Result of FASTA (omim) for
pFN21AE4579
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4579, 785 aa
1>>>pF1KE4579 785 - 785 aa - 785 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1482+/-0.000357; mu= 21.8180+/- 0.022
mean_var=74.7578+/-14.955, 0's: 0 Z-trim(114.1): 40 B-trim: 0 in 0/56
Lambda= 0.148336
statistics sampled from 23761 (23801) to 23761 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.655), E-opt: 0.2 (0.279), width: 16
Scan time: 10.920
The best scores are: opt bits E(85289)
NP_004707 (OMIM: 604872) proprotein convertase sub ( 785) 5444 1174.9 0
XP_016874035 (OMIM: 604872) PREDICTED: proprotein ( 426) 2941 639.1 1.2e-182
XP_006719003 (OMIM: 604872) PREDICTED: proprotein ( 426) 2941 639.1 1.2e-182
NP_002561 (OMIM: 167405) proprotein convertase sub ( 969) 1565 344.9 9.8e-94
NP_612192 (OMIM: 167405) proprotein convertase sub ( 956) 1558 343.4 2.7e-93
NP_006191 (OMIM: 600488) proprotein convertase sub ( 913) 1545 340.6 1.8e-92
NP_001177411 (OMIM: 600488) proprotein convertase (1860) 1545 340.8 3.1e-92
XP_011517071 (OMIM: 600488) PREDICTED: proprotein (1886) 1545 340.8 3.2e-92
XP_005252096 (OMIM: 600488) PREDICTED: proprotein (1887) 1545 340.8 3.2e-92
NP_612196 (OMIM: 167405) proprotein convertase sub ( 623) 1494 329.5 2.6e-89
NP_612197 (OMIM: 167405) proprotein convertase sub ( 652) 1494 329.6 2.7e-89
NP_612198 (OMIM: 167405) proprotein convertase sub ( 664) 1494 329.6 2.8e-89
NP_001276753 (OMIM: 136950) furin preproprotein [H ( 794) 1459 322.1 5.7e-87
NP_002560 (OMIM: 136950) furin preproprotein [Homo ( 794) 1459 322.1 5.7e-87
NP_001276752 (OMIM: 136950) furin preproprotein [H ( 794) 1459 322.1 5.7e-87
NP_060043 (OMIM: 600487) proprotein convertase sub ( 755) 1438 317.6 1.2e-85
NP_000430 (OMIM: 162150,600955,612362) neuroendocr ( 753) 1435 317.0 1.9e-85
XP_011526390 (OMIM: 600487) PREDICTED: proprotein ( 720) 1427 315.2 6.1e-85
XP_011526387 (OMIM: 600487) PREDICTED: proprotein ( 782) 1427 315.3 6.5e-85
XP_011526394 (OMIM: 600487) PREDICTED: proprotein ( 644) 1422 314.1 1.2e-84
XP_011526393 (OMIM: 600487) PREDICTED: proprotein ( 658) 1421 313.9 1.4e-84
NP_001171346 (OMIM: 162150,600955,612362) neuroend ( 706) 1413 312.2 4.8e-84
NP_001188458 (OMIM: 162151) neuroendocrine convert ( 603) 1307 289.5 2.9e-77
NP_001188457 (OMIM: 162151) neuroendocrine convert ( 619) 1307 289.5 2.9e-77
NP_002585 (OMIM: 162151) neuroendocrine convertase ( 638) 1307 289.5 3e-77
XP_011526395 (OMIM: 600487) PREDICTED: proprotein ( 593) 1304 288.9 4.4e-77
XP_011526389 (OMIM: 600487) PREDICTED: proprotein ( 724) 1304 288.9 5.1e-77
XP_011526388 (OMIM: 600487) PREDICTED: proprotein ( 773) 1214 269.7 3.4e-71
NP_612195 (OMIM: 167405) proprotein convertase sub ( 487) 1174 261.0 9e-69
NP_001278238 (OMIM: 167405) proprotein convertase ( 895) 1086 242.3 6.7e-63
XP_005259643 (OMIM: 600487) PREDICTED: proprotein ( 567) 985 220.6 1.5e-56
XP_011526396 (OMIM: 600487) PREDICTED: proprotein ( 567) 985 220.6 1.5e-56
XP_016882386 (OMIM: 600487) PREDICTED: proprotein ( 377) 862 194.1 9.3e-49
XP_011526398 (OMIM: 600487) PREDICTED: proprotein ( 533) 380 91.1 1.4e-17
XP_011526392 (OMIM: 600487) PREDICTED: proprotein ( 661) 380 91.2 1.6e-17
XP_011526391 (OMIM: 600487) PREDICTED: proprotein ( 688) 380 91.2 1.7e-17
XP_016870289 (OMIM: 600488) PREDICTED: proprotein (1450) 363 87.8 3.6e-16
XP_011517072 (OMIM: 600488) PREDICTED: proprotein (1441) 319 78.4 2.5e-13
