Result of FASTA (omim) for
pFN21AE4576
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4576, 763 aa
1>>>pF1KE4576 763 - 763 aa - 763 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8350+/-0.000436; mu= 17.1814+/- 0.027
mean_var=69.5139+/-13.879, 0's: 0 Z-trim(110.4): 59 B-trim: 22 in 1/49
Lambda= 0.153829
statistics sampled from 18645 (18704) to 18645 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.219), width: 16
Scan time: 8.660
The best scores are: opt bits E(85289)
NP_000173 (OMIM: 600890,609015,609016) trifunction ( 763) 4923 1102.3 0
NP_005318 (OMIM: 231530,601609,609975) hydroxyacyl ( 314) 548 131.3 6.3e-30
NP_001159887 (OMIM: 607037,615605) peroxisomal bif ( 627) 484 117.1 2.2e-25
XP_011510819 (OMIM: 607037,615605) PREDICTED: pero ( 627) 484 117.1 2.2e-25
NP_001957 (OMIM: 607037,615605) peroxisomal bifunc ( 723) 484 117.2 2.5e-25
XP_006713588 (OMIM: 607037,615605) PREDICTED: pero ( 515) 466 113.1 3e-24
XP_016861328 (OMIM: 607037,615605) PREDICTED: pero ( 515) 466 113.1 3e-24
NP_001317956 (OMIM: 231530,601609,609975) hydroxya ( 318) 460 111.7 4.8e-24
NP_001171634 (OMIM: 231530,601609,609975) hydroxya ( 331) 437 106.6 1.7e-22
NP_001689 (OMIM: 250950,600529) methylglutaconyl-C ( 339) 378 93.5 1.5e-18
XP_005252123 (OMIM: 250950,600529) PREDICTED: meth ( 349) 374 92.7 2.9e-18
XP_016870338 (OMIM: 250950,600529) PREDICTED: meth ( 323) 366 90.9 9.3e-18
XP_005252124 (OMIM: 250950,600529) PREDICTED: meth ( 333) 362 90.0 1.8e-17
XP_005252126 (OMIM: 250950,600529) PREDICTED: meth ( 298) 352 87.7 7.5e-17
XP_016870339 (OMIM: 250950,600529) PREDICTED: meth ( 230) 341 85.3 3.2e-16
XP_011517104 (OMIM: 250950,600529) PREDICTED: meth ( 230) 341 85.3 3.2e-16
NP_004083 (OMIM: 602292,616277) enoyl-CoA hydratas ( 290) 333 83.5 1.4e-15
XP_016870340 (OMIM: 250950,600529) PREDICTED: meth ( 214) 329 82.6 1.9e-15
NP_001293119 (OMIM: 250950,600529) methylglutacony ( 310) 272 70.0 1.7e-11
XP_006717213 (OMIM: 250950,600529) PREDICTED: meth ( 320) 272 70.0 1.8e-11
NP_001910 (OMIM: 600305) enoyl-CoA delta isomerase ( 302) 259 67.1 1.2e-10
XP_005252129 (OMIM: 250950,600529) PREDICTED: meth ( 255) 241 63.1 1.7e-09
XP_011517102 (OMIM: 250950,600529) PREDICTED: meth ( 265) 237 62.2 3.2e-09
NP_055177 (OMIM: 250620,610690) 3-hydroxyisobutyry ( 386) 239 62.7 3.3e-09
XP_011509255 (OMIM: 250620,610690) PREDICTED: 3-hy ( 386) 239 62.7 3.3e-09
NP_932164 (OMIM: 250620,610690) 3-hydroxyisobutyry ( 338) 238 62.5 3.5e-09
NP_001137442 (OMIM: 603778) chromodomain Y-like pr ( 412) 223 59.2 4.2e-08
NP_001137443 (OMIM: 603778) chromodomain Y-like pr ( 412) 223 59.2 4.2e-08
NP_057058 (OMIM: 609877) lambda-crystallin homolog ( 319) 221 58.7 4.5e-08
XP_011513299 (OMIM: 603778) PREDICTED: chromodomai ( 522) 223 59.2 5.1e-08
NP_004815 (OMIM: 603778) chromodomain Y-like prote ( 544) 223 59.2 5.3e-08
XP_005267105 (OMIM: 612136) PREDICTED: ethylmalony ( 301) 209 56.0 2.7e-07
XP_005267104 (OMIM: 612136) PREDICTED: ethylmalony ( 301) 209 56.0 2.7e-07
NP_001002030 (OMIM: 612136) ethylmalonyl-CoA decar ( 301) 209 56.0 2.7e-07
NP_001132982 (OMIM: 612136) ethylmalonyl-CoA decar ( 307) 209 56.0 2.7e-07
XP_016881937 (OMIM: 600696) PREDICTED: delta(3,5)- ( 248) 207 55.5 3.1e-07
NP_001389 (OMIM: 600696) delta(3,5)-Delta(2,4)-die ( 328) 207 55.6 4e-07
