FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4579, 785 aa 1>>>pF1KE4579 785 - 785 aa - 785 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1482+/-0.000357; mu= 21.8180+/- 0.022 mean_var=74.7578+/-14.955, 0's: 0 Z-trim(114.1): 40 B-trim: 0 in 0/56 Lambda= 0.148336 statistics sampled from 23761 (23801) to 23761 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.655), E-opt: 0.2 (0.279), width: 16 Scan time: 10.920 The best scores are: opt bits E(85289) NP_004707 (OMIM: 604872) proprotein convertase sub ( 785) 5444 1174.9 0 XP_016874035 (OMIM: 604872) PREDICTED: proprotein ( 426) 2941 639.1 1.2e-182 XP_006719003 (OMIM: 604872) PREDICTED: proprotein ( 426) 2941 639.1 1.2e-182 NP_002561 (OMIM: 167405) proprotein convertase sub ( 969) 1565 344.9 9.8e-94 NP_612192 (OMIM: 167405) proprotein convertase sub ( 956) 1558 343.4 2.7e-93 NP_006191 (OMIM: 600488) proprotein convertase sub ( 913) 1545 340.6 1.8e-92 NP_001177411 (OMIM: 600488) proprotein convertase (1860) 1545 340.8 3.1e-92 XP_011517071 (OMIM: 600488) PREDICTED: proprotein (1886) 1545 340.8 3.2e-92 XP_005252096 (OMIM: 600488) PREDICTED: proprotein (1887) 1545 340.8 3.2e-92 NP_612196 (OMIM: 167405) proprotein convertase sub ( 623) 1494 329.5 2.6e-89 NP_612197 (OMIM: 167405) proprotein convertase sub ( 652) 1494 329.6 2.7e-89 NP_612198 (OMIM: 167405) proprotein convertase sub ( 664) 1494 329.6 2.8e-89 NP_001276753 (OMIM: 136950) furin preproprotein [H ( 794) 1459 322.1 5.7e-87 NP_002560 (OMIM: 136950) furin preproprotein [Homo ( 794) 1459 322.1 5.7e-87 NP_001276752 (OMIM: 136950) furin preproprotein [H ( 794) 1459 322.1 5.7e-87 NP_060043 (OMIM: 600487) proprotein convertase sub ( 755) 1438 317.6 1.2e-85 NP_000430 (OMIM: 162150,600955,612362) neuroendocr ( 753) 1435 317.0 1.9e-85 XP_011526390 (OMIM: 600487) PREDICTED: proprotein ( 720) 1427 315.2 6.1e-85 XP_011526387 (OMIM: 600487) PREDICTED: proprotein ( 782) 1427 315.3 6.5e-85 XP_011526394 (OMIM: 600487) PREDICTED: proprotein ( 644) 1422 314.1 1.2e-84 XP_011526393 (OMIM: 600487) PREDICTED: proprotein ( 658) 1421 313.9 1.4e-84 NP_001171346 (OMIM: 162150,600955,612362) neuroend ( 706) 1413 312.2 4.8e-84 NP_001188458 (OMIM: 162151) neuroendocrine convert ( 603) 1307 289.5 2.9e-77 NP_001188457 (OMIM: 162151) neuroendocrine convert ( 619) 1307 289.5 2.9e-77 NP_002585 (OMIM: 162151) neuroendocrine convertase ( 638) 1307 289.5 3e-77 XP_011526395 (OMIM: 600487) PREDICTED: proprotein ( 593) 1304 288.9 4.4e-77 XP_011526389 (OMIM: 600487) PREDICTED: proprotein ( 724) 1304 288.9 5.1e-77 XP_011526388 (OMIM: 600487) PREDICTED: proprotein ( 773) 1214 269.7 3.4e-71 NP_612195 (OMIM: 167405) proprotein convertase sub ( 487) 1174 261.0 9e-69 NP_001278238 (OMIM: 167405) proprotein convertase ( 895) 1086 242.3 6.7e-63 XP_005259643 (OMIM: 600487) PREDICTED: proprotein ( 567) 985 220.6 1.5e-56 XP_011526396 (OMIM: 600487) PREDICTED: proprotein ( 567) 985 220.6 1.5e-56 XP_016882386 (OMIM: 600487) PREDICTED: proprotein ( 377) 862 194.1 9.3e-49 XP_011526398 (OMIM: 600487) PREDICTED: proprotein ( 533) 380 91.1 1.4e-17 XP_011526392 (OMIM: 600487) PREDICTED: proprotein ( 661) 380 91.2 1.6e-17 XP_011526391 (OMIM: 600487) PREDICTED: proprotein ( 688) 380 91.2 1.7e-17 XP_016870289 (OMIM: 600488) PREDICTED: proprotein (1450) 363 87.8 3.6e-16 XP_011517072 (OMIM: 600488) PREDICTED: proprotein (1441) 319 78.4 2.5e-13 XP_011526397 (OMIM: 600487) PREDICTED: proprotein ( 537) 309 75.9 5.1e-13 >>NP_004707 (OMIM: 604872) proprotein convertase subtili (785 aa) initn: 5444 init1: 5444 opt: 5444 Z-score: 6291.4 bits: 1174.9 E(85289): 0 Smith-Waterman score: 5444; 100.0% identity (100.0% similar) in 785 aa overlap (1-785:1-785) 10 20 30 40 50 60 pF1KE4 MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK 730 740 750 760 770 780 pF1KE4 EEQIC ::::: NP_004 EEQIC >>XP_016874035 (OMIM: 604872) PREDICTED: proprotein conv (426 aa) initn: 2941 init1: 2941 opt: 2941 Z-score: 3400.1 bits: 639.1 E(85289): 1.2e-182 Smith-Waterman score: 2941; 100.0% identity (100.0% similar) in 426 aa overlap (360-785:1-426) 330 340 350 360 370 380 pF1KE4 GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTD :::::::::::::::::::::::::::::: XP_016 MPFYAEECASMLAVTFSGGDKMLRSIVTTD 10 20 30 390 400 410 420 430 440 pF1KE4 WDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEW 40 50 60 70 80 90 450 460 470 480 490 500 pF1KE4 VTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVL 100 110 120 130 140 150 510 520 530 540 550 560 pF1KE4 WNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGF 160 170 180 190 200 210 570 580 590 600 610 620 pF1KE4 NDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLL 220 230 240 250 260 270 630 640 650 660 670 680 pF1KE4 ESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLS 280 290 300 310 320 330 690 700 710 720 730 740 pF1KE4 QRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLA 340 350 360 370 380 390 750 760 770 780 pF1KE4 PDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC :::::::::::::::::::::::::::::::::::: XP_016 PDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC 400 410 420 >>XP_006719003 (OMIM: 604872) PREDICTED: proprotein conv (426 aa) initn: 2941 init1: 2941 opt: 2941 Z-score: 3400.1 bits: 639.1 E(85289): 1.2e-182 Smith-Waterman score: 2941; 100.0% identity (100.0% similar) in 426 aa overlap (360-785:1-426) 330 340 350 360 370 380 pF1KE4 GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTD :::::::::::::::::::::::::::::: XP_006 MPFYAEECASMLAVTFSGGDKMLRSIVTTD 10 20 30 390 400 410 420 430 440 pF1KE4 WDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEW 40 50 60 70 80 90 450 460 470 480 490 500 pF1KE4 VTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVL 100 110 120 130 140 150 510 520 530 540 550 560 pF1KE4 WNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGF 160 170 180 190 200 210 570 580 590 600 610 620 pF1KE4 NDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLL 220 230 240 250 260 270 630 640 650 660 670 680 pF1KE4 ESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLS 280 290 300 310 320 330 690 700 710 720 730 740 pF1KE4 QRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLA 340 350 360 370 380 390 750 760 770 780 pF1KE4 PDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC :::::::::::::::::::::::::::::::::::: XP_006 PDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC 400 410 420 >>NP_002561 (OMIM: 167405) proprotein convertase subtili (969 aa) initn: 1391 init1: 883 opt: 1565 Z-score: 1803.8 bits: 344.9 E(85289): 9.8e-94 Smith-Waterman score: 1589; 41.8% identity (67.8% similar) in 668 aa overlap (34-673:51-695) 10 20 30 40 50 60 pF1KE4 GRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLA---GTGGPDGQGTGGPSWAVHLES :.. :: . ..: . . :::.. NP_002 TDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQV-- 30 40 50 60 70 70 80 90 100 110 pF1KE4 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEA : : .: :: .: : : .: :.::.:. .: : : ... .. .. .. NP_002 LGGPAE-------ADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHT 80 90 100 110 120 120 130 140 150 160 pF1KE4 VLAGHEAVRWHSEQRLLRRAKRSV-------HFNDPKYPQQWHLN--NRRSPGR-DINVT : :.: ..:.. ::.::.: .:::: . ..:.:. .. : : ..:: NP_002 FLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE4 GVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHG ..:.:. ::..:.:...:::.:.. :.::::. .:::.:.:: :: :. :. : :.:: NP_002 AAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE4 TRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWG ::::::.:: :::.: ::.::...:.:::.::: .:: .:: ... . . :::: ::: NP_002 TRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWG 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE4 PDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV ::::::::::: .:.: :...:. ::::.::::: ::::::...: :. :::.:::::. NP_002 PDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTI 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE4 TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAA ..... :.: :.: ::::: ::.:.:.: . :.::::: :. ::.::::::..: NP_002 SVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLR-QR---CTDGHTGTSVSA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE4 PLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNA :..::.::: :.. ::::::::..: :. . . ..: .: :: . :: .::::..: NP_002 PMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE4 WRLVNAAKIWTSVPYLASYVSPVLKENKAIP--QSPRSLEVLWNVSRMDLEMSGLKT--L :: :: ::.:: :. :. ..:: : :. . . : : .. : NP_002 EALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACA----EHSDQRVVYL 490 500 510 520 530 530 540 550 560 570 580 pF1KE4 EHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERAR :::.: .::.:::::.:.. : ::: : . : : .: . .::..: : ::.::::.:. NP_002 EHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAE 540 550 560 570 580 590 590 600 610 620 630 pF1KE4 GTYRLVIRDVGDE---SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYL : . : :.:. .. . : :..:.: :::.. ..:.:.:: .:. : NP_002 GQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPEL 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE4 HDDFALPCPPGLKIPE-EDGYTI--TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVAS . : : ...:: :. :: ::.. . : : NP_002 EPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVH 660 670 680 690 700 710 700 710 720 730 740 750 pF1KE4 NQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQ NP_002 FSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEM 720 730 740 750 760 770 >>NP_612192 (OMIM: 167405) proprotein convertase subtili (956 aa) initn: 1391 init1: 883 opt: 1558 Z-score: 1795.8 bits: 343.4 E(85289): 2.7e-93 Smith-Waterman score: 1582; 42.2% identity (68.4% similar) in 652 aa overlap (34-659:51-679) 10 20 30 40 50 60 pF1KE4 GRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLA---GTGGPDGQGTGGPSWAVHLES :.. :: . ..: . . :::.. NP_612 TDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQV-- 30 40 50 60 70 70 80 90 100 110 pF1KE4 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEA : : .: :: .: : : .: :.::.:. .: : : ... .. .. .. NP_612 LGGPAE-------ADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHT 80 90 100 110 120 120 130 140 150 160 pF1KE4 VLAGHEAVRWHSEQRLLRRAKRSV-------HFNDPKYPQQWHLN--NRRSPGR-DINVT : :.: ..:.. ::.::.: .:::: . ..:.:. .. : : ..:: NP_612 FLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE4 GVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHG ..:.:. ::..:.:...:::.:.. :.::::. .:::.:.:: :: :. :. : :.:: NP_612 AAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE4 TRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWG ::::::.:: :::.: ::.::...:.:::.::: .:: .:: ... . . :::: ::: NP_612 TRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWG 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE4 PDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV ::::::::::: .:.: :...:. ::::.::::: ::::::...: :. :::.:::::. NP_612 PDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTI 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE4 TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAA ..... :.: :.: ::::: ::.:.:.: . :.::::: :. ::.::::::..: NP_612 SVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLR-QR---CTDGHTGTSVSA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE4 PLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNA :..::.::: :.. ::::::::..: :. . . ..: .: :: . :: .::::..: NP_612 PMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE4 WRLVNAAKIWTSVPYLASYVSPVLKENKAIP--QSPRSLEVLWNVSRMDLEMSGLKT--L :: :: ::.:: :. :. ..:: : :. .. : : .. : NP_612 EALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA----LTSACAEHSDQRVVYL 490 500 510 520 530 530 