIEAVLVAAVTATVAFVLI
.: . :::. : . .:.... :: .: ... ..:.:..: . .
NP_001 LGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHF
290 300 310 320 330 340
440 450 460 470 480
pF1KE4 YSSRDCQPLQGGSMSYPLQ-LFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPL---
.:: ::. :. :: :.. .. . . : .. : :.:
NP_001 LASRL-------SMKQHLDSLF--DNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTI
350 360 370 380 390
490 500 510 520 530 540
pF1KE4 --TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD---
::..: .. :.. . . . :: :.: ...::: :::.: .:. .: .
NP_001 FGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVT
400 410 420 430 440 450
550 560 570 580 590
pF1KE4 ----PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIE
:: ::: :::: ..: : :.: ... .: :.......:.......:. ...
NP_001 NPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQP
460 470 480 490 500 510
600 610 620 630 640 650
pF1KE4 GLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASN
..:: : ....:.: . :: . ... :. .: : . . .: :. :...
NP_001 SFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVV--TSTD
520 530 540 550 560 570
660 670 680 690 700 710
pF1KE4 HNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYP-
. .:.:: .. ::..: :.::: .. .. :
NP_001 VTEYPLVESTE-------------SQILV-------------GIVQRAQLVQALQAEPPS
580 590 600
720 730 740 750 760 770
pF1KE4 RFPPIQSIHVSQD--ERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDN
: : : . :: : : . : :. .:..: .. .::. :.:. : :. .
NP_001 RAPGHQCL---QDILARGCPTE------PVTLTLFSETTLHQAQNLFKLLNLQSLFVT-S
610 620 630 640 650
780 790 800
pF1KE4 RNQVVGLVTRKDLARYRLGKRGLEELSLAQT
:...:: :. .. .
NP_001 RGRAVGCVSWVEMKKAISNLTNPPAPK
660 670 680
>>NP_004061 (OMIM: 602024,613090) chloride channel prote (687 aa)
initn: 313 init1: 130 opt: 539 Z-score: 623.4 bits: 126.0 E(85289): 5.5e-28
Smith-Waterman score: 556; 24.7% identity (56.3% similar) in 705 aa overlap (114-789:39-675)
90 100 110 120 130 140
pF1KE4 PHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACF
... .:: : : . .:.: .::.
NP_004 EGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGE--DWYFLMTLGVLMALVSYA
10 20 30 40 50 60
150 160 170 180 190 200
pF1KE4 IDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAAFVLVGSVIVAFIEPVAA
..... : :.... . : : . : :.. .:.: .: . : : ..
NP_004 MNFAI----GC---VVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG
70 80 90 100 110
210 220 230 240 250 260
pF1KE4 GSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LAVGKEGPMIHSGSVIAAG
:::::..: .: :: . . .:.. :: :. ... : : .:: ::..: . .:::
NP_004 GSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAY
120 130 140 150 160 170
270 280 290 300 310 320
pF1KE4 ISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWN
... :.:.. . . ... ... :.::.::...:.:: .:::::.: .: ..
NP_004 LGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFS
180 190 200 210 220 230
330 340 350 360 370 380
pF1KE4 QFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIA
:: :::. ..: . . :....... ..: .: : : . . . :: :.:
NP_004 VRDYWRGFFAATCGAFIFRL-LAVFNSEQETITSLYKTSF-RVD---VPFDLPEIFFFVA
240 250 260 270 280
390 400 410 420 430
pF1KE4 MGVVGGVLG-AVFNALNYWLTMFRI-RY------IHRPCLQVIEAVLVAAVTATVAFVLI
.: . :::. : . .:.... :: .: ... ..:.:..: . .
NP_004 LGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHF
290 300 310 320 330 340
440 450 460 470 480
pF1KE4 YSSRDCQPLQGGSMSYPLQ-LFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPL---
.:: ::. :. :: :.. .. . . : .. : :.:
NP_004 LASRL-------SMKQHLDSLF--DNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTI
350 360 370 380 390
490 500 510 520 530 540
pF1KE4 --TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD---
::..: .. :.. . . . :: :.: ...::: :::.: .:. .: .