XP_011526397 (OMIM: 600487) PREDICTED: proprotein ( 537) 309 75.9 5.1e-13
>>NP_004707 (OMIM: 604872) proprotein convertase subtili (785 aa)
initn: 5444 init1: 5444 opt: 5444 Z-score: 6291.4 bits: 1174.9 E(85289): 0
Smith-Waterman score: 5444; 100.0% identity (100.0% similar) in 785 aa overlap (1-785:1-785)
10 20 30 40 50 60
pF1KE4 MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK
730 740 750 760 770 780
pF1KE4 EEQIC
:::::
NP_004 EEQIC
>>XP_016874035 (OMIM: 604872) PREDICTED: proprotein conv (426 aa)
initn: 2941 init1: 2941 opt: 2941 Z-score: 3400.1 bits: 639.1 E(85289): 1.2e-182
Smith-Waterman score: 2941; 100.0% identity (100.0% similar) in 426 aa overlap (360-785:1-426)
330 340 350 360 370 380
pF1KE4 GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTD
::::::::::::::::::::::::::::::
XP_016 MPFYAEECASMLAVTFSGGDKMLRSIVTTD
10 20 30
390 400 410 420 430 440
pF1KE4 WDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEW
40 50 60 70 80 90
450 460 470 480 490 500
pF1KE4 VTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVL
100 110 120 130 140 150
510 520 530 540 550 560
pF1KE4 WNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGF
160 170 180 190 200 210
570 580 590 600 610 620
pF1KE4 NDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLL
220 230 240 250 260 270
630 640 650 660 670 680
pF1KE4 ESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLS
280 290 300 310 320 330
690 700 710 720 730 740
pF1KE4 QRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLA
340 350 360 370 380 390
750 760 770 780
pF1KE4 PDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC
::::::::::::::::::::::::::::::::::::
XP_016 PDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC
400 410 420
>>XP_006719003 (OMIM: 604872) PREDICTED: proprotein conv (426 aa)
initn: 2941 init1: 2941 opt: 2941 Z-score: 3400.1 bits: 639.1 E(85289): 1.2e-182
Smith-Waterman score: 2941; 100.0% identity (100.0% similar) in 426 aa overlap (360-785:1-426)
330 340 350 360 370 380
pF1KE4 GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTD
::::::::::::::::::::::::::::::
XP_006 MPFYAEECASMLAVTFSGGDKMLRSIVTTD
10 20 30
390 400 410 420 430 440
pF1KE4 WDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEW
40 50 60 70 80 90
450 460 470 480 490 500
pF1KE4 VTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVL
100 110 120 130 140 150
510 520 530 540 550 560
pF1KE4 WNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGF
160 170 180 190 200 210
570 580 590 600 610 620
pF1KE4 NDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLL
220 230 240 250 260 270
630 640 650 660 670 680
pF1KE4 ESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLS
280 290 300 310 320 330
690 700 710 720 730 740
pF1KE4 QRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLA
340 350 360 370 380 390
750 760 770 780
pF1KE4 PDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC
::::::::::::::::::::::::::::::::::::
XP_006 PDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC
400 410 420
>>NP_002561 (OMIM: 167405) proprotein convertase subtili (969 aa)
initn: 1391 init1: 883 opt: 1565 Z-score: 1803.8 bits: 344.9 E(85289): 9.8e-94
Smith-Waterman score: 1589; 41.8% identity (67.8% similar) in 668 aa overlap (34-673:51-695)
10 20 30 40 50 60
pF1KE4 GRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLA---GTGGPDGQGTGGPSWAVHLES
:.. :: . ..: . . :::..
