Result of FASTA (omim) for
pFN21AE4426
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4426, 443 aa
1>>>pF1KE4426 443 - 443 aa - 443 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3606+/-0.000395; mu= 17.2269+/- 0.024
mean_var=68.3969+/-13.563, 0's: 0 Z-trim(111.4): 50 B-trim: 0 in 0/53
Lambda= 0.155080
statistics sampled from 19883 (19930) to 19883 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.607), E-opt: 0.2 (0.234), width: 16
Scan time: 7.620
The best scores are: opt bits E(85289)
NP_001005502 (OMIM: 114860) carboxypeptidase M pre ( 443) 3050 691.7 9.8e-199
NP_001865 (OMIM: 114860) carboxypeptidase M precur ( 443) 3050 691.7 9.8e-199
NP_938079 (OMIM: 114860) carboxypeptidase M precur ( 443) 3050 691.7 9.8e-199
NP_001186704 (OMIM: 603102) carboxypeptidase D iso (1133) 1245 288.1 7.9e-77
NP_001295 (OMIM: 603102) carboxypeptidase D isofor (1380) 1245 288.2 9.3e-77
NP_001299 (OMIM: 212070,603103) carboxypeptidase N ( 458) 678 161.0 5.7e-39
NP_001864 (OMIM: 114855) carboxypeptidase E prepro ( 476) 657 156.4 1.5e-37
NP_001014448 (OMIM: 603105) carboxypeptidase Z iso ( 515) 593 142.1 3.3e-33
NP_003643 (OMIM: 603105) carboxypeptidase Z isofor ( 641) 593 142.1 4e-33
NP_001014447 (OMIM: 603105) carboxypeptidase Z iso ( 652) 593 142.1 4.1e-33
NP_062555 (OMIM: 609555) probable carboxypeptidase ( 734) 535 129.2 3.6e-29
NP_001171628 (OMIM: 609555) probable carboxypeptid ( 660) 382 94.9 6.7e-19
XP_011513464 (OMIM: 602981) PREDICTED: adipocyte e (1132) 370 92.4 6.7e-18
NP_001120 (OMIM: 602981) adipocyte enhancer-bindin (1158) 370 92.4 6.9e-18
NP_065094 (OMIM: 609562,614417,614418) carboxypept ( 437) 187 51.2 6.5e-06
XP_016869135 (OMIM: 609562,614417,614418) PREDICTE ( 289) 165 46.2 0.00014
XP_011515872 (OMIM: 609562,614417,614418) PREDICTE ( 289) 165 46.2 0.00014
NP_057436 (OMIM: 607635) carboxypeptidase A4 isofo ( 421) 158 44.7 0.00056
NP_001862 (OMIM: 114852) carboxypeptidase B prepro ( 417) 151 43.1 0.0016
NP_001860 (OMIM: 600688) carboxypeptidase A2 precu ( 419) 145 41.8 0.0042
NP_001156918 (OMIM: 607635) carboxypeptidase A4 is ( 388) 140 40.6 0.0086
>>NP_001005502 (OMIM: 114860) carboxypeptidase M precurs (443 aa)
initn: 3050 init1: 3050 opt: 3050 Z-score: 3688.9 bits: 691.7 E(85289): 9.8e-199
Smith-Waterman score: 3050; 100.0% identity (100.0% similar) in 443 aa overlap (1-443:1-443)
10 20 30 40 50 60
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP
370 380 390 400 410 420
430 440
pF1KE4 DHSAATKPSLFLFLVSLLHIFFK
:::::::::::::::::::::::
NP_001 DHSAATKPSLFLFLVSLLHIFFK
430 440
>>NP_001865 (OMIM: 114860) carboxypeptidase M precursor (443 aa)
initn: 3050 init1: 3050 opt: 3050 Z-score: 3688.9 bits: 691.7 E(85289): 9.8e-199
Smith-Waterman score: 3050; 100.0% identity (100.0% similar) in 443 aa overlap (1-443:1-443)
10 20 30 40 50 60
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP
370 380 390 400 410 420
430 440
pF1KE4 DHSAATKPSLFLFLVSLLHIFFK
:::::::::::::::::::::::
NP_001 DHSAATKPSLFLFLVSLLHIFFK
430 440
>>NP_938079 (OMIM: 114860) carboxypeptidase M precursor (443 aa)
initn: 3050 init1: 3050 opt: 3050 Z-score: 3688.9 bits: 691.7 E(85289): 9.8e-199
Smith-Waterman score: 3050; 100.0% identity (100.0% similar) in 443 aa overlap (1-443:1-443)
