Result of FASTA (omim) for
pFN21AE4554
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4554, 669 aa
1>>>pF1KE4554 669 - 669 aa - 669 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2631+/-0.000418; mu= 19.6994+/- 0.026
mean_var=65.9806+/-13.783, 0's: 0 Z-trim(110.9): 7 B-trim: 860 in 1/52
Lambda= 0.157894
statistics sampled from 19303 (19309) to 19303 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.575), E-opt: 0.2 (0.226), width: 16
Scan time: 10.930
The best scores are: opt bits E(85289)
NP_000144 (OMIM: 245200,606890) galactocerebrosida ( 685) 4572 1050.9 0
XP_011534920 (OMIM: 245200,606890) PREDICTED: gala ( 629) 4251 977.8 0
NP_001188331 (OMIM: 245200,606890) galactocerebros ( 659) 4251 977.8 0
NP_001188330 (OMIM: 245200,606890) galactocerebros ( 662) 4101 943.6 0
>>NP_000144 (OMIM: 245200,606890) galactocerebrosidase i (685 aa)
initn: 4572 init1: 4572 opt: 4572 Z-score: 5623.6 bits: 1050.9 E(85289): 0
Smith-Waterman score: 4572; 99.7% identity (99.9% similar) in 669 aa overlap (1-669:17-685)
10 20 30 40
pF1KE4 MTAAAGSAGRAAVPLLLCALLAPGGAYVLDDSDGLGREFDGIGA
::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAEWLLSASWQRRAKAMTAAAGSAGRAAVPLLLCALLAPGGAYVLDDSDGLGREFDGIGA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 VSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYA
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 LDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQLTAYYVVTWIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQLTAYYVVTWIV
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 GAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNYQGLQRVKIIASDNLWESISASMLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNYQGLQRVKIIASDNLWESISASMLLD
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 AELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSEDFSTLNSDMGAGCWGRILNQNYINGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSEDFSTLNSDMGAGCWGRILNQNYINGY
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 MTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQFTQPGWYYLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQFTQPGWYYLKT
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 VGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEI
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 PELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFTLSLHEDELFTLTTLTTGRKGSYPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFTLSLHEDELFTLTTLTTGRKGSYPLP
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 PKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFEYFTNIEDPGEHHFTLRQVLNQRPIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFEYFTNIEDPGEHHFTLRQVLNQRPIT
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE4 WAADASNTISIIGDYNWTNLTTKCDVYIETPDTGGVFIAGRVNKGGILIRSARGIFFWIF
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
NP_000 WAADASNTISIIGDYNWTNLTIKCDVYIETPDTGGVFIAGRVNKGGILIRSARGIFFWIF
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE4 ANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLTIKGHFASGMLNDKSLWTDIPVNFPK
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
NP_000 ANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLTIKGHFTSGMLNDKSLWTDIPVNFPK
610 620 630 640 650 660
650 660
pF1KE4 NGWAAIGTHSFEFAQFDNFLVEATR
:::::::::::::::::::::::::
NP_000 NGWAAIGTHSFEFAQFDNFLVEATR
670 680
>>XP_011534920 (OMIM: 245200,606890) PREDICTED: galactoc (629 aa)
initn: 4251 init1: 4251 opt: 4251 Z-score: 5229.0 bits: 977.8 E(85289): 0
Smith-Waterman score: 4251; 99.7% identity (99.8% similar) in 620 aa overlap (50-669:10-629)
20 30 40 50 60 70
pF1KE4 LLAPGGAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASL
::::::::::::::::::::::::::::::
XP_011 MGFMVADLWATSRLLVNYPEPYRSQILDYLFKPNFGASL
10 20 30
80 90 100 110 120 130
pF1KE4 HILKVEIGGDGQTTDGTEPSHMHYALDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HILKVEIGGDGQTTDGTEPSHMHYALDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPG
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 WLGKGFDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLGKGFDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNY
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 QGLQRVKIIASDNLWESISASMLLDAELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLQRVKIIASDNLWESISASMLLDAELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSED
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 FSTLNSDMGAGCWGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSTLNSDMGAGCWGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHY
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 VVESPVWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVESPVWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCI
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 RPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFT
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE4 LSLHEDELFTLTTLTTGRKGSYPLPPKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSLHEDELFTLTTLTTGRKGSYPLPPKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFE
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE4 YFTNIEDPGEHHFTLRQVLNQRPITWAADASNTISIIGDYNWTNLTTKCDVYIETPDTGG
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_011 YFTNIEDPGEHHFTLRQVLNQRPITWAADASNTISIIGDYNWTNLTIKCDVYIETPDTGG
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE4 VFIAGRVNKGGILIRSARGIFFWIFANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFIAGRVNKGGILIRSARGIFFWIFANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLT
