Result of FASTA (omim) for
pFN21AE4521
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4521, 557 aa
1>>>pF1KE4521 557 - 557 aa - 557 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.5111+/-0.000462; mu= 23.4089+/- 0.028
mean_var=75.2646+/-15.608, 0's: 0 Z-trim(109.3): 230 B-trim: 0 in 0/54
Lambda= 0.147836
statistics sampled from 17182 (17429) to 17182 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.551), E-opt: 0.2 (0.204), width: 16
Scan time: 9.850
The best scores are: opt bits E(85289)
NP_003051 (OMIM: 212140,603377) solute carrier fam ( 557) 3686 796.4 0
NP_003050 (OMIM: 180300,604190) solute carrier fam ( 551) 2864 621.1 2.8e-177
NP_001295051 (OMIM: 212140,603377) solute carrier ( 581) 2805 608.6 1.8e-173
XP_016865267 (OMIM: 212140,603377) PREDICTED: solu ( 381) 2494 542.0 1.2e-153
XP_011541892 (OMIM: 212140,603377) PREDICTED: solu ( 351) 2233 486.3 6.7e-137
XP_016865265 (OMIM: 180300,604190) PREDICTED: solu ( 375) 1747 382.7 1.1e-105
XP_006714738 (OMIM: 180300,604190) PREDICTED: solu ( 375) 1747 382.7 1.1e-105
XP_011541891 (OMIM: 180300,604190) PREDICTED: solu ( 459) 1175 260.8 6.7e-69
NP_003049 (OMIM: 602608) solute carrier family 22 ( 555) 995 222.5 2.8e-57
NP_003048 (OMIM: 602607) solute carrier family 22 ( 554) 994 222.3 3.2e-57
NP_068812 (OMIM: 604842) solute carrier family 22 ( 556) 972 217.6 8.3e-56
NP_006663 (OMIM: 604995) solute carrier family 22 ( 546) 942 211.2 6.9e-54
XP_011534506 (OMIM: 608276) PREDICTED: solute carr ( 534) 937 210.1 1.4e-53
XP_006715034 (OMIM: 604995) PREDICTED: solute carr ( 549) 937 210.1 1.4e-53
NP_149116 (OMIM: 608276) solute carrier family 22 ( 577) 937 210.2 1.5e-53
XP_005267159 (OMIM: 602607) PREDICTED: solute carr ( 610) 936 210.0 1.8e-53
XP_005267160 (OMIM: 602607) PREDICTED: solute carr ( 573) 935 209.7 2e-53
NP_696961 (OMIM: 604995) solute carrier family 22 ( 548) 928 208.2 5.5e-53
XP_006715033 (OMIM: 604995) PREDICTED: solute carr ( 551) 911 204.6 6.8e-52
NP_653186 (OMIM: 220150,607096) solute carrier fam ( 553) 894 201.0 8.4e-51
NP_695008 (OMIM: 607582) solute carrier family 22 ( 550) 890 200.1 1.5e-50
NP_004247 (OMIM: 604047) solute carrier family 22 ( 551) 886 199.3 2.7e-50
XP_016874051 (OMIM: 607582) PREDICTED: solute carr ( 551) 886 199.3 2.7e-50
NP_004781 (OMIM: 607582) solute carrier family 22 ( 563) 871 196.1 2.5e-49
XP_011534507 (OMIM: 608276) PREDICTED: solute carr ( 515) 859 193.5 1.4e-48
NP_694857 (OMIM: 602607) solute carrier family 22 ( 506) 855 192.6 2.5e-48
XP_006715615 (OMIM: 602607) PREDICTED: solute carr ( 483) 848 191.1 6.9e-48
NP_004245 (OMIM: 607581) solute carrier family 22 ( 542) 841 189.6 2.1e-47
NP_001171661 (OMIM: 607581) solute carrier family ( 542) 841 189.6 2.1e-47
NP_060890 (OMIM: 608275) solute carrier family 22 ( 547) 841 189.7 2.1e-47
NP_001171662 (OMIM: 607581) solute carrier family ( 451) 838 188.9 2.9e-47
NP_060954 (OMIM: 607097) solute carrier family 22 ( 550) 808 182.6 2.8e-45
