Result of FASTA (omim) for
pFN21AE4520
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4520, 557 aa
1>>>pF1KE4520 557 - 557 aa - 557 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6125+/-0.000586; mu= 17.3955+/- 0.036
mean_var=102.4619+/-20.704, 0's: 0 Z-trim(107.7): 378 B-trim: 594 in 1/53
Lambda= 0.126705
statistics sampled from 15271 (15717) to 15271 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.523), E-opt: 0.2 (0.184), width: 16
Scan time: 8.170
The best scores are: opt bits E(85289)
NP_005088 (OMIM: 600512,604619) leucine-rich gliom ( 557) 3734 694.4 2.4e-199
NP_001295205 (OMIM: 600512,604619) leucine-rich gl ( 509) 2803 524.2 3.9e-148
NP_060646 (OMIM: 608301) leucine-rich repeat LGI f ( 545) 2125 400.3 8.2e-111
NP_644807 (OMIM: 608302) leucine-rich repeat LGI f ( 548) 2068 389.9 1.1e-107
XP_016872400 (OMIM: 600512,604619) PREDICTED: leuc ( 281) 1888 356.7 5.7e-98
NP_001295204 (OMIM: 600512,604619) leucine-rich gl ( 291) 1878 354.9 2.1e-97
NP_644813 (OMIM: 608303) leucine-rich repeat LGI f ( 537) 1774 336.1 1.7e-91
XP_016881919 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 1098 212.4 2e-54
XP_016881917 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 1098 212.4 2e-54
XP_016881918 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 1098 212.4 2e-54
XP_011524897 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 1098 212.4 2e-54
XP_011512152 (OMIM: 608301) PREDICTED: leucine-ric ( 331) 1012 196.6 1e-49
XP_016863845 (OMIM: 608301) PREDICTED: leucine-ric ( 287) 998 194.0 5.4e-49
XP_016872401 (OMIM: 600512,604619) PREDICTED: leuc ( 243) 947 184.6 3.1e-46
XP_011515759 (OMIM: 615904) PREDICTED: peroxidasin (1439) 341 74.6 2.4e-12
XP_011515758 (OMIM: 615904) PREDICTED: peroxidasin (1439) 322 71.1 2.7e-11
XP_005264764 (OMIM: 269400,605158) PREDICTED: pero (1455) 314 69.6 7.5e-11
XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460) 310 68.9 1.2e-10
NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523) 310 68.9 1.3e-10
NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530) 310 68.9 1.3e-10
XP_011512212 (OMIM: 603746) PREDICTED: slit homolo (1159) 305 67.9 2e-10
XP_016864334 (OMIM: 603746) PREDICTED: slit homolo (1495) 305 68.0 2.4e-10
XP_011512211 (OMIM: 603746) PREDICTED: slit homolo (1499) 305 68.0 2.4e-10
XP_006714049 (OMIM: 603746) PREDICTED: slit homolo (1509) 305 68.0 2.4e-10
NP_001276065 (OMIM: 603746) slit homolog 2 protein (1521) 305 68.0 2.4e-10
NP_001276064 (OMIM: 603746) slit homolog 2 protein (1525) 305 68.0 2.4e-10
NP_004778 (OMIM: 603746) slit homolog 2 protein is (1529) 305 68.0 2.4e-10
XP_005248268 (OMIM: 603746) PREDICTED: slit homolo (1533) 305 68.0 2.4e-10
XP_016867994 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 295 65.8 4.7e-10
NP_071426 (OMIM: 610486) leucine-rich repeat-conta ( 653) 295 65.8 4.7e-10
XP_011514763 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 295 65.8 4.7e-10
XP_005271426 (OMIM: 608869,615112) PREDICTED: leuc ( 958) 296 66.2 5.4e-10
XP_016873559 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_011518544 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_016873563 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_016873562 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_016873560 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_016873567 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_016873561 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_011518543 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
NP_065980 (OMIM: 608817) leucine-rich repeat-conta ( 640) 289 64.7 9.9e-10
XP_016873565 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_016873564 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_011518541 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
NP_001245348 (OMIM: 608817) leucine-rich repeat-co ( 640) 289 64.7 9.9e-10
XP_011518540 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_011518542 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_011518546 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_011518545 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
XP_016873566 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10
>>NP_005088 (OMIM: 600512,604619) leucine-rich glioma-in (557 aa)
initn: 3734 init1: 3734 opt: 3734 Z-score: 3699.8 bits: 694.4 E(85289): 2.4e-199