NP_001171500 (OMIM: 600305) enoyl-CoA delta isomer ( 285) 205 55.1 4.8e-07
NP_004816 (OMIM: 400018,415000) testis-specific ch ( 541) 195 53.0 3.9e-06
XP_005266473 (OMIM: 609877) PREDICTED: lambda-crys ( 217) 189 51.5 4.4e-06
NP_733841 (OMIM: 400016,415000) testis-specific ch ( 540) 194 52.8 4.6e-06
NP_004671 (OMIM: 400016,415000) testis-specific ch ( 554) 194 52.8 4.7e-06
XP_011529814 (OMIM: 400016,415000) PREDICTED: test ( 470) 193 52.5 4.7e-06
NP_001099014 (OMIM: 612136) ethylmalonyl-CoA decar ( 226) 185 50.6 8.4e-06
XP_016866545 (OMIM: 612136) PREDICTED: ethylmalony ( 226) 185 50.6 8.4e-06
XP_016876113 (OMIM: 609877) PREDICTED: lambda-crys ( 234) 182 50.0 1.4e-05
XP_011534244 (OMIM: 612136) PREDICTED: ethylmalony ( 189) 174 48.2 3.9e-05
>>NP_000173 (OMIM: 600890,609015,609016) trifunctional e (763 aa)
initn: 4923 init1: 4923 opt: 4923 Z-score: 5899.4 bits: 1102.3 E(85289): 0
Smith-Waterman score: 4923; 100.0% identity (100.0% similar) in 763 aa overlap (1-763:1-763)
10 20 30 40 50 60
pF1KE4 MVACRAIGILSRFSAFRILRSRGYICRNFTGSSALLTRTHINYGVKGDVAVVRINSPNSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MVACRAIGILSRFSAFRILRSRGYICRNFTGSSALLTRTHINYGVKGDVAVVRINSPNSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLAACKTLQEVTQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLAACKTLQEVTQLS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEERTIEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEERTIEYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 EEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 PLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQKD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 ERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 ISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 DGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 EDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 LPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRF
670 680 690 700 710 720
730 740 750 760
pF1KE4 VDLYGAQKIVDRLKKYEAAYGKQFTPCQLLADHANSPNKKFYQ
:::::::::::::::::::::::::::::::::::::::::::
NP_000 VDLYGAQKIVDRLKKYEAAYGKQFTPCQLLADHANSPNKKFYQ
730 740 750 760
>>NP_005318 (OMIM: 231530,601609,609975) hydroxyacyl-coe (314 aa)
initn: 380 init1: 252 opt: 548 Z-score: 658.3 bits: 131.3 E(85289): 6.3e-30
Smith-Waterman score: 548; 33.9% identity (65.4% similar) in 289 aa overlap (361-640:27-314)
340 350 360 370 380 390
pF1KE4 VMTKESKALMGLYHGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILK
:::....:.::::::::::.. : ..:
NP_005 MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLV
10 20 30 40 50
400 410 420 430 440
pF1KE4 DATLTALDRGQQQVFKGLNDKVKKK------ALTSFERDSIFSNLTGQLDYQGFEKADMV
: : : .... . ..: .::: : : . .. . :. . ...:.:
NP_005 DQTEDILAKSKKGIEESLRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLV
60 70 80 90 100 110
450 460 470 480 490 500
pF1KE4 IEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVD
.::. :.:..:....:... .: :::::::.: :. :: .. : .. :.:.:.::
NP_005 VEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVP
120 130 140 150 160 170
510 520 530 540 550 560
pF1KE4 KMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQE
:.:.:.: : ::. : : : . :: . :: ::: ..: :.:.. :.::. ..
