Result of FASTA (omim) for
pFN21AE4514
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4514, 546 aa
1>>>pF1KE4514 546 - 546 aa - 546 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3800+/-0.000295; mu= 14.9738+/- 0.019
mean_var=123.2379+/-24.784, 0's: 0 Z-trim(121.1): 80 B-trim: 0 in 0/61
Lambda= 0.115532
statistics sampled from 37024 (37133) to 37024 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.435), width: 16
Scan time: 11.950
The best scores are: opt bits E(85289)
NP_056480 (OMIM: 231550,605378) aladin isoform 1 [ ( 546) 3852 653.1 6.5e-187
XP_011537080 (OMIM: 231550,605378) PREDICTED: alad ( 560) 3122 531.4 2.8e-150
NP_001166937 (OMIM: 231550,605378) aladin isoform ( 513) 2580 441.0 4.1e-123
XP_011537082 (OMIM: 231550,605378) PREDICTED: alad ( 527) 1850 319.4 1.8e-86
XP_016865474 (OMIM: 606929) PREDICTED: THO complex ( 263) 183 41.2 0.0047
NP_115737 (OMIM: 606929) THO complex subunit 3 [Ho ( 351) 183 41.4 0.0058
>>NP_056480 (OMIM: 231550,605378) aladin isoform 1 [Homo (546 aa)
initn: 3852 init1: 3852 opt: 3852 Z-score: 3476.7 bits: 653.1 E(85289): 6.5e-187
Smith-Waterman score: 3852; 100.0% identity (100.0% similar) in 546 aa overlap (1-546:1-546)
10 20 30 40 50 60
pF1KE4 MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 VQDGKPVILLFRTRNSPVFELLPCGIIQGEPGAQPQLITFHPSFNKGALLSVGWSTGRIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VQDGKPVILLFRTRNSPVFELLPCGIIQGEPGAQPQLITFHPSFNKGALLSVGWSTGRIA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 HIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSAPWDPLPGPPPVLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSAPWDPLPGPPPVLPH
490 500 510 520 530 540
pF1KE4 SPHSHL
::::::
NP_056 SPHSHL
>>XP_011537080 (OMIM: 231550,605378) PREDICTED: aladin i (560 aa)
initn: 3119 init1: 3119 opt: 3122 Z-score: 2818.9 bits: 531.4 E(85289): 2.8e-150
Smith-Waterman score: 3814; 97.5% identity (97.5% similar) in 560 aa overlap (1-546:1-560)
10 20 30 40 50 60
pF1KE4 MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR
370 380 390 400 410 420
430 440 450 460
pF1KE4 VQDGKPVILLFRTRNSPVFELLPC--------------GIIQGEPGAQPQLITFHPSFNK
:::::::::::::::::::::::: ::::::::::::::::::::::
XP_011 VQDGKPVILLFRTRNSPVFELLPCSLLASGCLLTFSSSGIIQGEPGAQPQLITFHPSFNK
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 GALLSVGWSTGRIAHIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GALLSVGWSTGRIAHIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSA
490 500 510 520 530 540
530 540
pF1KE4 PWDPLPGPPPVLPHSPHSHL
::::::::::::::::::::
XP_011 PWDPLPGPPPVLPHSPHSHL
550 560
>>NP_001166937 (OMIM: 231550,605378) aladin isoform 2 [H (513 aa)
initn: 3593 init1: 2562 opt: 2580 Z-score: 2331.2 bits: 441.0 E(85289): 4.1e-123
Smith-Waterman score: 3534; 94.0% identity (94.0% similar) in 546 aa overlap (1-546:1-513)
10 20 30 40 50 60
pF1KE4 MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNA
:::::::::::::::::::::::::::: :
NP_001 ASSLHGSLFPHLSLRSEDLIAEFAQVTN---C----------------------------
130 140
190 200 210 220 230 240
pF1KE4 SSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --TIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE4 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE4 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE4 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE4 VQDGKPVILLFRTRNSPVFELLPCGIIQGEPGAQPQLITFHPSFNKGALLSVGWSTGRIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQDGKPVILLFRTRNSPVFELLPCGIIQGEPGAQPQLITFHPSFNKGALLSVGWSTGRIA
