Result of FASTA (omim) for
pFN21AE4509
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4509, 532 aa
1>>>pF1KE4509 532 - 532 aa - 532 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1149+/-0.000336; mu= 20.4990+/- 0.021
mean_var=76.1961+/-15.823, 0's: 0 Z-trim(115.5): 40 B-trim: 0 in 0/56
Lambda= 0.146929
statistics sampled from 26037 (26077) to 26037 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.306), width: 16
Scan time: 10.750
The best scores are: opt bits E(85289)
NP_003029 (OMIM: 600229,616657) neutral amino acid ( 532) 3366 723.0 5.4e-208
XP_006712142 (OMIM: 600229,616657) PREDICTED: neut ( 312) 1976 428.2 1.8e-119
NP_005619 (OMIM: 109190) neutral amino acid transp ( 541) 1893 410.8 5.4e-114
XP_005259224 (OMIM: 109190) PREDICTED: neutral ami ( 469) 1724 374.9 3e-103
NP_001138617 (OMIM: 109190) neutral amino acid tra ( 339) 1381 302.1 1.8e-81
NP_001138616 (OMIM: 109190) neutral amino acid tra ( 313) 1323 289.8 8.5e-78
NP_001180422 (OMIM: 600229,616657) neutral amino a ( 234) 1178 258.9 1.2e-68
XP_011512386 (OMIM: 600111,612656) PREDICTED: exci ( 435) 1041 230.1 1.1e-59
NP_001276868 (OMIM: 600111,612656) excitatory amin ( 496) 1041 230.1 1.2e-59
NP_004163 (OMIM: 600111,612656) excitatory amino a ( 542) 1041 230.2 1.3e-59
XP_005248399 (OMIM: 600111,612656) PREDICTED: exci ( 542) 1041 230.2 1.3e-59
NP_005062 (OMIM: 600637) excitatory amino acid tra ( 564) 1006 222.8 2.2e-57
XP_006722905 (OMIM: 600637) PREDICTED: excitatory ( 564) 1006 222.8 2.2e-57
XP_006722907 (OMIM: 600637) PREDICTED: excitatory ( 564) 1006 222.8 2.2e-57
XP_016882641 (OMIM: 600637) PREDICTED: excitatory ( 564) 1006 222.8 2.2e-57
XP_011516312 (OMIM: 133550,615232) PREDICTED: exci ( 477) 984 218.0 5e-56
XP_011516311 (OMIM: 133550,615232) PREDICTED: exci ( 504) 984 218.1 5.2e-56
NP_004161 (OMIM: 133550,615232) excitatory amino a ( 524) 984 218.1 5.3e-56
XP_011516310 (OMIM: 133550,615232) PREDICTED: exci ( 527) 984 218.1 5.4e-56
XP_011516309 (OMIM: 133550,615232) PREDICTED: exci ( 547) 984 218.1 5.5e-56
XP_016873626 (OMIM: 600300,617105) PREDICTED: exci ( 565) 983 217.9 6.5e-56
NP_001239581 (OMIM: 600300,617105) excitatory amin ( 565) 983 217.9 6.5e-56
XP_016873627 (OMIM: 600300,617105) PREDICTED: exci ( 565) 983 217.9 6.5e-56
NP_001182657 (OMIM: 600300,617105) excitatory amin ( 565) 983 217.9 6.5e-56
XP_011518587 (OMIM: 600300,617105) PREDICTED: exci ( 570) 983 217.9 6.6e-56
XP_005253124 (OMIM: 600300,617105) PREDICTED: exci ( 571) 983 217.9 6.6e-56
NP_004162 (OMIM: 600300,617105) excitatory amino a ( 574) 983 217.9 6.6e-56
XP_016873625 (OMIM: 600300,617105) PREDICTED: exci ( 579) 983 217.9 6.7e-56
NP_006662 (OMIM: 604471) excitatory amino acid tra ( 560) 942 209.2 2.7e-53
NP_001274526 (OMIM: 604471) excitatory amino acid ( 472) 938 208.3 4.3e-53
NP_001276869 (OMIM: 600111,612656) excitatory amin ( 430) 863 192.4 2.4e-48
NP_001160167 (OMIM: 600111,612656) excitatory amin ( 497) 747 167.8 6.8e-41
XP_016870532 (OMIM: 133550,615232) PREDICTED: exci ( 488) 728 163.8 1.1e-39
XP_016870531 (OMIM: 133550,615232) PREDICTED: exci ( 511) 728 163.8 1.1e-39
XP_011540304 (OMIM: 604471) PREDICTED: excitatory ( 337) 578 131.9 3.1e-30
NP_001274524 (OMIM: 604471) excitatory amino acid ( 619) 578 132.1 4.9e-30
XP_016873628 (OMIM: 600300,617105) PREDICTED: exci ( 496) 549 125.9 2.9e-28
NP_001259017 (OMIM: 600637) excitatory amino acid ( 312) 456 106.0 1.8e-22
NP_001259016 (OMIM: 600637) excitatory amino acid ( 312) 456 106.0 1.8e-22
NP_001274525 (OMIM: 604471) excitatory amino acid ( 158) 346 82.4 1.1e-15
>>NP_003029 (OMIM: 600229,616657) neutral amino acid tra (532 aa)
initn: 3366 init1: 3366 opt: 3366 Z-score: 3855.1 bits: 723.0 E(85289): 5.4e-208
