Result of FASTA (omim) for
pFN21AE4528
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4528, 577 aa
1>>>pF1KE4528 577 - 577 aa - 577 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.5817+/-0.000411; mu= 22.6399+/- 0.025
mean_var=60.7011+/-13.036, 0's: 0 Z-trim(111.0): 26 B-trim: 1115 in 1/49
Lambda= 0.164617
statistics sampled from 19417 (19429) to 19417 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.228), width: 16
Scan time: 8.700
The best scores are: opt bits E(85289)
NP_001284365 (OMIM: 601463) hyaluronan synthase 1 ( 577) 3932 942.8 0
NP_001514 (OMIM: 601463) hyaluronan synthase 1 iso ( 578) 3920 940.0 0
XP_011525186 (OMIM: 601463) PREDICTED: hyaluronan ( 328) 2050 495.7 9.9e-140
NP_001186209 (OMIM: 602428) hyaluronan synthase 3 ( 553) 1677 407.3 6.8e-113
XP_011521363 (OMIM: 602428) PREDICTED: hyaluronan ( 553) 1677 407.3 6.8e-113
XP_005255978 (OMIM: 602428) PREDICTED: hyaluronan ( 553) 1677 407.3 6.8e-113
NP_005320 (OMIM: 602428) hyaluronan synthase 3 iso ( 553) 1677 407.3 6.8e-113
NP_005319 (OMIM: 601636) hyaluronan synthase 2 [Ho ( 552) 1671 405.9 1.8e-112
NP_619515 (OMIM: 602428) hyaluronan synthase 3 iso ( 281) 357 93.5 9.6e-19
>>NP_001284365 (OMIM: 601463) hyaluronan synthase 1 isof (577 aa)
initn: 3932 init1: 3932 opt: 3932 Z-score: 5041.9 bits: 942.8 E(85289): 0
Smith-Waterman score: 3932; 99.7% identity (99.8% similar) in 577 aa overlap (1-577:1-577)
10 20 30 40 50 60
pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARAL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSDTR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_001 AYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 YSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 TMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHL
490 500 510 520 530 540
550 560 570
pF1KE4 AAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
:::::::::::::::::::::::::::::::::::::
NP_001 AAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
550 560 570
>>NP_001514 (OMIM: 601463) hyaluronan synthase 1 isoform (578 aa)
initn: 3919 init1: 3919 opt: 3920 Z-score: 5026.5 bits: 940.0 E(85289): 0
Smith-Waterman score: 3920; 99.5% identity (99.7% similar) in 578 aa overlap (1-577:1-578)
10 20 30 40 50
pF1KE4 MRQ-DAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG
::: ::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSDT
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
NP_001 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDT
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 CVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSR
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 CYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 RLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLAL
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE4 VTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYH
490 500 510 520 530 540
540 550 560 570
pF1KE4 LAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
::::::::::::::::::::::::::::::::::::::
NP_001 LAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
550 560 570
>>XP_011525186 (OMIM: 601463) PREDICTED: hyaluronan synt (328 aa)
initn: 2049 init1: 2049 opt: 2050 Z-score: 2629.6 bits: 495.7 E(85289): 9.9e-140
Smith-Waterman score: 2050; 99.0% identity (99.4% similar) in 310 aa overlap (1-309:1-310)
10 20 30 40 50
pF1KE4 MRQ-DAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG
::: ::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSDT
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_011 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDT
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 CVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSR
::::::::::
XP_011 CVSCISGPLGTPPGPAATQRRPRPSCGG
310 320
>>NP_001186209 (OMIM: 602428) hyaluronan synthase 3 isof (553 aa)
initn: 2044 init1: 1619 opt: 1677 Z-score: 2147.8 bits: 407.3 E(85289): 6.8e-113
Smith-Waterman score: 2081; 55.6% identity (77.7% similar) in 556 aa overlap (20-573:10-546)
10 20 30 40 50 60
pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA
: : : ::: .:: . ::..: . . :.::::::
NP_001 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA
10 20 30 40 50
70 80 90 100 110
pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA
.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::.
NP_001 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG
. .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ...