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE4 HIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSAPWDPLPGPPPVLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSAPWDPLPGPPPVLPH
450 460 470 480 490 500
pF1KE4 SPHSHL
::::::
NP_001 SPHSHL
510
>>XP_011537082 (OMIM: 231550,605378) PREDICTED: aladin i (527 aa)
initn: 2860 init1: 1829 opt: 1850 Z-score: 1673.5 bits: 319.4 E(85289): 1.8e-86
Smith-Waterman score: 3496; 91.6% identity (91.6% similar) in 560 aa overlap (1-546:1-527)
10 20 30 40 50 60
pF1KE4 MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNA
:::::::::::::::::::::::::::: :
XP_011 ASSLHGSLFPHLSLRSEDLIAEFAQVTN---C----------------------------
130 140
190 200 210 220 230 240
pF1KE4 SSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 --TIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE4 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE4 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE4 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR
330 340 350 360 370 380
430 440 450 460
pF1KE4 VQDGKPVILLFRTRNSPVFELLPC--------------GIIQGEPGAQPQLITFHPSFNK
:::::::::::::::::::::::: ::::::::::::::::::::::
XP_011 VQDGKPVILLFRTRNSPVFELLPCSLLASGCLLTFSSSGIIQGEPGAQPQLITFHPSFNK
390 400 410 420 430 440
470 480 490 500 510 520
pF1KE4 GALLSVGWSTGRIAHIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GALLSVGWSTGRIAHIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSA
450 460 470 480 490 500
530 540
pF1KE4 PWDPLPGPPPVLPHSPHSHL
::::::::::::::::::::
XP_011 PWDPLPGPPPVLPHSPHSHL
510 520
>>XP_016865474 (OMIM: 606929) PREDICTED: THO complex sub (263 aa)
initn: 183 init1: 81 opt: 183 Z-score: 175.8 bits: 41.2 E(85289): 0.0047
Smith-Waterman score: 183; 29.4% identity (55.5% similar) in 119 aa overlap (243-360:9-125)
220 230 240 250 260 270
pF1KE4 CQSCILIWTLDPTSLSTRPSSGCAQVLSHPGH-TPVTSLAWAPSGGRLLSASPVDAAIRV
:: : .: : ::. :. .. : .::.
XP_016 MVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRI
10 20 30
280 290 300 310 320 330
pF1KE4 WDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTCERWPTLSGRC
::: : :. .: .. :. :::::. : . . . : .:. . .. .
XP_016 WDVRTTKCIATVNTKGENI-NICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEV
40 50 60 70 80 90
340 350 360 370 380 390
pF1KE4 QTGCWSPDGSRLLFTVLGEPLIYSLSFPERCGEGKGCVGGAKSATIVADLSETTIQTPDG
. :. :.. ..: . :. : ::.::
XP_016 NEISWNNDNN-MFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSA
100 110 120 130 140 150
>>NP_115737 (OMIM: 606929) THO complex subunit 3 [Homo s (351 aa)
initn: 163 init1: 81 opt: 183 Z-score: 174.2 bits: 41.4 E(85289): 0.0058
Smith-Waterman score: 183; 29.4% identity (55.5% similar) in 119 aa overlap (243-360:97-213)
220 230 240 250 260 270
pF1KE4 CQSCILIWTLDPTSLSTRPSSGCAQVLSHPGH-TPVTSLAWAPSGGRLLSASPVDAAIRV
:: : .: : ::. :. .. : .::.
NP_115 GRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRI
70 80 90 100 110 120
280 290 300 310 320 330
pF1KE4 WDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTCERWPTLSGRC
::: : :. .: .. :. :::::. : . . . : .:. . .. .
NP_115 WDVRTTKCIATVNTKGENI-NICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEV
130 140 150 160 170 180
340 350 360 370 380 390
pF1KE4 QTGCWSPDGSRLLFTVLGEPLIYSLSFPERCGEGKGCVGGAKSATIVADLSETTIQTPDG
. :. :.. ..: . :. : ::.::
NP_115 NEISWNNDNN-MFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSA
190 200 210 220 230 240
546 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:20:01 2016 done: Sun Nov 6 00:20:03 2016
Total Scan time: 11.950 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]