Smith-Waterman score: 3366; 100.0% identity (100.0% similar) in 532 aa overlap (1-532:1-532)
10 20 30 40 50 60
pF1KE4 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK
430 440 450 460 470 480
490 500 510 520 530
pF1KE4 ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
490 500 510 520 530
>>XP_006712142 (OMIM: 600229,616657) PREDICTED: neutral (312 aa)
initn: 1976 init1: 1976 opt: 1976 Z-score: 2265.8 bits: 428.2 E(85289): 1.8e-119
Smith-Waterman score: 1976; 100.0% identity (100.0% similar) in 312 aa overlap (221-532:1-312)
200 210 220 230 240 250
pF1KE4 YATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRF
::::::::::::::::::::::::::::::
XP_006 MNILGLVLFALVLGVALKKLGSEGEDLIRF
10 20 30
260 270 280 290 300 310
pF1KE4 FNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGG
40 50 60 70 80 90
320 330 340 350 360 370
pF1KE4 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFI
100 110 120 130 140 150
380 390 400 410 420 430
pF1KE4 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT
160 170 180 190 200 210
440 450 460 470 480 490
pF1KE4 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA
220 230 240 250 260 270
500 510 520 530
pF1KE4 EVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
::::::::::::::::::::::::::::::::::::::::::
XP_006 EVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
280 290 300 310
>>NP_005619 (OMIM: 109190) neutral amino acid transporte (541 aa)
initn: 1800 init1: 1271 opt: 1893 Z-score: 2167.5 bits: 410.8 E(85289): 5.4e-114
Smith-Waterman score: 1893; 60.9% identity (81.9% similar) in 524 aa overlap (17-532:32-541)
10 20 30 40
pF1KE4 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVL
: ::: : :. ..::: :: . :::
NP_005 VADPPRDSKGLAAAEPTANGGLALASIEDQGAAAG-GYCGSR-DQVRRC---LRANLLVL
10 20 30 40 50
50 60 70 80 90 100
pF1KE4 LTVSGVLAGAGLGAALRG----LSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGA
::: .:.::..:: .. : :.:. ... ..::::.:::.:::::::::::::..::
NP_005 LTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGA
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 ASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPP
:::: . :::::. :. .: .::: ::::.:.::. ..::... ....: .: :.
NP_005 ASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINAS-VGAAGSAENA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 VPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMN
::..:::::::::.:::::: ::::.:.: :. . . .: :. :.:.: :.::::
NP_005 PSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYE---ERNITG--TRVKVPVGQEVEGMN
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 ILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIV
:::::.::.:.::::.::: ::: :::::::.::::::::::::::.::::::::..:::
NP_005 ILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIV
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 EMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFAT
::.:. .: . :::::. .:::.::: .:::::::.::::::.::: :...:.::::.:
NP_005 EMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGT
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 CSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELN
::::::: ::::.:::::: :.::::::::::::::::::.::::::::::::.. :.
NP_005 SSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLD
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 AGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVV
.:.:::::::::::::::.:::::::.::::::..::. . :::::::.:::. ::.
NP_005 FVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVL
420 430 440 450 460 470
470 480 490 500 510
pF1KE4 NVEGDALGAGILH-HLNQKATKKGEQELAEVKVEAI--PNCKSEEETSPLVTH-QNPAGP
::::::::::.:. .... ... : :: .:: : : :: .::. : ..:::
NP_005 NVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGD
480 490 500 510 520 530
520 530
pF1KE4 VASAPELESKESVL
.. : : ::::.