Smith-Waterman score: 3734; 100.0% identity (100.0% similar) in 557 aa overlap (1-557:1-557)
10 20 30 40 50 60
pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS
490 500 510 520 530 540
550
pF1KE4 FKGNTQIYKHVIVDLSA
:::::::::::::::::
NP_005 FKGNTQIYKHVIVDLSA
550
>>NP_001295205 (OMIM: 600512,604619) leucine-rich glioma (509 aa)
initn: 2802 init1: 2802 opt: 2803 Z-score: 2780.6 bits: 524.2 E(85289): 3.9e-148
Smith-Waterman score: 3319; 91.4% identity (91.4% similar) in 557 aa overlap (1-557:1-509)
10 20 30 40 50 60
pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL
::::::::::::::::::::::::::::::::::::
NP_001 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL------------------------
70 80 90
130 140 150 160 170 180
pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
::::::::::::::::::::::::::::::::::::
NP_001 ------------------------SLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
100 110 120 130
190 200 210 220 230 240
pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE4 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF
320 330 340 350 360 370
430 440 450 460 470 480
pF1KE4 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ
380 390 400 410 420 430
490 500 510 520 530 540
pF1KE4 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS
440 450 460 470 480 490
550
pF1KE4 FKGNTQIYKHVIVDLSA
:::::::::::::::::
NP_001 FKGNTQIYKHVIVDLSA
500
>>NP_060646 (OMIM: 608301) leucine-rich repeat LGI famil (545 aa)
initn: 2268 init1: 1484 opt: 2125 Z-score: 2110.4 bits: 400.3 E(85289): 8.2e-111
Smith-Waterman score: 2125; 55.9% identity (81.1% similar) in 540 aa overlap (19-556:11-544)
10 20 30 40 50
pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAK--PKCPAVCTCTKDNALCENA
.. .: ::.: : . .. .:::.:.:::.. .: ..
NP_060 MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGS
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLE
.:: :: :. :::.: . :.::.. : :::::::..:::: .: :::: :: :::
NP_060 SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD
:::::.:.:..:::..::::..: :::::::....::.:.:. :::: ..:::::.:.::
NP_060 YLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 CKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLS
:: ::: :: ::.:: :. : :::::...:.:...: :..: :.:. : :::::.:
NP_060 CKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 IDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVI
.:::. :: ::.:::: .:. :::::.: .::.:::::: : : :: :.:. :..:.
NP_060 VDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 VAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTT
:::::::::::: : .::.:.::::. .: :::::: :.:... .::.:::::::..:
NP_060 VAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLST
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 IYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQ
.::::..::::.:::: :.::::.:...: :::::: :: :.: ::::...
NP_060 VYKWNSKGFYSYQSLHEWFRDTDAEFVDIDG------KSHLILSSRSQVPIILQWNKSSK
360 370 380 390 400
420 430 440 450 460 470
pF1KE4 LFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMV
:. . :::::::: ::: : ... .:. ::::::::.::.:....: .:: .::::.:.
NP_060 KFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMT
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE4 FQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFA
.::..... .: :::::.:.:.:.:: :: : ::.:. :::::::: :: ..:.:.::
NP_060 LQPFSFKDNHYLALGSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFA
470 480 490 500 510 520
540 550
pF1KE4 SSFKGNTQIYKHVIVDLSA
:::::.:.:..:.:::::
NP_060 SSFKGKTKIFEHIIVDLSL
530 540
>>NP_644807 (OMIM: 608302) leucine-rich repeat LGI famil (548 aa)
initn: 1503 init1: 1468 opt: 2068 Z-score: 2054.0 bits: 389.9 E(85289): 1.1e-107
Smith-Waterman score: 2068; 52.0% identity (81.5% similar) in 535 aa overlap (23-557:22-548)
10 20 30 40 50 60
pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
.::. : .. . : : :: :.::.:.:.: ....
NP_644 MAGLRARGGPGPGLLALSALGFCLM--LQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKA
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL
.::..: .::::..: ..:.::..:.: : ::.::..::.: .:.:.:: :: ::.::
NP_644 VPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
:::::.: ..:. :::::::: :::::::::::::.:::. :: :...::::::.:::::
NP_644 FIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCK
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
.:::::::.:::.:: ::: .::.....:...: ..:::: :.:. : : . ..: .
