Result of FASTA (omim) for
pFN21AE4466
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4466, 488 aa
1>>>pF1KE4466 488 - 488 aa - 488 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3337+/-0.000375; mu= 13.6616+/- 0.023
mean_var=98.1568+/-19.751, 0's: 0 Z-trim(115.2): 20 B-trim: 0 in 0/52
Lambda= 0.129454
statistics sampled from 25453 (25467) to 25453 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.299), width: 16
Scan time: 8.040
The best scores are: opt bits E(85289)
NP_036211 (OMIM: 604900,615863) diacylglycerol O-a ( 488) 3345 635.3 1.2e-181
XP_011515658 (OMIM: 604900,615863) PREDICTED: diac ( 431) 2876 547.7 2.5e-155
XP_011537152 (OMIM: 601311) PREDICTED: sterol O-ac ( 466) 432 91.2 6.7e-18
XP_011537151 (OMIM: 601311) PREDICTED: sterol O-ac ( 502) 432 91.3 7.1e-18
NP_003569 (OMIM: 601311) sterol O-acyltransferase ( 522) 432 91.3 7.3e-18
NP_001239441 (OMIM: 102642) sterol O-acyltransfera ( 485) 405 86.2 2.3e-16
NP_001239440 (OMIM: 102642) sterol O-acyltransfera ( 492) 405 86.2 2.3e-16
NP_003092 (OMIM: 102642) sterol O-acyltransferase ( 550) 405 86.2 2.5e-16
XP_011508213 (OMIM: 102642) PREDICTED: sterol O-ac ( 550) 405 86.2 2.5e-16
>>NP_036211 (OMIM: 604900,615863) diacylglycerol O-acylt (488 aa)
initn: 3345 init1: 3345 opt: 3345 Z-score: 3382.3 bits: 635.3 E(85289): 1.2e-181
Smith-Waterman score: 3345; 100.0% identity (100.0% similar) in 488 aa overlap (1-488:1-488)
10 20 30 40 50 60
pF1KE4 MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
430 440 450 460 470 480
pF1KE4 YEAPAAEA
::::::::
NP_036 YEAPAAEA
>>XP_011515658 (OMIM: 604900,615863) PREDICTED: diacylgl (431 aa)
initn: 2875 init1: 2875 opt: 2876 Z-score: 2909.7 bits: 547.7 E(85289): 2.5e-155
Smith-Waterman score: 2876; 99.5% identity (99.5% similar) in 424 aa overlap (65-488:8-431)
40 50 60 70 80 90
pF1KE4 AAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVV
: :::::::::::::::::::::::::::
XP_011 MGAELVGEAWCHRLQDSLFSSDSGFSNYRGILNWCVV
10 20 30
100 110 120 130 140 150
pF1KE4 MLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRL
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE4 AVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE4 NSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE4 KRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIW
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE4 LIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPML
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE4 RRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGN
340 350 360 370 380 390
460 470 480
pF1KE4 AAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
::::::::::::::::::::::::::::::::::
XP_011 AAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
400 410 420 430
>>XP_011537152 (OMIM: 601311) PREDICTED: sterol O-acyltr (466 aa)
initn: 306 init1: 213 opt: 432 Z-score: 442.4 bits: 91.2 E(85289): 6.7e-18
Smith-Waterman score: 473; 31.2% identity (56.9% similar) in 343 aa overlap (145-477:123-441)
120 130 140 150 160 170
pF1KE4 VDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGL-LLHVANLA
.: .:. . : :. :. .:: .: :
XP_011 LLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHA
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE4 TILC-FPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKA
..:: .:. :. :: : .: .:. . . :: . :: :. :.: . : ...
XP_011 VVLCALPVHVA--VEHQLPPASRCVLVFEQVRFL-MKSY----SFLREAVPGTLRA-RRG
160 170 180 190 200
240 250 260 270 280 290
pF1KE4 SSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQ
. :: :: :::: ::: :. ..::.: .: .. . . . : .