10 20 30 40 50 60
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP
370 380 390 400 410 420
430 440
pF1KE4 DHSAATKPSLFLFLVSLLHIFFK
:::::::::::::::::::::::
NP_938 DHSAATKPSLFLFLVSLLHIFFK
430 440
>>NP_001186704 (OMIM: 603102) carboxypeptidase D isoform (1133 aa)
initn: 1260 init1: 1019 opt: 1245 Z-score: 1500.3 bits: 288.1 E(85289): 7.9e-77
Smith-Waterman score: 1245; 50.7% identity (77.1% similar) in 363 aa overlap (19-377:253-609)
10 20 30 40
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSI
::..:. :: ::. :..: ..:.:.:.
NP_001 TTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSL
230 240 250 260 270 280
50 60 70 80 90 100
pF1KE4 GKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDP
::::..:.:.:. .. : :. : :::::..::::.:.:::::::.::.:: . : ::
NP_001 GKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDP
290 300 310 320 330 340
110 120 130 140 150 160
pF1KE4 EITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQ
:.:.:...::::.::::::::.: .. : :::.: :..:::::::: : . :
NP_001 EVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQ
350 360 370 380 390 400
170 180 190 200 210 220
pF1KE4 PETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHT
:::.:::.:.:. ::::::::::.::..::::. :. : ::.: ::: ::: .: .
NP_001 PETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGL-ATYSKS--PDDAVFQQIALS
410 420 430 440 450
230 240 250 260 270 280
pF1KE4 YASRNPNMKKGDECKNKMN---FPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCC
:...: .: .: ::: . ::.:.::: ::: . :::::.::. ..:::.:.::.:
NP_001 YSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCV
460 470 480 490 500 510
290 300 310 320 330 340
pF1KE4 KYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQ-NGNPLPNVIVEVQDRKHICPYR
::: :..::.::..:. :::...:::: ::.: :.: .: . :. . : . .: :
NP_001 KYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINH--PVT
520 530 540 550 560 570
350 360 370 380 390 400
pF1KE4 TNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIP
: : :.:. ::.::.: :.... :..: .:: .
NP_001 TYKTGDYWRLLVPGTYKITASARGYNP-VTKNVTVKSEGAIQVNFTLVRSSTDSNNESKK
580 590 600 610 620 630
410 420 430 440
pF1KE4 VSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK
NP_001 GKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFL
640 650 660 670 680 690
>--
initn: 607 init1: 346 opt: 779 Z-score: 936.9 bits: 183.9 E(85289): 1.9e-45
Smith-Waterman score: 779; 34.4% identity (66.9% similar) in 369 aa overlap (14-378:679-1028)
10 20 30 40
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVT
:. :: . :: . . ::. ...:: .:
NP_001 DPTTKEFETLIKDLSAENGLESLMLRSSSNLALAL-YRYHSYKDLSEFLRGLVMNYPHIT
650 660 670 680 690 700
50 60 70 80 90 100
pF1KE4 HLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTS
.: ..:.:.. :..: : .. :. . :....::..::. :: :::: : ..: .
NP_001 NLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLN
710 720 730 740 750 760
110 120 130 140 150 160
pF1KE4 DGKDPEITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYN
:.: .:.:.. ::: :.::.:::: : ... :: .::. : ::. .: :
NP_001 YKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFT-----N
770 780 790 800 810 820
170 180 190 200 210 220
pF1KE4 NVSRQPETVAVMKWL-KTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVF
:.: :::: :... : . . : ::. : ::.....::.:. ::.. . ...