NP_005 ATVASE---KESVM
540
>>XP_005259224 (OMIM: 109190) PREDICTED: neutral amino a (469 aa)
initn: 1638 init1: 1168 opt: 1724 Z-score: 1974.7 bits: 374.9 E(85289): 3e-103
Smith-Waterman score: 1724; 63.9% identity (84.4% similar) in 443 aa overlap (17-455:32-463)
10 20 30 40
pF1KE4 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVL
: ::: : :. ..::: :: . :::
XP_005 VADPPRDSKGLAAAEPTANGGLALASIEDQGAAAG-GYCGSR-DQVRRC---LRANLLVL
10 20 30 40 50
50 60 70 80 90 100
pF1KE4 LTVSGVLAGAGLGAALRG----LSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGA
::: .:.::..:: .. : :.:. ... ..::::.:::.:::::::::::::..::
XP_005 LTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGA
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 ASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPP
:::: . :::::. :. .: .::: ::::.:.::. ..::... ....: .: :.
XP_005 ASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINAS-VGAAGSAENA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 VPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMN
::..:::::::::.:::::: ::::.:.: :. . . .: :. :.:.: :.::::
XP_005 PSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYE---ERNITG--TRVKVPVGQEVEGMN
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 ILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIV
:::::.::.:.::::.::: ::: :::::::.::::::::::::::.::::::::..:::
XP_005 ILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIV
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 EMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFAT
::.:. .: . :::::. .:::.::: .:::::::.::::::.::: :...:.::::.:
XP_005 EMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGT
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 CSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELN
::::::: ::::.:::::: :.::::::::::::::::::.::::::::::::.. :.
XP_005 SSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLD
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 AGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVV
.:.:::::::::::::::.:::::::.::::::..::. . :::::::.:
XP_005 FVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVTSGKTF
420 430 440 450 460
470 480 490 500 510 520
pF1KE4 NVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASA
>>NP_001138617 (OMIM: 109190) neutral amino acid transpo (339 aa)
initn: 1353 init1: 1271 opt: 1381 Z-score: 1583.7 bits: 302.1 E(85289): 1.8e-81
Smith-Waterman score: 1381; 65.0% identity (84.1% similar) in 346 aa overlap (191-532:2-339)
170 180 190 200 210 220
pF1KE4 PPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEG
:.: :. . . .: :. :.:.: :.::
NP_001 MYSTTYE---ERNITG--TRVKVPVGQEVEG
10 20
230 240 250 260 270 280
pF1KE4 MNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSK
:::::::.::.:.::::.::: ::: :::::::.::::::::::::::.::::::::..:
NP_001 MNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGK
30 40 50 60 70 80
290 300 310 320 330 340
pF1KE4 IVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAF
::::.:. .: . :::::. .:::.::: .:::::::.::::::.::: :...:.::::
NP_001 IVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAF
90 100 110 120 130 140
350 360 370 380 390 400
pF1KE4 ATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVE
.: ::::::: ::::.:::::: :.::::::::::::::::::.::::::::::::..
NP_001 GTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQS
150 160 170 180 190 200
410 420 430 440 450 460
pF1KE4 LNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTT
:. .:.:::::::::::::::.:::::::.::::::..::. . :::::::.:::. :
NP_001 LDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCT
210 220 230 240 250 260
470 480 490 500 510
pF1KE4 VVNVEGDALGAGILH-HLNQKATKKGEQELAEVKVEAI--PNCKSEEETSPLVTH-QNPA
:.::::::::::.:. .... ... : :: .:: : : :: .::. : ..::
NP_001 VLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPA
270 280 290 300 310 320
520 530
pF1KE4 GPVASAPELESKESVL
: .. : : ::::.