NP_005 VMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYER
180 190 200 210 220 230
570 580 590 600 610 620
pF1KE4 GVDPKKLD---SLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELLTQ
: : .: : .. . :.:.: :.: ::.:..: ... .. .: :..
NP_005 G-DASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNK
240 250 260 270 280 290
630 640 650 660 670 680
pF1KE4 MVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRF
.:... .:.:.:.::: :.
NP_005 LVAENKFGKKTGEGFYKYK
300 310
>>NP_001159887 (OMIM: 607037,615605) peroxisomal bifunct (627 aa)
initn: 783 init1: 385 opt: 484 Z-score: 576.7 bits: 117.1 E(85289): 2.2e-25
Smith-Waterman score: 902; 30.3% identity (61.1% similar) in 647 aa overlap (146-761:3-616)
120 130 140 150 160 170
pF1KE4 VTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVL
.:::::.:..:.:::: . . .: :::
NP_001 MAFGGGLELALGCHYRIAHAEAQ--VGLPEVT
10 20 30
180 190 200 210 220 230
pF1KE4 LGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEER
:: :::: ::: ::...:::::::.. .:: : ::.: :.:..:..:. : ::
NP_001 LGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKLGILDKVVNS-----DPVEE-
40 50 60 70 80
240 250 260 270 280 290
pF1KE4 TIEYLEEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTK
:: ::. ..:. . .: : .: ...: . ....... :.:.:
NP_001 --------AIRFAQRVSDQPLESRR---LCNK---PIQSLPNM-DSIFSEALLKMRRQHP
90 100 110 120
300 310 320 330 340 350
pF1KE4 GLYPAPLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFG
: : . .:..... ..: : . : :... ...::. . .. : ::..
NP_001 GCL-AQEACVRAVQAAVQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAER--KANKWS
130 140 150 160 170 180
360 370 380 390 400
pF1KE4 APQ---------KDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFK
.:. . :. ....: : :: ::. . . .: :. . : ..... .
NP_001 TPSGASWKTASARPVSSVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITS
190 200 210 220 230 240
410 420 430 440 450 460
pF1KE4 GLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVI
:. ...: .. .. ::... : .:.:::::::..:::..:. :. ::
NP_001 VLEKEASKMQQSGHPWSGPKPRLTSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVC
250 260 270 280 290 300
470 480 490 500 510 520
pF1KE4 PDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAV
. .. .::::: ..:::. . ::. ::: :.:::. :.:::.: .. .: : :...