NP_002 TDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQV--
30 40 50 60 70
70 80 90 100 110
pF1KE4 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEA
: : .: :: .: : : .: :.::.:. .: : : ... .. .. ..
NP_002 LGGPAE-------ADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHT
80 90 100 110 120
120 130 140 150 160
pF1KE4 VLAGHEAVRWHSEQRLLRRAKRSV-------HFNDPKYPQQWHLN--NRRSPGR-DINVT
: :.: ..:.. ::.::.: .:::: . ..:.:. .. : : ..::
NP_002 FLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 GVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHG
..:.:. ::..:.:...:::.:.. :.::::. .:::.:.:: :: :. :. : :.::
NP_002 AAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHG
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 TRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWG
::::::.:: :::.: ::.::...:.:::.::: .:: .:: ... . . :::: :::
NP_002 TRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWG
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 PDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV
::::::::::: .:.: :...:. ::::.::::: ::::::...: :. :::.:::::.
NP_002 PDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTI
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAA
..... :.: :.: ::::: ::.:.:.: . :.::::: :. ::.::::::..:
NP_002 SVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLR-QR---CTDGHTGTSVSA
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 PLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNA
:..::.::: :.. ::::::::..: :. . . ..: .: :: . :: .::::..:
NP_002 PMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDA
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 WRLVNAAKIWTSVPYLASYVSPVLKENKAIP--QSPRSLEVLWNVSRMDLEMSGLKT--L
:: :: ::.:: :. :. ..:: : :. . . : : .. :
NP_002 EALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACA----EHSDQRVVYL
490 500 510 520 530
530 540 550 560 570 580
pF1KE4 EHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERAR
:::.: .::.:::::.:.. : ::: : . : : .: . .::..: : ::.::::.:.
NP_002 EHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAE
540 550 560 570 580 590
590 600 610 620 630
pF1KE4 GTYRLVIRDVGDE---SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYL
: . : :.:. .. . : :..:.: :::.. ..:.:.:: .:. :
NP_002 GQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPEL
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE4 HDDFALPCPPGLKIPE-EDGYTI--TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVAS
. : : ...:: :. :: ::.. . : :
NP_002 EPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVH
660 670 680 690 700 710
700 710 720 730 740 750
pF1KE4 NQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQ
NP_002 FSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEM
720 730 740 750 760 770
>>NP_612192 (OMIM: 167405) proprotein convertase subtili (956 aa)
initn: 1391 init1: 883 opt: 1558 Z-score: 1795.8 bits: 343.4 E(85289): 2.7e-93
Smith-Waterman score: 1582; 42.2% identity (68.4% similar) in 652 aa overlap (34-659:51-679)
10 20 30 40 50 60
pF1KE4 GRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLA---GTGGPDGQGTGGPSWAVHLES
:.. :: . ..: . . :::..
NP_612 TDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQV--
30 40 50 60 70
70 80 90 100 110
pF1KE4 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEA
: : .: :: .: : : .: :.::.:. .: : : ... .. .. ..