XP_011 EGIQAPSFSSY---------LYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYA
210 220 230 240 250
300 310 320 330 340 350
pF1KE4 VGLIQQWMVPTIQN-SMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAE
.. . ::.. : : .::. .. .:. ..:. .. :..:. ..: ::: ::
XP_011 CFILGRLCVPVFANMSREPFST---RALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAE
260 270 280 290 300 310
360 370 380 390 400
pF1KE4 LMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRR-GS-SKWMARTGVFL
...:::: :::::::: : . ....::. :: : . :. :: :. .. .: ::::
XP_011 MLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFL
320 330 340 350 360 370
410 420 430 440 450 460
pF1KE4 ASAFFHEYLVSVPLRMFR-----LWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIG
.:: :::. : .: :. : : : ... : :. .: :..:
XP_011 VSAVAHEYIFCFVLGFFYPVMLILFLVIGGM----LNFMMHDQRTGPAWNVLMWTMLFLG
380 390 400 410 420
470 480
pF1KE4 QPIAVLMYVHDYYVLNYEAPAAEA
: : : .: ...:
XP_011 QGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
430 440 450 460
>>XP_011537151 (OMIM: 601311) PREDICTED: sterol O-acyltr (502 aa)
initn: 306 init1: 213 opt: 432 Z-score: 441.9 bits: 91.3 E(85289): 7.1e-18
Smith-Waterman score: 473; 31.2% identity (56.9% similar) in 343 aa overlap (145-477:159-477)
120 130 140 150 160 170
pF1KE4 VDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGL-LLHVANLA
.: .:. . : :. :. .:: .: :
XP_011 LLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 TILC-FPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKA
..:: .:. :. :: : .: .:. . . :: . :: :. :.: . : ...
XP_011 VVLCALPVHVA--VEHQLPPASRCVLVFEQVRFL-MKSY----SFLREAVPGTLRA-RRG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 SSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQ
. :: :: :::: ::: :. ..::.: .: .. . . . : .
XP_011 EGIQAPSFSSY---------LYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYA
250 260 270 280 290
300 310 320 330 340 350
pF1KE4 VGLIQQWMVPTIQN-SMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAE
.. . ::.. : : .::. .. .:. ..:. .. :..:. ..: ::: ::
XP_011 CFILGRLCVPVFANMSREPFST---RALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAE
300 310 320 330 340
360 370 380 390 400
pF1KE4 LMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRR-GS-SKWMARTGVFL
...:::: :::::::: : . ....::. :: : . :. :: :. .. .: ::::
XP_011 MLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFL
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE4 ASAFFHEYLVSVPLRMFR-----LWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIG
.:: :::. : .: :. : : : ... : :. .: :..:
XP_011 VSAVAHEYIFCFVLGFFYPVMLILFLVIGGM----LNFMMHDQRTGPAWNVLMWTMLFLG
410 420 430 440 450 460
470 480
pF1KE4 QPIAVLMYVHDYYVLNYEAPAAEA
: : : .: ...:
XP_011 QGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
470 480 490 500
>>NP_003569 (OMIM: 601311) sterol O-acyltransferase 2 [H (522 aa)
initn: 306 init1: 213 opt: 432 Z-score: 441.7 bits: 91.3 E(85289): 7.3e-18
Smith-Waterman score: 479; 27.9% identity (54.8% similar) in 451 aa overlap (45-477:79-497)
20 30 40 50 60
pF1KE4 RPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAP-----NKDGDAGVGSGHWELRCH
: : : : .. . ..:. . . .
NP_003 KAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRK
50 60 70 80 90 100
70 80 90 100 110 120
pF1KE4 RLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLEN---LIKYGILVDPIQVVSLFLK
: : :. . . :. .. :..: . : :... :... .:. . . : :
NP_003 SLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLAL-
110 120 130 140 150 160
130 140 150 160 170 180
pF1KE4 DPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGL-LLHVANLATILC-FPAAVVL
.: .: .. . .: .:. . : :. :. .:: .: :..:: .:. :.