NP_644 VKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAE
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA
: : .: :...::: .. : .:.::.::. .:.:: : . :.: :::.:...::::.::
NP_644 PFLYSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVA
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY
::::::.::. : ...: ..:::. ..:::::.:.:.:...:::.:::::::: :..:
NP_644 QLFGGSYIYHWDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLY
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF
.:. :::::::.:: :.::::.:... :.::.::::: ::::::... . :
NP_644 RWHQNGFYSHQALHPWHRDTDLEFVD------GEGKPRLIVSSSSQAPVIYQWSRTQKQF
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ
. : .. .. :. ::::: . : :.::.:.:::::...: :. :...: .:::::...:
NP_644 VAQGEVTQVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE4 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS
:. ... .: ::::.::::.:.:: . :::.:::: :::::.: .. . ..:.: :
NP_644 PFLVGGRRYLALGSDFSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPS
480 490 500 510 520 530
550
pF1KE4 FKGNTQIYKHVIVDLSA
:::.: .:.:..:::::
NP_644 FKGQTLVYRHIVVDLSA
540
>>XP_016872400 (OMIM: 600512,604619) PREDICTED: leucine- (281 aa)
initn: 1977 init1: 1888 opt: 1888 Z-score: 1879.9 bits: 356.7 E(85289): 5.7e-98
Smith-Waterman score: 1888; 99.6% identity (100.0% similar) in 281 aa overlap (1-281:1-281)
10 20 30 40 50 60
pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA
::::::::::::::::::::::::::::::::::::::::.
XP_016 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGS
250 260 270 280
310 320 330 340 350 360
pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY
>>NP_001295204 (OMIM: 600512,604619) leucine-rich glioma (291 aa)
initn: 1878 init1: 1878 opt: 1878 Z-score: 1869.8 bits: 354.9 E(85289): 2.1e-97
Smith-Waterman score: 1878; 100.0% identity (100.0% similar) in 279 aa overlap (1-279:1-279)
10 20 30 40 50 60
pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA
:::::::::::::::::::::::::::::::::::::::
NP_001 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITVLREIHRFTNMS
250 260 270 280 290
310 320 330 340 350 360
pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY
>>NP_644813 (OMIM: 608303) leucine-rich repeat LGI famil (537 aa)
initn: 1909 init1: 1208 opt: 1774 Z-score: 1763.7 bits: 336.1 E(85289): 1.7e-91
Smith-Waterman score: 1774; 48.6% identity (75.7% similar) in 539 aa overlap (22-557:7-537)
10 20 30 40 50 60
pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
.: ::.. .. . .: : ::: :.:.::.::::.. .
NP_644 MGGAGILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGSPD
10 20 30 40
70 80 90 100 110 120
pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL
.: . : ..:::.::.: :... :::: :::.:::::::::.:: :::: :: ::.::
NP_644 LPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK
:::.:.: :::....:::.:: :::::::.:.:::. .:.:::.::.:::::: :.:::.
NP_644 FIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCR
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
. ::..:. .::.: : :: .. ... :. : : : :.. : . ..::..
NP_644 VLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVE
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA
::: .. ..:.::::.:.:..: ::. . :: ... ..:.: :::.:. .:.:..:
NP_644 PFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAA
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY
.:.:::... : : . .. : . .. .::: : . .:.. :::::.:::: ::.
NP_644 RLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLL
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF
.: ::: :::::::.::::.: ::. : ::.:.:.:::::...:. . :
NP_644 CRDGPGFYPHQSLHAWHRDTDAEALELDGRP------HLLLASASQRPVLFHWTGGR--F
350 360 370 380 390
430 440 450 460 470 480
pF1KE4 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ
.::::. :::::..::.. :::..::::.:::: ::.: :: :. .:..::::. :::
NP_644 ERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQ
400 410 420 430 440 450
490 500 510 520 530
pF1KE4 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELN---VQAPRSFTHVSINKRNFLF
:: : : ::::::..:.:: . .:. . .:::. . :::.:.:... : :::
NP_644 PLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLF
460 470 480 490 500 510
540 550
pF1KE4 ASSFKGNTQIYKHVIVDLSA
:. ::: ::::.: .::::
NP_644 AACFKGPTQIYQHHEIDLSA
520 530
>>XP_016881919 (OMIM: 608303) PREDICTED: leucine-rich re (365 aa)
initn: 1115 init1: 536 opt: 1098 Z-score: 1098.0 bits: 212.4 E(85289): 2e-54
Smith-Waterman score: 1098; 45.0% identity (72.1% similar) in 369 aa overlap (192-557:5-365)
170 180 190 200 210 220
pF1KE4 LDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDC
::.: : :: .. ... :. : : :
XP_016 MPTVNASVGTGACAGPASLSHMQLHHLDPKTFKC
10 20 30
230 240 250 260 270 280
pF1KE4 IITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGT
:.. : . ..::.. ::: .. ..:.::::.:.:..: ::. . :: ... ..