NP_612 LGGPAE-------ADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHT
80 90 100 110 120
120 130 140 150 160
pF1KE4 VLAGHEAVRWHSEQRLLRRAKRSV-------HFNDPKYPQQWHLN--NRRSPGR-DINVT
: :.: ..:.. ::.::.: .:::: . ..:.:. .. : : ..::
NP_612 FLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 GVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHG
..:.:. ::..:.:...:::.:.. :.::::. .:::.:.:: :: :. :. : :.::
NP_612 AAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHG
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 TRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWG
::::::.:: :::.: ::.::...:.:::.::: .:: .:: ... . . :::: :::
NP_612 TRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWG
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 PDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV
::::::::::: .:.: :...:. ::::.::::: ::::::...: :. :::.:::::.
NP_612 PDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTI
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAA
..... :.: :.: ::::: ::.:.:.: . :.::::: :. ::.::::::..:
NP_612 SVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLR-QR---CTDGHTGTSVSA
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 PLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNA
:..::.::: :.. ::::::::..: :. . . ..: .: :: . :: .::::..:
NP_612 PMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDA
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 WRLVNAAKIWTSVPYLASYVSPVLKENKAIP--QSPRSLEVLWNVSRMDLEMSGLKT--L
:: :: ::.:: :. :. ..:: : :. .. : : .. :
NP_612 EALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA----LTSACAEHSDQRVVYL
490 500 510 520 530
530 540 550 560 570 580
pF1KE4 EHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERAR
:::.: .::.:::::.:.. : ::: : . : : .: . .::..: : ::.::::.:.
NP_612 EHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAE
540 550 560 570 580 590
590 600 610 620 630
pF1KE4 GTYRLVIRDVGDE---SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYL
: . : :.:. .. . : :..:.: :::.. ..:.:.:: .:. :
NP_612 GQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPEL
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE4 HDDFALPCPPGLKIPE-EDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQ
. : : ...:: :. ::
NP_612 EPPKAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCV
660 670 680 690 700 710
>>NP_006191 (OMIM: 600488) proprotein convertase subtili (913 aa)
initn: 1487 init1: 854 opt: 1545 Z-score: 1781.0 bits: 340.6 E(85289): 1.8e-92
Smith-Waterman score: 1571; 42.8% identity (70.3% similar) in 603 aa overlap (73-648:49-638)
50 60 70 80 90 100
pF1KE4 GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA
.:. .:. :..: :.:: :. .: :
NP_006 LALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFY---
20 30 40 50 60 70
110 120 130 140 150
pF1KE4 GHRPALEVEAIRQQ-VEAVLAGHEAVRWHSEQRLLRRAKR--------SVHFNDPKYPQQ
: ... .: .. ... .. . :.: ..: . .:.:: :..:::::.:..
NP_006 -HSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSM
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE4 W--HLNNRRSPGR-DINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLN
: : .. : . :.:. :.:.:. ::....:...:::.:.: :. ::. .: :.:
NP_006 WYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVN
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE4 SNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSME
.:: ::::. :. : :.::::::::.::. ::: :.::.:....:.:.:.::: .:: .:
NP_006 GNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVE
200 210 220 230 240 250
280 290 300 310 320
pF1KE4 A--VAFN-KHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVAS
: :.:: .: .: :: :::::::::::::: : . :...:: ::.:.::.:: ::
NP_006 AKSVSFNPQHVHI---YSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS
260 270 280 290 300 310
330 340 350 360 370 380
pF1KE4 GNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVT
::::. .:.:. :::.:::::..:... : :. :.: :::.: ::.:.:.:... ..:.:
NP_006 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT
320 330 340 350 360 370
390 400 410 420 430 440
pF1KE4 TDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRA
:: :. ::..::::::.::.:::.::: :.. : ::::::::.:: :. .
NP_006 TDLR-QR---CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN
380 390 400 410 420
450 460 470 480 490 500
pF1KE4 EWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAI-PQSP-RS
.: :: :::. :: .::::..: .: :. ::.:: : . .. :.: :.: ::
NP_006 DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRS
430 440 450 460 470 480
510 520 530 540 550 560
pF1KE4 LEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSD
. . : : .. ::::.: ..:::::::.: . : ::: : . : : .: .