NP_001 KPEAFLCTNTSALDVDEIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVM
310 320 330 340 350 360
530 540 550 560 570 580
pF1KE4 AVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAAT
.. : :. .:: . :: .: : :..... .:.:: :...:.. ::: .:
NP_001 NLSKKIKKIGVVVGNCFGFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFR
370 380 390 400 410 420
590 600 610 620 630
pF1KE4 LVDEVGVDVAKHVAEDLGKVFGERFGG------GN------PELLTQMVSKGFLGRKSGK
. : .:.::. . . : . . : :: :..: .. : .:.:.::
NP_001 VSDLAGLDVGWKSRKGQGLTGPTLLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGK
430 440 450 460 470 480
640 650 660 670 680
pF1KE4 GFYIYQEG---VKRKD--LNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCL
:.: :.. ... : :.. .. . .. :.. .:.:: .. : . ..::: :
NP_001 GWYQYDKPLGRIHKPDPWLSKFLSRYRKTHHIEPRT-ISQDEILE-RCLYSLINEAFRIL
490 500 510 520 530
690 700 710 720 730 740
pF1KE4 QEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPC
::: :.: . :. . : :.: :::. ... : ....:.:: . :. :
NP_001 GEGIAASPEHIDVVYLHGYGWPRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPS
540 550 560 570 580 590
750 760
pF1KE4 QLL---ADHANSPNKKFYQ
. : :...: : :..
NP_001 DYLKKLASQGNPPLKEWQSLAGSPSSKL
600 610 620
>>XP_011510819 (OMIM: 607037,615605) PREDICTED: peroxiso (627 aa)
initn: 783 init1: 385 opt: 484 Z-score: 576.7 bits: 117.1 E(85289): 2.2e-25
Smith-Waterman score: 902; 30.3% identity (61.1% similar) in 647 aa overlap (146-761:3-616)
120 130 140 150 160 170
pF1KE4 VTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVL
.:::::.:..:.:::: . . .: :::
XP_011 MAFGGGLELALGCHYRIAHAEAQ--VGLPEVT
10 20 30
180 190 200 210 220 230
pF1KE4 LGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEER
:: :::: ::: ::...:::::::.. .:: : ::.: :.:..:..:. : ::
XP_011 LGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKLGILDKVVNS-----DPVEE-
40 50 60 70 80
240 250 260 270 280 290
pF1KE4 TIEYLEEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTK
:: ::. ..:. . .: : .: ...: . ....... :.:.:
XP_011 --------AIRFAQRVSDQPLESRR---LCNK---PIQSLPNM-DSIFSEALLKMRRQHP
90 100 110 120
300 310 320 330 340 350
pF1KE4 GLYPAPLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFG
: : . .:..... ..: : . : :... ...::. . .. : ::..
XP_011 GCL-AQEACVRAVQAAVQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAER--KANKWS
130 140 150 160 170 180
360 370 380 390 400
pF1KE4 APQ---------KDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFK
.:. . :. ....: : :: ::. . . .: :. . : ..... .
XP_011 TPSGASWKTASARPVSSVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITS
190 200 210 220 230 240
410 420 430 440 450 460
pF1KE4 GLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVI
:. ...: .. .. ::... : .:.:::::::..:::..:. :. ::
XP_011 VLEKEASKMQQSGHPWSGPKPRLTSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVC
250 260 270 280 290 300
470 480 490 500 510 520
pF1KE4 PDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAV
. .. .::::: ..:::. . ::. ::: :.:::. :.:::.: .. .: : :...
XP_011 KPEAFLCTNTSALDVDEIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVM
310 320 330 340 350 360
530 540 550 560 570 580
pF1KE4 AVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAAT
.. : :. .:: . :: .: : :..... .:.:: :...:.. ::: .:
XP_011 NLSKKIKKIGVVVGNCFGFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFR
370 380 390 400 410 420
590 600 610 620 630
pF1KE4 LVDEVGVDVAKHVAEDLGKVFGERFGG------GN------PELLTQMVSKGFLGRKSGK
. : .:.::. . . : . . : :: :..: .. : .:.:.::
XP_011 VSDLAGLDVGWKSRKGQGLTGPTLLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGK
430 440 450 460 470 480
640 650 660 670 680
pF1KE4 GFYIYQEG---VKRKD--LNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCL
:.: :.. ... : :.. .. . .. :.. .:.:: .. : . ..::: :
XP_011 GWYQYDKPLGRIHKPDPWLSKFLSRYRKTHHIEPRT-ISQDEILE-RCLYSLINEAFRIL
490 500 510 520 530
690 700 710 720 730 740
pF1KE4 QEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPC
::: :.: . :. . : :.: :::. ... : ....:.:: . :. :
XP_011 GEGIAASPEHIDVVYLHGYGWPRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPS
540 550 560 570 580 590
750 760
pF1KE4 QLL---ADHANSPNKKFYQ
. : :...: : :..