NP_001 NAS-QPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTV---------ENKETL
830 840 850 860 870
230 240 250 260 270
pF1KE4 QYLAHTYASRNPNMKKGDE-CKNKM--NFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEIT
..:: ::. .:.:. :. : :: :.:.:: : :. :.:.::. ...: :::
NP_001 KHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEIT
880 890 900 910 920 930
280 290 300 310 320 330
pF1KE4 LELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKH
. ::: .: .:::.: .:: ::. .. .:: ::.: : :..:.:. .... ... .
NP_001 VYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIK
940 950 960 970 980 990
340 350 360 370 380 390
pF1KE4 ICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQ
. .:.. : ...:: :: . : . . :.. . ..:..
NP_001 V---QTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGL
1000 1010 1020 1030 1040
400 410 420 430 440
pF1KE4 LDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK
NP_001 PRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSK
1050 1060 1070 1080 1090 1100
>--
initn: 591 init1: 353 opt: 651 Z-score: 782.1 bits: 155.2 E(85289): 8e-37
Smith-Waterman score: 651; 50.2% identity (75.6% similar) in 205 aa overlap (183-380:3-202)
160 170 180 190 200 210
pF1KE4 NRNFPDAFEYNNVSRQPETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQ--ATGAL
::::.:::::..:::::::.. . ::: .
NP_001 MRFVLSGNLHGGSVVASYPFDDSPEHKATG-I
10 20 30
220 230 240 250 260
pF1KE4 YSRSLTPDDDVFQYLAHTYASRNPNMKKGD-ECKNKMN--FPNGVTNGYSWYPLQGGMQD
::. : ::.::.:::..::: .: :: :. .: . . : .:.::: :: ..:::::
NP_001 YSK--TSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQD
40 50 60 70 80
270 280 290 300 310 320
pF1KE4 YNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQ-NGNP
:::.::.:::::::::::::: .: . :.::. ::: :..::.:::: : :. .:.
NP_001 YNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSG
90 100 110 120 130 140
330 340 350 360 370 380
pF1KE4 LPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDP-HITKVIIPEKSQNF
: :. . : .: :...:..: ::.::.: ..:.. :. : .:.:.. :
NP_001 LENATISVAGINH--NITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATE
150 160 170 180 190 200
390 400 410 420 430 440
pF1KE4 SALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK
NP_001 VDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLR
210 220 230 240 250 260
>>NP_001295 (OMIM: 603102) carboxypeptidase D isoform 1 (1380 aa)
initn: 1260 init1: 1019 opt: 1245 Z-score: 1499.0 bits: 288.2 E(85289): 9.3e-77
Smith-Waterman score: 1245; 50.7% identity (77.1% similar) in 363 aa overlap (19-377:500-856)
10 20 30 40
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSI
::..:. :: ::. :..: ..:.:.:.
NP_001 TTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSL
470 480 490 500 510 520
50 60 70 80 90 100
pF1KE4 GKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDP
::::..:.:.:. .. : :. : :::::..::::.:.:::::::.::.:: . : ::
NP_001 GKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDP
530 540 550 560 570 580
110 120 130 140 150 160
pF1KE4 EITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQ
:.:.:...::::.::::::::.: .. : :::.: :..:::::::: : . :
NP_001 EVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQ
590 600 610 620 630 640
170 180 190 200 210 220
pF1KE4 PETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHT
:::.:::.:.:. ::::::::::.::..::::. :. : ::.: ::: ::: .: .
NP_001 PETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGL-ATYSKS--PDDAVFQQIALS
650 660 670 680 690 700
230 240 250 260 270 280
pF1KE4 YASRNPNMKKGDECKNKMN---FPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCC
:...: .: .: ::: . ::.:.::: ::: . :::::.::. ..:::.:.::.:
NP_001 YSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCV
710 720 730 740 750 760
290 300 310 320 330 340
pF1KE4 KYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQ-NGNPLPNVIVEVQDRKHICPYR
::: :..::.::..:. :::...:::: ::.: :.: .: . :. . : . .: :
NP_001 KYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINH--PVT
770 780 790 800 810 820
350 360 370 380 390 400
pF1KE4 TNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIP
: : :.:. ::.::.: :.... :..: .:: .
