Result of FASTA (omim) for
pFN21AE4455
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4455, 475 aa
1>>>pF1KE4455 475 - 475 aa - 475 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8721+/-0.000456; mu= 19.8920+/- 0.028
mean_var=68.2188+/-14.237, 0's: 0 Z-trim(110.1): 18 B-trim: 0 in 0/48
Lambda= 0.155282
statistics sampled from 18392 (18403) to 18392 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.216), width: 16
Scan time: 7.830
The best scores are: opt bits E(85289)
NP_001157289 (OMIM: 270400,602858) 7-dehydrocholes ( 475) 3371 764.8 0
NP_001351 (OMIM: 270400,602858) 7-dehydrocholester ( 475) 3371 764.8 0
XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-de ( 456) 2277 519.7 6.5e-147
NP_003264 (OMIM: 603414) delta(14)-sterol reductas ( 418) 546 131.9 3.3e-30
XP_011542487 (OMIM: 169400,215140,600024,613471) P ( 615) 425 104.9 6.4e-22
NP_919424 (OMIM: 169400,215140,600024,613471) lami ( 615) 425 104.9 6.4e-22
NP_002287 (OMIM: 169400,215140,600024,613471) lami ( 615) 425 104.9 6.4e-22
XP_005273182 (OMIM: 169400,215140,600024,613471) P ( 573) 357 89.7 2.3e-17
NP_001264162 (OMIM: 603414) delta(14)-sterol reduc ( 391) 349 87.8 6e-17
>>NP_001157289 (OMIM: 270400,602858) 7-dehydrocholestero (475 aa)
initn: 3371 init1: 3371 opt: 3371 Z-score: 4082.9 bits: 764.8 E(85289): 0
Smith-Waterman score: 3371; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
430 440 450 460 470
>>NP_001351 (OMIM: 270400,602858) 7-dehydrocholesterol r (475 aa)
initn: 3371 init1: 3371 opt: 3371 Z-score: 4082.9 bits: 764.8 E(85289): 0
Smith-Waterman score: 3371; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
430 440 450 460 470
>>XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-dehydr (456 aa)
initn: 2277 init1: 2277 opt: 2277 Z-score: 2758.6 bits: 519.7 E(85289): 6.5e-147
Smith-Waterman score: 2277; 100.0% identity (100.0% similar) in 321 aa overlap (1-321:1-321)
10 20 30 40 50 60
pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
:::::::::::::::::::::
XP_011 HFGWYLGWGDCVWLPYLYTLQKRTRRQGVCQRQSWGLTPGRWAPEPTLLSSPWAKHRLTP
310 320 330 340 350 360
>>NP_003264 (OMIM: 603414) delta(14)-sterol reductase is (418 aa)
initn: 864 init1: 427 opt: 546 Z-score: 663.3 bits: 131.9 E(85289): 3.3e-30
Smith-Waterman score: 901; 37.6% identity (63.8% similar) in 431 aa overlap (46-475:22-418)
20 30 40 50 60 70
pF1KE4 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI
:::. : ......: . : :: ...
NP_003 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL
10 20 30 40 50
80 90 100 110 120 130
pF1KE4 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT
: : .: .: .: :. :. .:. :: .::. . ::
NP_003 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL
60 70 80 90
140 150 160 170 180 190
pF1KE4 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA
.: :::.:: .:: :: .. . . . . . .:: . :.. .. : :
NP_003 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL
100 110 120 130 140
200 210 220 230 240 250
pF1KE4 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS
..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::.
NP_003 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA
150 160 170 180 190 200
260 270 280 290 300 310
pF1KE4 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL
. :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:.
NP_003 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV
210 220 230 240 250 260
320 330 340 350 360 370
pF1KE4 PYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRK
:. :.::. .:..:: :. : : . :.. .:::::: :: ::. ::.. . . : .
NP_003 PFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLE
270 280 290 300 310 320
380 390 400 410 420 430
pF1KE4 PKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYII
. ..: :. ::::::.::..:: ::.:::. .::. : :: .:::::::..