XP_011 DYLKKLASQGNPPLKEWQSLAGSPSSKL
600 610 620
>>NP_001957 (OMIM: 607037,615605) peroxisomal bifunction (723 aa)
initn: 847 init1: 385 opt: 484 Z-score: 575.7 bits: 117.2 E(85289): 2.5e-25
Smith-Waterman score: 1028; 30.2% identity (61.2% similar) in 744 aa overlap (49-761:11-712)
20 30 40 50 60 70
pF1KE4 LRSRGYICRNFTGSSALLTRTHINYGVKGDVAVVRINSPNSKVNTLSKELHSEFSEVMNE
.:..:. .: ::..: : ...: ...
NP_001 MAEYTRLHNALALIRLRNP--PVNAISTTLLRDIKEGLQK
10 20 30
80 90 100 110 120 130
pF1KE4 IWASDQIRSAVLISSKPGCFIAGADINMLAACKTLQEVTQLSQEAQRIVEKLEKSTKPIV
. :. :..: . : : ::::: ..: .:. . ..:...... ::.:
NP_001 AVIDHTIK-AIVICGAEGKFSAGADIRGFSAPRTF------GLTLGHVVDEIQRNEKPVV
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 AAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALPGAGGTQRLPKMVGVPAAL
:::.: .:::::.:..:.:::: . . .: ::: :: :::: ::: ::...::::::
NP_001 AAIQGMAFGGGLELALGCHYRIAHAEAQ--VGLPEVTLGLLPGARGTQLLPRLTGVPAAL
100 110 120 130 140
200 210 220 230 240 250
pF1KE4 DMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEERTIEYLEEVAITFAKGLADKKISP
:.. .:: : ::.: :.:..:..:. : :: :: ::. ..:. .
NP_001 DLITSGRRILADEALKLGILDKVVNS-----DPVEE---------AIRFAQRVSDQPLES
150 160 170 180 190
260 270 280 290 300 310
pF1KE4 KRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKTGIEQGSDA
.: : .: ...: . ....... :.:.: : : . .:..... ..
NP_001 RR---LCNK---PIQSLPNM-DSIFSEALLKMRRQHPGCL-AQEACVRAVQAAVQYPYEV
200 210 220 230 240
320 330 340 350 360
pF1KE4 GYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQ---------KDVKHLAILGA
: : . : :... ...::. . .. : ::...:. . :. ....:
NP_001 GIKKEEELFLYLLQSGQARALQYAFFAER--KANKWSTPSGASWKTASARPVSSVGVVGL
250 260 270 280 290 300
370 380 390 400 410 420
pF1KE4 GLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFERDSIFSNL
: :: ::. . . .: :. . : ..... . :. ...: .. .. :
NP_001 GTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPWSGPKPRL
310 320 330 340 350 360
430 440 450 460 470 480
pF1KE4 TGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSK
:... : .:.:::::::..:::..:. :. :: . .. .::::: ..:::. .
NP_001 TSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVDEIASSTD
370 380 390 400 410 420
490 500 510 520 530 540
pF1KE4 RPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTR
::. ::: :.:::. :.:::.: .. .: : :... .. : :. .:: . :: .:
NP_001 RPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIGVVVGNCFGFVGNR
430 440 450 460 470 480
550 560 570 580 590 600
pF1KE4 CLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGE
: :..... .:.:: :...:.. ::: .: . : .:.::. . . : .