NP_001 GDATVASE---KESVM
330
>>NP_001138616 (OMIM: 109190) neutral amino acid transpo (313 aa)
initn: 1339 init1: 1257 opt: 1323 Z-score: 1517.7 bits: 289.8 E(85289): 8.5e-78
Smith-Waterman score: 1323; 67.7% identity (85.8% similar) in 316 aa overlap (221-532:1-313)
200 210 220 230 240 250
pF1KE4 YATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRF
:::::::.::.:.::::.::: ::: ::::
NP_001 MNILGLVVFAIVFGVALRKLGPEGELLIRF
10 20 30
260 270 280 290 300 310
pF1KE4 FNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGG
:::.::::::::::::::.::::::::..:::::.:. .: . :::::. .:::.:::
NP_001 FNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGL
40 50 60 70 80 90
320 330 340 350 360 370
pF1KE4 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFI
.:::::::.::::::.::: :...:.::::.: ::::::: ::::.:::::: :.:::::
NP_001 LVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFI
100 110 120 130 140 150
380 390 400 410 420 430
pF1KE4 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT
:::::::::::::.::::::::::::.. :. .:.:::::::::::::::.:::::::
NP_001 LPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLT
160 170 180 190 200 210
440 450 460 470 480
pF1KE4 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILH-HLNQKATKKGEQEL
.::::::..::. . :::::::.:::. ::.::::::::::.:. .... ... : ::
NP_001 LAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPEL
220 230 240 250 260 270
490 500 510 520 530
pF1KE4 AEVKVEAI--PNCKSEEETSPLVTH-QNPAGPVASAPELESKESVL
.:: : : :: .::. : ..::: .. : : ::::.
NP_001 IQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASE---KESVM
280 290 300 310
>>NP_001180422 (OMIM: 600229,616657) neutral amino acid (234 aa)
initn: 1447 init1: 1178 opt: 1178 Z-score: 1353.3 bits: 258.9 E(85289): 1.2e-68
Smith-Waterman score: 1298; 75.0% identity (75.0% similar) in 312 aa overlap (221-532:1-234)
200 210 220 230 240 250
pF1KE4 YATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRF
::::::::::::::::::::::::::::::
NP_001 MNILGLVLFALVLGVALKKLGSEGEDLIRF
10 20 30
260 270 280 290 300 310
pF1KE4 FNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGG
::::::::::::::::
NP_001 FNSLNEATMVLVSWIM--------------------------------------------
40
320 330 340 350 360 370
pF1KE4 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFI
:: ::::::::::::::::::::::::
NP_001 --------------------------------CS--ATLPSMMKCIEENNGVDKRISRFI
50 60 70
380 390 400 410 420 430
pF1KE4 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT
80 90 100 110 120 130
440 450 460 470 480 490
pF1KE4 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA
140 150 160 170 180 190
500 510 520 530
pF1KE4 EVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
::::::::::::::::::::::::::::::::::::::::::
NP_001 EVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
200 210 220 230
>>XP_011512386 (OMIM: 600111,612656) PREDICTED: excitato (435 aa)
initn: 1170 init1: 992 opt: 1041 Z-score: 1192.7 bits: 230.1 E(85289): 1.1e-59
Smith-Waterman score: 1179; 46.4% identity (74.4% similar) in 414 aa overlap (103-495:2-408)
80 90 100 110 120 130
pF1KE4 TYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALA
:.::.. :..: ::.:. ::. : ...
XP_011 MAALDSKASGKMGMRAVVYYMTTTIIAVVIG
10 20 30
140 150 160 170 180 190
pF1KE4 VALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYA
. ...::.::.:.. ... : : ..:.:::: ::.:: ::: : :. .
XP_011 IIIVIIIHPGKGTKE------NMHREGKI-VRVTAADAFLDLIRNMFPPNLVEACFKQFK
40 50 60 70 80
200 210 220 230
pF1KE4 TDY-----KVVTQNSSS--GNV--------------THEKIPIGTEIEGMNILGLVLFAL
:.: :: : . . : : :.: .:. ..:.: ::::.:..
XP_011 TNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGLVVFSM
90 100 110 120 130 140
240 250 260 270 280 290
pF1KE4 VLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLV
.: .. .. .:. : .::.::::: : ::. ::::.::::.::...:::::.:. :.
XP_011 CFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIG
150 160 170 180 190 200
300 310 320 330 340 350
pF1KE4 TSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPS
.:. : . :.: .::. :::::.::. :::::. :. ::: . ::..: :::::::
XP_011 GQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPI
210 220 230 240 250 260
360 370 380 390 400 410
pF1KE4 MMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILV
.::.:::::::::..::.::.:::.::::.:... .::.::::.:: ::: :::.:: .