NP_003 --VTW-VPMFLSTL----LAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVA-
170 180 190 200 210
190 200 210 220 230 240
pF1KE4 LVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYP
:: : .: .:. . . :: . :: :. :.: . : ... . :: ::
NP_003 -VEHQLPPASRCVLVFEQVRFL-MKSY----SFLREAVPGTLRA-RRGEGIQAPSFSSY-
220 230 240 250 260 270
250 260 270 280 290 300
pF1KE4 DNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTI
:::: ::: :. ..::.: .: .. . . . : . .. . ::..
NP_003 --------LYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVF
280 290 300 310 320
310 320 330 340 350 360
pF1KE4 QN-SMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRD
: : .::. .. .:. ..:. .. :..:. ..: ::: ::...:::: ::::
NP_003 ANMSREPFST---RALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRD
330 340 350 360 370 380
370 380 390 400 410 420
pF1KE4 WWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRR-GS-SKWMARTGVFLASAFFHEYLVSV
:::: : . ....::. :: : . :. :: :. .. .: ::::.:: :::.
NP_003 WWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCF
390 400 410 420 430 440
430 440 450 460 470
pF1KE4 PLRMFR-----LWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDY
: .: :. : : : ... : :. .: :..:: : : .: ...
NP_003 VLGFFYPVMLILFLVIGGM----LNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEW
450 460 470 480 490
480
pF1KE4 YVLNYEAPAAEA
:
NP_003 YARRHCPLPQATFWGLVTPRSWSCHT
500 510 520
>>NP_001239441 (OMIM: 102642) sterol O-acyltransferase 1 (485 aa)
initn: 358 init1: 231 opt: 405 Z-score: 414.9 bits: 86.2 E(85289): 2.3e-16
Smith-Waterman score: 446; 26.6% identity (56.0% similar) in 448 aa overlap (53-477:45-458)
30 40 50 60 70 80
pF1KE4 GPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGF
:: : .:. . . : : :. :
NP_001 LIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVD---
20 30 40 50 60 70
90 100 110 120 130
pF1KE4 SNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSL-FLKDP---YSWPAPCLVI
. : : . ...::: .. . : : :: ....: : : : ..: ..
NP_001 -HIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTW----WIM
80 90 100 110 120
140 150 160 170 180 190
pF1KE4 AANVFAVAAFQVEKRLAVGALTEQA--------GLLLHVANLATILCFPAAVVLLVESIT
..:.: : . .. :.: . :.:. . ... .: : . :.:. ..
NP_001 FLSTFSVPYF-LFQHWATGYSKSSHPLIRSLFHGFLFMIFQIG-VLGFGPTYVVLAYTLP
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE4 PVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYR
:.. .. :.: .. ..:. :. .. ...:. :: :: : :
NP_001 PASRFI------IIFEQIRFVMKAHSFVRENVPRVLNSAKEKSS-----TVPIP---TVN
190 200 210 220 230
260 270 280 290 300
pF1KE4 DLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEML--FFTQLQVGLIQQWMVPTIQN-S
. :::::::: :. ..::.: .: .. .. ... :: . ... .: ..: .