NP_001 MLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKGQGLTGPT
490 500 510 520 530 540
610 620 630 640 650
pF1KE4 RFGG------GN------PELLTQMVSKGFLGRKSGKGFYIYQEG---VKRKD--LNSDM
. : :: :..: .. : .:.:.:::.: :.. ... : :.. .
NP_001 LLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGKGWYQYDKPLGRIHKPDPWLSKFL
550 560 570 580 590 600
660 670 680 690 700 710
pF1KE4 DSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPP
. . .. :.. .:.:: : : . ..::: : ::: :.: . :. . : :.:
NP_001 SRYRKTHHIEPRT-ISQDE-ILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGWPR
610 620 630 640 650
720 730 740 750 760
pF1KE4 CLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPCQLL---ADHANSPNKKFYQ
:::. ... : ....:.:: . :. : . : :...: : :..
NP_001 HKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPSDYLKKLASQGNPPLKEWQSLAGS
660 670 680 690 700 710
NP_001 PSSKL
720
>>XP_006713588 (OMIM: 607037,615605) PREDICTED: peroxiso (515 aa)
initn: 507 init1: 385 opt: 466 Z-score: 556.4 bits: 113.1 E(85289): 3e-24
Smith-Waterman score: 629; 27.6% identity (59.9% similar) in 511 aa overlap (282-761:4-504)
260 270 280 290 300 310
pF1KE4 ADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKTG
..... :.:.: : : . .:...
XP_006 MDSIFSEALLKMRRQHPGCL-AQEACVRAVQAA
10 20 30
320 330 340 350 360
pF1KE4 IEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQ---------KDVK
.. ..: : . : :... ...::. . .. : ::...:. . :.
XP_006 VQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAER--KANKWSTPSGASWKTASARPVS
40 50 60 70 80 90
370 380 390 400 410 420
pF1KE4 HLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFER
....: : :: ::. . . .: :. . : ..... . :. ...: ..
XP_006 SVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPW
100 110 120 130 140 150
430 440 450 460 470 480
pF1KE4 DSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPIS
.. ::... : .:.:::::::..:::..:. :. :: . .. .::::: ..
XP_006 SGPKPRLTSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVD
160 170 180 190 200
490 500 510 520 530 540
pF1KE4 EIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDG
:::. . ::. ::: :.:::. :.:::.: .. .: : :... .. : :. .:: .
XP_006 EIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIGVVVGNC
210 220 230 240 250 260
550 560 570 580 590 600
pF1KE4 PGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAED
:: .: : :..... .:.:: :...:.. ::: .: . : .:.::. . .
XP_006 FGFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKG
270 280 290 300 310 320
610 620 630 640
pF1KE4 LGKVFGERFGG------GN------PELLTQMVSKGFLGRKSGKGFYIYQEG---VKRKD
: . . : :: :..: .. : .:.:.:::.: :.. ... :
XP_006 QGLTGPTLLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGKGWYQYDKPLGRIHKPD
330 340 350 360 370 380
650 660 670 680 690 700
pF1KE4 --LNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAV
:.. .. . .. :.. .:.:: .. : . ..::: : ::: :.: . :. .
XP_006 PWLSKFLSRYRKTHHIEPRT-ISQDEILE-RCLYSLINEAFRILGEGIAASPEHIDVVYL
390 400 410 420 430 440
710 720 730 740 750 760
pF1KE4 FGLGFPPCLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPCQLL---ADHANSPNKK
: :.: :::. ... : ....:.:: . :. : . : :...: : :.
XP_006 HGYGWPRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPSDYLKKLASQGNPPLKE
450 460 470 480 490 500
pF1KE4 FYQ
.