NP_003 ------TISTATGR----KLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLL
330 340 350 360 370
440 450 460 470
pF1KE4 YMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
:.. ::.:: :::..: .::: :..: ::::..: :.
NP_003 YFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
380 390 400 410
>>XP_011542487 (OMIM: 169400,215140,600024,613471) PREDI (615 aa)
initn: 881 init1: 355 opt: 425 Z-score: 514.6 bits: 104.9 E(85289): 6.4e-22
Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (31-475:203-615)
10 20 30 40 50
pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
:: ... :. . .::..:. : ... ...
XP_011 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
180 190 200 210 220 230
60 70 80 90 100 110
pF1KE4 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
: : . .: ... : ..: .. .: :: .:::.:
XP_011 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
240 250 260 270
120 130 140 150 160 170
pF1KE4 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
.:: .: . ::. : ::..::. :..:: . .. :.. ......
XP_011 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
280 290 300 310 320
180 190 200 210 220 230
pF1KE4 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
. :... ..:.. .... : . . .:: :....: :.::::: ::.: :
XP_011 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
330 340 350 360 370 380
240 250 260 270 280 290
pF1KE4 NGRPGIVAWTLINLSFAAKQRELHSHVTN--AMVLVNVLQAIYVIDFFWNETWYLKTIDI
. :::...:..::: . . ....... ::.::: .: .::.: .::: : :.::
XP_011 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI
390 400 410 420 430 440
300 310 320 330 340 350
pF1KE4 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ
:: ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: :
XP_011 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ
450 460 470 480 490 500
360 370 380 390 400 410
pF1KE4 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL
:. ::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .:
XP_011 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL
510 520 530 540 550
420 430 440 450 460 470
pF1KE4 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
:. : :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :.
XP_011 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
560 570 580 590 600 610
>>NP_919424 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa)
initn: 881 init1: 355 opt: 425 Z-score: 514.6 bits: 104.9 E(85289): 6.4e-22
Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (31-475:203-615)
10 20 30 40 50
pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
:: ... :. . .::..:. : ... ...
NP_919 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
180 190 200 210 220 230
60 70 80 90 100 110
pF1KE4 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
: : . .: ... : ..: .. .: :: .:::.:
NP_919 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
240 250 260 270
120 130 140 150 160 170
pF1KE4 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
.:: .: . ::. : ::..::. :..:: . .. :.. ......
NP_919 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
280 290 300 310 320
180 190 200 210 220 230
pF1KE4 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
. :... ..:.. .... : . . .:: :....: :.::::: ::.: :
NP_919 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
330 340 350 360 370 380
240 250 260 270 280 290
pF1KE4 NGRPGIVAWTLINLSFAAKQRELHSHVTN--AMVLVNVLQAIYVIDFFWNETWYLKTIDI
. :::...:..::: . . ....... ::.::: .: .::.: .::: : :.::
NP_919 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI
390 400 410 420 430 440
300 310 320 330 340 350
pF1KE4 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ
:: ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: :
NP_919 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ
450 460 470 480 490 500
360 370 380 390 400 410
pF1KE4 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL
:. ::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .:
NP_919 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL
510 520 530 540 550
420 430 440 450 460 470
pF1KE4 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
:. : :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :.
NP_919 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
560 570 580 590 600 610
>>NP_002287 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa)
initn: 881 init1: 355 opt: 425 Z-score: 514.6 bits: 104.9 E(85289): 6.4e-22
Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (31-475:203-615)
10 20 30 40 50
pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
:: ... :. . .::..:. : ... ...
NP_002 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
180 190 200 210 220 230
60 70 80 90 100 110
pF1KE4 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
: : . .: ... : ..: .. .: :: .:::.:
NP_002 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
240 250 260 270
120 130 140 150 160 170
pF1KE4 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
.:: .: . ::. : ::..::. :..:: . .. :.. ......