NP_001 TYKTGDYWRLLVPGTYKITASARGYNP-VTKNVTVKSEGAIQVNFTLVRSSTDSNNESKK
830 840 850 860 870 880
410 420 430 440
pF1KE4 VSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK
NP_001 GKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFL
890 900 910 920 930 940
>--
initn: 925 init1: 353 opt: 952 Z-score: 1144.8 bits: 222.6 E(85289): 5e-57
Smith-Waterman score: 1007; 42.5% identity (69.0% similar) in 400 aa overlap (18-380:55-449)
10 20 30 40
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHS
.: ::..: :. ...: . ....: :
NP_001 LGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFS
30 40 50 60 70 80
50 60 70 80
pF1KE4 IGKSVKGRNLWVLVV----GRFPKEHRIGI---------------PEFKYVANMHGDETV
::.::.:: :::: . : . : : :. : :.::::::::
NP_001 IGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETV
90 100 110 120 130 140
90 100 110 120 130 140
pF1KE4 GRELLLHLIDYLVTSDGK-DPEITNLINSTRIHIMPSMNPDGFEAVKKPDCYY-------
.:..:..: :... . ::... :.:.: ....::.:::::: ... :: .
NP_001 SRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSG
150 160 170 180 190 200
150 160 170 180 190
pF1KE4 SIGRENYNQYDLNRNFPDAF---EYNNVSRQPETVAVMKWLKTETFVLSANLHGGALVAS
. ::.: ::::.::: : : ... ::. :...:.. . ::::.:::::..:::
NP_001 ASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVAS
210 220 230 240 250 260
200 210 220 230 240 250
pF1KE4 YPFDNGVQ--ATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD-ECKNKMN--FPNGV
::::.. . ::: .::. : ::.::.:::..::: .: :: :. .: . . : .:.
NP_001 YPFDDSPEHKATG-IYSK--TSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGI
270 280 290 300 310 320
260 270 280 290 300 310
pF1KE4 TNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVH
::: :: ..::::::::.::.:::::::::::::: .: . :.::. ::: :..::
NP_001 TNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVH
330 340 350 360 370 380
320 330 340 350 360 370
pF1KE4 LGVKGQVFDQ-NGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDP
.:::: : :. .:. : :. . : .: :...:..: ::.::.: ..:.. :. :
NP_001 IGVKGFVKDSITGSGLENATISVAGINH--NITTGRFGDFYRLLVPGTYNLTVVLTGYMP
390 400 410 420 430
380 390 400 410 420 430
pF1KE4 -HITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSL
.:.:.. :
NP_001 LTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPK
440 450 460 470 480 490
>--
initn: 607 init1: 346 opt: 779 Z-score: 935.6 bits: 183.9 E(85289): 2.3e-45
Smith-Waterman score: 779; 34.4% identity (66.9% similar) in 369 aa overlap (14-378:926-1275)
10 20 30 40
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVT
:. :: . :: . . ::. ...:: .:
NP_001 DPTTKEFETLIKDLSAENGLESLMLRSSSNLALAL-YRYHSYKDLSEFLRGLVMNYPHIT
900 910 920 930 940 950
50 60 70 80 90 100
pF1KE4 HLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTS
.: ..:.:.. :..: : .. :. . :....::..::. :: :::: : ..: .
NP_001 NLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLN
960 970 980 990 1000 1010
110 120 130 140 150 160
pF1KE4 DGKDPEITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYN
:.: .:.:.. ::: :.::.:::: : ... :: .::. : ::. .: :
NP_001 YKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFT-----N
1020 1030 1040 1050 1060
170 180 190 200 210 220
pF1KE4 NVSRQPETVAVMKWL-KTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVF
:.: :::: :... : . . : ::. : ::.....::.:. ::.. . ...