NP_004 FGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVT
400 410 420 430 440 450
550 560 570 580 590
pF1KE4 ----PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIE
:: ::: :::: ..: : :.: ... .: :.......:.......:. ...
NP_004 NPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQP
460 470 480 490 500 510
600 610 620 630 640 650
pF1KE4 GLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASN
..:: : ....:.: . :: . ... :. .: : . . .: :. :...
NP_004 SFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVV--TSTD
520 530 540 550 560 570
660 670 680 690 700 710
pF1KE4 HNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPR
. .:.:: .:. : :.. :.::. :. .
NP_004 VTEYPLVE---STESQILVGIVQRAQLVQALQAE--------------------------
580 590 600
720 730 740 750 760 770
pF1KE4 FPPIQSIHVSQDERECTMDLSEFMNPS-PYTVP--QEASLPRVFKLFRALGLRHLVVVDN
:: . . ...: .:. :. : :. .:..: .. .::. :.:. : :. .
NP_004 -PPSR----APGHQQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVT-S
610 620 630 640 650 660
780 790 800
pF1KE4 RNQVVGLVTRKDLARYRLGKRGLEELSLAQT
:...:: :. .. .
NP_004 RGRAVGCVSWVEMKKAISNLTNPPAPK
670 680
>>NP_001244068 (OMIM: 602024,613090) chloride channel pr (644 aa)
initn: 310 init1: 130 opt: 530 Z-score: 613.3 bits: 124.0 E(85289): 2e-27
Smith-Waterman score: 534; 25.2% identity (57.4% similar) in 664 aa overlap (157-789:30-632)
130 140 150 160 170 180
pF1KE4 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKG---GLSFSLLLWATLN
:.:.:... . .: : .. .:. ::.
NP_001 MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLM--TLG
10 20 30 40 50
190 200 210 220 230 240
pF1KE4 AAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--
. ..::. .. : :. :::::..: .: :: . . .:.. :: :. ... :
NP_001 VLMALVSYAMNFAIGCVVRGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGST
60 70 80 90 100 110
250 260 270 280 290 300
pF1KE4 LAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAF
: .:: ::..: . .::: ... :.:.. . . ... ... :.::.::...:
NP_001 LFLGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVF
120 130 140 150 160 170
310 320 330 340 350 360
pF1KE4 GAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFG
.:: .:::::.: .: .. :: :::. ..: . . :....... ..: .:
NP_001 AAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRL-LAVFNSEQETITSLYKTSF-
180 190 200 210 220
370 380 390 400 410
pF1KE4 RFDSEKMAYTIHEIPVFIAMGVVGGVLG-AVFNALNYWLTMFRI-RY------IHRPCLQ
: : . . . :: :.:.: . :::. : . .:.... :: .: .
NP_001 RVD---VPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYS
230 240 250 260 270 280
420 430 440 450 460 470
pF1KE4 VIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQ-LFCADGEYNSMAAAFFNTPEK
.. ..:.:..: . . .:: ::. :. :: :.. .. . . :
NP_001 ALATLLLASITYPPGVGHFLASRL-------SMKQHLDSLF--DNHSWALMTQNSSPPWP
290 300 310 320 330
480 490 500 510 520
pF1KE4 SVVSLFHDPPGSYNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRL
.. : :.: ::..: .. :.. . . . :: :.: ...::: :::
NP_001 EELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRL
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE4 FGISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYG
.: .:. .: . :: ::: :::: ..: : :.: ... .: :......
NP_001 LGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHA
400 410 420 430 440 450
590 600 610 620 630
pF1KE4 FPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCL
.:.......:. ... ..:: : ....:.: . :: . ... :. .: :
NP_001 LPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTL
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE4 RRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSN
. . .: :. :... . .:.:: .:. : :.. :.::. :. .