XP_005267163 (OMIM: 604842) PREDICTED: solute carr ( 425) 792 179.1 2.5e-44
XP_016865687 (OMIM: 604995) PREDICTED: solute carr ( 602) 776 175.8 3.3e-43
XP_011512559 (OMIM: 604995) PREDICTED: solute carr ( 607) 773 175.2 5.2e-43
XP_016865689 (OMIM: 604995) PREDICTED: solute carr ( 543) 767 173.9 1.2e-42
XP_011512558 (OMIM: 604995) PREDICTED: solute carr ( 610) 767 173.9 1.3e-42
XP_016866692 (OMIM: 604842) PREDICTED: solute carr ( 404) 759 172.0 3.2e-42
XP_011534378 (OMIM: 604842) PREDICTED: solute carr ( 404) 759 172.0 3.2e-42
XP_011534377 (OMIM: 604842) PREDICTED: solute carr ( 404) 759 172.0 3.2e-42
XP_011543666 (OMIM: 607581) PREDICTED: solute carr ( 419) 752 170.5 9.1e-42
NP_001171665 (OMIM: 607581) solute carrier family ( 419) 752 170.5 9.1e-42
XP_016865690 (OMIM: 604995) PREDICTED: solute carr ( 420) 751 170.3 1.1e-41
XP_011512563 (OMIM: 604995) PREDICTED: solute carr ( 420) 751 170.3 1.1e-41
XP_011534508 (OMIM: 608276) PREDICTED: solute carr ( 483) 732 166.3 1.9e-40
XP_005267241 (OMIM: 608276) PREDICTED: solute carr ( 407) 728 165.4 3.1e-40
XP_011534511 (OMIM: 608276) PREDICTED: solute carr ( 442) 728 165.4 3.3e-40
XP_011534510 (OMIM: 608276) PREDICTED: solute carr ( 447) 728 165.5 3.3e-40
XP_011534509 (OMIM: 608276) PREDICTED: solute carr ( 459) 728 165.5 3.4e-40
XP_011543318 (OMIM: 607580) PREDICTED: solute carr ( 541) 720 163.8 1.2e-39
>>NP_003051 (OMIM: 212140,603377) solute carrier family (557 aa)
initn: 3686 init1: 3686 opt: 3686 Z-score: 4251.3 bits: 796.4 E(85289): 0
Smith-Waterman score: 3686; 99.8% identity (99.8% similar) in 557 aa overlap (1-557:1-557)
10 20 30 40 50 60
pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCPDGWEFS
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_003 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR
490 500 510 520 530 540
550
pF1KE4 MLKDGQERPTILKSTAF
:::::::::::::::::
NP_003 MLKDGQERPTILKSTAF
550
>>NP_003050 (OMIM: 180300,604190) solute carrier family (551 aa)
initn: 2845 init1: 1888 opt: 2864 Z-score: 3303.8 bits: 621.1 E(85289): 2.8e-177
Smith-Waterman score: 2864; 76.3% identity (90.7% similar) in 557 aa overlap (1-557:1-551)
10 20 30 40 50 60
pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS
::::::: ::::::::::::::::::::::::::.:.: ::: .::::::::::::::::
NP_003 MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCPDGWEFS
::::..::::::::::::::: ::::::::::::::::::::::::::::::: ::::::
NP_003 AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ
:::::::.::::::::::.::.::: ::::::::::::.:::::::::::::::.::..:
NP_003 QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA
:::::::::: ..:::.::::.::::::::::.::.:::::::::::::::::::: :.:
NP_003 TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA
:::.:::::::::::::::.:::.:::::: ::::::::::::::: ::.::: ::.::
NP_003 VGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG
:: :.:.::..::: : .:. :::. ::::.:: :: ..::::..::: :::::.