NP_001 NAS-QPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTV---------ENKETL
1070 1080 1090 1100 1110
230 240 250 260 270
pF1KE4 QYLAHTYASRNPNMKKGDE-CKNKM--NFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEIT
..:: ::. .:.:. :. : :: :.:.:: : :. :.:.::. ...: :::
NP_001 KHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEIT
1120 1130 1140 1150 1160 1170
280 290 300 310 320 330
pF1KE4 LELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKH
. ::: .: .:::.: .:: ::. .. .:: ::.: : :..:.:. .... ... .
NP_001 VYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIK
1180 1190 1200 1210 1220 1230
340 350 360 370 380 390
pF1KE4 ICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQ
. .:.. : ...:: :: . : . . :.. . ..:..
NP_001 V---QTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGL
1240 1250 1260 1270 1280 1290
400 410 420 430 440
pF1KE4 LDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK
NP_001 PRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSK
1300 1310 1320 1330 1340 1350
>>NP_001299 (OMIM: 212070,603103) carboxypeptidase N cat (458 aa)
initn: 1047 init1: 364 opt: 678 Z-score: 820.6 bits: 161.0 E(85289): 5.7e-39
Smith-Waterman score: 1049; 43.5% identity (69.2% similar) in 416 aa overlap (6-392:9-419)
10 20 30 40 50
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNL
: : ::. ::: . : .:: . . : : .. ..:...:::.::.::.:
NP_001 MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 WVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTS-DGKDPEITNLINS
.:: . : :. :: :::.::::.:..::::.:.: ..: ... .:..::..
NP_001 YVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQD
70 80 90 100 110 120
120 130 140 150 160
pF1KE4 TRIHIMPSMNPDGFE--AVKKPDCY-YSIGRENYNQYDLNRNFPDAFEY-----------
:::::.:::::::.: :.. :. : .::.: : :::::::: :
NP_001 TRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPN
130 140 150 160 170 180
170 180 190 200 210
pF1KE4 ------NNVSRQ--PETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQ--ATGALYS
.: . : ::: ::..:... .:::::::::::.::.::.:.. . . :. .
NP_001 HHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRT
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE4 RSL-TPDDDVFQYLAHTYASRNPNMKKGDECKNKMNFPNGVTNGYSWYPLQGGMQDYNYI
: :::: .:: ::..:. . : .: .: . ::.:.::: ::: :. ::::.::.
NP_001 ASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGD--YFPDGITNGASWYSLSKGMQDFNYL
250 260 270 280 290
280 290 300 310 320 330
pF1KE4 WAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVI
..:::::::::: :.: ::.: : .:. .::....::: :.::.:.:.: : : :..
NP_001 HTNCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAV
300 310 320 330 340 350
340 350 360 370 380
pF1KE4 VEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVII-PEKSQ--NFSAL
. :. .: .. .:.:. ::::: : ...:.::.::. . : . : . :: :
NP_001 ISVSGINH--DVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFH-L
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE4 KKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK
:..:
NP_001 KRSIPQVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA
420 430 440 450
>>NP_001864 (OMIM: 114855) carboxypeptidase E preproprot (476 aa)
initn: 1053 init1: 364 opt: 657 Z-score: 795.0 bits: 156.4 E(85289): 1.5e-37
Smith-Waterman score: 1015; 42.9% identity (67.5% similar) in 394 aa overlap (18-379:49-438)
10 20 30 40
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHS
..:.::: .. : .: . ........
NP_001 CGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYT
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE4 IGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKD
.:.: .::.: :. .. : :. : :::::..::::.:.::::::. : .:: . :
NP_001 VGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKG
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE4 PE-ITNLINSTRIHIMPSMNPDGFE-AVKKPDCY--YSIGRENYNQYDLNRNFPDA--FE
: :.:::.:::::::::.:::::: :...: . .:: : . :::::::: .
NP_001 NETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIV
140 150 160 170 180 190
170 180 190 200
pF1KE4 Y---------------------NNVSRQPETVAVMKWLKTETFVLSANLHGGALVASYPF
: .:.. ::: ::..:. :::::::::: :::.::.