540 550 560 570 580 pF1KE4 EHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERAR :::.: .::.:::::.:.. : ::: : . : : .: . .::..: : ::.::::.:. NP_612 EHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAE 540 550 560 570 580 590 590 600 610 620 630 pF1KE4 GTYRLVIRDVGDE---SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYL : . : :.:. .. . : :..:.: :::.. ..:.:.:: .:. : NP_612 GQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPEL 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE4 HDDFALPCPPGLKIPE-EDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQ . : : ...:: :. :: NP_612 EPPKAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCV 660 670 680 690 700 710 >>NP_006191 (OMIM: 600488) proprotein convertase subtili (913 aa) initn: 1487 init1: 854 opt: 1545 Z-score: 1781.0 bits: 340.6 E(85289): 1.8e-92 Smith-Waterman score: 1571; 42.8% identity (70.3% similar) in 603 aa overlap (73-648:49-638) 50 60 70 80 90 100 pF1KE4 GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA .:. .:. :..: :.:: :. .: : NP_006 LALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFY--- 20 30 40 50 60 70 110 120 130 140 150 pF1KE4 GHRPALEVEAIRQQ-VEAVLAGHEAVRWHSEQRLLRRAKR--------SVHFNDPKYPQQ : ... .: .. ... .. . :.: ..: . .:.:: :..:::::.:.. NP_006 -HSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSM 80 90 100 110 120 130 160 170 180 190 200 210 pF1KE4 W--HLNNRRSPGR-DINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLN : : .. : . :.:. :.:.:. ::....:...:::.:.: :. ::. .: :.: NP_006 WYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVN 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE4 SNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSME .:: ::::. :. : :.::::::::.::. ::: :.::.:....:.:.:.::: .:: .: NP_006 GNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVE 200 210 220 230 240 250 280 290 300 310 320 pF1KE4 A--VAFN-KHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVAS : :.:: .: .: :: :::::::::::::: : . :...:: ::.:.::.:: :: NP_006 AKSVSFNPQHVHI---YSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS 260 270 280 290 300 310 330 340 350 360 370 380 pF1KE4 GNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVT ::::. .:.:. :::.:::::..:... : :. :.: :::.: ::.:.:.:... ..:.: NP_006 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT 320 330 340 350 360 370 390 400 410 420 430 440 pF1KE4 TDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRA :: :. ::..::::::.::.:::.::: :.. : ::::::::.:: :. . NP_006 TDLR-QR---CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN 380 390 400 410 420 450 460 470 480 490 500 pF1KE4 EWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAI-PQSP-RS .: :: :::. :: .::::..: .: :. ::.:: : . .. :.: :.: :: NP_006 DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRS 430 440 450 460 470 480 510 520 530 540 550 560 pF1KE4 LEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSD . . : : .. ::::.: ..:::::::.: . : ::: : . : : .: . NP_006 IYKASGCS--DNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHS 490 500 510 520 530 540 570 580 590 600 610 620 pF1KE4 PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--SFQV-GILRQWQLTLYGSVWSAVDI .::..: : :..:::::: : . : . :. .. .:.. : :..:.:.:::. . . NP_006 MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSP 550 560 570 580 590 600 630 640 650 660 670 pF1KE4 RDR----QRLLESAM---SGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFT .. .:. : . . : .:.: :: : NP_006 TNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN 610 620 630 640 650 660 680 690 700 710 720 730 pF1KE4 VFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVE NP_006 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP 670 680 690 700 710 720 >>NP_001177411 (OMIM: 600488) proprotein convertase subt (1860 aa) initn: 1454 init1: 854 opt: 1545 Z-score: 1776.8 bits: 340.8 E(85289): 3.1e-92 Smith-Waterman score: 1571; 