NP_006 IYKASGCS--DNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHS
490 500 510 520 530 540
570 580 590 600 610 620
pF1KE4 PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--SFQV-GILRQWQLTLYGSVWSAVDI
.::..: : :..:::::: : . : . :. .. .:.. : :..:.:.:::. . .
NP_006 MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSP
550 560 570 580 590 600
630 640 650 660 670
pF1KE4 RDR----QRLLESAM---SGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFT
.. .:. : . . : .:.: :: :
NP_006 TNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN
610 620 630 640 650 660
680 690 700 710 720 730
pF1KE4 VFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVE
NP_006 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP
670 680 690 700 710 720
>>NP_001177411 (OMIM: 600488) proprotein convertase subt (1860 aa)
initn: 1454 init1: 854 opt: 1545 Z-score: 1776.8 bits: 340.8 E(85289): 3.1e-92
Smith-Waterman score: 1571; 42.8% identity (70.3% similar) in 603 aa overlap (73-648:49-638)
50 60 70 80 90 100
pF1KE4 GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA
.:. .:. :..: :.:: :. .: :
NP_001 LALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFY---
20 30 40 50 60 70
110 120 130 140 150
pF1KE4 GHRPALEVEAIRQQ-VEAVLAGHEAVRWHSEQRLLRRAKR--------SVHFNDPKYPQQ
: ... .: .. ... .. . :.: ..: . .:.:: :..:::::.:..
NP_001 -HSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSM
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE4 W--HLNNRRSPGR-DINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLN
: : .. : . :.:. :.:.:. ::....:...:::.:.: :. ::. .: :.:
NP_001 WYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVN
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE4 SNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSME
.:: ::::. :. : :.::::::::.::. ::: :.::.:....:.:.:.::: .:: .:
NP_001 GNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVE
200 210 220 230 240 250
280 290 300 310 320
pF1KE4 A--VAFN-KHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVAS
: :.:: .: .: :: :::::::::::::: : . :...:: ::.:.::.:: ::
NP_001 AKSVSFNPQHVHI---YSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS
260 270 280 290 300 310
330 340 350 360 370 380
pF1KE4 GNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVT
::::. .:.:. :::.:::::..:... : :. :.: :::.: ::.:.:.:... ..:.:
NP_001 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT
320 330 340 350 360 370
390 400 410 420 430 440
pF1KE4 TDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRA
:: :. ::..::::::.::.:::.::: :.. : ::::::::.:: :. .
NP_001 TDLR-QR---CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN
380 390 400 410 420
450 460 470 480 490 500
pF1KE4 EWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAI-PQSP-RS
.: :: :::. :: .::::..: .: :. ::.:: : . .. :.: :.: ::
NP_001 DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRS
430 440 450 460 470 480
510 520 530 540 550 560
pF1KE4 LEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSD
. . : : .. ::::.: ..:::::::.: . : ::: : . : : .: .
NP_001 IYKASGCS--DNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHS
490 500 510 520 530 540
570 580 590 600 610 620
pF1KE4 PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--SFQV-GILRQWQLTLYGSVWSAVDI
.::..: : :..:::::: : . : . :. .. .:.. : :..:.:.:::. . .
NP_001 MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSP
550 560 570 580 590 600
630 640 650 660 670
pF1KE4 RDR----QRLLESAM---SGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFT
.. .:. : . . : .:.: :: :
NP_001 TNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN
610 620 630 640 650 660
680 690 700 710 720 730
pF1KE4 VFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVE
NP_001 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP
670 680 690 700 710 720
>>XP_011517071 (OMIM: 600488) PREDICTED: proprotein conv (1886 aa)
initn: 1454 init1: 854 opt: 1545 Z-score: 1776.7 bits: 340.8 E(85289): 3.2e-92
Smith-Waterman score: 1571; 42.8% identity (70.3% similar) in 603 aa overlap (73-648:49-638)
50 60 70 80 90 100
pF1KE4 GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA
.:. .:. :..: :.:: :. .: :
XP_011 LALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFY---
20 30 40 50 60 70
110 120 130 140 150
pF1KE4 GHRPALEVEAIRQQ-VEAVLAGHEAVRWHSEQRLLRRAKR--------SVHFNDPKYPQQ
: ... .: .. ... .. . :.: ..: . .:.:: :..:::::.:..