NP_001 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ
120 130 140 150 160
180 190 200 210 220 230
pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD
: : :. .::. :. :.::::::::::::::::::.::.::::::
NP_001 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD
170 180 190 200 210
240 250 260 270 280 290
pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF
: ::: .:..:::.:::.::.:::::.::: :::.:::::.:::.::::::::::::
NP_001 TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYF
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE4 HCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRS
::.:::::::.:::.::::::: ::.:::::..:.::::::::::.::.:: ::::.::
NP_001 GCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARS
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE4 RCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATV
.: .:::...::::.::::::::::::::::.::.:.:: :::::.::.:.::::. :::
NP_001 KCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATV
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE4 LRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLA
..::: :: : .: :: :: :.. ::..: .::: .:...:::. ::: .:::::..:
NP_001 IQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFA
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE4 LVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAY
..:.:.::::::::. ...:.. :.:...:. .:::::. .. . : . .. :
NP_001 IATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQ---DLFSETELA---
460 470 480 490 500 510
540 550 560 570
pF1KE4 HLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
:..:: : ::::.: :: . . : : .. :
NP_001 FLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV
520 530 540 550
>>XP_011521363 (OMIM: 602428) PREDICTED: hyaluronan synt (553 aa)
initn: 2044 init1: 1619 opt: 1677 Z-score: 2147.8 bits: 407.3 E(85289): 6.8e-113
Smith-Waterman score: 2081; 55.6% identity (77.7% similar) in 556 aa overlap (20-573:10-546)
10 20 30 40 50 60
pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA
: : : ::: .:: . ::..: . . :.::::::
XP_011 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA
10 20 30 40 50
70 80 90 100 110
pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA
.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::.
XP_011 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG
. .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ...
XP_011 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ
120 130 140 150 160
180 190 200 210 220 230
pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD
: : :. .::. :. :.::::::::::::::::::.::.::::::
XP_011 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD
170 180 190 200 210
240 250 260 270 280 290
pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF
: ::: .:..:::.:::.::.:::::.::: :::.:::::.:::.::::::::::::
XP_011 TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYF
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE4 HCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRS
::.:::::::.:::.::::::: ::.:::::..:.::::::::::.::.:: ::::.::
XP_011 GCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARS
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE4 RCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATV
.: .:::...::::.::::::::::::::::.::.:.:: :::::.::.:.::::. :::
XP_011 KCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATV
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE4 LRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLA
..::: :: : .: :: :: :.. ::..: .::: .:...:::. ::: .:::::..:
XP_011 IQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFA
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE4 LVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAY
..:.:.::::::::. ...:.. :.:...:. .:::::. .. . : . .. :
XP_011 IATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQ---DLFSETELA---
460 470 480 490 500 510
540 550 560 570
pF1KE4 HLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
:..:: : ::::.: :: . . : : .. :
XP_011 FLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV
520 530 540 550
>>XP_005255978 (OMIM: 602428) PREDICTED: hyaluronan synt (553 aa)
initn: 2044 init1: 1619 opt: 1677 Z-score: 2147.8 bits: 407.3 E(85289): 6.8e-113
Smith-Waterman score: 2081; 55.6% identity (77.7% similar) in 556 aa overlap (20-573:10-546)
10 20 30 40 50 60
pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA
: : : ::: .:: . ::..: . . :.::::::
XP_005 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA
10 20 30 40 50
70 80 90 100 110
pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA
.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::.
XP_005 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG
. .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ...
XP_005 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ
120 130 140 150 160
180 190 200 210 220 230
pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD
: : :. .::. :. :.::::::::::::::::::.::.::::::
XP_005 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD
170 180 190 200 210
240 250 260 270 280 290
pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF
: ::: .:..:::.:::.::.:::::.::: :::.:::::.:::.::::::::::::
XP_005 TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYF
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE4 HCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRS
::.:::::::.:::.::::::: ::.:::::..:.::::::::::.::.:: ::::.::
XP_005 GCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARS
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE4 RCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATV
.: .:::...::::.::::::::::::::::.::.:.:: :::::.::.:.::::. :::
XP_005 KCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATV
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE4 LRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLA
..::: :: : .: :: :: :.. ::..: .::: .:...:::. ::: .:::::..:
XP_005 IQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFA
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE4 LVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAY
..:.:.::::::::. ...:.. :.:...:. .:::::. .. . : . .. :
XP_005 IATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQ---DLFSETELA---
460 470 480 490 500 510
540 550 560 570
pF1KE4 HLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
:..:: : ::::.: :: . . : : .. :
XP_005 FLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV
520 530 540 550
>>NP_005320 (OMIM: 602428) hyaluronan synthase 3 isoform (553 aa)
initn: 2044 init1: 1619 opt: 1677 Z-score: 2147.8 bits: 407.3 E(85289): 6.8e-113
Smith-Waterman score: 2081; 55.6% identity (77.7% similar) in 556 aa overlap (20-573:10-546)
10 20 30 40 50 60
pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA
: : : ::: .:: . ::..: . . :.::::::
NP_005 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA
10 20 30 40 50
70 80 90 100 110
pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA
.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::.