42.8% identity (70.3% similar) in 603 aa overlap (73-648:49-638) 50 60 70 80 90 100 pF1KE4 GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA .:. .:. :..: :.:: :. .: : NP_001 LALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFY--- 20 30 40 50 60 70 110 120 130 140 150 pF1KE4 GHRPALEVEAIRQQ-VEAVLAGHEAVRWHSEQRLLRRAKR--------SVHFNDPKYPQQ : ... .: .. ... .. . :.: ..: . .:.:: :..:::::.:.. NP_001 -HSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSM 80 90 100 110 120 130 160 170 180 190 200 210 pF1KE4 W--HLNNRRSPGR-DINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLN : : .. : . :.:. :.:.:. ::....:...:::.:.: :. ::. .: :.: NP_001 WYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVN 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE4 SNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSME .:: ::::. :. : :.::::::::.::. ::: :.::.:....:.:.:.::: .:: .: NP_001 GNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVE 200 210 220 230 240 250 280 290 300 310 320 pF1KE4 A--VAFN-KHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVAS : :.:: .: .: :: :::::::::::::: : . :...:: ::.:.::.:: :: NP_001 AKSVSFNPQHVHI---YSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS 260 270 280 290 300 310 330 340 350 360 370 380 pF1KE4 GNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVT ::::. .:.:. :::.:::::..:... : :. :.: :::.: ::.:.:.:... ..:.: NP_001 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT 320 330 340 350 360 370 390 400 410 420 430 440 pF1KE4 TDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRA :: :. ::..::::::.::.:::.::: :.. : ::::::::.:: :. . NP_001 TDLR-QR---CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN 380 390 400 410 420 450 460 470 480 490 500 pF1KE4 EWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAI-PQSP-RS .: :: :::. :: .::::..: .: :. ::.:: : . .. :.: :.: :: NP_001 DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRS 430 440 450 460 470 480 510 520 530 540 550 560 pF1KE4 LEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSD . . : : .. ::::.: ..:::::::.: . : ::: : . : : .: . NP_001 IYKASGCS--DNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHS 490 500 510 520 530 540 570 580 590 600 610 620 pF1KE4 PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--SFQV-GILRQWQLTLYGSVWSAVDI .::..: : :..:::::: : . : . :. .. .:.. : :..:.:.:::. . . NP_001 MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSP 550 560 570 580 590 600 630 640 650 660 670 pF1KE4 RDR----QRLLESAM---SGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFT .. .:. : . . : .:.: :: : NP_001 TNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN 610 620 630 640 650 660 680 690 700 710 720 730 pF1KE4 VFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVE NP_001 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP 670 680 690 700 710 720 >>XP_011517071 (OMIM: 600488) PREDICTED: proprotein conv (1886 aa) initn: 1454 init1: 854 opt: 1545 Z-score: 1776.7 bits: 340.8 E(85289): 3.2e-92 Smith-Waterman score: 1571; 42.8% identity (70.3% similar) in 603 aa overlap (73-648:49-638) 50 60 70 80 90 100 pF1KE4 GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA .:. .:. :..: :.:: :. .: : XP_011 LALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFY--- 20 30 40 50 60 70 110 120 130 140 150 pF1KE4 GHRPALEVEAIRQQ-VEAVLAGHEAVRWHSEQRLLRRAKR--------SVHFNDPKYPQQ : ... .: .. ... .. . :.: ..: . .:.:: :..:::::.:.. XP_011 -HSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSM 80 90 100 110 120 130 160 170 180 190 200 210 pF1KE4 W--HLNNRRSPGR-DINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLN : : .. : . :.:. :.:.:. ::....:...:::.:.: :. ::. .: :.: XP_011 WYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVN 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE4 SNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSME .:: ::::. :. : :.::::::::.::. ::: :.::.:....:.:.:.::: .:: .: XP_011 GNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVE 200 210 220 230 240 250 280 290 300 310 320 pF1KE4 A--VAFN-KHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVAS : :.:: .: .: :: :::::::::::::: : . :...:: ::.:.::.:: :: XP_011 AKSVSFNPQHVHI---YSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS 260 270 280 290 300 310 330 340 350 360 370 380 pF1KE4 GNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVT ::::. .:.:. :::.:::::..:... : :. :.: :::.: ::.:.:.:... ..:.: XP_011 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT 320 330 340 350 360 370 390 400 410 420 430 440 pF1KE4 TDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRA :: :. ::..::::::.::.:::.::: :.. : ::::::::.:: :. . XP_011 TDLR-QR---CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN 380 390 400 410 420 450 460 470 480 490 500 pF1KE4 EWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAI-PQSP-RS .: :: :::. :: .::::..: .: :. ::.:: : . .. :.: :.: :: XP_011 DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRS 430 440 450 460 470 480 510 520 530 540 550 560 pF1KE4 LEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSD . . : : .. ::::.: ..:::::::.: . : ::: : . : : .: . XP_011 IYKASGCS--DNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHS 490 500 510 520 530 540 570 580 590 600 610 620 pF1KE4 PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--SFQV-GILRQWQLTLYGSVWSAVDI .::..: : :..:::::: : . : . :. .. .:.. : :..:.:.:::. . . XP_011 MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSP 550 560 570 580 590 600 630 640 650 660 670 pF1KE4 RDR----QRLLESAM---SGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFT .. .:. : . . : .:.: :: : XP_011 TNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN 610 620 630 640 650 660 680 690 700 710 720 730 pF1KE4 VFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVE XP_011 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP 670 680 690 700 710 720 >>XP_005252096 (OMIM: 600488) PREDICTED: proprotein conv (1887 aa) initn: 1454 init1: 854 opt: 1545 Z-score: 1776.7 bits: 340.8 E(85289): 3.2e-92 Smith-Waterman score: 1571; 42.8% identity (70.3% similar) in 603 aa overlap (73-648:49-638) 50 60 70 80 90 100 pF1KE4 GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA .:. .:. :..: :.:: :. .: : XP_005 LALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFY--- 20 30 40 50 60 70 110 120 130 140 150 pF1KE4 GHRPALEVEAIRQQ-VEAVLAGHEAVRWHSEQRLLRRAKR--------SVHFNDPKYPQQ : ... .: .. ... .. . :.: ..: . .:.:: :..:::::.:.. XP_005 -HSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSM 80 90 100 110 120 130 160 170 180 190 200 210 pF1KE4 W--HLNNRRSPGR-DINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLN : : .. : . :.:. :.:.:. ::....:...:::.:.: :. ::. .: :.: XP_005 WYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVN 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE4 SNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSME .:: ::::. :. : :.::::::::.::. ::: :.::.:....:.:.:.::: .:: .: XP_005 GNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVE 200 210 220 230 240 250 280 290 300 310 320 pF1KE4 A--VAFN-KHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVAS : :.:: .: .: :: :::::::::::::: : . :...:: ::.:.::.:: :: XP_005 AKSVSFNPQHVHI---YSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWAS 260 270 280 290 300 310 330 340 350 360 370 380 pF1KE4 GNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVT ::::. .:.:. :::.:::::..:... : :. :.: :::.: ::.:.:.:... ..:.: XP_005 GNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIIT 320 330 340 350 360 370 390 400 410 420 430 440 pF1KE4 TDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRA :: :. ::..::::::.::.:::.::: :.. : ::::::::.:: :. . XP_005 TDLR-QR---CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN 380 390 400 410 420 450 460 470 480 