NP_001 QYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYI--FERLCAPLFRNIK
240 250 260 270 280
310 320 330 340 350 360
pF1KE4 MKPFKDMDYSRI-IERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWN
..::. .:. . ... .:. :: .. :. ..: ::: ::...:::: ::.::::
NP_001 QEPFS----ARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWN
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 SESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKW--MARTGVFLASAFFHEYLVSVPLR
: : . ....::. :: : . :: .: :... : .:: .:: ::: ..: :
NP_001 STSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLS
350 360 370 380 390 400
430 440 450 460 470
pF1KE4 -----MFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVL
.: :. : :: . ..:. . :. .: ::..:. . . .: ...:
NP_001 FFYPVLFVLFMFFGMA----FNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYAR
410 420 430 440 450 460
480
pF1KE4 NYEAPAAEA
NP_001 QHCPLKNPTFLDYVRPRSWTCRYVF
470 480
>>NP_001239440 (OMIM: 102642) sterol O-acyltransferase 1 (492 aa)
initn: 358 init1: 231 opt: 405 Z-score: 414.8 bits: 86.2 E(85289): 2.3e-16
Smith-Waterman score: 446; 26.6% identity (56.0% similar) in 448 aa overlap (53-477:52-465)
30 40 50 60 70 80
pF1KE4 GPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGF
:: : .:. . . : : :. :
NP_001 LIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVD---
30 40 50 60 70
90 100 110 120 130
pF1KE4 SNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSL-FLKDP---YSWPAPCLVI
. : : . ...::: .. . : : :: ....: : : : ..: ..
NP_001 -HIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTW----WIM
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE4 AANVFAVAAFQVEKRLAVGALTEQA--------GLLLHVANLATILCFPAAVVLLVESIT
..:.: : . .. :.: . :.:. . ... .: : . :.:. ..
NP_001 FLSTFSVPYF-LFQHWATGYSKSSHPLIRSLFHGFLFMIFQIG-VLGFGPTYVVLAYTLP
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE4 PVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYR
:.. .. :.: .. ..:. :. .. ...:. :: :: : :
NP_001 PASRFI------IIFEQIRFVMKAHSFVRENVPRVLNSAKEKSS-----TVPIP---TVN
200 210 220 230
260 270 280 290 300
pF1KE4 DLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEML--FFTQLQVGLIQQWMVPTIQN-S
. :::::::: :. ..::.: .: .. .. ... :: . ... .: ..: .
NP_001 QYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYI--FERLCAPLFRNIK
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 MKPFKDMDYSRI-IERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWN
..::. .:. . ... .:. :: .. :. ..: ::: ::...:::: ::.::::
NP_001 QEPFS----ARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWN
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 SESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKW--MARTGVFLASAFFHEYLVSVPLR
: : . ....::. :: : . :: .: :... : .:: .:: ::: ..: :
NP_001 STSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLS
360 370 380 390 400 410
430 440 450 460 470
pF1KE4 -----MFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVL
.: :. : :: . ..:. . :. .: ::..:. . . .: ...:
NP_001 FFYPVLFVLFMFFGMA----FNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYAR
420 430 440 450 460
480
pF1KE4 NYEAPAAEA
NP_001 QHCPLKNPTFLDYVRPRSWTCRYVF
470 480 490
>>NP_003092 (OMIM: 102642) sterol O-acyltransferase 1 is (550 aa)
initn: 358 init1: 231 opt: 405 Z-score: 414.1 bits: 86.2 E(85289): 2.5e-16
Smith-Waterman score: 446; 26.6% identity (56.0% similar) in 448 aa overlap (53-477:110-523)
30 40 50 60 70 80
pF1KE4 GPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGF
:: : .:. . . : : :. :
NP_003 LIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVD---
80 90 100 110 120 130
90 100 110 120 130
pF1KE4 SNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSL-FLKDP---YSWPAPCLVI
. : : . ...::: .. . : : :: ....: : : : ..: ..
NP_003 -HIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTW----WIM
140 150 160 170 180 190
140 150 160 170 180 190
pF1KE4 AANVFAVAAFQVEKRLAVGALTEQA--------GLLLHVANLATILCFPAAVVLLVESIT
..:.: : . .. :.: . :.:. . ... .: : . :.:. ..
NP_003 FLSTFSVPYF-LFQHWATGYSKSSHPLIRSLFHGFLFMIFQIG-VLGFGPTYVVLAYTLP
200 210 220 230 240
200 210 220 230 240 250
pF1KE4 PVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYR
:.. .. :.: .. ..:. :. .. ...:. :: :: : :
NP_003 PASRFI------IIFEQIRFVMKAHSFVRENVPRVLNSAKEKSS-----TVPIP---TVN
250 260 270 280 290
260 270 280 290 300
pF1KE4 DLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEML--FFTQLQVGLIQQWMVPTIQN-S
. :::::::: :. ..::.: .: .. .. ... :: . ... .: ..: .