XP_011 -HSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSM
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE4 W--HLNNRRSPGR-DINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLN
: : .. : . :.:. :.:.:. ::....:...:::.:.: :. ::. .: :.:
XP_011 WYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVN
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE4 SNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSME
.:: ::::. :. : :.::::::::.::. ::: :.::.:....:.:.:.::: .:: .:
XP_011 GNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVE
200 210 220 230 240 250
280 290 300 310 320
pF1KE4 A--VAFN-KHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVAS
: :.:: .: .: :: :::::::::::::: : . :...:: ::.:.::.:: ::
XP_011 AKSVSFNPQHVHI---YSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS
260 270 280 290 300 310
330 340 350 360 370 380
pF1KE4 GNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVT
::::. .:.:. :::.:::::..:... : :. :.: :::.: ::.:.:.:... ..:.:
XP_011 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT
320 330 340 350 360 370
390 400 410 420 430 440
pF1KE4 TDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRA
:: :. ::..::::::.::.:::.::: :.. : ::::::::.:: :. .
XP_011 TDLR-QR---CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN
380 390 400 410 420
450 460 470 480 490 500
pF1KE4 EWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAI-PQSP-RS
.: :: :::. :: .::::..: .: :. ::.:: : . .. :.: :.: ::
XP_011 DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRS
430 440 450 460 470 480
510 520 530 540 550 560
pF1KE4 LEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSD
. . : : .. ::::.: ..:::::::.: . : ::: : . : : .: .
XP_011 IYKASGCS--DNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHS
490 500 510 520 530 540
570 580 590 600 610 620
pF1KE4 PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--SFQV-GILRQWQLTLYGSVWSAVDI
.::..: : :..:::::: : . : . :. .. .:.. : :..:.:.:::. . .
XP_011 MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSP
550 560 570 580 590 600
630 640 650 660 670
pF1KE4 RDR----QRLLESAM---SGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFT
.. .:. : . . : .:.: :: :
XP_011 TNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN
610 620 630 640 650 660
680 690 700 710 720 730
pF1KE4 VFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVE
XP_011 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP
670 680 690 700 710 720
>>XP_005252096 (OMIM: 600488) PREDICTED: proprotein conv (1887 aa)
initn: 1454 init1: 854 opt: 1545 Z-score: 1776.7 bits: 340.8 E(85289): 3.2e-92
Smith-Waterman score: 1571; 42.8% identity (70.3% similar) in 603 aa overlap (73-648:49-638)
50 60 70 80 90 100
pF1KE4 GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA
.:. .:. :..: :.:: :. .: :
XP_005 LALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFY---
20 30 40 50 60 70
110 120 130 140 150
pF1KE4 GHRPALEVEAIRQQ-VEAVLAGHEAVRWHSEQRLLRRAKR--------SVHFNDPKYPQQ
: ... .: .. ... .. . :.: ..: . .:.:: :..:::::.:..
XP_005 -HSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSM
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE4 W--HLNNRRSPGR-DINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLN
: : .. : . :.:. :.:.:. ::....:...:::.:.: :. ::. .: :.:
XP_005 WYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVN
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE4 SNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSME
.:: ::::. :. : :.::::::::.::. ::: :.::.:....:.:.:.::: .:: .:
XP_005 GNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVE
200 210 220 230 240 250
280 290 300 310 320
pF1KE4 A--VAFN-KHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVAS
: :.:: .: .: :: :::::::::::::: : . :...:: ::.:.::.:: ::
XP_005 AKSVSFNPQHVHI---YSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS
260 270 280 290 300 310
330 340 350 360 370 380
pF1KE4 GNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVT
::::. .:.:. :::.:::::..:... : :. :.: :::.: ::.:.:.:... ..:.:
XP_005 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT
320 330 340 350 360 370
390 400 410 420 430 440
pF1KE4 TDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRA
:: :. ::..::::::.::.:::.::: :.. : ::::::::.:: :. .