NP_003 AKMNNIAVPAVIFDSVE--ELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFA
310 320 330 340 350
370 380 390 400 410 420
pF1KE4 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV
::::.:::::: ..::::::..:.:::. :::::. ::::: .:..:: ::.::::.:::
NP_003 LSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF
: : :.:. :::.::::.:.::::.::.:::::::.::::.:::.:::::.:::..:::
NP_003 PVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYF
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE4 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR
::::::.:.::::.:::::.: .:::::.:::.: ::.:..:: .:: .. : .::
NP_003 VYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGK---KTR
480 490 500 510 520 530
550
pF1KE4 MLKDGQERPTILKSTAF
. .: : .: :::
NP_003 DSMETEENPKVLI-TAF
540 550
>>NP_001295051 (OMIM: 212140,603377) solute carrier fami (581 aa)
initn: 2803 init1: 2803 opt: 2805 Z-score: 3235.5 bits: 608.6 E(85289): 1.8e-173
Smith-Waterman score: 3628; 95.7% identity (95.7% similar) in 581 aa overlap (1-557:1-581)
10 20 30 40 50 60
pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCPDGWEFS
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_001 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
70 80 90 100 110 120
130 140 150
pF1KE4 QDVYLSTIVTE------------------------WNLVCEDDWKAPLTISLFFVGVLLG
::::::::::: :::::::::::::::::::::::::
NP_001 QDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLG
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE4 SFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFV
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE4 LGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWF
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE4 IPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLR
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE4 TWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQY
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE4 LPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPT
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE4 VVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTP
490 500 510 520 530 540
520 530 540 550
pF1KE4 LPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
:::::::::::::::::::::::::::::::::::::::::
NP_001 LPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
550 560 570 580
>>XP_016865267 (OMIM: 212140,603377) PREDICTED: solute c (381 aa)
initn: 2494 init1: 2494 opt: 2494 Z-score: 2879.3 bits: 542.0 E(85289): 1.2e-153
Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 381 aa overlap (177-557:1-381)
150 160 170 180 190 200
pF1KE4 SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMG
::::::::::::::::::::::::::::::
XP_016 MGMQTGFSFLQIFSKNFEMFVVLFVLVGMG
10 20 30
210 220 230 240 250 260
pF1KE4 QISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMP
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE4 GVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE4 QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPA
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE4 YVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMV
220 230 240 250 260 270
450 460 470 480 490 500
pF1KE4 YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILT
280 290 300 310 320 330
510 520 530 540 550
pF1KE4 LFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
340 350 360 370 380
>>XP_011541892 (OMIM: 212140,603377) PREDICTED: solute c (351 aa)
initn: 2233 init1: 2233 opt: 2233 Z-score: 2578.8 bits: 486.3 E(85289): 6.7e-137
Smith-Waterman score: 2233; 100.0% identity (100.0% similar) in 340 aa overlap (218-557:12-351)
190 200 210 220 230 240
pF1KE4 IFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLP
::::::::::::::::::::::::::::::
XP_011 MWQHLSWVWPSGTEILGKSVRIIFSTLGVCIFYAFGYMVLP
10 20 30 40
250 260 270 280 290 300
pF1KE4 LFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIV
50 60 70 80 90 100
310 320 330 340 350 360
pF1KE4 VPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPN
110 120 130 140 150 160
370 380 390 400 410 420
pF1KE4 LHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYL
170 180 190 200 210 220
430 440 450 460 470 480
pF1KE4 ATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYD
230 240 250 260 270 280
490 500 510 520 530 540
pF1KE4 RFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQE
290 300 310 320 330 340
550
pF1KE4 RPTILKSTAF
::::::::::
XP_011 RPTILKSTAF
350
>>XP_016865265 (OMIM: 180300,604190) PREDICTED: solute c (375 aa)
initn: 1728 init1: 971 opt: 1747 Z-score: 2018.3 bits: 382.7 E(85289): 1.1e-105
Smith-Waterman score: 1747; 69.6% identity (87.9% similar) in 381 aa overlap (177-557:1-375)
150 160 170 180 190 200
pF1KE4 SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMG
:..::::::::::: ..:::.::::.::::
XP_016 MAVQTGFSFLQIFSISWEMFTVLFVIVGMG
10 20 30
210 220 230 240 250 260
pF1KE4 QISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMP
::::::.::.:::::::::::::::::::: :.: :::.:::::::::::::::.:::.:
XP_016 QISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVP
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE4 GVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ
::::: ::::::::::::::: ::.::: ::.:::: :.:.::..::: : .:. ::
XP_016 GVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVE--ELNPLKQ
100 110 120 130 140
330 340 350 360 370 380
pF1KE4 QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPA
:. ::::.:: :: ..::::..::: :::::.::::.:::::: ..::::::..:.::
XP_016 QKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPA
150 160 170 180 190 200
390 400 410 420 430 440
pF1KE4 YVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMV
:. :::::. ::::: .:..:: ::.::::.:::: : :.:. :::.::::.:.::::.
