Result of FASTA (omim) for
pFN21AE4435
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4435, 452 aa
1>>>pF1KE4435 452 - 452 aa - 452 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2792+/-0.000414; mu= 17.4974+/- 0.026
mean_var=63.7943+/-12.988, 0's: 0 Z-trim(110.6): 39 B-trim: 69 in 1/49
Lambda= 0.160577
statistics sampled from 18981 (19013) to 18981 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.59), E-opt: 0.2 (0.223), width: 16
Scan time: 6.430
The best scores are: opt bits E(85289)
NP_002159 (OMIM: 147650,613657) isocitrate dehydro ( 452) 3074 721.2 1.3e-207
NP_001276839 (OMIM: 147650,613657) isocitrate dehy ( 400) 2726 640.6 2.2e-183
NP_001277043 (OMIM: 147650,613657) isocitrate dehy ( 322) 2215 522.2 8e-148
NP_001269315 (OMIM: 137800,147700) isocitrate dehy ( 414) 1934 457.1 3.9e-128
NP_001269316 (OMIM: 137800,147700) isocitrate dehy ( 414) 1934 457.1 3.9e-128
NP_005887 (OMIM: 137800,147700) isocitrate dehydro ( 414) 1934 457.1 3.9e-128
>>NP_002159 (OMIM: 147650,613657) isocitrate dehydrogena (452 aa)
initn: 3074 init1: 3074 opt: 3074 Z-score: 3848.1 bits: 721.2 E(85289): 1.3e-207
Smith-Waterman score: 3074; 100.0% identity (100.0% similar) in 452 aa overlap (1-452:1-452)
10 20 30 40 50 60
pF1KE4 MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
370 380 390 400 410 420
430 440 450
pF1KE4 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
::::::::::::::::::::::::::::::::
NP_002 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
430 440 450
>>NP_001276839 (OMIM: 147650,613657) isocitrate dehydrog (400 aa)
initn: 2726 init1: 2726 opt: 2726 Z-score: 3413.2 bits: 640.6 E(85289): 2.2e-183
Smith-Waterman score: 2726; 100.0% identity (100.0% similar) in 400 aa overlap (53-452:1-400)
30 40 50 60 70 80
pF1KE4 PAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYF
::::::::::::::::::::::::::::::
NP_001 MDGDEMTRIIWQFIKEKLILPHVDIQLKYF
10 20 30
90 100 110 120 130 140
pF1KE4 DLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNI
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE4 LGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGS
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE4 GVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRF
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE4 KDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQ
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE4 GFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHR
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE4 GKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIK
340 350 360 370 380 390
450
pF1KE4 SNLDRALGRQ
::::::::::
NP_001 SNLDRALGRQ
400
>>NP_001277043 (OMIM: 147650,613657) isocitrate dehydrog (322 aa)
initn: 2215 init1: 2215 opt: 2215 Z-score: 2774.8 bits: 522.2 E(85289): 8e-148
Smith-Waterman score: 2215; 100.0% identity (100.0% similar) in 322 aa overlap (131-452:1-322)
110 120 130 140 150 160
pF1KE4 ALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRL
::::::::::::::::::::::::::::::
NP_001 MWKSPNGTIRNILGGTVFREPIICKNIPRL
10 20 30
170 180 190 200 210 220
pF1KE4 VPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMG
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE4 MYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDK
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE4 NKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGK
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE4 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEK
220 230 240 250 260 270
410 420 430 440 450
pF1KE4 VCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
280 290 300 310 320
>>NP_001269315 (OMIM: 137800,147700) isocitrate dehydrog (414 aa)
initn: 1912 init1: 1134 opt: 1934 Z-score: 2421.4 bits: 457.1 E(85289): 3.9e-128
Smith-Waterman score: 1934; 70.8% identity (88.4% similar) in 397 aa overlap (50-445:10-405)
20 30 40 50 60 70
pF1KE4 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL
::::.:::::::::..::::::.:.:...:
NP_001 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDL
10 20 30
80 90 100 110 120 130
pF1KE4 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI
. .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.:::::::::
NP_001 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK
::::::::::: :::::::::: ::.::: :::::.::::.:::::. : ....::.
NP_001 RNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY
::. . :.:: .:::.::::: :.:: :::: ::.:..: ::::.:::::::: :
NP_001 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD
:::::::::::.::.::..:. .:::::::::::::::..:: :::.:::::::::::::
NP_001 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG
.:::.::::.::::::::::::.:::::::::::::: .:::. :::::::::::::::
NP_001 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL
: ::.:::.:..: ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:.
NP_001 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM
340 350 360 370 380 390
440 450
pF1KE4 DTIKSNLDRALGRQ
: . ::
NP_001 DKLGENLKIKLAQAKL
400 410
>>NP_001269316 (OMIM: 137800,147700) isocitrate dehydrog (414 aa)
initn: 1912 init1: 1134 opt: 1934 Z-score: 2421.4 bits: 457.1 E(85289): 3.9e-128
Smith-Waterman score: 1934; 70.8% identity (88.4% similar) in 397 aa overlap (50-445:10-405)
20 30 40 50 60 70
pF1KE4 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL
::::.:::::::::..::::::.:.:...:
NP_001 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDL
10 20 30
80 90 100 110 120 130
pF1KE4 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI
. .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.:::::::::
NP_001 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK
::::::::::: :::::::::: ::.::: :::::.::::.:::::. : ....::.
NP_001 RNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY
::. . :.:: .:::.::::: :.:: :::: ::.:..: ::::.:::::::: :
NP_001 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD
:::::::::::.::.::..:. .:::::::::::::::..:: :::.:::::::::::::
NP_001 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG
.:::.::::.::::::::::::.:::::::::::::: .:::. :::::::::::::::
NP_001 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL
: ::.:::.:..: ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:.
NP_001 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM
340 350 360 370 380 390
440 450
pF1KE4 DTIKSNLDRALGRQ
: . ::
NP_001 DKLGENLKIKLAQAKL
400 410
>>NP_005887 (OMIM: 137800,147700) isocitrate dehydrogena (414 aa)
initn: 1912 init1: 1134 opt: 1934 Z-score: 2421.4 bits: 457.1 E(85289): 3.9e-128
Smith-Waterman score: 1934; 70.8% identity (88.4% similar) in 397 aa overlap (50-445:10-405)
20 30 40 50 60 70
pF1KE4 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL
::::.:::::::::..::::::.:.:...:
NP_005 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDL
10 20 30
80 90 100 110 120 130
pF1KE4 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI
. .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.:::::::::
NP_005 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK
::::::::::: :::::::::: ::.::: :::::.::::.:::::. : ....::.
NP_005 RNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY
::. . :.:: .:::.::::: :.:: :::: ::.:..: ::::.:::::::: :
NP_005 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD
:::::::::::.::.::..:. .:::::::::::::::..:: :::.:::::::::::::
NP_005 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG
.:::.::::.::::::::::::.:::::::::::::: .:::. :::::::::::::::
NP_005 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL
: ::.:::.:..: ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:.
NP_005 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM
340 350 360 370 380 390
440 450
pF1KE4 DTIKSNLDRALGRQ
: . ::
NP_005 DKLGENLKIKLAQAKL
400 410
452 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:09:12 2016 done: Sun Nov 6 01:09:13 2016
Total Scan time: 6.430 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]