XP_005 TDLR-QR---CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN
380 390 400 410 420
450 460 470 480 490 500
pF1KE4 EWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAI-PQSP-RS
.: :: :::. :: .::::..: .: :. ::.:: : . .. :.: :.: ::
XP_005 DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRS
430 440 450 460 470 480
510 520 530 540 550 560
pF1KE4 LEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSD
. . : : .. ::::.: ..:::::::.: . : ::: : . : : .: .
XP_005 IYKASGCS--DNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHS
490 500 510 520 530 540
570 580 590 600 610 620
pF1KE4 PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--SFQV-GILRQWQLTLYGSVWSAVDI
.::..: : :..:::::: : . : . :. .. .:.. : :..:.:.:::. . .
XP_005 MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSP
550 560 570 580 590 600
630 640 650 660 670
pF1KE4 RDR----QRLLESAM---SGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFT
.. .:. : . . : .:.: :: :
XP_005 TNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN
610 620 630 640 650 660
680 690 700 710 720 730
pF1KE4 VFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVE
XP_005 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP
670 680 690 700 710 720
>>NP_612196 (OMIM: 167405) proprotein convertase subtili (623 aa)
initn: 1447 init1: 883 opt: 1494 Z-score: 1724.3 bits: 329.5 E(85289): 2.6e-89
Smith-Waterman score: 1518; 44.0% identity (70.2% similar) in 580 aa overlap (34-595:51-609)
10 20 30 40 50 60
pF1KE4 GRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLA---GTGGPDGQGTGGPSWAVHLES
:.. :: . ..: . . :::..
NP_612 TDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQV--
30 40 50 60 70
70 80 90 100 110
pF1KE4 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEA
: : .: :: .: : : .: :.::.:. .: : : ... .. .. ..
NP_612 LGGPAE-------ADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHT
80 90 100 110 120
120 130 140 150 160
pF1KE4 VLAGHEAVRWHSEQRLLRRAKRSV-------HFNDPKYPQQWHLN--NRRSPGR-DINVT
: :.: ..:.. ::.::.: .:::: . ..:.:. .. : : ..::
NP_612 FLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 GVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHG
..:.:. ::..:.:...:::.:.. :.::::. .:::.:.:: :: :. :. : :.::
NP_612 AAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHG
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 TRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWG
::::::.:: :::.: ::.::...:.:::.::: .:: .:: ... . . :::: :::
NP_612 TRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWG
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 PDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV
::::::::::: .:.: :...:. ::::.::::: ::::::...: :. :::.:::::.
NP_612 PDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTI
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAA
..... :.: :.: ::::: ::.:.:.: . :.::::: :. ::.::::::..:
NP_612 SVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLR-QR---CTDGHTGTSVSA
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 PLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNA
:..::.::: :.. ::::::::..: :. . . ..: .: :: . :: .::::..:
NP_612 PMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDA
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 WRLVNAAKIWTSVPYLASYVSPVLKENKAIP--QSPRSLEVLWNVSRMDLEMSGLKT--L
:: :: ::.:: :. :. ..:: : :. .. : : .. :
NP_612 EALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTT----ALTSACAEHSDQRVVYL
490 500 510 520 530
530 540 550 560 570 580
pF1KE4 EHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERAR
:::.: .::.:::::.:.. : ::: : . : : .: . .::..: : ::.::::.:.
NP_612 EHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAE
540 550 560 570 580 590
590 600 610 620 630 640
pF1KE4 GTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALP
: . : :.:.
NP_612 GQWTLEIQDLPSQVRNPEKQGNLD
600 610 620
785 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:48:03 2016 done: Sat Nov 5 23:48:05 2016
Total Scan time: 10.920 Total Display time: 0.190
Function used was FASTA [36.3.4 Apr, 2011]