XP_016 YITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSML
210 220 230 240 250 260
450 460 470 480 490 500
pF1KE4 YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILT
::.:::::::.::::.:::.:::::.:::..:::::::::.:.::::.:::::.: .:::
XP_016 YVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILT
270 280 290 300 310 320
510 520 530 540 550
pF1KE4 LFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
::.:::.: ::.:..:: .:: .. : .:: . .: : .: :::
XP_016 LFFPESLGMTLPETLEQMQKVKWFRSGK---KTRDSMETEENPKVLI-TAF
330 340 350 360 370
>>XP_006714738 (OMIM: 180300,604190) PREDICTED: solute c (375 aa)
initn: 1728 init1: 971 opt: 1747 Z-score: 2018.3 bits: 382.7 E(85289): 1.1e-105
Smith-Waterman score: 1747; 69.6% identity (87.9% similar) in 381 aa overlap (177-557:1-375)
150 160 170 180 190 200
pF1KE4 SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMG
:..::::::::::: ..:::.::::.::::
XP_006 MAVQTGFSFLQIFSISWEMFTVLFVIVGMG
10 20 30
210 220 230 240 250 260
pF1KE4 QISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMP
::::::.::.:::::::::::::::::::: :.: :::.:::::::::::::::.:::.:
XP_006 QISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVP
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE4 GVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ
::::: ::::::::::::::: ::.::: ::.:::: :.:.::..::: : .:. ::
XP_006 GVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVE--ELNPLKQ
100 110 120 130 140
330 340 350 360 370 380
pF1KE4 QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPA
:. ::::.:: :: ..::::..::: :::::.::::.:::::: ..::::::..:.::
XP_006 QKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPA
150 160 170 180 190 200
390 400 410 420 430 440
pF1KE4 YVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMV
:. :::::. ::::: .:..:: ::.::::.:::: : :.:. :::.::::.:.::::.
XP_006 YITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSML
210 220 230 240 250 260
450 460 470 480 490 500
pF1KE4 YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILT
::.:::::::.::::.:::.:::::.:::..:::::::::.:.::::.:::::.: .:::
XP_006 YVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILT
270 280 290 300 310 320
510 520 530 540 550
pF1KE4 LFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
::.:::.: ::.:..:: .:: .. : .:: . .: : .: :::
XP_006 LFFPESLGMTLPETLEQMQKVKWFRSGK---KTRDSMETEENPKVLI-TAF
330 340 350 360 370
>>XP_011541891 (OMIM: 180300,604190) PREDICTED: solute c (459 aa)
initn: 1973 init1: 971 opt: 1175 Z-score: 1357.9 bits: 260.8 E(85289): 6.7e-69
Smith-Waterman score: 1821; 56.8% identity (71.0% similar) in 558 aa overlap (1-557:1-459)
10 20 30 40 50 60
pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS
::::::: ::::::::::::::::::::::::::.:.: ::: .::::::::::::::::
XP_011 MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCPDGWEFS
::::..::::::::::::::: ::::::::::::::::::::::::::::::: ::::::
XP_011 AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ
:::::::.::: :. .: :.. : .:
XP_011 QDVYLSTVVTEV-------WQE----------------------ERSLRNH--GCTDWLQ
130 140
190 200 210 220 230 240
pF1KE4 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA
.::. .:.. :..
XP_011 LPADFLH----------------QLGDVH--------------------------CVICH
150 160
250 260 270 280 290
pF1KE4 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWW-FIPESPRWLISQGRFEEAEVIIRK
:. : : . :: .: :::::::::::: ::.::: ::.:
XP_011 RGHG--P-------DLQ-----------LCGSLHTRFIPESPRWLISQRRFREAEDIIQK
170 180 190 200
300 310 320 330 340 350
pF1KE4 AAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYF
::: :.:.::..::: : .:. :::. ::::.:: :: ..::::..::: :::::
XP_011 AAKMNNIAVPAVIFDSVE--ELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYF
210 220 230 240 250 260
360 370 380 390 400 410
pF1KE4 GLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQL
.::::.:::::: ..::::::..:.:::. :::::. ::::: .:..:: ::.::::.::
XP_011 ALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQL
270 280 290 300 310 320
420 430 440 450 460 470
pF1KE4 VPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPY
:: : :.:. :::.::::.:.::::.::.:::::::.::::.:::.:::::.:::..::
XP_011 VPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPY
330 340 350 360 370 380
480 490 500 510 520 530
pF1KE4 FVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHT
:::::::.:.::::.:::::.: .:::::.:::.: ::.:..:: .:: .. : .:
XP_011 FVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGK---KT
390 400 410 420 430 440
540 550
pF1KE4 RMLKDGQERPTILKSTAF
: . .: : .: :::
XP_011 RDSMETEENPKVLI-TAF
450
>>NP_003049 (OMIM: 602608) solute carrier family 22 memb (555 aa)
initn: 939 init1: 350 opt: 995 Z-score: 1149.4 bits: 222.5 E(85289): 2.8e-57
Smith-Waterman score: 995; 34.7% identity (64.9% similar) in 547 aa overlap (5-533:6-541)
10 20 30 40 50
pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLL---SASIIPNGFTGLSSVFLIATPEHRCRVPDAA
:.: ::. ::. .:::: ::.. : ..:. ::: ::.:::: : .:
NP_003 MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPI-YVGI--VFLGFTPDHRCRSPGVA
10 20 30 40 50
60 70 80 90 100
pF1KE4 NLS--SAWR-----NHTVPLRLRDGREVPHSCRRYRLA-TIANFSALGLEPGRDVDLGQL
.:: .: :.::: :. :..::::.. . ..:. . . :.. ..:
NP_003 ELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 EQESCPDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFG
: ::: . .. :.::::.:::: ..: : : :: ..::. : ..::::
NP_003 PLGPCRDGWVY--ETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 RKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRI
:: :..:. .... . :. .: .. .... .. :. . .... ...: ::..:. :
NP_003 RKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYR-
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 IFSTLGVC--IFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLIS
:.:. . :. : .:: :: . :: : ....:. . . .: ::::::::::
NP_003 --RTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLIS
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 QGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIM
:.. :: ::.. :: :: .:... . .:.. ..:: . ..:::.:: .:: :..