NP_001 AKDTPLEEVVKVV--TSTDVTEYPLVE---STESQILVGIVQRAQLVQALQAE-------
520 530 540 550 560
700 710 720 730 740 750
pF1KE4 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPS-PYTVP--QEASLP
:: .. ...: .:. :. : :. .:..:
NP_001 --------------------PPSRA----PGHQQCLQDILARGCPTEPVTLTLFSETTLH
570 580 590
760 770 780 790 800
pF1KE4 RVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT
.. .::. :.:. : :. .:...:: :. .. .
NP_001 QAQNLFKLLNLQSLFVT-SRGRAVGCVSWVEMKKAISNLTNPPAPK
600 610 620 630 640
>>NP_000075 (OMIM: 300008,300009,300554,308990,310468) H (746 aa)
initn: 889 init1: 219 opt: 478 Z-score: 551.9 bits: 112.9 E(85289): 5.3e-24
Smith-Waterman score: 901; 31.2% identity (58.5% similar) in 727 aa overlap (127-790:58-731)
100 110 120 130 140 150
pF1KE4 LDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKY
:.. :::.:.: .: .::: .. .. ::
NP_000 RDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKE
30 40 50 60 70 80
160 170 180
pF1KE4 RVIKGNI-------------------DKF------------TEKGGLS-----FSLLLWA
. :.. :: :..:... : .:::
NP_000 GICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWA
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE4 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
: :.... .: . : : :::::.:: .:.: : . :::::. ..:.: .
NP_000 LL---FAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSS
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE4 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
::..:::::..: .. .. : . :. .: . ....:. .::.::::::.:
NP_000 GLSLGKEGPLVH--------VACCCGNILCHCFN--KYRKNEAKRREVLSAAAAAGVSVA
210 220 230 240 250
310 320 330 340 350 360
pF1KE4 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
::::.::::::::: . .. :: :::.....::: . . :: : .. .
NP_000 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPF--GN-----SRLVLFY
260 270 280 290 300
370 380 390 400 410
pF1KE4 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVL
.: . . . :. :: .:. ::. ::.: : : . . . :::...
NP_000 VEFHTP---WHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLV
310 320 330 340 350 360
420 430 440 450 460 470
pF1KE4 VAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAA-FFNTPEKSVVSLF
:.:.:: .:: :. . . : .: .:: : .: . : . : . .
NP_000 VTAITAILAFPNEYTRMSTSEL----IS---ELFNDCGLLDSSKLCDYENRFNTSKGGEL
370 380 390 400 410
480 490 500 510 520 530
pF1KE4 HDPP---GSYNPL-TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSY
: : : :. . :.: .. . .. .:.:. . .:.::::. .:: :::.:...
NP_000 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ
420 430 440 450 460 470
540 550 560 570 580
pF1KE4 L-------TGAAIW----AD---PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYG
: : : :: :: ::..:::: :::..:::.::.:::.: :... :
NP_000 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI
480 490 500 510 520 530
590 600 610 620 630
pF1KE4 FPIMLVLMTAKIVGDVFI-EGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVM----STPV
:.: . ::.: :.:.. ::.:: ::.:.. :::. . .:. : .:: . :.
NP_000 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPL
540 550 560 570 580 590
640 650 660 670 680 690
pF1KE4 TCLRRREKVGV--IVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF
. .... : . ..:.: ...::::: . ..: :: :..:: .::. ...
NP_000 LTVLTQDSMTVEDVETIISET--TYSGFPVVV-SRESQ--RLVGFVLRRDLIISIEN---
600 610 620 630 640
700 710 720 730 740 750
pF1KE4 VERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEAS
..... :.:. . : . : .:: :. : .... ::.:: . .
NP_000 ARKKQDGVVSTSIIY--FTEHSPPLPPYTPP---------TLKLRNILDLSPFTVTDLTP
650 660 670 680 690
760 770 780 790 800
pF1KE4 LPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT
. : .:: ::::. .:. : ....:..:.::. ..
NP_000 MEIVVDIFRKLGLRQCLVTHN-GRLLGIITKKDVLKHIAQMANQDPDSILFN
700 710 720 730 740
805 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 15:18:20 2016 done: Mon Nov 7 15:18:22 2016
Total Scan time: 10.400 Total Display time: 0.230
Function used was FASTA [36.3.4 Apr, 2011]