XP_016 RAIELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAA
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE4 STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIE
:.: :::.:. .:.:..:.:.:::... : : . .. : . .. .::: : . .:
XP_016 SVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLE
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE4 NNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLIL
.. :::::.:::: ::. .: ::: :::::::.::::.: ::. :::.:
XP_016 GQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGR------PHLLL
160 170 180 190 200
410 420 430 440 450 460
pF1KE4 SSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWG
.:.:::::...:. . : .::::. :::::..::.. :::..::::.:::: ::.:
XP_016 ASASQRPVLFHWTGGR--FERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWD
210 220 230 240 250 260
470 480 490 500 510
pF1KE4 GSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELN---
:: :. .:..::::. ::::: : : ::::::..:.:: . .:. . .:::.
XP_016 GSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPA
270 280 290 300 310 320
520 530 540 550
pF1KE4 VQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA
. :::.:.:... : ::::. ::: ::::.: .::::
XP_016 LVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA
330 340 350 360
>>XP_016881917 (OMIM: 608303) PREDICTED: leucine-rich re (365 aa)
initn: 1115 init1: 536 opt: 1098 Z-score: 1098.0 bits: 212.4 E(85289): 2e-54
Smith-Waterman score: 1098; 45.0% identity (72.1% similar) in 369 aa overlap (192-557:5-365)
170 180 190 200 210 220
pF1KE4 LDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDC
::.: : :: .. ... :. : : :
XP_016 MPTVNASVGTGACAGPASLSHMQLHHLDPKTFKC
10 20 30
230 240 250 260 270 280
pF1KE4 IITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGT
:.. : . ..::.. ::: .. ..:.::::.:.:..: ::. . :: ... ..
XP_016 RAIELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAA
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE4 STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIE
:.: :::.:. .:.:..:.:.:::... : : . .. : . .. .::: : . .:
XP_016 SVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLE
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE4 NNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLIL
.. :::::.:::: ::. .: ::: :::::::.::::.: ::. :::.:
XP_016 GQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGR------PHLLL
160 170 180 190 200
410 420 430 440 450 460
pF1KE4 SSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWG
.:.:::::...:. . : .::::. :::::..::.. :::..::::.:::: ::.:
XP_016 ASASQRPVLFHWTGGR--FERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWD
210 220 230 240 250 260
470 480 490 500 510
pF1KE4 GSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELN---
:: :. .:..::::. ::::: : : ::::::..:.:: . .:. . .:::.
XP_016 GSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPA
270 280 290 300 310 320
520 530 540 550
pF1KE4 VQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA
. :::.:.:... : ::::. ::: ::::.: .::::
XP_016 LVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA
330 340 350 360
>>XP_016881918 (OMIM: 608303) PREDICTED: leucine-rich re (365 aa)
initn: 1115 init1: 536 opt: 1098 Z-score: 1098.0 bits: 212.4 E(85289): 2e-54
Smith-Waterman score: 1098; 45.0% identity (72.1% similar) in 369 aa overlap (192-557:5-365)
170 180 190 200 210 220
pF1KE4 LDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDC
::.: : :: .. ... :. : : :
XP_016 MPTVNASVGTGACAGPASLSHMQLHHLDPKTFKC
10 20 30
230 240 250 260 270 280
pF1KE4 IITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGT
:.. : . ..::.. ::: .. ..:.::::.:.:..: ::. . :: ... ..
XP_016 RAIELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAA
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE4 STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIE
:.: :::.:. .:.:..:.:.:::... : : . .. : . .. .::: : . .:
XP_016 SVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLE
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE4 NNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLIL
.. :::::.:::: ::. .: ::: :::::::.::::.: ::. :::.:
XP_016 GQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGR------PHLLL
160 170 180 190 200
410 420 430 440 450 460
pF1KE4 SSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWG
.:.:::::...:. . : .::::. :::::..::.. :::..::::.:::: ::.:
XP_016 ASASQRPVLFHWTGGR--FERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWD
210 220 230 240 250 260
470 480 490 500 510
pF1KE4 GSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELN---
:: :. .:..::::. ::::: : : ::::::..:.:: . .:. . .:::.
XP_016 GSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPA
270 280 290 300 310 320
520 530 540 550
pF1KE4 VQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA
. :::.:.:... : ::::. ::: ::::.: .::::
XP_016 LVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA
330 340 350 360
557 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:17:25 2016 done: Sun Nov 6 00:17:27 2016
Total Scan time: 8.170 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]