XP_006 WQSLAGSPSSKL
510
>>XP_016861328 (OMIM: 607037,615605) PREDICTED: peroxiso (515 aa)
initn: 507 init1: 385 opt: 466 Z-score: 556.4 bits: 113.1 E(85289): 3e-24
Smith-Waterman score: 629; 27.6% identity (59.9% similar) in 511 aa overlap (282-761:4-504)
260 270 280 290 300 310
pF1KE4 ADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKTG
..... :.:.: : : . .:...
XP_016 MDSIFSEALLKMRRQHPGCL-AQEACVRAVQAA
10 20 30
320 330 340 350 360
pF1KE4 IEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQ---------KDVK
.. ..: : . : :... ...::. . .. : ::...:. . :.
XP_016 VQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAER--KANKWSTPSGASWKTASARPVS
40 50 60 70 80 90
370 380 390 400 410 420
pF1KE4 HLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFER
....: : :: ::. . . .: :. . : ..... . :. ...: ..
XP_016 SVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPW
100 110 120 130 140 150
430 440 450 460 470 480
pF1KE4 DSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPIS
.. ::... : .:.:::::::..:::..:. :. :: . .. .::::: ..
XP_016 SGPKPRLTSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVD
160 170 180 190 200
490 500 510 520 530 540
pF1KE4 EIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDG
:::. . ::. ::: :.:::. :.:::.: .. .: : :... .. : :. .:: .
XP_016 EIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIGVVVGNC
210 220 230 240 250 260
550 560 570 580 590 600
pF1KE4 PGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAED
:: .: : :..... .:.:: :...:.. ::: .: . : .:.::. . .
XP_016 FGFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKG
270 280 290 300 310 320
610 620 630 640
pF1KE4 LGKVFGERFGG------GN------PELLTQMVSKGFLGRKSGKGFYIYQEG---VKRKD
: . . : :: :..: .. : .:.:.:::.: :.. ... :
XP_016 QGLTGPTLLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGKGWYQYDKPLGRIHKPD
330 340 350 360 370 380
650 660 670 680 690 700
pF1KE4 --LNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAV
:.. .. . .. :.. .:.:: .. : . ..::: : ::: :.: . :. .
XP_016 PWLSKFLSRYRKTHHIEPRT-ISQDEILE-RCLYSLINEAFRILGEGIAASPEHIDVVYL
390 400 410 420 430 440
710 720 730 740 750 760
pF1KE4 FGLGFPPCLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPCQLL---ADHANSPNKK
: :.: :::. ... : ....:.:: . :. : . : :...: : :.
XP_016 HGYGWPRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPSDYLKKLASQGNPPLKE
450 460 470 480 490 500
pF1KE4 FYQ
.
XP_016 WQSLAGSPSSKL
510
>>NP_001317956 (OMIM: 231530,601609,609975) hydroxyacyl- (318 aa)
initn: 280 init1: 252 opt: 460 Z-score: 552.6 bits: 111.7 E(85289): 4.8e-24
Smith-Waterman score: 460; 31.2% identity (63.0% similar) in 276 aa overlap (374-640:44-318)
350 360 370 380 390 400
pF1KE4 HGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQ
: . .:.. : ..: : : : ....
NP_001 LGVCWRKEHDPAEMLRVGRAELGGWKPSWEAIVKEVAAATGHTVVLVDQTEDILAKSKKG
20 30 40 50 60 70
410 420 430 440 450
pF1KE4 VFKGLNDKVKKK------ALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHR
. ..: .::: : : . .. . :. . ...:.:.::. :.:..:..
NP_001 IEESLRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNE
80 90 100 110 120 130
460 470 480 490 500 510
pF1KE4 VLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKT
..:... .: :::::::.: :. :: .. : .. :.:.:.:: :.:.:.: : :
NP_001 LFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMT
140 150 160 170 180 190
520 530 540 550 560 570
pF1KE4 SKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLD---SL
:. : : : . :: . :: ::: ..: :.:.. :.::. ..: : .: : ..