XP_011 TFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISI
270 280 290 300 310 320
420 430 440 450 460 470
pF1KE4 TATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGA
::::.:.::::.: .:..:..:.: ..:::: :. ::.::::..:: :..:: ::.:::
XP_011 TATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGA
330 340 350 360 370 380
480 490 500 510 520 530
pF1KE4 GILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESV
::..::... :. . :... .:
XP_011 GIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM
390 400 410 420 430
>>NP_001276868 (OMIM: 600111,612656) excitatory amino ac (496 aa)
initn: 1170 init1: 992 opt: 1041 Z-score: 1192.0 bits: 230.1 E(85289): 1.2e-59
Smith-Waterman score: 1204; 45.4% identity (74.1% similar) in 432 aa overlap (85-495:45-469)
60 70 80 90 100 110
pF1KE4 GAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLG
..: .. :.: ... : :.::.. :..:
NP_001 MERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGMAALDSKASGKMG
20 30 40 50 60 70
120 130 140 150 160 170
pF1KE4 GIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDL
::.:. ::. : .... ...::.::.:.. ... : : ..:.::::
NP_001 MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKE------NMHREGKI-VRVTAADAFLDL
80 90 100 110 120
180 190 200 210
pF1KE4 ARNLFPSNLVVAAFRTYATDY-----KVVTQNSSS--GNV--------------THEKIP
::.:: ::: : :. . :.: :: : . . : : :.: .:
NP_001 IRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVP
130 140 150 160 170 180
220 230 240 250 260 270
pF1KE4 IGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGI
. ..:.: ::::.:.. .: .. .. .:. : .::.::::: : ::. ::::.::::
NP_001 VPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGI
190 200 210 220 230 240
280 290 300 310 320 330
pF1KE4 MFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLL
.::...:::::.:. :. .:. : . :.: .::. :::::.::. :::::. :. :::
NP_001 LFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLL
250 260 270 280 290 300
340 350 360 370 380 390
pF1KE4 APFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFI
. ::..: ::::::: .::.:::::::::..::.::.:::.::::.:... .::.::
NP_001 QALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFI
310 320 330 340 350 360
400 410 420 430 440 450
pF1KE4 AQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDW
::.:: ::: :::.:: .::::.:.::::.: .:..:..:.: ..:::: :. ::.::::
NP_001 AQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDW
370 380 390 400 410 420
460 470 480 490 500 510
pF1KE4 IVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQ
..:: :..:: ::.:::::..::... :. . :... .:
NP_001 FLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETE
430 440 450 460 470 480
520 530
pF1KE4 NPAGPVASAPELESKESVL
NP_001 KPIDSETKM
490
>>NP_004163 (OMIM: 600111,612656) excitatory amino acid (542 aa)
initn: 1400 init1: 992 opt: 1041 Z-score: 1191.4 bits: 230.2 E(85289): 1.3e-59
Smith-Waterman score: 1403; 47.0% identity (75.6% similar) in 479 aa overlap (38-495:44-515)
10 20 30 40 50 60
pF1KE4 NGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGAALRGLSL
.: :.:.:::::..:..:. :: .:: .
NP_004 RMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPYRM
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE4 SRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLS
: .: :..::::.:.:::.:..:::.. :::.: :.::.. :..: ::.:. ::.
NP_004 SYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTII
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE4 ASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAA
: .... ...::.::.:.. ... : : ..:.:::: ::.:: ::: :
NP_004 AVVIGIIIVIIIHPGKGTKE------NMHREGKI-VRVTAADAFLDLIRNMFPPNLVEAC
140 150 160 170 180
190 200 210 220
pF1KE4 FRTYATDY-----KVVTQNSSS--GNV--------------THEKIPIGTEIEGMNILGL
:. . :.: :: : . . : : :.: .:. ..:.: :::
NP_004 FKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 VLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKD
:.:.. .: .. .. .:. : .::.::::: : ::. ::::.::::.::...:::::.:
NP_004 VVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMED
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 IIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSS
. :. .:. : . :.: .::. :::::.::. :::::. :. ::: . ::..: :::
NP_004 MGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 ATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQI
:::: .::.:::::::::..::.::.:::.::::.:... .::.::::.:: ::: :::
NP_004 ATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQI
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 FTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEG
.:: .::::.:.::::.: .:..:..:.: ..:::: :. ::.::::..:: :..:: :
NP_004 ITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLG
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 DALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELE
:.:::::..::... :. . :... .:
NP_004 DSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM
490 500 510 520 530 540
532 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:22:00 2016 done: Sun Nov 6 00:22:02 2016
Total Scan time: 10.750 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]