NP_005 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG
. .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ...
NP_005 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ
120 130 140 150 160
180 190 200 210 220 230
pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD
: : :. .::. :. :.::::::::::::::::::.::.::::::
NP_005 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD
170 180 190 200 210
240 250 260 270 280 290
pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF
: ::: .:..:::.:::.::.:::::.::: :::.:::::.:::.::::::::::::
NP_005 TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYF
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE4 HCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRS
::.:::::::.:::.::::::: ::.:::::..:.::::::::::.::.:: ::::.::
NP_005 GCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARS
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE4 RCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATV
.: .:::...::::.::::::::::::::::.::.:.:: :::::.::.:.::::. :::
NP_005 KCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATV
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE4 LRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLA
..::: :: : .: :: :: :.. ::..: .::: .:...:::. ::: .:::::..:
NP_005 IQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFA
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE4 LVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAY
..:.:.::::::::. ...:.. :.:...:. .:::::. .. . : . .. :
NP_005 IATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQ---DLFSETELA---
460 470 480 490 500 510
540 550 560 570
pF1KE4 HLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
:..:: : ::::.: :: . . : : .. :
NP_005 FLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV
520 530 540 550
>>NP_005319 (OMIM: 601636) hyaluronan synthase 2 [Homo s (552 aa)
initn: 2058 init1: 1603 opt: 1671 Z-score: 2140.1 bits: 405.9 E(85289): 1.8e-112
Smith-Waterman score: 2081; 53.9% identity (78.5% similar) in 553 aa overlap (20-571:11-543)
10 20 30 40 50
pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVP-LASDRYGLLAFGLYG
: . : :.. .: .: :: .: . .: : ..:::::
NP_005 MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNY-YFSFGLYG
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA
:::..::. :::::.::::.. . . :. ..::: :.:::::: :::.:: :..
NP_005 AFLASHLIIQSLFAFLEHRKMKKSLETPI--KLNKTVALCIAAYQEDPDYLRKCLQSVKR
60 70 80 90 100
120 130 140 150 160 170
pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA
: :: ..:.::.::: .::::.:.: ::.. . :::.: .:.:. :
NP_005 LTYPG--IKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEK---------GP
110 120 130 140 150
180 190 200 210 220 230
pF1KE4 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSDT
: : . :. . : :: . . .:. :.::::::::::::.::: :.::::::::::
NP_005 GETDESHKESSQH--VTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDT
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE4 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH
::: . .:.:.::.::: ::.:::::.::: :::.:::::.:::.:::.::::::::
NP_005 MLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFG
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE4 CVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSR
::.:::::::.:::.::..:.: ::::.:.:..:.::::::::::.::.:::::::.::.
NP_005 CVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSK
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE4 CYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVL
: .::: .::::.:::::::::::::::::.:.:.:: ::::::...:.::::. :::.
NP_005 CLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVI
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE4 RLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLAL
.::: :. : .: :: :: :.: :..::. ::: . ::..:::. ::: .:::::..:.
NP_005 QLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAI
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE4 VTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYH
.:.:..:::::::. ...:.. :.:...: .::::.. .. .:.. .: ....
NP_005 ATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTV----
460 470 480 490 500 510
540 550 560 570
pF1KE4 LAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
: .:. :. ::: .:::: : . . ::. :
NP_005 LIVGTLLYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV
520 530 540 550
>>NP_619515 (OMIM: 602428) hyaluronan synthase 3 isoform (281 aa)
initn: 727 init1: 355 opt: 357 Z-score: 457.5 bits: 93.5 E(85289): 9.6e-19
Smith-Waterman score: 761; 50.4% identity (70.8% similar) in 250 aa overlap (20-267:10-246)
10 20 30 40 50 60
pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA
: : : ::: .:: . ::..: . . :.::::::
NP_619 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA
10 20 30 40 50
70 80 90 100 110
pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA
.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::.
NP_619 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG
. .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ...
NP_619 ISFP--DLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ
120 130 140 150 160
180 190 200 210 220 230
pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD
: : :. .::. :. :.::::::::::::::::::.::.::::::
NP_619 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD
170 180 190 200 210
240 250 260 270 280 290
pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF
: ::: .:..:::.:::.::.:::::.
NP_619 TVLDPACTIEMLRVLEEDPQVGGVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHV
220 230 240 250 260 270
577 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:14:18 2016 done: Sun Nov 6 00:14:19 2016
Total Scan time: 8.700 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]