NP_001 YVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPY
200 210 220 230 240 250
210 220 230 240 250
pF1KE4 DNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDE--CK---NKMNFPNGVTNG
:. .:. . : .::: .:: ::..:.: :: :. .. :. . .: .:.:::
NP_001 DE--TRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNG
260 270 280 290 300 310
260 270 280 290 300 310
pF1KE4 YSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGV
.:: . :::::.::. ..:::::.:::: :.: :: : ..:..:: ::: :..:.: ::
NP_001 GAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGV
320 330 340 350 360 370
320 330 340 350 360 370
pF1KE4 KGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITK
:: : : .:::. :. . :. : . : :.:. ::.::.: .....::. :
NP_001 KGFVRDLQGNPIANATISVEGIDH--DVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKK
380 390 400 410 420 430
380 390 400 410 420 430
pF1KE4 VIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLV
: .:
NP_001 VAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF
440 450 460 470
>>NP_001014448 (OMIM: 603105) carboxypeptidase Z isoform (515 aa)
initn: 900 init1: 301 opt: 593 Z-score: 717.1 bits: 142.1 E(85289): 3.3e-33
Smith-Waterman score: 903; 38.5% identity (63.1% similar) in 426 aa overlap (20-415:48-467)
10 20 30 40
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIG
:..: : :. .:. . :.. .:::
NP_001 EGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIG
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE4 KSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSD--GKD
.: ::.: :. . : .:.. :: : ..:.::.:..:::.:..: .:: . : .
NP_001 RSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLG-N
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE4 PEITNLINSTRIHIMPSMNPDGFEAVKKPDCYY---SIGRENYNQYDLNRNFPD-AFEYN
:.: :.:.::::..:::::::.:.. : . ::.: .. :::::::: . ::
NP_001 PRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYY
140 150 160 170 180 190
170 180 190 200
pF1KE4 NVSRQ--------------------PETVAVMKWLKTETFVLSANLHGGALVASYPFDNG
... ::: :.:::..: :::::.:::: ::.::::: .
NP_001 RLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFS
200 210 220 230 240 250
210 220 230 240 250 260
pF1KE4 VQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNF--PNGVTNGYSWYPL
. : :::. .:. :...::. .: : .: . :: ... :: .:: .
NP_001 -KHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSF
260 270 280 290 300 310
270 280 290 300 310 320
pF1KE4 QGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFD
:::.:.::. ..:::::.::.: :.: :: : ..:..:: ::..... :: :.:: : :
NP_001 TGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTD
320 330 340 350 360 370
330 340 350 360 370 380
pF1KE4 QNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEK
. :.:. :. . :. .: : :.:. :: :: .:. . .::. : ::::: .
NP_001 KFGKPVKNARISVKGIRH--DITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPAR
380 390 400 410 420 430
390 400 410 420 430
pF1KE4 SQNFSALKKD-ILLPF-QGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLH
. : . : :: :. .: . : . : ::
NP_001 MKR--AGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSAD
440 450 460 470 480 490
440
pF1KE4 IFFK
NP_001 GSKPWWWSYFTSLSTHRPRWLLKY
500 510
>>NP_003643 (OMIM: 603105) carboxypeptidase Z isoform 2 (641 aa)
initn: 900 init1: 301 opt: 593 Z-score: 715.6 bits: 142.1 E(85289): 4e-33
Smith-Waterman score: 903; 38.5% identity (63.1% similar) in 426 aa overlap (20-415:174-593)
10 20 30 40
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIG
:..: : :. .:. . :.. .:::
NP_003 EGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIG
150 160 170 180 190 200
50 60 70 80 90 100
pF1KE4 KSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSD--GKD
.: ::.: :. . : .:.. :: : ..:.::.:..:::.:..: .:: . : .