490 500 pF1KE4 EWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAI-PQSP-RS .: :: :::. :: .::::..: .: :. ::.:: : . .. :.: :.: :: XP_005 DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRS 430 440 450 460 470 480 510 520 530 540 550 560 pF1KE4 LEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSD . . : : .. ::::.: ..:::::::.: . : ::: : . : : .: . XP_005 IYKASGCS--DNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHS 490 500 510 520 530 540 570 580 590 600 610 620 pF1KE4 PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--SFQV-GILRQWQLTLYGSVWSAVDI .::..: : :..:::::: : . : . :. .. .:.. : :..:.:.:::. . . XP_005 MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSP 550 560 570 580 590 600 630 640 650 660 670 pF1KE4 RDR----QRLLESAM---SGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFT .. .:. : . . : .:.: :: : XP_005 TNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN 610 620 630 640 650 660 680 690 700 710 720 730 pF1KE4 VFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVE XP_005 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP 670 680 690 700 710 720 >>NP_612196 (OMIM: 167405) proprotein convertase subtili (623 aa) initn: 1447 init1: 883 opt: 1494 Z-score: 1724.3 bits: 329.5 E(85289): 2.6e-89 Smith-Waterman score: 1518; 44.0% identity (70.2% similar) in 580 aa overlap (34-595:51-609) 10 20 30 40 50 60 pF1KE4 GRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLA---GTGGPDGQGTGGPSWAVHLES :.. :: . ..: . . :::.. NP_612 TDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQV-- 30 40 50 60 70 70 80 90 100 110 pF1KE4 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEA : : .: :: .: : : .: :.::.:. .: : : ... .. .. .. NP_612 LGGPAE-------ADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHT 80 90 100 110 120 120 130 140 150 160 pF1KE4 VLAGHEAVRWHSEQRLLRRAKRSV-------HFNDPKYPQQWHLN--NRRSPGR-DINVT : :.: ..:.. ::.::.: .:::: . ..:.:. .. : : ..:: NP_612 FLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE4 GVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHG ..:.:. ::..:.:...:::.:.. :.::::. .:::.:.:: :: :. :. : :.:: NP_612 AAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE4 TRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWG ::::::.:: :::.: ::.::...:.:::.::: .:: .:: ... . . :::: ::: NP_612 TRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWG 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE4 PDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV ::::::::::: .:.: :...:. ::::.::::: ::::::...: :. :::.:::::. NP_612 PDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTI 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE4 TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAA ..... :.: :.: ::::: ::.:.:.: . :.::::: :. ::.::::::..: NP_612 SVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLR-QR---CTDGHTGTSVSA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE4 PLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNA :..::.::: :.. ::::::::..: :. . . ..: .: :: . :: .::::..: NP_612 PMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE4 WRLVNAAKIWTSVPYLASYVSPVLKENKAIP--QSPRSLEVLWNVSRMDLEMSGLKT--L :: :: ::.:: :. :. ..:: : :. .. : : .. : NP_612 EALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTT----ALTSACAEHSDQRVVYL 490 500 510 520 530 530 540 550 560 570 580 pF1KE4 EHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERAR :::.: .::.:::::.:.. : ::: : . : : .: . .::..: : ::.::::.:. NP_612 EHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAE 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE4 GTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALP : . : :.:. NP_612 GQWTLEIQDLPSQVRNPEKQGNLD 600 610 620 785 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:48:03 2016 done: Sat Nov 5 23:48:05 2016 Total Scan time: 10.920 Total Display time: 0.190 Function used was FASTA [36.3.4 Apr, 2011]