NP_002 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
280 290 300 310 320
180 190 200 210 220 230
pF1KE4 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
. :... ..:.. .... : . . .:: :....: :.::::: ::.: :
NP_002 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
330 340 350 360 370 380
240 250 260 270 280 290
pF1KE4 NGRPGIVAWTLINLSFAAKQRELHSHVTN--AMVLVNVLQAIYVIDFFWNETWYLKTIDI
. :::...:..::: . . ....... ::.::: .: .::.: .::: : :.::
NP_002 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI
390 400 410 420 430 440
300 310 320 330 340 350
pF1KE4 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ
:: ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: :
NP_002 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ
450 460 470 480 490 500
360 370 380 390 400 410
pF1KE4 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL
:. ::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .:
NP_002 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL
510 520 530 540 550
420 430 440 450 460 470
pF1KE4 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
:. : :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :.
NP_002 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
560 570 580 590 600 610
>>XP_005273182 (OMIM: 169400,215140,600024,613471) PREDI (573 aa)
initn: 767 init1: 355 opt: 357 Z-score: 432.6 bits: 89.7 E(85289): 2.3e-17
Smith-Waterman score: 736; 31.8% identity (58.6% similar) in 447 aa overlap (31-475:203-573)
10 20 30 40 50
pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
:: ... :. . .::..:. : ... ...
XP_005 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
180 190 200 210 220 230
60 70 80 90 100 110
pF1KE4 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
: : . .: ... : ..: .. .: :: .:::.:
XP_005 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
240 250 260 270
120 130 140 150 160 170
pF1KE4 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
.:: .: . ::. : ::..::. :..:: . .. :.. ......
XP_005 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
280 290 300 310 320
180 190 200 210 220 230
pF1KE4 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
. :... ..:.. .... : . . .:: :....: :.::::: ::.: :
XP_005 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
330 340 350 360 370 380
240 250 260 270 280 290
pF1KE4 NGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICH
. :::...: . : :.:: :
XP_005 ELRPGLIGWEAL----------------------------------------LTTMDIIH
390 400
300 310 320 330 340 350
pF1KE4 DHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKD
: ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: ::.
XP_005 DGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKN
410 420 430 440 450 460
360 370 380 390 400 410
pF1KE4 LFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAY
::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .::.
XP_005 AFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMALAW
470 480 490 500 510
420 430 440 450 460 470
pF1KE4 CLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
: :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :.
XP_005 SLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
520 530 540 550 560 570
>>NP_001264162 (OMIM: 603414) delta(14)-sterol reductase (391 aa)
initn: 783 init1: 349 opt: 349 Z-score: 425.2 bits: 87.8 E(85289): 6e-17
Smith-Waterman score: 779; 35.3% identity (59.6% similar) in 431 aa overlap (46-475:22-391)
20 30 40 50 60 70
pF1KE4 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI
:::. : ......: . : :: ...
NP_001 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL
10 20 30 40 50
80 90 100 110 120 130
pF1KE4 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT
: : .: .: .: :. :. .:. :: .::. . ::
NP_001 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL
60 70 80 90
140 150 160 170 180 190
pF1KE4 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA
.: :::.:: .:: :: .. . . . . . .:: . :.. .. : :
NP_001 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL
100 110 120 130 140
200 210 220 230 240 250
pF1KE4 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS
..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::.
NP_001 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA
150 160 170 180 190 200
260 270 280 290 300 310
pF1KE4 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL
. :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:.
NP_001 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV
210 220 230 240 250 260
320 330 340 350 360 370
pF1KE4 PYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRK
:. :.::. .:..:: :. : : . ::: : .
NP_001 PFTYSLQAQFLLHHPQPLGLPMASVI---------------------------CLINGLE
270 280 290 300
380 390 400 410 420 430
pF1KE4 PKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYII
. ..: :. ::::::.::..:: ::.:::. .::. : :: .:::::::..
NP_001 ------TISTATGR----KLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLL
310 320 330 340 350
440 450 460 470
pF1KE4 YMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
:.. ::.:: :::..: .::: :..: ::::..: :.
NP_001 YFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
360 370 380 390
475 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:00:31 2016 done: Sun Nov 6 01:00:32 2016
Total Scan time: 7.830 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]