NP_003 QYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYI--FERLCAPLFRNIK
300 310 320 330 340 350
310 320 330 340 350 360
pF1KE4 MKPFKDMDYSRI-IERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWN
..::. .:. . ... .:. :: .. :. ..: ::: ::...:::: ::.::::
NP_003 QEPFS----ARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWN
360 370 380 390 400
370 380 390 400 410 420
pF1KE4 SESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKW--MARTGVFLASAFFHEYLVSVPLR
: : . ....::. :: : . :: .: :... : .:: .:: ::: ..: :
NP_003 STSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLS
410 420 430 440 450 460
430 440 450 460 470
pF1KE4 -----MFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVL
.: :. : :: . ..:. . :. .: ::..:. . . .: ...:
NP_003 FFYPVLFVLFMFFGMA----FNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYAR
470 480 490 500 510 520
480
pF1KE4 NYEAPAAEA
NP_003 QHCPLKNPTFLDYVRPRSWTCRYVF
530 540 550
>>XP_011508213 (OMIM: 102642) PREDICTED: sterol O-acyltr (550 aa)
initn: 358 init1: 231 opt: 405 Z-score: 414.1 bits: 86.2 E(85289): 2.5e-16
Smith-Waterman score: 446; 26.6% identity (56.0% similar) in 448 aa overlap (53-477:110-523)
30 40 50 60 70 80
pF1KE4 GPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGF
:: : .:. . . : : :. :
XP_011 LIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVD---
80 90 100 110 120 130
90 100 110 120 130
pF1KE4 SNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSL-FLKDP---YSWPAPCLVI
. : : . ...::: .. . : : :: ....: : : : ..: ..
XP_011 -HIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTW----WIM
140 150 160 170 180 190
140 150 160 170 180 190
pF1KE4 AANVFAVAAFQVEKRLAVGALTEQA--------GLLLHVANLATILCFPAAVVLLVESIT
..:.: : . .. :.: . :.:. . ... .: : . :.:. ..
XP_011 FLSTFSVPYF-LFQHWATGYSKSSHPLIRSLFHGFLFMIFQIG-VLGFGPTYVVLAYTLP
200 210 220 230 240
200 210 220 230 240 250
pF1KE4 PVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYR
:.. .. :.: .. ..:. :. .. ...:. :: :: : :
XP_011 PASRFI------IIFEQIRFVMKAHSFVRENVPRVLNSAKEKSS-----TVPIP---TVN
250 260 270 280 290
260 270 280 290 300
pF1KE4 DLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEML--FFTQLQVGLIQQWMVPTIQN-S
. :::::::: :. ..::.: .: .. .. ... :: . ... .: ..: .
XP_011 QYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYI--FERLCAPLFRNIK
300 310 320 330 340 350
310 320 330 340 350 360
pF1KE4 MKPFKDMDYSRI-IERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWN
..::. .:. . ... .:. :: .. :. ..: ::: ::...:::: ::.::::
XP_011 QEPFS----ARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWN
360 370 380 390 400
370 380 390 400 410 420
pF1KE4 SESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKW--MARTGVFLASAFFHEYLVSVPLR
: : . ....::. :: : . :: .: :... : .:: .:: ::: ..: :
XP_011 STSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLS
410 420 430 440 450 460
430 440 450 460 470
pF1KE4 -----MFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVL
.: :. : :: . ..:. . :. .: ::..:. . . .: ...:
XP_011 FFYPVLFVLFMFFGMA----FNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYAR
470 480 490 500 510 520
480
pF1KE4 NYEAPAAEA
XP_011 QHCPLKNPTFLDYVRPRSWTCRYVF
530 540 550
488 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:31:37 2016 done: Sun Nov 6 00:31:38 2016
Total Scan time: 8.040 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]