520 530 540 550 560 570
620 630 640 650 660
pF1KE4 IKGHFASGMLNDKSLWTDIPVNFPKNGWAAIGTHSFEFAQFDNFLVEATR
:::::.::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKGHFTSGMLNDKSLWTDIPVNFPKNGWAAIGTHSFEFAQFDNFLVEATR
580 590 600 610 620
>>NP_001188331 (OMIM: 245200,606890) galactocerebrosidas (659 aa)
initn: 4251 init1: 4251 opt: 4251 Z-score: 5228.7 bits: 977.8 E(85289): 0
Smith-Waterman score: 4251; 99.7% identity (99.8% similar) in 620 aa overlap (50-669:40-659)
20 30 40 50 60 70
pF1KE4 LLAPGGAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASL
::::::::::::::::::::::::::::::
NP_001 THGPLPLADLGIHLPCVKVLHQVTPEEKPAATSRLLVNYPEPYRSQILDYLFKPNFGASL
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE4 HILKVEIGGDGQTTDGTEPSHMHYALDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HILKVEIGGDGQTTDGTEPSHMHYALDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPG
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE4 WLGKGFDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLGKGFDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNY
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE4 QGLQRVKIIASDNLWESISASMLLDAELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGLQRVKIIASDNLWESISASMLLDAELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSED
190 200 210 220 230 240
260 270 280 290 300 310
pF1KE4 FSTLNSDMGAGCWGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSTLNSDMGAGCWGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHY
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE4 VVESPVWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVESPVWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCI
310 320 330 340 350 360
380 390 400 410 420 430
pF1KE4 RPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFT
370 380 390 400 410 420
440 450 460 470 480 490
pF1KE4 LSLHEDELFTLTTLTTGRKGSYPLPPKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLHEDELFTLTTLTTGRKGSYPLPPKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFE
430 440 450 460 470 480
500 510 520 530 540 550
pF1KE4 YFTNIEDPGEHHFTLRQVLNQRPITWAADASNTISIIGDYNWTNLTTKCDVYIETPDTGG
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_001 YFTNIEDPGEHHFTLRQVLNQRPITWAADASNTISIIGDYNWTNLTIKCDVYIETPDTGG
490 500 510 520 530 540
560 570 580 590 600 610
pF1KE4 VFIAGRVNKGGILIRSARGIFFWIFANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFIAGRVNKGGILIRSARGIFFWIFANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLT
550 560 570 580 590 600
620 630 640 650 660
pF1KE4 IKGHFASGMLNDKSLWTDIPVNFPKNGWAAIGTHSFEFAQFDNFLVEATR
:::::.::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKGHFTSGMLNDKSLWTDIPVNFPKNGWAAIGTHSFEFAQFDNFLVEATR
610 620 630 640 650
>>NP_001188330 (OMIM: 245200,606890) galactocerebrosidas (662 aa)
initn: 4408 init1: 4101 opt: 4101 Z-score: 5044.0 bits: 943.6 E(85289): 0
Smith-Waterman score: 4366; 96.3% identity (96.4% similar) in 669 aa overlap (1-669:17-662)
10 20 30 40
pF1KE4 MTAAAGSAGRAAVPLLLCALLAPGGAYVLDDSDGLGREFDGIGA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEWLLSASWQRRAKAMTAAAGSAGRAAVPLLLCALLAPGGAYVLDDSDGLGREFDGIGA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 VSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYA
::::: ::::::::::::::::::::::::::::::::
NP_001 VSGGG-----------------------PNFGASLHILKVEIGGDGQTTDGTEPSHMHYA
70 80 90
110 120 130 140 150 160
pF1KE4 LDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQLTAYYVVTWIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQLTAYYVVTWIV
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE4 GAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNYQGLQRVKIIASDNLWESISASMLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNYQGLQRVKIIASDNLWESISASMLLD
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 AELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSEDFSTLNSDMGAGCWGRILNQNYINGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSEDFSTLNSDMGAGCWGRILNQNYINGY
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE4 MTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQFTQPGWYYLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQFTQPGWYYLKT
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE4 VGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEI
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE4 PELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFTLSLHEDELFTLTTLTTGRKGSYPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFTLSLHEDELFTLTTLTTGRKGSYPLP
400 410 420 430 440 450
470 480 490 500 510 520
pF1KE4 PKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFEYFTNIEDPGEHHFTLRQVLNQRPIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFEYFTNIEDPGEHHFTLRQVLNQRPIT
460 470 480 490 500 510
530 540 550 560 570 580
pF1KE4 WAADASNTISIIGDYNWTNLTTKCDVYIETPDTGGVFIAGRVNKGGILIRSARGIFFWIF
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
NP_001 WAADASNTISIIGDYNWTNLTIKCDVYIETPDTGGVFIAGRVNKGGILIRSARGIFFWIF
520 530 540 550 560 570
590 600 610 620 630 640
pF1KE4 ANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLTIKGHFASGMLNDKSLWTDIPVNFPK
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
NP_001 ANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLTIKGHFTSGMLNDKSLWTDIPVNFPK
580 590 600 610 620 630
650 660
pF1KE4 NGWAAIGTHSFEFAQFDNFLVEATR
:::::::::::::::::::::::::
NP_001 NGWAAIGTHSFEFAQFDNFLVEATR
640 650 660
669 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:36:25 2016 done: Mon Nov 7 18:36:26 2016
Total Scan time: 10.930 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]