NP_003 QNKNAEAMRIIKHIAKKNGKSLPASL-QRLRLEEETGKKL-NPSFLDLVRTPQIRKHTMI
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 SIMLWMTISVGYFGLSLDTPNLHGD-IFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT
.. :.: :: : :: . .: :: :... : ::.:: :: . : .. . ::: :.
NP_003 LMYNWFTSSVLYQGLIMHM-GLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAA
360 370 380 390 400
410 420 430 440 450 460
pF1KE4 ALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGV
. ...:.. : ..: :: .: .. .:..:.: :. .: . .:::::: .::.:: .
NP_003 SNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHI
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE4 SSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQ-
:. .:.:..:..:: : :: ...: : .... :.:.:::. : ::.::..
NP_003 CSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEA
470 480 490 500 510 520
530 540 550
pF1KE4 --MLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
: : . :..
NP_003 ENMQRPRKNKEKMIYLQVQKLDIPLN
530 540 550
>>NP_003048 (OMIM: 602607) solute carrier family 22 memb (554 aa)
initn: 883 init1: 332 opt: 994 Z-score: 1148.3 bits: 222.3 E(85289): 3.2e-57
Smith-Waterman score: 994; 35.6% identity (64.4% similar) in 567 aa overlap (1-550:1-552)
10 20 30 40 50
pF1KE4 MRDYDEVTAFLGEWGPFQR---LIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAAN
: :.. .:: : ::. ::. ::::.. : .:. ::: ::.:.:. : .:.
NP_003 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPI-CVGI--VFLGFTPDHHCQSPGVAE
10 20 30 40 50
60 70 80 90 100
pF1KE4 LSS--AWR-----NHTVPLRLRDGREVPHSCRRYRLATIANFSALG-LEPGRDV--DLGQ
::. .: :.::: :. .::::.. : :::. ..: .. . ..
NP_003 LSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVD--WNQSALSCVDPLASLATNRSH
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 LEQESCPDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRF
: : ::: . :. :.::::.:::: :.:: : : . .: :.::. : ..:::
NP_003 LPLGPCQDGWVY--DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRF
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 GRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR
::: :. :. ... . :. :: :. .... .: :. . .:..:...: ::..:.. :
NP_003 GRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 IIFSTLGVCIFYAF--GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI
:... .:: : ..: .:: . :: : .:...: : . .: .:::::::.
NP_003 ---RTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 SQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTI
:: : :: :. . :. :: . :. . : .:.. : : .. ::.:: .: :.
NP_003 SQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEK--LSPSFADLFRTPRLRKRTF
300 310 320 330 340
350 360 370 380 390 400
pF1KE4 MSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT
. ..::.: :: : :: : :..... . ::.::.:. .: . .. . : : ::
NP_003 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE4 ALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGV
. .:.:.. : : .. :::..: ... ::..:.: :..:. . .:::::: :::.:: :
NP_003 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMV
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE4 SSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQM
:. .:.:..:..:. : . :: ::.. : .:.: .::.:::. :. ::.: :
NP_003 CSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPET---M
470 480 490 500 510 520
530 540 550
pF1KE4 LRVKGMKHRKTPS-HTRMLKDGQERPTILKSTAF
.... .. :. .: .:: .:.
NP_003 KDAENLGRKAKPKENTIYLKVQTSEPSGT
530 540 550
557 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:16:49 2016 done: Sun Nov 6 00:16:51 2016
Total Scan time: 9.850 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]