NP_001 SQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERG-DASKEDIDTAM
200 210 220 230 240 250
580 590 600 610 620 630
pF1KE4 TTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGK
. :.:.: :.: ::.:..: ... .. .: :...:... .:.:.:.
NP_001 KLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGE
260 270 280 290 300 310
640 650 660 670 680 690
pF1KE4 GFYIYQEGVKRKDLNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGIL
::: :.
NP_001 GFYKYK
>>NP_001171634 (OMIM: 231530,601609,609975) hydroxyacyl- (331 aa)
initn: 372 init1: 244 opt: 437 Z-score: 524.8 bits: 106.6 E(85289): 1.7e-22
Smith-Waterman score: 509; 32.1% identity (62.3% similar) in 305 aa overlap (361-640:27-331)
340 350 360 370 380 390
pF1KE4 VMTKESKALMGLYHGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILK
:::....:.::::::::::.. : ..:
NP_001 MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLV
10 20 30 40 50
400 410 420 430 440
pF1KE4 DATLTALDRGQQQVFKGLNDKVKKK------ALTSFERDSIFSNLTGQLDYQGFEKADMV
: : : .... . ..: .::: : : . .. . :. . ...:.:
NP_001 DQTEDILAKSKKGIEESLRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLV
60 70 80 90 100 110
450 460 470 480 490 500
pF1KE4 IEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVD
.::. :.:..:....:... .: :::::::.: :. :: .. : .. :.:.:.::
NP_001 VEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVP
120 130 140 150 160 170
510 520 530 540 550 560
pF1KE4 KMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQE
:.:.:.: : ::. : : : . :: . :: ::: ..: :.:.. :.::. ..
NP_001 VMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYER
180 190 200 210 220 230
570 580 590 600
pF1KE4 ----------GV------DPKKLD---SLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGK
:. : .: : .. . :.:.: :.: ::.:..: ... .
NP_001 DFQTCGDSNSGLGFSLKGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHE
240 250 260 270 280 290
610 620 630 640 650 660
pF1KE4 VFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLKLPPKS
. .: :...:... .:.:.:.::: :.
NP_001 MDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK
300 310 320 330
670 680 690 700 710 720
pF1KE4 EVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYG
>>NP_001689 (OMIM: 250950,600529) methylglutaconyl-CoA h (339 aa)
initn: 356 init1: 133 opt: 378 Z-score: 453.8 bits: 93.5 E(85289): 1.5e-18
Smith-Waterman score: 378; 30.4% identity (63.8% similar) in 260 aa overlap (22-276:65-317)
10 20 30 40 50
pF1KE4 MVACRAIGILSRFSAFRILRSRGYICRNFTGSSALLTRTHINYGVKGDVAV
::: .. . : .: :.. .: ..:
NP_001 RLPGSLAGRRAGPAIWAQGWVPAAGGPAPKRGY-SSEMKTEDELRVR-HLEEENRG-IVV
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE4 VRINSPNSKVNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLAACK
. :: .: :.:::.: . .:.... . .. ..:. .. : :: : ::::.. : .
NP_001 LGINRAYGK-NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMS
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE4 TLQEVTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGT
. .:: . .. . ... . . : .:::.: ::::::.:..:. :.:... : .:
NP_001 S-SEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK--MGL
160 170 180 190 200
180 190 200 210 220
pF1KE4 PEVLLGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPG---
:. :. .::.:::::::. .:. : ......: . . .:: .::.....: :
NP_001 VETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAA
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE4 LKPPEERTIEYLEE--VAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKV
. . . :.: . ::. :: .. . ::. . . ::.:::
NP_001 YRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLA
270 280 290 300 310 320
290 300 310 320 330 340
pF1KE4 EEKVRKQTKGLYPAPLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQ
NP_001 FKEKRPPRYKGE
330
763 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:48:48 2016 done: Sat Nov 5 23:48:49 2016
Total Scan time: 8.660 Total Display time: 0.140
Function used was FASTA [36.3.4 Apr, 2011]