NP_003 RSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLG-N
210 220 230 240 250 260
110 120 130 140 150 160
pF1KE4 PEITNLINSTRIHIMPSMNPDGFEAVKKPDCYY---SIGRENYNQYDLNRNFPD-AFEYN
:.: :.:.::::..:::::::.:.. : . ::.: .. :::::::: . ::
NP_003 PRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYY
270 280 290 300 310 320
170 180 190 200
pF1KE4 NVSRQ--------------------PETVAVMKWLKTETFVLSANLHGGALVASYPFDNG
... ::: :.:::..: :::::.:::: ::.::::: .
NP_003 RLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFS
330 340 350 360 370 380
210 220 230 240 250 260
pF1KE4 VQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNF--PNGVTNGYSWYPL
. : :::. .:. :...::. .: : .: . :: ... :: .:: .
NP_003 -KHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSF
390 400 410 420 430 440
270 280 290 300 310 320
pF1KE4 QGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFD
:::.:.::. ..:::::.::.: :.: :: : ..:..:: ::..... :: :.:: : :
NP_003 TGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTD
450 460 470 480 490 500
330 340 350 360 370 380
pF1KE4 QNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEK
. :.:. :. . :. .: : :.:. :: :: .:. . .::. : ::::: .
NP_003 KFGKPVKNARISVKGIRH--DITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPAR
510 520 530 540 550
390 400 410 420 430
pF1KE4 SQNFSALKKD-ILLPF-QGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLH
. : . : :: :. .: . : . : ::
NP_003 MKR--AGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSAD
560 570 580 590 600 610
440
pF1KE4 IFFK
NP_003 GSKPWWWSYFTSLSTHRPRWLLKY
620 630 640
>>NP_001014447 (OMIM: 603105) carboxypeptidase Z isoform (652 aa)
initn: 900 init1: 301 opt: 593 Z-score: 715.5 bits: 142.1 E(85289): 4.1e-33
Smith-Waterman score: 903; 38.5% identity (63.1% similar) in 426 aa overlap (20-415:185-604)
10 20 30 40
pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIG
:..: : :. .:. . :.. .:::
NP_001 EGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIG
160 170 180 190 200 210
50 60 70 80 90 100
pF1KE4 KSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSD--GKD
.: ::.: :. . : .:.. :: : ..:.::.:..:::.:..: .:: . : .
NP_001 RSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLG-N
220 230 240 250 260 270
110 120 130 140 150 160
pF1KE4 PEITNLINSTRIHIMPSMNPDGFEAVKKPDCYY---SIGRENYNQYDLNRNFPD-AFEYN
:.: :.:.::::..:::::::.:.. : . ::.: .. :::::::: . ::
NP_001 PRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYY
280 290 300 310 320 330
170 180 190 200
pF1KE4 NVSRQ--------------------PETVAVMKWLKTETFVLSANLHGGALVASYPFDNG
... ::: :.:::..: :::::.:::: ::.::::: .
NP_001 RLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFS
340 350 360 370 380 390
210 220 230 240 250 260
pF1KE4 VQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNF--PNGVTNGYSWYPL
. : :::. .:. :...::. .: : .: . :: ... :: .:: .
NP_001 -KHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSF
400 410 420 430 440 450
270 280 290 300 310 320
pF1KE4 QGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFD
:::.:.::. ..:::::.::.: :.: :: : ..:..:: ::..... :: :.:: : :
NP_001 TGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTD
460 470 480 490 500 510
330 340 350 360 370 380
pF1KE4 QNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEK
. :.:. :. . :. .: : :.:. :: :: .:. . .::. : ::::: .
NP_001 KFGKPVKNARISVKGIRH--DITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPAR
520 530 540 550 560 570
390 400 410 420 430
pF1KE4 SQNFSALKKD-ILLPF-QGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLH
. : . : :: :. .: . : . : ::
NP_001 MKR--AGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSAD
580 590 600 610 620
440
pF1KE4 IFFK
NP_001 GSKPWWWSYFTSLSTHRPRWLLKY
630 640 650
443 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:11:48 2016 done: Sun Nov 6 01:11:50 2016
Total Scan time: 7.620 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]